Hematology, transfusion and cell therapy最新文献_第4页

The role of autologous bone marrow transplantation in primary effusion lymphoma: a case report and literature review 自体骨髓移植在原发性渗出淋巴瘤中的作用：病例报告和文献综述

Hematology, transfusion and cell therapy Pub Date : 2024-07-01 DOI: 10.1016/j.htct.2024.04.119

Vitor Abreu de Goes, A. Cortez, Diogo Lago Morbeck, Felipe D’Almeida Costa, Talita Máira Bueno da Silveira

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Relationship between response to first-line steroid treatment in adult immune thrombocytopenic purpura and the course of the disease 成人免疫性血小板减少性紫癜患者对一线类固醇治疗的反应与病程之间的关系

Hematology, transfusion and cell therapy Pub Date : 2024-07-01 DOI: 10.1016/j.htct.2024.03.008

Esra Seçkin

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Pregnant women's knowledge and clinical management of hemolytic disease of the fetus and newborn in Pará, Brazil. 巴西帕拉州孕妇对胎儿和新生儿溶血病的认识和临床处理。

Hematology, transfusion and cell therapy Pub Date : 2024-05-25 DOI: 10.1016/j.htct.2024.03.007

Jhemily de Nazaré Gonçalves E Silva, Andrya Maia de Souza, Fabiane Monteiro do Rosario, Laine Celestino Pinto

{"title":"Pregnant women's knowledge and clinical management of hemolytic disease of the fetus and newborn in Pará, Brazil.","authors":"Jhemily de Nazaré Gonçalves E Silva, Andrya Maia de Souza, Fabiane Monteiro do Rosario, Laine Celestino Pinto","doi":"10.1016/j.htct.2024.03.007","DOIUrl":"https://doi.org/10.1016/j.htct.2024.03.007","url":null,"abstract":"Objective: To evaluate the knowledge of pregnant women and the clinical management of hemolytic disease of the fetus and newborn, as well as to describe the gestational profile, risk factors and socio-epidemiological profile of pregnant women treated at two municipal health units in Belém (Pará, Brazil).Methods: This was a cross-sectional analytical study, which consisted in the application of questionnaires to pregnant women who underwent prenatal care at the municipal health units.Results: A total of 104 pregnant women were evaluated; most were aged between 24 and 29 years old, had high school degrees (38 %), family incomes between 1 and 2 minimum wages (45 %) and blood type O+ (43 %). Regarding the gestational profile, the participants were predominantly in the third trimester of pregnancy (49 %), started prenatal care in the first gestational trimester (81 %) and were primiparous (61 %). Failures in the management of prenatal care were observed, especially with regard to access to information about the disease, since most pregnant women did not receive information about blood incompatibility during prenatal care. This led to limited knowledge about the pathology of the disease evidenced by the fact that most of the correct answers were between Questions 0-4, which were significantly associated with the women's education and income.Conclusions: Although hemolytic disease of the fetus and newborn is serious, the pregnant women in this study demonstrated little knowledge about the disease and had inadequate care by health professionals, reinforcing the importance of improving care for women's health and prenatal care.","PeriodicalId":94026,"journal":{"name":"Hematology, transfusion and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Subcutaneous low-dose azacitidine as maintenance therapy following hematopoietic stem cell transplantation for acute myeloid leukemia and high-risk myelodysplastic syndrome-A propensity score matched analysis. 急性髓性白血病和高危骨髓增生异常综合征造血干细胞移植后皮下注射小剂量阿扎胞苷作为维持疗法--倾向得分匹配分析。

Hematology, transfusion and cell therapy Pub Date : 2024-05-25 DOI: 10.1016/j.htct.2024.03.006

André Dias Américo, Cinthya Correa Silva, Mariana Nassif Kerbauy, Leonardo Javier Arcuri, Andressa Alice Feitosa Ribeiro, Nelson Hamerschlak, Fábio Pires Souza Santos

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Clinical and laboratory profile of patients with positive direct antiglobulin test attended at a university hospital in Goias, Brazil 巴西戈亚斯一所大学医院直接抗球蛋白试验阳性患者的临床和实验室概况

Hematology, transfusion and cell therapy Pub Date : 2024-05-01 DOI: 10.1016/j.htct.2024.04.118

Isadora Cristina Mendes, Pâmela Cristina Gomes Farias de Assis, Raíssa Santos de Almeida, Luma Romeiro Rodrigues de Sousa, Lilian Carla Carneiro, R. S. Jesuíno

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Effect of fetal distress on viability and yield of umbilical cord blood stem cells–a prospective comparative study 胎儿窘迫对脐带血干细胞存活率和产量的影响--一项前瞻性比较研究

Hematology, transfusion and cell therapy Pub Date : 2024-05-01 DOI: 10.1016/j.htct.2024.03.004

Bharathi Muthu, P. Manivannan, Murali Subbaiah, Shreya Vanju, A. Basavarajegowda

引用次数: 0

Evaluation of blood cell count using an automatic hematology analyzer to optimize collection of peripheral blood progenitor cells by leukapheresis. 使用自动血液分析仪评估血细胞计数，以优化通过白细胞清除术收集外周血祖细胞的工作。

Hematology, transfusion and cell therapy Pub Date : 2024-04-29 DOI: 10.1016/j.htct.2024.04.117

Paula Renata Machado Passos Pederzoli, Karen de Lima Prata, Nathália Gomide Cruz, Pedro Victorio de Almeida Marzano, Maurício Colombini Martins, Luciana de Almeida Costa, Roberta Kelly de Andrade, Marcia Regina Issa Salomão Libânio, Brian Custer, André Rolim Belisário

{"title":"Evaluation of blood cell count using an automatic hematology analyzer to optimize collection of peripheral blood progenitor cells by leukapheresis.","authors":"Paula Renata Machado Passos Pederzoli, Karen de Lima Prata, Nathália Gomide Cruz, Pedro Victorio de Almeida Marzano, Maurício Colombini Martins, Luciana de Almeida Costa, Roberta Kelly de Andrade, Marcia Regina Issa Salomão Libânio, Brian Custer, André Rolim Belisário","doi":"10.1016/j.htct.2024.04.117","DOIUrl":"https://doi.org/10.1016/j.htct.2024.04.117","url":null,"abstract":"Background: Autologous stem cell transplantation is a treatment modality for several diseases. Prediction of successful mobilization may be useful to optimize hematopoietic stem cell collection.Study design and methods: This was a retrospective study with data from transplantation candidates between September 2015 and December 2021 being analyzed. The medical record of each patient was reviewed to mine mobilization information. The laboratory data analyzed were CD34+ cell enumeration and pre-collection peripheral blood cell count. The primary outcome, good mobilization, was defined as a CD34+ cell count ≥20/μL.Results: This study included 807 patients. Increased patient weight, low mean corpuscular volume, high nucleated red blood cells, peripheral blood mononuclear cell and immature granulocyte counts were significantly associated with good mobilization. In addition, patients diagnosed with multiple myeloma were two times more likely to be good mobilizers than patients with lymphoma. The model was applied to a validation set to identify patients who underwent apheresis (CD34+ cell count ≥10 µL), resulting in a sensitivity of 69 %, a specificity of 95 %, positive predictive value of 98 %, and a negative predictive value of 50 %.Conclusion: Success in mobilization was greater in patients who underwent the first mobilization cycle and who had a diagnosis of multiple myeloma. Furthermore, higher body weight, and nucleated red blood cells, immature granulocytes and mononuclear cell counts, as well as low mean corpuscular volumes, were associated with successful mobilization.","PeriodicalId":94026,"journal":{"name":"Hematology, transfusion and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Blood chimerism associated with IVF in monochorionic twins with concordant sex: case report. 性别一致的单绒毛膜双胞胎体外受精相关的血液嵌合体：病例报告。

Hematology, transfusion and cell therapy Pub Date : 2024-04-01 DOI: 10.1016/j.htct.2024.02.022

Chao Zhou, Xiaozhen Hong, Xinyu Huang, Jihua Ma, Xuejun Chen

引用次数: 0

NT157 exhibits antineoplastic effects by targeting IRS and STAT3/5 signaling in multiple myeloma. NT157 通过靶向多发性骨髓瘤中的 IRS 和 STAT3/5 信号发挥抗肿瘤作用。

Hematology, transfusion and cell therapy Pub Date : 2024-03-21 DOI: 10.1016/j.htct.2024.02.017

Gustavo Nery de Queiroz, Keli Lima, Livia Bassani Lins de Miranda, Eduardo Magalhães Rego, Fabiola Traina, João Agostinho Machado-Neto

{"title":"NT157 exhibits antineoplastic effects by targeting IRS and STAT3/5 signaling in multiple myeloma.","authors":"Gustavo Nery de Queiroz, Keli Lima, Livia Bassani Lins de Miranda, Eduardo Magalhães Rego, Fabiola Traina, João Agostinho Machado-Neto","doi":"10.1016/j.htct.2024.02.017","DOIUrl":"https://doi.org/10.1016/j.htct.2024.02.017","url":null,"abstract":"Multiple myeloma (MM) is a prevalent hematological malignancy with high recurrence and no definitive cure. The current study revisits the role of the IGF1/IGF1R axis in MM, introducing a novel inhibitor, NT157. The IGF1/IGF1R pathway is pivotal in MM, influencing cell survival, proliferation, and migration and impacting patient survival outcomes. NT157 targets intracellular proteins such as IRS and STAT proteins and demonstrates antineoplastic potential in hematological malignancies and solid tumors. In the present study, we assessed IGF1R signaling-related gene expression in MM patients and healthy donors, unveiling significant distinctions. MM cell lines displayed varying expression patterns of IGF1R-related proteins. A gene dependence analysis indicated the importance of targeting receptor and intracellular elements over autocrine IGF1. NT157 exhibited inhibitory effects on MM cell viability, clonal growth, cell cycle progression, and survival. Moreover, NT157 reduced IRS2 expression and STAT3, STAT5, and RPS6 activation and modulated oncogenes and tumor suppressors, fostering a tumor-suppressive molecular profile. In summary, our study demonstrates that the IGF1/IGF1R/IRS signaling axis is differentially activated in MM cells and the NT157's capacity to modulate crucial molecular targets, promoting antiproliferative effects and apoptosis in MM cells. NT157 may offer a multifaceted approach to enhance MM therapy.","PeriodicalId":94026,"journal":{"name":"Hematology, transfusion and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sickle cell disease and increased adverse maternal and perinatal outcomes in different genotypes. 镰状细胞病以及不同基因型的孕产妇和围产期不良结局的增加。

Hematology, transfusion and cell therapy Pub Date : 2024-03-14 DOI: 10.1016/j.htct.2024.02.013

Camilla Olivares Figueira, José Paulo S Guida, Fernanda G Surita, Arthur Antolini-Tavares, Sara T Saad, Fernando F Costa, Kleber Y Fertrin, Maria Laura Costa

{"title":"Sickle cell disease and increased adverse maternal and perinatal outcomes in different genotypes.","authors":"Camilla Olivares Figueira, José Paulo S Guida, Fernanda G Surita, Arthur Antolini-Tavares, Sara T Saad, Fernando F Costa, Kleber Y Fertrin, Maria Laura Costa","doi":"10.1016/j.htct.2024.02.013","DOIUrl":"https://doi.org/10.1016/j.htct.2024.02.013","url":null,"abstract":"Background: Sickle cell disease (SCD) comprises a heterogeneous group of inherited hemolytic disorders that increases the risk of maternal and perinatal complications due to chronic systemic inflammatory response, endothelial damage and vaso-occlusion. The contribution of genotypes to the severity of outcomes during pregnancy is not completely established.Methods: A retrospective study of medical charts was performed to compare maternal and perinatal outcomes in Hb SS, Hb SC disease and sickle-beta thalassemia (Hb Sβ) pregnancies followed at a high-risk antenatal care unit over a 6-year period. A descriptive analysis of morphological findings was performed of the placenta when pathology reports were available.Results: Sixty-two SCD pregnant women [25 Hb SS (40 %), 29 Hb SC (47 %) and 8 Hb Sβ (13 %)] were included. Overall, SCD was associated with maternal complications (77 %), preterm birth (30 %), cesarean section (80 %) and a need of blood transfusion. In general there were no statistically significant differences between genotypes. The only significant difference was the hemoglobin level at first antenatal care visit which was lower for the homozygous genotype (7.7 g/dL) compared to Hb SC and Hb Sβ (9.7 g/dL and 8.4 g/dL, respectively; p-value = 0.01). Ten of 15 evaluated placentas showed abnormal morphological findings CONCLUSION: SCD, regardless of the underlying genotype, is associated with increased adverse maternal and perinatal outcomes and placental abnormalities associated with maternal vascular malperfusion.","PeriodicalId":94026,"journal":{"name":"Hematology, transfusion and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0