Hemodialysis international. International Symposium on Home Hemodialysis最新文献

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Enhancing Postoperative Pain Management: Assessing the Influence of Ultrasound-Guided Stellate Ganglion Block on Arteriovenous Fistula Surgery. 加强术后疼痛管理:评估超声引导星状神经节阻滞对动静脉瘘手术的影响。
Hashemian Morteza, Bahaadini Azadeh, Aflatoonian Behnaz, Vehedian Mehrdad, Nozarinia Mostafa, Shahdadi Hamed, Abolhasani Zadeh Firoozeh
{"title":"Enhancing Postoperative Pain Management: Assessing the Influence of Ultrasound-Guided Stellate Ganglion Block on Arteriovenous Fistula Surgery.","authors":"Hashemian Morteza, Bahaadini Azadeh, Aflatoonian Behnaz, Vehedian Mehrdad, Nozarinia Mostafa, Shahdadi Hamed, Abolhasani Zadeh Firoozeh","doi":"10.1111/hdi.13220","DOIUrl":"https://doi.org/10.1111/hdi.13220","url":null,"abstract":"<p><strong>Introduction: </strong>The effectiveness of stellate ganglion block in managing acute postoperative pain remains uncertain due to limited high-quality evidence. This study evaluates the impact of stellate ganglion block on acute pain following arteriovenous fistula surgery.</p><p><strong>Methods: </strong>A randomized controlled clinical trial was conducted in the Surgery Department of Bahonar and Shafa Hospitals at Kerman University of Medical Sciences, Iran. Patients undergoing arteriovenous fistula surgery were randomly assigned to either the intervention group, which received an ultrasound-guided stellate ganglion block with 5 mL of 5% lidocaine, or the control group, which received no intervention. A total of 60 patients were selected based on age and gender similarity. Pain levels were assessed using the visual analog scale immediately after surgery and at 6 and 12 h postoperatively.</p><p><strong>Findings: </strong>Pain scores differed significantly between the two groups at all time points (p ≤ 0.05). The intervention group reported lower pain levels at 6 and 12 h postoperatively compared to the control group. Repeated measures analysis confirmed a significant reduction in pain over time in both groups (p ≤ 0.05), with a more pronounced decrease in the intervention group (p ≤ 0.05).</p><p><strong>Conclusion: </strong>Preoperative stellate ganglion block effectively reduces acute postoperative pain following arteriovenous fistula surgery. However, its effects beyond the 12-h postoperative period remain unknown. Further research is needed to evaluate its long-term impact.</p>","PeriodicalId":94027,"journal":{"name":"Hemodialysis international. International Symposium on Home Hemodialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship Between Fluid Control and Health Literacy in Patients Receiving Hemodialysis Treatment. 血液透析患者体液控制与健康素养的关系
Havva Doğankaya, Ezgi Mutluay Yayla
{"title":"The Relationship Between Fluid Control and Health Literacy in Patients Receiving Hemodialysis Treatment.","authors":"Havva Doğankaya, Ezgi Mutluay Yayla","doi":"10.1111/hdi.13240","DOIUrl":"https://doi.org/10.1111/hdi.13240","url":null,"abstract":"<p><strong>Background: </strong>Failure to adhere to fluid restrictions negatively affects the quality of life and increases the risk of complications among hemodialysis patients. In chronic diseases, including chronic kidney disease, health literacy plays a crucial role in mitigating disease complications. The level of health literacy in chronic diseases such as chronic kidney disease can play a significant role in reducing the complications of the disease. This study aimed to assess the relationship between fluid control and health literacy in hemodialysis patients, representing the first such research in Turkey.</p><p><strong>Methods: </strong>This descriptive, cross-sectional, and correlational study was conducted in all dialysis centers in Bolu province, Turkey, from September 2022 to August 2023. The study included 144 hemodialysis outpatients meeting the inclusion criteria. Patient fluid control and health literacy were assessed using the \"Fluid Restriction Scale in Patients Receiving Hemodialysis Treatment\" and the \"Turkey Health Literacy Scale-32\". Statistical analysis was performed using SPSS version 25.0.</p><p><strong>Results: </strong>The mean total score on the Health Literacy Scale was 22.6 ± 10.2, indicating a relatively low level of health literacy among the hemodialysis patients. 54.2% of patients receiving hemodialysis treatment exhibited inadequate health literacy. The mean score on the Fluid Restriction Scale was 50.4 ± 8.63, suggesting moderate fluid control adherence among the study population. 56.3% of hemodialysis patients had moderate levels of fluid control. A statistically significant moderate positive correlation was found between fluid control and health literacy levels (r = 0.456, p < 0.001). Health literacy scores accounted for 20.2% of the variance in fluid restriction scores (R<sup>2</sup> = 0.20), indicating a moderate contribution of health literacy to fluid control adherence.</p><p><strong>Conclusion: </strong>This study revealed a positive correlation between health literacy and fluid control adherence. Therefore, it is recommended that hemodialysis nurses concurrently assess patients' health literacy and fluid control and develop tailored educational programs based on these assessments.</p>","PeriodicalId":94027,"journal":{"name":"Hemodialysis international. International Symposium on Home Hemodialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship Between Uric Acid and Mortality in Hemodialysis Patients. 血液透析患者尿酸与死亡率的关系。
Can Hüzmeli, Ayşe Şeker, Hatice Ortaç, Ali Borazan, Serhan Pişkinpaşa, Ferhan Candan
{"title":"The Relationship Between Uric Acid and Mortality in Hemodialysis Patients.","authors":"Can Hüzmeli, Ayşe Şeker, Hatice Ortaç, Ali Borazan, Serhan Pişkinpaşa, Ferhan Candan","doi":"10.1111/hdi.13237","DOIUrl":"https://doi.org/10.1111/hdi.13237","url":null,"abstract":"<p><strong>Introduction: </strong>Uric acid, the end product of purine metabolism, is an antioxidant molecule. Both low and high serum uric acid levels are associated with increased mortality. The aim is to investigate the relationship between serum uric acid levels and mortality in hemodialysis patients.</p><p><strong>Methods: </strong>This retrospective study was conducted on hemodialysis patients in Hatay, Turkey, between 2010 and 2023. Records were reviewed, and serum uric acid levels, other laboratory tests, and hemodialysis duration were noted. Patients on hemodialysis for at least 3 months were included. A p-value of less than 0.05 was considered statistically significant.</p><p><strong>Findings: </strong>A total of 3443 hemodialysis patients were included. The average age was 64.39 ± 13.57 years (minimum: 18 years, maximum: 90 years), and 58% were male. The mean serum uric acid level was 6.23 ± 1.43 mg/dL (range: 0.1-16). The prevalence of hyperuricemia was 39.3%, and hypouricemia was 0.2%. The median parathyroid hormone (PTH) value was lower in the group with a serum uric acid level ≤ 4 mg/dL (p < 0.001) and higher in the group with a serum uric acid level > 7 mg/dL (p < 0.001). There were significant differences in mortality among the study groups (p < 0.001). Subgroup analyses revealed that the mortality rate was higher in the patient group with serum uric acid levels ≤ 4 mg/dL and lower in the group with serum uric acid levels > 7 mg/dL (p < 0.001).</p><p><strong>Discussion: </strong>Low serum uric acid levels have been associated with increased mortality; this may be because serum uric acid is an indicator of nutritional status. Higher serum uric acid levels were associated with higher PTH levels; further studies are needed to elucidate the causal relationship. Low serum uric acid levels were associated with an increased risk of cerebrovascular disease.</p>","PeriodicalId":94027,"journal":{"name":"Hemodialysis international. International Symposium on Home Hemodialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Socioeconomic Factors on the Prevalence of Hemodialysis in Mainland China. 社会经济因素对中国大陆血液透析流行的影响。
Zenghui Xing, Sichen Li, Delong Zhao, Chao Liu, Guangyan Cai, Xiangmei Chen, Xuefeng Sun
{"title":"The Impact of Socioeconomic Factors on the Prevalence of Hemodialysis in Mainland China.","authors":"Zenghui Xing, Sichen Li, Delong Zhao, Chao Liu, Guangyan Cai, Xiangmei Chen, Xuefeng Sun","doi":"10.1111/hdi.13218","DOIUrl":"https://doi.org/10.1111/hdi.13218","url":null,"abstract":"<p><strong>Objective: </strong>The prevalence of hemodialysis varies significantly across countries and regions with different levels of socioeconomic development. This paper aims to analyze the socioeconomic factors influencing hemodialysis in mainland China, providing a basis for formulating reasonable hemodialysis strategies.</p><p><strong>Methods: </strong>All the hemodialysis prevalence data and socioeconomic data were obtained from the National Medical Service and Quality Safety Report and the China Statistical Yearbook. The 31 regions were categorized into low, medium, and high groups based on the per capita gross domestic product, and the changes in hemodialysis prevalence rates and their growth rates were compared. Linear regression analysis was conducted to identify the independent risk factors affecting hemodialysis prevalence rates.</p><p><strong>Results: </strong>Significant differences in hemodialysis prevalence rates were observed across different years and per capita gross domestic product groups (p < 0.001). The prevalence of hemodialysis in the low and medium per capita gross domestic product groups significantly increased from 2011 to 2020 (p < 0.001), while an increase in the high per capita gross domestic product group was not statistically significant (p > 0.05). The growth in hemodialysis prevalence rates over the 10-year period decreased with increasing per capita gross domestic product levels in 2011 (325.2% ± 98.6%, 209.3% ± 61.9%, and 52.6% ± 73.7% for the low, medium, and high per capita gross domestic product groups, respectively). The incidence of hemodialysis, per capita gross domestic product, the proportion of rural-urban population, highway mileage per square kilometer, and the number of beds in medical facilities per 1000 population were identified as independent factors of hemodialysis prevalence rates (p < 0.05).</p><p><strong>Conclusions: </strong>With the development of the social economy and the enhancement of medical service capabilities, the prevalence of hemodialysis in Mainland China has increased. Compared to economically less developed and moderately developed regions, the increase in hemodialysis prevalence in economically developed areas has been attenuated.</p>","PeriodicalId":94027,"journal":{"name":"Hemodialysis international. International Symposium on Home Hemodialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Nickel Concentrations in Patients Receiving Chronic Hemodialysis. 慢性血液透析患者血清镍浓度。
Wen-Yu Ho, Ju-Ching Yen, Cheng-Hao Weng, Wen-Hung Huang, Li-Chung Chiu, Po-Yen Kuo, Kai-Fan Tsai, I-Kuan Wang, Tzung-Hai Yen, Ching-Wei Hsu
{"title":"Serum Nickel Concentrations in Patients Receiving Chronic Hemodialysis.","authors":"Wen-Yu Ho, Ju-Ching Yen, Cheng-Hao Weng, Wen-Hung Huang, Li-Chung Chiu, Po-Yen Kuo, Kai-Fan Tsai, I-Kuan Wang, Tzung-Hai Yen, Ching-Wei Hsu","doi":"10.1111/hdi.13235","DOIUrl":"https://doi.org/10.1111/hdi.13235","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic nickel accumulation is harmful to multiple organ systems, and nickel is classified as a human carcinogen. Nevertheless, few studies have examined serum nickel concentrations in end-stage kidney disease (ESKD) patients receiving chronic hemodialysis, and the relationship of serum nickel with clinical outcomes remains unclear.</p><p><strong>Methods: </strong>This prospective observational study recruited 409 hemodialysis patients in 2019 and followed them for 18 months. The patients were stratified into four quartiles, that is, < 2.9 μg/L (n = 92), 2.9 μg/L to < 3.4 g/L (n = 104), 3.4 μg/L to < 3.9 μg/L (n = 104), and ≥ 3.9 μg/L (n = 109), according to their serum nickel concentrations. Baseline demographic, hematologic, biochemical, dialysis-related, and mortality data were obtained for analysis.</p><p><strong>Findings: </strong>The mean age of the patients was 62.9 ± 11.7 years. A total of 401 (98.04%) patients had elevated serum nickel concentrations, with an average level of 3.6 ± 1.3 μg/L. Higher quartiles of serum nickel were associated with longer dialysis vintage (p < 0.001), higher Kt/V values (p < 0.001), and higher urea removal rates (p < 0.001). Multivariate analysis identified albumin level and dialysis vintage as independent factors positively correlated with serum nickel concentrations (R = 0.163, p = 0.001; R = 0.212, p < 0.001, respectively). Nevertheless, no association was found between serum nickel levels and all-cause mortality.</p><p><strong>Conclusion: </strong>ESKD patients on hemodialysis commonly exhibit elevated serum nickel concentrations, possibly linked to serum albumin levels and dialysis vintage. Further studies are warranted.</p>","PeriodicalId":94027,"journal":{"name":"Hemodialysis international. International Symposium on Home Hemodialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations Between Type of Hemodialysis Access and Pulmonary Hypertension: A Single-Center Retrospective Cohort. 血液透析途径类型与肺动脉高压的关系:一项单中心回顾性队列研究
Muhammad Umair Jahngir, Christine De Antonis, Rizwan Rabbani, Amir Ashiq, Ajiya Fatima, Rabia Ahmed, Avrum Gillespie
{"title":"Associations Between Type of Hemodialysis Access and Pulmonary Hypertension: A Single-Center Retrospective Cohort.","authors":"Muhammad Umair Jahngir, Christine De Antonis, Rizwan Rabbani, Amir Ashiq, Ajiya Fatima, Rabia Ahmed, Avrum Gillespie","doi":"10.1111/hdi.13231","DOIUrl":"https://doi.org/10.1111/hdi.13231","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary hypertension affects patients with hemodialysis-dependent end-stage kidney failure; however, the estimated prevalence varies greatly due to the underutilization of right heart catheterization and the evolving diagnostic criteria of pulmonary hypertension. Pulmonary hypertension in end-stage kidney failure is often attributed to arteriovenous (AV) access; therefore, we hypothesized that patients with AV fistula/graft would have a greater prevalence of pulmonary hypertension on right heart catheterization compared to those with central venous (CV) catheter accesses.</p><p><strong>Methods: </strong>In this retrospective single-center cohort study, we identified and randomly sampled patients from July 2012 to August 2022 receiving hemodialysis for ≥ 3 months and who underwent right heart catheterization, using Current Procedural Terminology codes. Pulmonary hypertension was defined as mean pulmonary arterial pressure (mPAP) > 20 mmHg. Our primary outcome was the prevalence of pulmonary hypertension among patients with AV fistula/graft versus CV hemodialysis access, tested with descriptive statistics. We evaluated survival as a secondary outcome using a Cox proportional hazards model.</p><p><strong>Results: </strong>A total of 3834 patient charts were extracted. Overall, 444 charts were randomly sampled, resulting in 137 subjects meeting the inclusion criteria. The mean age was 63.8 ± 10.5 years, and 62% were male. The most common etiology of end-stage kidney failure was diabetic kidney disease (57.7%). Eighty percent of end-stage kidney failure patients had pulmonary hypertension; however, the type of hemodialysis access was not associated with pulmonary hypertension (85% CV catheter vs. 79.5% AV access, p = 0.59). Patients with pulmonary hypertension had lower hemoglobin (9.6 ± 0.8 vs. 11.2 ± 1.3 g/dL, p < 0.0001) and serum albumin (2.3 ± 0.9 vs. 3.4 ± 0.6 g/dL, p < 0.0001) than those without pulmonary hypertension. Those with pulmonary hypertension had an increased risk of mortality (hazard ratio: 2.2, 95% confidence interval: 1.04-4.61; p = 0.04).</p><p><strong>Conclusion: </strong>Our findings show a high burden of pulmonary hypertension among this heterogeneous cohort of end-stage kidney failure patients, with no association between pulmonary hypertension and the type of hemodialysis access. This study highlights the need for prospective investigations incorporating current strategies for pulmonary hypertension diagnosis and treatment among the dialysis-dependent population.</p>","PeriodicalId":94027,"journal":{"name":"Hemodialysis international. International Symposium on Home Hemodialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carbon Dioxide Digital Subtraction Angiography for Central Venous Recanalization in a Kidney Transplant Patient: A Case Report. 二氧化碳数字减影血管造影用于肾移植患者中心静脉再通:1例报告。
Limei Chen, Ruining Liu, Tianlei Cui
{"title":"Carbon Dioxide Digital Subtraction Angiography for Central Venous Recanalization in a Kidney Transplant Patient: A Case Report.","authors":"Limei Chen, Ruining Liu, Tianlei Cui","doi":"10.1111/hdi.13234","DOIUrl":"https://doi.org/10.1111/hdi.13234","url":null,"abstract":"<p><strong>Background: </strong>We present the case of a kidney transplant recipient with elevated serum creatinine who developed left upper limb swelling due to left subclavian vein thrombosis. Concerned about potential hemodialysis resumption, the patient prioritized preserving their arteriovenous fistula.</p><p><strong>Methods: </strong>To address the swelling and maintain fistula function, central venous recanalization was necessary. Given the risk of iodine contrast-induced acute kidney injury, particularly with elevated creatinine, the patient opted for carbon dioxide (CO<sub>2</sub>) angiography. Following forearm fistula puncture, a catheter was inserted, and 50 mL of CO<sub>2</sub> was injected. Angiography revealed a left subclavian vein filling defect and stenosis, preventing guidewire passage. The stenosis was dilated using an 8 mm × 20 mm balloon, followed by implantation of a 6 mm × 10 mm vascular stent. Postintervention CO<sub>2</sub> angiography confirmed successful vein opening. Oral rivaroxaban was prescribed for anticoagulation.</p><p><strong>Results: </strong>The patient's limb swelling gradually resolved, and serum creatinine remained stable.</p><p><strong>Conclusion: </strong>CO<sub>2</sub>-DSA represents a potentially viable alternative imaging modality for patients requiring vascular interventions who are at elevated risk of iodinated contrast-induced nephropathy.</p>","PeriodicalId":94027,"journal":{"name":"Hemodialysis international. International Symposium on Home Hemodialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment Strategies for Refractory Catheter-Related Central Venous Occlusive Disorders: Review. 难治性导管相关中心静脉闭塞性疾病的治疗策略:综述。
Xiao Ma, Jiehao Chen, Tianqiao Yang, Lan Gao, Yaoxiong Xia
{"title":"Treatment Strategies for Refractory Catheter-Related Central Venous Occlusive Disorders: Review.","authors":"Xiao Ma, Jiehao Chen, Tianqiao Yang, Lan Gao, Yaoxiong Xia","doi":"10.1111/hdi.13229","DOIUrl":"https://doi.org/10.1111/hdi.13229","url":null,"abstract":"<p><strong>Background: </strong>Catheter-related central vein occlusive disease (CVOD) is a frequent complication in hemodialysis patients and significantly affects their prognosis. Current treatment options for catheter-related CVOD include standard guidewire and catheter techniques, radiofrequency ablation, and sharp recanalization. However, large-scale clinical trials evaluating these techniques are lacking, making CVOD management challenging. This article reviews current treatment strategies for catheter-related CVOD.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted via PubMed, focusing on studies evaluating the effectiveness and safety of various treatment modalities for CVOD. The following keywords were used in PubMed: \"hemodialysis\", \"central vein occlusion\", \"central vein stenosis\", and \"catheter\".</p><p><strong>Results: </strong>The treatment methods for refractory CVOD in hemodialysis patients are diverse, including sharp recanalization, radiofrequency ablation, and percutaneous superior vena cava puncture. Complications and success rates vary widely across treatments, and evidence is generally limited to small studies or case series. However, a standardized treatment protocol is still lacking.</p><p><strong>Conclusions: </strong>While several techniques show promise in treating catheter-related CVOD, high-quality clinical studies are necessary to identify the more effective and safe procedure. The choice of treatment should be based on individual patient characteristics, extent of the occlusion, and available resources. Percutaneous SVC puncture may be a feasible alternative after failed sharp recanalization for refractory CVOD.</p>","PeriodicalId":94027,"journal":{"name":"Hemodialysis international. International Symposium on Home Hemodialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Sodium Bicarbonate vs. Use of Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis: A Randomized Controlled Trial. 口服碳酸氢钠与使用高透析液碳酸氢钠治疗血透患者代谢性酸中毒:一项随机对照试验
Hoda M M Abdulaziz, Alaa Sabry, Marwa Saleh, Ghada El-Said
{"title":"Oral Sodium Bicarbonate vs. Use of Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis: A Randomized Controlled Trial.","authors":"Hoda M M Abdulaziz, Alaa Sabry, Marwa Saleh, Ghada El-Said","doi":"10.1111/hdi.13230","DOIUrl":"https://doi.org/10.1111/hdi.13230","url":null,"abstract":"<p><strong>Introduction: </strong>The optimal strategy for correcting metabolic acidosis and maintaining acid-base balance in hemodialysis patients remains unclear. This study aimed to evaluate and compare the effects of oral bicarbonate administration vs. increased dialysate bicarbonate concentration on predialysis serum bicarbonate levels in hemodialysis patients with metabolic acidosis.</p><p><strong>Methods: </strong>This was a single-center, open-label, randomized controlled trial. Adult hemodialysis patients with metabolic acidosis (serum bicarbonate < 22 mmol/L) were randomly assigned in a 1:1:1 ratio to one of three treatment groups for 16 weeks: (1) standard dialysate (32 mM bicarbonate plus 3 mM acetate), (2) increased dialysate bicarbonate (34 mM bicarbonate plus 3 mM acetate), or (3) standard dialysate with daily oral sodium bicarbonate supplementation (0.3-0.5 mmol/kg). Of the 75 eligible participants, 66 completed the study. The primary outcome was the difference in predialysis serum bicarbonate levels between the groups at 16 weeks.</p><p><strong>Results: </strong>Baseline predialysis serum bicarbonate levels averaged approximately 19.5 mmol/L across all three groups. At 16 weeks, there was no statistically significant difference in predialysis serum bicarbonate levels among the groups (p = 0.701). The mean levels were 20.1 (SD 2.16) mmol/L in the standard dialysate group, 20.5 (SD 2.04) mmol/L in the increased dialysate bicarbonate group, and 20.8 (SD 2.61) mmol/L in the oral supplementation group. Compared to baseline, predialysis bicarbonate levels significantly increased within the increased dialysate bicarbonate group (p = 0.010) and the oral supplementation group (p = 0.021), but not in the control (standard dialysate, no oral supplementation) group.</p><p><strong>Conclusion: </strong>Oral or dialytic bicarbonate supplementation at the doses used in this study demonstrated equivalent effects on predialysis serum bicarbonate concentrations in acidotic hemodialysis patients. However, the amount of supplemental bicarbonate administered via either route was insufficient to achieve the target correction of acidosis (e.g., predialysis serum bicarbonate ≥ 22 mmol/L).</p>","PeriodicalId":94027,"journal":{"name":"Hemodialysis international. International Symposium on Home Hemodialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frequent In-Center Hemodialysis: Who Can Benefit From a Frequent Dialysis Approach? 频繁中心血液透析:谁能从频繁透析方法中受益?
Steven G Achinger, Juan Carlos Ayus
{"title":"Frequent In-Center Hemodialysis: Who Can Benefit From a Frequent Dialysis Approach?","authors":"Steven G Achinger, Juan Carlos Ayus","doi":"10.1111/hdi.13225","DOIUrl":"https://doi.org/10.1111/hdi.13225","url":null,"abstract":"<p><p>Frequent (a.k.a daily hemodialysis) has continued to spark interest in the nephrology community as a way to possibly improve outcomes for the end-stage renal disease population. This is a patient population with a very high disease burden and mortality rate. The concept of dialysis adequacy in its current form has consolidated mainly around three times weekly dialysis, which has become the worldwide accepted standard. The current drive to encourage more home hemodialysis (which is a frequent dialysis regimen) has made the lessons from daily in-center hemodialysis more relevant. Frequent hemodialysis has been shown in both observational and randomized controlled studies to have some cardiovascular, mineral metabolism, and quality of life benefits. Some of what is learned from this body of literature is applicable today with increasing emphasis on home hemodialysis. This review will focus on the benefits and potential harms of daily hemodialysis to assist the practitioner in shared decision making with patients about the expected benefits and drawbacks of frequent in-center dialysis and what the expected goals should be for a frequent dialysis regimen.</p>","PeriodicalId":94027,"journal":{"name":"Hemodialysis international. International Symposium on Home Hemodialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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