Hematology, transfusion and cell therapy最新文献_第9页

Outpatient administration of high-dose methotrexate in adults without drug monitoring – a case-control study of risk factors for acute kidney injury 成人在门诊服用大剂量甲氨蝶呤而未进行药物监测--关于急性肾损伤风险因素的病例对照研究

Hematology, transfusion and cell therapy Pub Date : 2023-12-01 DOI: 10.1016/j.htct.2023.10.005

Camila Alves, Juliana Pereira, Eduardo M Rego, Vanderson Rocha, W. Silva

引用次数: 0

The multiple presentation of oral actinomycosis in post-hematopoietic stem cell transplantation patients: case series 造血干细胞移植后患者口腔放线菌病的多种表现：病例系列

Hematology, transfusion and cell therapy Pub Date : 2023-12-01 DOI: 10.1016/j.htct.2023.11.003

A. C. S. Menezes, L. D. B. Alves, Gabriela de Assis Ramos, Marcelo Ribeiro Schirmer, M. Moreira, Maria Midori Miura Piragibe, A. C. de Melo, H. Antunes

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Machine-learning prediction models for any blood component transfusion in hospitalized dengue patients. 住院登革热患者任何血液成分输血的机器学习预测模型。

Hematology, transfusion and cell therapy Pub Date : 2023-11-17 DOI: 10.1016/j.htct.2023.09.2365

Md Shahid Ansari, Dinesh Jain, Sandeep Budhiraja

{"title":"Machine-learning prediction models for any blood component transfusion in hospitalized dengue patients.","authors":"Md Shahid Ansari, Dinesh Jain, Sandeep Budhiraja","doi":"10.1016/j.htct.2023.09.2365","DOIUrl":"https://doi.org/10.1016/j.htct.2023.09.2365","url":null,"abstract":"Background: Blood component transfusions are a common and often necessary medical practice during the epidemics of dengue. Transfusions are required for patients when they developed severe dengue fever or thrombocytopenia of 10×109/L or less. This study therefore investigated the risk factors, performance and effectiveness of eight different machine-learning algorithms to predict blood component transfusion requirements in confirmed dengue cases admitted to hospital. The objective was to study the risk factors that can help to predict blood component transfusion needs.Methods: Eight predictive models were developed based on retrospective data from a private group of hospitals in India. A python package SHAP (SHapley Additive exPlanations) was used to explain the output of the \"XGBoost\" model.Results: Sixteen vital variables were finally selected as having the most significant effects on blood component transfusion prediction. The XGBoost model presented significantly better predictive performance (area under the curve: 0.793; 95 % confidence interval: 0.699-0.795) than the other models.Conclusion: Predictive modelling techniques can be utilized to streamline blood component preparation procedures and can help in the triage of high-risk patients and readiness of caregivers to provide blood component transfusions when required. This study demonstrates the potential of multilayer algorithms to reasonably predict any blood component transfusion needs which may help healthcare providers make more informed decisions regarding patient care.","PeriodicalId":94026,"journal":{"name":"Hematology, transfusion and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138300740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of immune thrombocytopenia: study of adult patients at a referral hematology service in Northeastern Brazil. 免疫性血小板减少症的流行病学：对巴西东北部一家血液科转诊机构成年患者的研究。

Hematology, transfusion and cell therapy Pub Date : 2023-11-17 DOI: 10.1016/j.htct.2023.09.2363

Bruna Sobreira Kubrusly, Elsie Sobreira Kubrusly, Hermano Alexandre Lima Rocha, Antonio Brazil Viana Júnior, Marcela Sobreira Kubrusly, Lucas Loiola Ponte Albuquerque Ribeiro, Rosângela de Albuquerque Ribeiro, Fernando Barroso Duarte

{"title":"Epidemiology of immune thrombocytopenia: study of adult patients at a referral hematology service in Northeastern Brazil.","authors":"Bruna Sobreira Kubrusly, Elsie Sobreira Kubrusly, Hermano Alexandre Lima Rocha, Antonio Brazil Viana Júnior, Marcela Sobreira Kubrusly, Lucas Loiola Ponte Albuquerque Ribeiro, Rosângela de Albuquerque Ribeiro, Fernando Barroso Duarte","doi":"10.1016/j.htct.2023.09.2363","DOIUrl":"https://doi.org/10.1016/j.htct.2023.09.2363","url":null,"abstract":"Immune thrombocytopenia (ITP) is an acquired bleeding disorder observed in the clinical practice. Little is known about its epidemiology in Brazil. The present study was conducted at a hematology referral center which covers a population of over 8 million in 184 municipalities in the state of Ceará. The purpose of this study was to draw a demographic profile of adult ITP patients with regard to sex, age, geographical origin and distribution across the state, and the proportion of secondary ITP. Following ethics committee approval, information was collected with an ad hoc instrument. The sample consisted of 187 adult ITP patients attending the Walter Cantídio University Hospital in 2015. The median follow-up time was 67 months (range: 1 month to 29 years). Female sex (n = 154; 82.35 %) was strongly prevalent in all age brackets, with an overall female/male ratio of 4.7:1. The median age was 41 ± 16.1 with an interquartile range of 29-55.5 years; there was no difference between the genders. Secondary ITP (18/187; 9.6 %) displayed a bimodal distribution and a linear increase between 38 and >68 years of age. The results of this survey on the epidemiology of ITP in Brazil suggest that ethnic and geographical factors may have a great impact on age and sex distribution and on the distribution of secondary ITP.","PeriodicalId":94026,"journal":{"name":"Hematology, transfusion and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applicability and validation of different prognostic scores in allogeneic hematopoietic cell transplant (HCT) in the post-transplant cyclophosphamide era. 异基因造血细胞移植（HCT）不同预后评分在移植后环磷酰胺时代的适用性和验证。

Hematology, transfusion and cell therapy Pub Date : 2023-10-12 DOI: 10.1016/j.htct.2023.07.008

María Queralt Salas, Luis Gerardo Rodríguez-Lobato, Paola Charry, Maria Suárez-Lledó, Alexandra Pedraza, María Teresa Solano, Jordi Arcarons, Joan Cid, Miquel Lozano, Laura Rosiñol, Jordi Esteve, Enric Carreras, Francesc Fernández-Avilés, Carmen Martínez, Montserrat Rovira

{"title":"Applicability and validation of different prognostic scores in allogeneic hematopoietic cell transplant (HCT) in the post-transplant cyclophosphamide era.","authors":"María Queralt Salas, Luis Gerardo Rodríguez-Lobato, Paola Charry, Maria Suárez-Lledó, Alexandra Pedraza, María Teresa Solano, Jordi Arcarons, Joan Cid, Miquel Lozano, Laura Rosiñol, Jordi Esteve, Enric Carreras, Francesc Fernández-Avilés, Carmen Martínez, Montserrat Rovira","doi":"10.1016/j.htct.2023.07.008","DOIUrl":"https://doi.org/10.1016/j.htct.2023.07.008","url":null,"abstract":"We investigated the predictive capacity of six prognostic indices [Karnofsky Performance Status (KPS), Hematopoietic Cell Transplant-Specific Comorbidity Index (HCT-CI), Disease Risk Index (DRI), European Bone Marrow Transplantation (EBMT) and Revised Pre-Transplantation Assessment of Mortality (rPAM) Scores and Endothelial Activation and Stress Index (EASIX)] in 205 adults undergoing post-transplant cyclophosphamide (PTCy)-based allo-HCT. KPS, HCT-CI, DRI and EASIX grouped patients into higher and lower risk strata. KPS and EASIX maintained appropriate discrimination for OS prediction across the first 2 years after allo-HCT [receiver operating characteristic curve (area under the curve (AUC) > 55 %)]. The discriminative capacity of DRI and HCT-CI increased during the post-transplant period, with a peak of prediction at 2 years (AUC of 61.1 % and 61.8 %). The maximum rPAM discriminative capacity was at 1 year (1-year AUC of 58.2 %). The predictive capacity of the EBMT score was not demonstrated. This study validates the discrimination capacity for OS prediction of KPS, HCT-CI, DRI and EASIX in PTCy-based allo-HCT.","PeriodicalId":94026,"journal":{"name":"Hematology, transfusion and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61567080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prehospital blood transfusion in Brazil: results of the first year of implementation in an emergency medical service. 巴西的院前输血：在紧急医疗服务中实施第一年的结果。

Hematology, transfusion and cell therapy Pub Date : 2023-10-07 DOI: 10.1016/j.htct.2023.08.003

Lucas Certain, João Vitor Cerávolo Rostirola, Gabriela Cerávolo Rostirola, Juliana Silva Pereira, Isabella Gonçalves, Karize Ribeiro Gabrigna, Filipe Duo Speri, Matheus Ferreira Mendes, Tainá Serena Mottin, Israel da Silva, Jussara Aparecida Rodrigues, Juliana de Cássia Schevenin, Ana Barbara Regiani de Oliveira, Amanda Bonamichi Franceli, Camila Emanuele Camargo Lisboa, Bruno Deltreggia Benites

{"title":"Prehospital blood transfusion in Brazil: results of the first year of implementation in an emergency medical service.","authors":"Lucas Certain, João Vitor Cerávolo Rostirola, Gabriela Cerávolo Rostirola, Juliana Silva Pereira, Isabella Gonçalves, Karize Ribeiro Gabrigna, Filipe Duo Speri, Matheus Ferreira Mendes, Tainá Serena Mottin, Israel da Silva, Jussara Aparecida Rodrigues, Juliana de Cássia Schevenin, Ana Barbara Regiani de Oliveira, Amanda Bonamichi Franceli, Camila Emanuele Camargo Lisboa, Bruno Deltreggia Benites","doi":"10.1016/j.htct.2023.08.003","DOIUrl":"https://doi.org/10.1016/j.htct.2023.08.003","url":null,"abstract":"Introduction: Hemorrhagic shock is the main cause of death in the prehospital environment, which highlights the need to standardize measures aiming at bleeding control and volume replacement in this environment. In Brazil, the first prehospital packed red blood cell transfusion service started in September 2020, in Bragança Paulista, state of São Paulo.Objectives: Describe the trends and characteristics of patients who received prehospital transfusions prior to hospital treatment during the first year of operation.Methods: A retrospective data review was made of all patients who received transfusions from the mobile intensive care unit in Bragança Paulista over one year.Results: In this period, 19 patients were transfused. Since activation, the average response time was 20 min. The mean shock indexes before and after blood transfusion were 2.16 and 1.1, respectively. During the course of the 1st year of prehospital transfusions, no blood was wasted and there were no adverse effects.Conclusion: Introduction of the prehospital packed red blood cell transfusion service was successful, with significant improvement in hemodynamic parameters.","PeriodicalId":94026,"journal":{"name":"Hematology, transfusion and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autologous stem cell transplantation in patients older than 65 years with multiple myeloma: a real-world study. 自体干细胞移植治疗65岁以上多发性骨髓瘤患者：一项真实世界的研究。

Hematology, transfusion and cell therapy Pub Date : 2023-09-05 DOI: 10.1016/j.htct.2023.07.012

Cristian Maximiliano Seehaus, Natalia Schutz, Erika Brulc, Gonzalo Ferini, Jorge Arbelbide, Dorotea Fantl, Ana Lisa Basquiera

{"title":"Autologous stem cell transplantation in patients older than 65 years with multiple myeloma: a real-world study.","authors":"Cristian Maximiliano Seehaus, Natalia Schutz, Erika Brulc, Gonzalo Ferini, Jorge Arbelbide, Dorotea Fantl, Ana Lisa Basquiera","doi":"10.1016/j.htct.2023.07.012","DOIUrl":"https://doi.org/10.1016/j.htct.2023.07.012","url":null,"abstract":"Introduction: The treatment of elderly multiple myeloma (MM) patients with autologous stem cell transplantation (ASCT) is a controversial procedure. Most clinical trials evaluating the safety and efficacy of ASCT have primarily included patients younger than 65 years.Design and methods: This was a retrospective analysis of patients with MM who underwent ASCT between 2008 and 2018. Patients at or over 65 years were compared with patients under 65 years. We analyzed treatment-related mortality (TRM), response rate, progression-free survival (PFS) and overall survival (OS).Results: Two hundred and twenty-one patients were included: 50 patients at or over 65 years, (median age 68 years), including 7 patients over 70 years and 151 patients under 65 years, (median age 57 years). No differences were found in the neutrophil and platelet engraftment, median days of hospitalization and life support requirement during the hospitalization period for the ASCT. No statistically significant differences were found in the incidence of TRM between both groups at 100 days post-transplant (2% vs. 2.9%, p = 0.322). The ASCT improved complete response and stringent complete response rates (44% vs. 37%, p < 0.001). Survival was not modified by age: after a median follow-up of 53 months, the estimated PFS rates at three years were 63% and 60% (p = 0.88) and the OS rates at five years were 75% and 74% (p = 0.72), respectively.Conclusions: Our data suggest that the ASCT is feasible in selected elderly patients with MM over 65 years of age, achieving response and survival rates similar to those of younger patients.","PeriodicalId":94026,"journal":{"name":"Hematology, transfusion and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0