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Development and validation of a nomogram for predicting mortality for ICU patients with severe thoracic trauma: data from the MIMIC-IV. 预测重症监护室严重胸外伤患者死亡率的nomogram发展和验证:来自MIMIC-IV的数据
IF 2
Injury Pub Date : 2025-10-01 Epub Date: 2025-08-07 DOI: 10.1016/j.injury.2025.112666
Ziming Huang, Hengfa Ge, Ying Sun
{"title":"Development and validation of a nomogram for predicting mortality for ICU patients with severe thoracic trauma: data from the MIMIC-IV.","authors":"Ziming Huang, Hengfa Ge, Ying Sun","doi":"10.1016/j.injury.2025.112666","DOIUrl":"10.1016/j.injury.2025.112666","url":null,"abstract":"<p><strong>Background: </strong>Severe thoracic trauma is a leading contributor to mortality in critically injured patients, particularly when complicated by concomitant severe traumatic brain injury (TBI), which may independently impair neurological and respiratory function. Accurate assessment and timely intervention play a crucial role in these patients. However, risk factors for severe thoracic trauma remain unclear, and a prediction rule remains to be established. We developed and internally validated a nomogram that allows clinicians to quantify the risk of severe thoracic trauma.</p><p><strong>Methods: </strong>Clinical data from the MIMIC-IV database were retrospectively searched to identify a study cohort comprising patients with severe thoracic trauma. Using LASSO regression analysis, We screened out independent risk factors associated with 28-day mortality and incorporated them into nomogram model. The performance of each model was assessed by calculating receiver operating characteristic (ROC) curves, calibration plots and decision curve analysis (DCA).</p><p><strong>Results: </strong>The final analysis incorporated 2159 patients, with 192 deaths (8.9 %) occurring within 28-day of ICU admission. we constructed a nomogram that incorporates risk factors including heart rate (HR), traumatic brain injury (TBI), oxygen saturation (SpO2), systolic blood pressure (SBP), ventilation, and Sequential Organ Failure Assessment (SOFA) score on the first day of admission to ICU. The nomogram outperformed SOFA and Model 1 (risk factors including SBP, SpO2, TBI and ventilation) with an area under the receiver operating characteristic curve (ROC) of 0.854 (95 %CI 0.736-0.791, P < 0.001) in the training cohort and 0.859 (95 %CI 0.713-0.794, P < 0.001) in the validation cohort. The analysis of the calibration curve demonstrated that the nomogram exhibited a strong alignment with the observed 28-day mortality rates in severe thoracic trauma patients.</p><p><strong>Conclusions: </strong>The study identified independent risk factors associated with the 28-day mortality risk and developed predictive nomogram models for ICU patients suffering from severe thoracic trauma. The nomogram shows promise in guiding strategies aimed at improving prognosis for patients with such injuries.</p>","PeriodicalId":94042,"journal":{"name":"Injury","volume":"56 10","pages":"112666"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term outcome after surgical management of symptomatic non-union rib fractures 手术治疗无症状不愈合肋骨骨折后的长期疗效
Injury Pub Date : 2023-12-20 DOI: 10.1016/j.injury.2023.111297
Julia Nilsson, Eva-Corina Caragounis
{"title":"Long-term outcome after surgical management of symptomatic non-union rib fractures","authors":"Julia Nilsson, Eva-Corina Caragounis","doi":"10.1016/j.injury.2023.111297","DOIUrl":"https://doi.org/10.1016/j.injury.2023.111297","url":null,"abstract":"<h3>Introduction</h3><p>Traumatic chest wall injuries are common however the incidence of non-union rib fractures is unknown. Previous studies have suggested that surgical management of symptomatic non-union rib fractures could be beneficial in selected patients, although many experience persisting pain despite surgery. The aim of this study is to investigate the long-term outcome after surgical management of symptomatic non-union rib fractures.</p><h3>Methods</h3><p>This is a cross-sectional study including adults (≥18 years) managed surgically for symptomatic non-union rib fractures with plate fixation during the period 2010–2020 at Sahlgrenska University Hospital. Patients operated for acute chest wall injury or injury due to cardiopulmonary resuscitation were excluded. Patients answered standardized questionnaires concerning remaining symptoms and satisfaction with surgery, quality of life (QoL, EQ-5D-5L) and disability (Disability Rating Index, DRI). Lung function, movement of chest wall and thoracic spine, and shoulder function (Boström index) were assessed.</p><h3>Results</h3><p>Sixteen patients, 12 men and four women, with mean age 61.6±11.1 were included in the study. The mechanism of injury was trauma in 10 patients and cough-induced injuries in five patients. Lung disease was significantly more prevalent in cough-induced injuries compared to traumatic injuries, 5 vs 1 (p=0.008). The mean follow-up time was 3.5 years. Ninety-four percent were satisfied with the surgery and reported that their symptoms had decreased, although 69% had remaining symptoms, especially pain, from the chest wall. Quality of Life was decreased with EQ-5D-5L index 0.819 (0.477–0.976) and EQ-VAS 69 (10–100). Disability Rating Index was 31.5 (1.3–76.7) with problems running, lifting heavy objects, and performing heavy work. Predicted lung function was decreased with Forced Vital Capacity (FVC) 86.2±14.2%, Forced Expiratory Volume in 1 second (FEV1) 79.1±10.7% and Peak Expiratory Flow (PEF) 89.7±14.5%. Patients with cough-induced injuries had full shoulder mobility.</p><h3>Conclusions</h3><p>Chest wall surgery for symptomatic non-union rib fractures results in decreased symptoms and patient satisfaction in most cases despite remaining symptoms, reduced lung function, chest wall movement, and QoL and persistent disability.</p>","PeriodicalId":94042,"journal":{"name":"Injury","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139030740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Diagnosis and Treatment of Criss-Cross Injury of The Forearm: A Retrospective Analysis 前臂十字交叉伤的诊断与治疗:回顾性分析
Injury Pub Date : 2023-12-01 DOI: 10.1016/j.injury.2023.111295
Tan Jie, Xiong Jie, Xigong Zhang, Minghui Yang, Li Ting, Gong Maoqi
{"title":"The Diagnosis and Treatment of Criss-Cross Injury of The Forearm: A Retrospective Analysis","authors":"Tan Jie, Xiong Jie, Xigong Zhang, Minghui Yang, Li Ting, Gong Maoqi","doi":"10.1016/j.injury.2023.111295","DOIUrl":"https://doi.org/10.1016/j.injury.2023.111295","url":null,"abstract":"","PeriodicalId":94042,"journal":{"name":"Injury","volume":"163 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139015605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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