European urologyPub Date : 2026-07-24DOI: 10.1016/j.eururo.2026.07.002
Georges Mjaess, Michele Nicolazzini, Daniele Amparore, Axel Bex, Riccardo Campi, Francesco Cei, Sabrina L Noyes, Chiara Re, Giuseppe Rosiello, Grant D Stewart, Alessandro Volpe, Carlotta Palumbo
{"title":"Systematic Review and Meta-analysis on Renal Tumor Biopsy: Accuracy, Safety, and Impact on Clinical Decision-making.","authors":"Georges Mjaess, Michele Nicolazzini, Daniele Amparore, Axel Bex, Riccardo Campi, Francesco Cei, Sabrina L Noyes, Chiara Re, Giuseppe Rosiello, Grant D Stewart, Alessandro Volpe, Carlotta Palumbo","doi":"10.1016/j.eururo.2026.07.002","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.07.002","url":null,"abstract":"<p><strong>Background and objectives: </strong>We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy, safety, and clinical impact of renal tumor biopsy (RTB) in managing renal cell carcinoma.</p><p><strong>Methods: </strong>MEDLINE, Embase, and Cochrane CENTRAL were systematically searched for studies evaluating diagnostic accuracy, complications, and clinical impact of RTB. Diagnostic performance was synthesized using hierarchical bivariate random-effects models; concordance between biopsy and surgical specimens was assessed using pooled proportions that were estimated using random-effects meta-analysis. Risk of bias was evaluated with QUADAS-2.</p><p><strong>Key findings and limitations: </strong>Overall, 103 studies were included. The pooled diagnostic yield of RTB was 90%. Summary sensitivity and specificity for malignancy were 99% and 85%, respectively. Concordance between RTB and surgical pathology was high for benign versus malignant (96%) and histological subtype (89%), but moderate for grade (four-tier: 64%; two-tier: 78%). The overall complication rate was low (3%), with negligible (<1%) Clavien-Dindo ≥3 complications and 1% bleeding events (with only two patients requiring embolization). Tumor seeding was reported only in one study with a pooled seeding proportion of 0%. RTB findings was associated with a change in clinical management in 39% of patients and avoidance of active treatment in 28%. Most studies were at high risk of bias, mainly due to patient selection and flow/timing, and were predominantly retrospective.</p><p><strong>Conclusions and clinical implications: </strong>RTB is safe and high-yield, with excellent sensitivity, high concordance for benign vs malignant and histotype, but only moderate reliability for tumor grade. RTB is therefore an important aid in refining diagnosis in patients with a renal mass and supporting individualized decision-making.</p>","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-07-23DOI: 10.1016/j.eururo.2026.07.011
Alessandro Uleri, Michael Baboudjian, Giovanni Lughezzani, Guillaume Ploussard
{"title":"Re: James P. Buteau, Daniel Moon, Michael T. Fahey, et al. Effect of [<sup>68</sup>Ga]Ga-PSMA-11 PET-CT in the Diagnosis of Prostate Cancer in Men with Equivocal or Clinically High-risk Non-suspicious Findings on Multiparametric MRI (PRIMARY2): A Multicenter, Non-inferiority, Phase 3, Randomized Controlled Trial. Lancet Oncol 2026;27:839-848.","authors":"Alessandro Uleri, Michael Baboudjian, Giovanni Lughezzani, Guillaume Ploussard","doi":"10.1016/j.eururo.2026.07.011","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.07.011","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-07-23DOI: 10.1016/j.eururo.2026.06.026
Francesco Di Bello, Andrea Gallioli, Alberto Breda, Joan Palou
{"title":"Re: Kitamura H, Tsukamoto T, Kakehi Y, et al. Active Surveillance Versus Intravesical Bacillus Calmette-Guérin for High-grade T1 Bladder Cancer with Negative Second Transurethral Resection: The Randomized Noninferiority Phase 3 JCOG1019 Trial. Eur Urol 2026;89:437-45.","authors":"Francesco Di Bello, Andrea Gallioli, Alberto Breda, Joan Palou","doi":"10.1016/j.eururo.2026.06.026","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.06.026","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-07-23DOI: 10.1016/j.eururo.2026.06.027
Jae Sik Kim, Ah Ram Chang, Jae Heon Kim
{"title":"Re: Robert M. Meier, Nima Aghdam, Alan C. Beckman et al. 10-yr Survival and Toxicity Outcomes of Stereotactic Body Radiotherapy for Prostate Cancer: A Nonrandomized Clinical Trial. Eur Urol In press. http://dx.doi.org/10.1016/j.eururo.2026.04.029.","authors":"Jae Sik Kim, Ah Ram Chang, Jae Heon Kim","doi":"10.1016/j.eururo.2026.06.027","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.06.027","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-07-22DOI: 10.1016/j.eururo.2026.07.010
Massimo Lazzeri, Rodolfo Hurle, Giovanni Lughezzani, Nicolò Maria Buffi, Paolo Casale
{"title":"Re: Comprehensive Genome-wide Association Study Into Multiple Recurrence and Progression Risk in Non-muscle-invasive Bladder Cancer.","authors":"Massimo Lazzeri, Rodolfo Hurle, Giovanni Lughezzani, Nicolò Maria Buffi, Paolo Casale","doi":"10.1016/j.eururo.2026.07.010","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.07.010","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-07-21DOI: 10.1016/j.eururo.2026.07.015
David-Dan Nguyen, Borna Tadayon Najafabadi, Lauren Lin, Jethro C C Kwong, Girish S Kulkarni
{"title":"Reply to J.H. Kim and Y.S. Shin's Letter to the Editor re: Re: Effect of Prostate Cancer Screening with Prostate-specific Antigen Testing on Long-term Prostate Cancer-specific Mortality: A Systematic Review and Meta-analysis of Randomized Controlled Trials.","authors":"David-Dan Nguyen, Borna Tadayon Najafabadi, Lauren Lin, Jethro C C Kwong, Girish S Kulkarni","doi":"10.1016/j.eururo.2026.07.015","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.07.015","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-07-18DOI: 10.1016/j.eururo.2026.07.008
Aldo Brassetti, Giuseppe Simone
{"title":"Reply to Yan Huang and Yang Liu's Letter to the Editor Re: Brassetti A, Tuderti G, Anceschi U, et al. Sutureless Purely Off-clamp Robotic Partial Nephrectomy: Evidence from a Randomized Controlled Noninferiority Trial. Eur Urol 2026;15:S0302-2838(26)02139-1.","authors":"Aldo Brassetti, Giuseppe Simone","doi":"10.1016/j.eururo.2026.07.008","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.07.008","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-07-16DOI: 10.1016/j.eururo.2026.07.006
Aldo Brassetti, Giuseppe Simone
{"title":"Reply to Gianluca Giannarini, Antonio Amodeo, Angelo Porreca and Alessandro Crestani's Letter to the Editor Re: Aldo Brassetti, Gabriele Tuderti, Umberto Anceschi, et al. Sutureless Purely Off clamp Robotic Partial Nephrectomy: Evidence from a Randomized Controlled Noninferiority Trial. Eur Urol 2026;15:S0302-2838(26)02139-1.","authors":"Aldo Brassetti, Giuseppe Simone","doi":"10.1016/j.eururo.2026.07.006","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.07.006","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148458249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-07-15DOI: 10.1016/j.eururo.2026.07.005
Michael E O'Callaghan, Luke Selth, Gary Wittert
{"title":"Re: Testosterone Treatment in Prostate Cancer Survivors with Hypogonadism: A Randomized Clinical Trial.","authors":"Michael E O'Callaghan, Luke Selth, Gary Wittert","doi":"10.1016/j.eururo.2026.07.005","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.07.005","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148458224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}