Federal practitioner : for the health care professionals of the VA, DoD, and PHS最新文献

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A Veteran Presenting With Symptomatic Postprandial Episodes. 一位退伍军人出现症状性餐后发作。
Federal practitioner : for the health care professionals of the VA, DoD, and PHS Pub Date : 2025-02-01 Epub Date: 2025-02-18 DOI: 10.12788/fp.0541
Dayna Isaacs, Mehran Kashefi, Ian Downs, Jane Weinreb
{"title":"A Veteran Presenting With Symptomatic Postprandial Episodes.","authors":"Dayna Isaacs, Mehran Kashefi, Ian Downs, Jane Weinreb","doi":"10.12788/fp.0541","DOIUrl":"10.12788/fp.0541","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic postprandial syndrome (IPP) presents with hypoglycemic-like symptoms in the absence of biochemical hypoglycemia and remains a diagnosis of exclusion. Its pathophysiology is poorly understood. The diagnosis requires thorough evaluation and the Whipple triad criteria. Treatment typically involves dietary modifications, including reduced carbohydrate intake, increased protein and fiber, and frequent small meals. Continuous glucose monitoring (CGM) may be a useful adjunct in correlating symptoms with glucose trends, but its role is still evolving.</p><p><strong>Case presentation: </strong>A 41-year-old male veteran presented with chronic postprandial episodes characterized by lightheadedness, nausea, tremulousness, anxiety, and other adrenergic symptoms occurring after carbohydrate-heavy meals. An extensive workup was unremarkable. CGM confirmed normoglycemia during episodes, ruling out true hypoglycemia and supporting a diagnosis of idiopathic postprandial syndrome. He was referred to a nutritionist for guidance on a high-protein, high-fiber, low-carbohydrate diet and subsequently reported symptomatic improvement.</p><p><strong>Conclusions: </strong>This case highlights the importance of recognizing IPP as a distinct clinical entity, especially due to its nonspecific clinical presentation. Early identification allows for a more accurate diagnosis and targeted treatment through tailored dietary and behavioral strategies, helping to alleviate symptoms.</p>","PeriodicalId":94009,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"42 2","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Heart Matters: Women Veterans, Cardiovascular Disease, and PTSD. 心脏问题:女性退伍军人,心血管疾病和创伤后应激障碍。
Federal practitioner : for the health care professionals of the VA, DoD, and PHS Pub Date : 2025-02-01 Epub Date: 2025-02-14 DOI: 10.12788/fp.0557
Cynthia M A Geppert
{"title":"The Heart Matters: Women Veterans, Cardiovascular Disease, and PTSD.","authors":"Cynthia M A Geppert","doi":"10.12788/fp.0557","DOIUrl":"10.12788/fp.0557","url":null,"abstract":"","PeriodicalId":94009,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"42 2","pages":"80-81"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilization and Cost of Veterans Health Administration Referrals to Community Care-Based Physical Therapy. 退伍军人健康管理局转介到社区护理为基础的物理治疗的利用和费用。
Federal practitioner : for the health care professionals of the VA, DoD, and PHS Pub Date : 2025-02-01 Epub Date: 2025-02-18 DOI: 10.12788/fp.0556
Kelsea LeBeau, Zaccheus J Ahonle, Sharon N Mburu, Sergio Romero, Keith J Myers
{"title":"Utilization and Cost of Veterans Health Administration Referrals to Community Care-Based Physical Therapy.","authors":"Kelsea LeBeau, Zaccheus J Ahonle, Sharon N Mburu, Sergio Romero, Keith J Myers","doi":"10.12788/fp.0556","DOIUrl":"10.12788/fp.0556","url":null,"abstract":"<p><strong>Background: </strong>The Veterans Health Administration (VHA) provides health care in rural communities through the Telerehabilitation Enterprise-Wide Initiative (TR-EWI) and other community care (CC) programs. Telehealth may allow clinicians to overcome challenges associated with CC, but there is a lack of understanding of the use of CC for rehabilitation services.</p><p><strong>Methods: </strong>This study explores CC physical therapy (PT) referral use and cost trends for 7 Veterans Integrated Services Networks (VISNs) with TR-EWI sites, using US Department of Veterans Affairs Corporate Data Warehouse and VHA Support Service Center referral data, as well as cost data from the VHA Community Care Referral Dashboard. We used descriptive statistics to analyze data. This study also qualitatively analyzed provisional diagnosis data to ascertain which PT diagnosis groups were most frequently referred to CC.</p><p><strong>Results: </strong>There were 344,406 PT referrals to CC from fiscal year (FY) 2019 to FY 2022. Referrals decreased from FY 2019 to FY 2020 but increased from FY 2020 to FY 2022, most notably in VISNs 19 and 22; VISN 8 consistently had high PT referrals over time. More referrals were made for veterans living in urban communities (56.2%) than rural communities (39.8%) and for those aged 60 to 69 years (20.7%) and aged 70 to 79 years (26.9%). There were 200,204 PT referrals with cost data from FY 2020 to FY 2022, totaling about $221 million in selected VISNs. Referral costs nearly doubled from FY 2020 to FY 2021, but only slightly increased from FY 2021 to FY 2022.</p><p><strong>Conclusions: </strong>This study highlights the variations in PT referrals and costs across VISNs and eligibility reasons for CC referral. Cost trends underscore the financial commitment to provide PT to veterans. Understanding the factors driving cost is necessary for the VHA to optimally provide and manage the rehabilitation resources needed to serve veterans through traditional in-person care, telehealth, and CC while ensuring timely, high-quality care.</p>","PeriodicalId":94009,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"42 2","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Testing for Patients With Suspected Ocular Manifestations of Lyme Disease. 疑似莱姆病眼部表现患者的诊断检测。
Federal practitioner : for the health care professionals of the VA, DoD, and PHS Pub Date : 2025-01-01 Epub Date: 2025-01-15 DOI: 10.12788/fp.0547
Morgan L Thomsen, Fatima M Raposo, Paul B Greenberg, Robert H Janigian, Melissa M Gaitanis, Amanda M Hunter
{"title":"Diagnostic Testing for Patients With Suspected Ocular Manifestations of Lyme Disease.","authors":"Morgan L Thomsen, Fatima M Raposo, Paul B Greenberg, Robert H Janigian, Melissa M Gaitanis, Amanda M Hunter","doi":"10.12788/fp.0547","DOIUrl":"10.12788/fp.0547","url":null,"abstract":"<p><strong>Background: </strong>Lyme disease is a bacterial infection caused by the spirochete <i>Borrelia burgdorferi sensu lato</i> complex transmitted by the <i>Ixodes</i> tick genus. There is uncertainty regarding proper diagnostic testing for suspected cases. Ocular manifestations have been documented in all stages of Lyme disease, but are more prevalent in early disseminated disease.</p><p><strong>Observations: </strong>This review article provides guidelines for the appropriate diagnostic testing to obtain when encountering ocular manifestations of suspected Lyme disease.</p><p><strong>Conclusions: </strong>To ensure timely diagnosis and treatment, eye care clinicians should be familiar with the appropriate diagnostic testing for patients suspected to have ocular manifestations of Lyme disease. If testing confirms Lyme disease, refer the patient to an infectious disease specialist for antimicrobial treatment and additional management.</p>","PeriodicalId":94009,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"42 1","pages":"58-61"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncommon Locations for Brain Herniations Into Arachnoid Granulations: 5 Cases and Literature Review. 蛛网膜颗粒内脑疝少见部位5例及文献复习。
Federal practitioner : for the health care professionals of the VA, DoD, and PHS Pub Date : 2025-01-01 Epub Date: 2025-06-18 DOI: 10.12788/fp.0489
Noah Gafen, Igor Sirotkin, Amanda Pennington, Brittany Rea, Carlos R Martinez
{"title":"Uncommon Locations for Brain Herniations Into Arachnoid Granulations: 5 Cases and Literature Review.","authors":"Noah Gafen, Igor Sirotkin, Amanda Pennington, Brittany Rea, Carlos R Martinez","doi":"10.12788/fp.0489","DOIUrl":"10.12788/fp.0489","url":null,"abstract":"<p><strong>Background: </strong>Arachnoid granulations are extensions of the subarachnoid space, an important component of the complex circulation of brain cerebrospinal fluid. While these structures primarily transmit cerebrospinal fluid into the dural venous sinuses, they also may serve as a conduit for brain tissue herniation. Such occurrences have been referred to in the literature as brain herniations into arachnoid granulations (BHAGs), which are considered incidental and asymptomatic but can be associated with nonspecific neurologic symptoms such as headache, tinnitus, vertigo, and seizure. BHAGs can be visualized more readily due to improved cross-sectional magnetic resonance imaging (MRI) with increased spatial and contrast resolution.</p><p><strong>Case presentation: </strong>We present 5 cases where brain herniations were detected in patients undergoing MRI for various neurologic symptoms. All patients experienced chronic symptoms, including headaches and seizures. Two cases included BHAG in locations that were associated with the patients' symptoms.</p><p><strong>Conclusions: </strong>BHAGs are increasingly recognized due to improved spatial resolution in MRIs. While there is still no definitive evidence that these lesions are responsible for various neurologic symptoms, some of these abnormalities may hold clinical significance, such as the visual symptoms seen in 2 of the cases described. BHAG can be associated with gliosis of adjacent brain tissue, which may be a mechanism for symptom development.</p>","PeriodicalId":94009,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"42 1","pages":"48-52a"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic Sleeve Gastroplasty is an Effective Treatment for Obesity in a Veteran With Metabolic and Psychiatric Comorbidities. 内镜下套管胃成形术是治疗有代谢和精神合并症的退伍军人肥胖症的有效方法。
Federal practitioner : for the health care professionals of the VA, DoD, and PHS Pub Date : 2025-01-01 Epub Date: 2025-01-17 DOI: 10.12788/fp.0546
Philip Kozan, Mehran Kashefi, Maria Romanova, Jennifer M Kolb
{"title":"Endoscopic Sleeve Gastroplasty is an Effective Treatment for Obesity in a Veteran With Metabolic and Psychiatric Comorbidities.","authors":"Philip Kozan, Mehran Kashefi, Maria Romanova, Jennifer M Kolb","doi":"10.12788/fp.0546","DOIUrl":"10.12788/fp.0546","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a chronic disease associated with several metabolic comorbidities. Weight loss interventions, such as bariatric surgery and endoscopic procedures like endoscopic sleeve gastroplasty (ESG), are known to improve obesity-related health conditions. However, there is limited data on the impact of endoscopic procedures on psychiatric disorders. Our report aims to describe the clinical course of a veteran with psychiatric comorbidities that prevented him from proceeding with bariatric surgery, and ultimately underwent an ESG.</p><p><strong>Case presentation: </strong>A 59-year-old male veteran with severe obesity had limited exercise capability and poor quality of life due to a large ventral hernia. The patient's dietary, lifestyle modification, and medication-assisted weight loss attempts were unsuccessful. A planned weight loss surgery was canceled due to anxiety and a panic attack. He underwent ESG with a successful total body weight loss of 16.7% at 12 months. Subsequent improvement in metabolic and psychiatric comorbidities ultimately enabled the patient to undergo ventral hernia repair, which significantly improved his quality of life.</p><p><strong>Conclusions: </strong>This report demonstrates that ESG may be an option for weight loss in patients with psychiatric comorbidities and can lead to significant clinical improvement in multiple obesity-associated comorbidities. This case further highlights the value of endoscopic procedures as alternatives to bariatric surgery in select cases when lifestyle changes and medications have not been effective, and surgery may not be a viable option.</p>","PeriodicalId":94009,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"42 1","pages":"62-65"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacist-Led Deprescribing of Aspirin for Primary Prevention of Cardiovascular Disease Among Geriatric Veterans. 药师主导的阿司匹林在老年退伍军人心血管疾病一级预防中的应用
Federal practitioner : for the health care professionals of the VA, DoD, and PHS Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.12788/fp.0537
Shelby Koen, Matthew Cavaletto, Lindsay Garris, Jennie Hewitt
{"title":"Pharmacist-Led Deprescribing of Aspirin for Primary Prevention of Cardiovascular Disease Among Geriatric Veterans.","authors":"Shelby Koen, Matthew Cavaletto, Lindsay Garris, Jennie Hewitt","doi":"10.12788/fp.0537","DOIUrl":"10.12788/fp.0537","url":null,"abstract":"<p><strong>Background: </strong>Aspirin is a commonly prescribed antiplatelet agent for primary and secondary prevention of cardiovascular events. Guidelines recommend avoiding aspirin for primary prevention in most patients aged ≥ 70 years, but there is limited data on the most effective way to deprescribe aspirin in outpatient settings.</p><p><strong>Methods: </strong>This prospective quality improvement study used the US Department of Veterans Affairs (VA) VIONE medication safety dashboard to identify eligible patients at a Durham VA Health Care System (DVAHCS) community-based outpatient clinic. Patients were aged ≥ 70 years without known atherosclerotic cardiovascular disease and an active aspirin prescription as of September 1, 2022. Two pharmacists gave a deprescribing presentation to primary care practitioners (PCPs) 90 days later. The primary objective was to compare the efficiency of pharmacist direct deprescribing of aspirin with PCP deprescribing for primary prevention over a 12-week period following the education session. Secondary objectives assessed the number of aspirin orders discontinued, the effect of the education on aspirin deprescribing for primary prevention, and pharmacist time to complete the intervention.</p><p><strong>Results: </strong>Two aspirin orders were deprescribed per hour of pharmacist time compared with 67 aspirin orders per hour for PCPs. In the 12 weeks following the PCP education session, 230 aspirin orders were discontinued, 97 by pharmacists and 133 by PCPs. Among the 868 patients identified, 224 met inclusion criteria for the pharmacist direct deprescribing intervention, and all patients were eligible through the PCP education method. Pharmacists spent about 48 hours on the pharmacist intervention and 1 hour on the PCP education intervention.</p><p><strong>Conclusions: </strong>PCP education was more efficient for deprescribing aspirin compared with direct deprescribing by pharmacists based on the number of aspirin orders discontinued by time spent.</p>","PeriodicalId":94009,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"42 1","pages":"22-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an Integrative Medicine Rotation for Family Medicine and Preventive Medicine Residency. 家庭医学和预防医学住院医师中西医结合轮转的发展。
Federal practitioner : for the health care professionals of the VA, DoD, and PHS Pub Date : 2025-01-01 Epub Date: 2025-01-15 DOI: 10.12788/fp.0544
Marissa Khajavi, Delia Chiaramonte, Beth Hogans, Jacob Blumenthal, Leslie Katzel, Jeffrey Beans, Jamie Giffuni, Elizabeth A Dennis
{"title":"Development of an Integrative Medicine Rotation for Family Medicine and Preventive Medicine Residency.","authors":"Marissa Khajavi, Delia Chiaramonte, Beth Hogans, Jacob Blumenthal, Leslie Katzel, Jeffrey Beans, Jamie Giffuni, Elizabeth A Dennis","doi":"10.12788/fp.0544","DOIUrl":"10.12788/fp.0544","url":null,"abstract":"<p><strong>Background: </strong>Integrative medicine or complementary and alternative medicine (IM/CAM) is widely utilized by patients despite the limited training available across health care education. There is a gap between patient interest and the need for guidance amid a lack of preparation among clinicians in IM/CAM. To address this, the Baltimore Geriatric Research Education and Clinical Center created a US Department of Veterans Affairs-based whole health rotation that incorporates core IM/CAM competencies for family medicine and preventive medicine residents.</p><p><strong>Observations: </strong>A structured 2-week IM/CAM curriculum was developed by medical school faculty in cooperation with a range of health care professionals. Assessments, including surveys and a case analysis, measured overall program satisfaction, perception of IM/CAM modalities, IM/CAM knowledge, confidence in pain care, self-care perception, self-care practice, and burnout symptom frequency. Residents participating in the IM/CAM rotation reported positive experiences overall, gained knowledge for their own personal benefit, and acquired resources and skills they felt confident discussing with their patients. They also reported a slight decrease in feelings of burnout and perceived stress.</p><p><strong>Conclusions: </strong>IM/CAM education, delivered as a standardized family medicine rotation, enhances resident capacity to make informed decisions and counsel patients on IM/CAM options, while also providing strategies for maintaining optimal health and well-being.</p>","PeriodicalId":94009,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"42 1","pages":"35-41f"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Interprofessional Neurology Training Using Tele-Education. 利用远程教育改进神经病学跨专业培训。
Federal practitioner : for the health care professionals of the VA, DoD, and PHS Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.12788/fp.0545
Fariha Jamal, Amtul Farheen, Christine Rizk
{"title":"Improving Interprofessional Neurology Training Using Tele-Education.","authors":"Fariha Jamal, Amtul Farheen, Christine Rizk","doi":"10.12788/fp.0545","DOIUrl":"10.12788/fp.0545","url":null,"abstract":"<p><strong>Background: </strong>Neurological disorders are a leading cause of disability and death worldwide. Their burden on the health care system has substantially increased in the past 25 years, due to more effective treatments and longer life expectancies. The Veterans Health Administration has seen increases in neurology referrals and patients with neurologic disorders.</p><p><strong>Observations: </strong>Collaborative efforts among primary care, geriatrics, neurology, psychiatry, physical medicine and rehabilitation, social work, and other disciplines are needed to properly care for veterans with neurologic disorders. Neurology education is an important tool for clinicians to better care for veterans with neurologic disorders. The use of technology and online resources have improved education dissemination. This article describes how an annual neurology education program has expanded its reach and availability over 4 years.</p><p><strong>Conclusions: </strong>A small, in-person neurology symposium evolved into an annual virtual conference that included more clinicians from outside the specialty. Increased participation and survey data suggest the seminar improved neurologic knowledge in non-neurologist clinical personnel and increased their comfort level during initial evaluations of neurologic disorders in veterans.</p>","PeriodicalId":94009,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"42 1","pages":"53-57a"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of NSAID Use on Bleeding Rates for Patients Taking Rivaroxaban or Apixaban. 非甾体抗炎药使用对服用利伐沙班或阿哌沙班患者出血率的影响。
Federal practitioner : for the health care professionals of the VA, DoD, and PHS Pub Date : 2024-12-01 Epub Date: 2024-12-23 DOI: 10.12788/fp.0540
Rebecca Worsham, Robert Wood, Andrea Jill Radford
{"title":"Impact of NSAID Use on Bleeding Rates for Patients Taking Rivaroxaban or Apixaban.","authors":"Rebecca Worsham, Robert Wood, Andrea Jill Radford","doi":"10.12788/fp.0540","DOIUrl":"10.12788/fp.0540","url":null,"abstract":"<p><strong>Background: </strong>Posthoc analyses have found an increased bleeding risk in oral anticoagulation with concomitant nonsteroidal anti-inflammatory drug (NSAID) use. However, this research was primarily conducted in mixed populations prescribed both direct oral anticoagulants (DOACs) and warfarin. Research evaluating bleeding risk with NSAID use among DOACs alone is limited. This study evaluates bleeding rates in patients taking rivaroxaban and apixaban with and without NSAID use and investigates the potential impact of NSAID selectivity or proton pump inhibitor (PPI) coprescribing.</p><p><strong>Methods: </strong>This single-center retrospective cohort study compared bleeding rates between rivaroxaban or apixaban among NSAID and non-NSAID users. The primary endpoint was a composite of any bleeding event per International Society on Thrombosis and Haemostatis criteria. The secondary endpoint was bleeding rates for NSAID users based on NSAID choice and PPI coprescribing.</p><p><strong>Results: </strong>The study included 681 patients on rivaroxaban and 3225 patients on apixaban. Seventy-two patients on rivaroxaban (10.6%) and 300 patients on apixaban (9.3%) were NSAID users. There was no statistically significant difference between rivaroxaban and apixaban among NSAID users (hazard ratio 1.04; 95% CI, 0.98-1.12) or non-NSAID users (hazard ratio 1.15; 95% CI, 0.80-1.66). There was no clinically significant difference observed for NSAID selectivity or PPI coprescribing for NSAID users.</p><p><strong>Conclusions: </strong>Bleeding rates were not significantly different between patients taking rivaroxaban and patients taking apixaban, regardless of NSAID use. A population health management tool may provide a safe approach for coprescribing NSAIDs with DOACs. Additional prospective studies are needed to quantify the comparative bleeding risk with concomitant NSAID use among DOACs alone.</p>","PeriodicalId":94009,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"41 12","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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