Experimental and therapeutic medicine最新文献

{"title":"[Retracted] TIPE2 suppresses atherosclerosis by exerting a protective effect on macrophages via the inhibition of the Akt signaling pathway.","authors":"Dan Li, Ying Tan","doi":"10.3892/etm.2024.12782","DOIUrl":"https://doi.org/10.3892/etm.2024.12782","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.3892/etm.2019.7316.].</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"29 2","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of intravenous plus intrathecal/intracerebral ventricle injection of tigecycline for post‑neurosurgical intracranial infections due to MDR/XDR <i>Acinetobacter baumannii</i>: A retrospective cohort study.","authors":"Xia Tian, Xianbing Meng, Lichao Guo, Yan Li, Guoqing Gu, Tianyan Zhang, Rufeng An","doi":"10.3892/etm.2024.12781","DOIUrl":"10.3892/etm.2024.12781","url":null,"abstract":"<p><p>Intracranial infection is a complication of neurosurgery that can lead to severe neurological complications, greatly increasing the risk of mortality. Intracranial infection caused by multidrug-resistant <i>Acinetobacter baumannii</i> (MDR-AB) is one of the most severe complications of craniotomy. However, the availability of effective therapeutic options for such infections remains limited. Therefore, the present study aimed to assess the therapeutic efficacy of intrathecal/intracerebral (ITC) ventricle tigecycline injection for managing post-neurosurgical intracranial infections caused by MDR-AB. The present retrospective study was conducted from January 2014 to December 2023 at the Second Affiliated Hospital of Shandong First Medical University (Taian, China), which included 15 cases of MDR-AB positivity in the cerebrospinal fluid (CSF) cultures after neurosurgery. Patients treated with intravenous and intrathecal/ITC tigecycline ventricle injection were assigned to the 'ITV + ITC' group, whereas patients treated without intrathecal/ITC injection were assigned to the 'ITV' group. Data for general information, treatment history, the results of biochemical indicators in CSF and the microbiological clearance rate were collected and analyzed. No significant differences were observed in characteristics, susceptibility testing or empirical antimicrobial use between the two groups after treatment. However, after treatment, the ITV + ITC group exhibited a significantly decreased body temperature, whilst the biochemical indicators present in CSF were significantly improved. In addition, the ITV + ITC group had a significantly higher microbiological clearance rate (5/6; 83.33%) compared with that in the ITV group (2/9; 22.22%). These findings suggest that intravenous plus intrathecal/ITC ventricle injection of tigecycline is an effective regimen for treating intracranial infections caused by MDR-AB.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"29 2","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blockade of cysteinyl leukotriene receptor 1 alleviates asthma by inhibiting bronchial epithelial cell apoptosis and activating the Nrf2 signaling pathway.","authors":"Xiangjie Wu, Yiqiong Chen, Suping Chen, Yiping Lin","doi":"10.3892/etm.2024.12780","DOIUrl":"10.3892/etm.2024.12780","url":null,"abstract":"<p><p>The therapeutic role of blockade of cysteinyl leukotriene receptor 1 (CysLTR1) in asthma has been previously studied. However, the effect of CysLTR1 blockade on bronchial epithelial cell apoptosis and the nuclear factor erythroid-derived 2-related factor 2 (Nrf2) signaling pathway remains unclear. The present study established an ovalbumin (OVA)-induced asthmatic rat model. Varying doses (1, 4 and 30 mg/kg) of montelukast sodium, a specific CysLTR1 antagonist, were used to inhibit CysLTR1 function in an asthmatic rat model. Reverse transcription-quantitative PCR was used to detect the expression levels of CysLTR1, NAD(P)H quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1). CysLTR1 and Nrf2 protein expression levels were determined using western blotting. Immunofluorescence assays were used to evaluate the relative fluorescence intensity of Nrf2 in rat lung tissues. Lung tissue histology was assessed through hematoxylin & eosin, alcian blue and periodic acid-Schiff and Masson's trichrome staining assays. The levels of IL-17, IL-4, serum IgE and the reduced/oxidized glutathione ratio were determined using ELISA assay kits. The number of inflammatory cells was analyzed using Wright-Giemsa staining. Bronchial epithelial cell apoptosis was measured using a TUNEL assay. The results indicated that OVA-induced inflammatory responses and increased eosinophil, lymphocyte and macrophage counts were significantly attenuated following blockade of CysLTR1. Downregulated expression of antioxidant genes NQO1 and HO-1 and the reduced GSH/GSSG ratio caused by OVA challenge were restored by blockade of CysLTR1. Additionally, CysLTR1 blockade also reduced collagen deposition, suppressed goblet cell hyperplasia and inhibited bronchial epithelial cell apoptosis in a rat model of asthma. Furthermore, it was demonstrated that the blockade of CysLTR1 could significantly increase Nrf2 expression. In conclusion, the blockade of CysLTR1 could alleviate asthma in an OVA-induced rat model by inhibiting bronchial epithelial cell apoptosis and activating the Nrf2 signaling pathway. These data may potentially provide a theoretical basis for future asthma therapy in a clinical setting.</p>","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"29 2","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEfficacy and safety of apatinib in the treatment of patients with platinum‑resistant ovarian cancer: A systematic review and network meta‑analysis","authors":"Wei Wang, Fayong Liu, Shan Qiu, Yan Jiao, Yanfei Zhu","doi":"10.3892/etm.2024.12665","DOIUrl":"https://doi.org/10.3892/etm.2024.12665","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"27 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141800570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between preterm delivery and the risk of maternal renal disease: A systematic review and meta‑analysis","authors":"Wenting Wu, Yingying Chen, Xiaoxing Zhang, Qing Zhu, Qilong Shen","doi":"10.3892/etm.2024.12667","DOIUrl":"https://doi.org/10.3892/etm.2024.12667","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"27 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified reconstruction approach after pancreaticoduodenectomy optimizes postoperative outcomes: Results from a multivariate cohort analysis","authors":"Stavros Parasyris, Vasiliki Ntella, Theodoros A. Sidiropoulos, Stefanos A. Maragkos, N. Pantazis, P. Patapis, P. Matsota, P. Vassiliu, Vasileios Smyrniotis, Nikolaos Arkadopoulos","doi":"10.3892/etm.2024.12666","DOIUrl":"https://doi.org/10.3892/etm.2024.12666","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"29 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141799401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Corrigendum] ACSM3 suppresses proliferation and induces apoptosis and cell cycle arrest in acute myeloid leukemia cells via the regulation of IGF2BP2","authors":"Xin Zheng, Jinjun Wu, Linlan Song, Bo Huang","doi":"10.3892/etm.2024.12663","DOIUrl":"https://doi.org/10.3892/etm.2024.12663","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"12 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N6‑methyladenosine methyltransferase METTL14 is associated with macrophage polarization in rheumatoid arthritis","authors":"Ziheng Zhu, Lei Wan","doi":"10.3892/etm.2024.12664","DOIUrl":"https://doi.org/10.3892/etm.2024.12664","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"36 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of telitacicept in patients with lupus nephritis","authors":"Hong Zhu, Hui-Qian Hu, Hui-Ling Wei, De-Xin Zhang, Hua Yang, Qian-kun Zhang, Lie Jin","doi":"10.3892/etm.2024.12660","DOIUrl":"https://doi.org/10.3892/etm.2024.12660","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"111 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141811814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interference of FZD2 suppresses proliferation, vasculogenic mimicry and stemness in glioma cells via blocking the Notch/NF‑κB signaling pathway","authors":"Yuge Ran, Shuai Han, Dongxue Gao, Xiaobo Chen, Chan Liu","doi":"10.3892/etm.2024.12662","DOIUrl":"https://doi.org/10.3892/etm.2024.12662","url":null,"abstract":"","PeriodicalId":94002,"journal":{"name":"Experimental and therapeutic medicine","volume":"16 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}