European urologyPub Date : 2026-06-17DOI: 10.1016/j.eururo.2026.05.022
Laura S Mertens, Jan-Jaap J Mellema, Srikala Sridhar, Michiel S van der Heijden
{"title":"Re: Neoadjuvant Sacituzumab Govitecan plus Pembrolizumab, Followed by Adjuvant Pembrolizumab, in Patients with Muscle-invasive Bladder Cancer (SURE-02): A Single-arm, Phase 2 Study.","authors":"Laura S Mertens, Jan-Jaap J Mellema, Srikala Sridhar, Michiel S van der Heijden","doi":"10.1016/j.eururo.2026.05.022","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.05.022","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-06-17DOI: 10.1016/j.eururo.2026.05.009
Michael F Basin, Siamak Daneshmand
{"title":"Cystectomy Remains Standard of Care Following Neoadjuvant Therapy in Patients with Muscle-Invasive Bladder Cancer.","authors":"Michael F Basin, Siamak Daneshmand","doi":"10.1016/j.eururo.2026.05.009","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.05.009","url":null,"abstract":"<p><p>Radical cystectomy remains the standard of care after neoadjuvant therapy for muscle-invasive bladder cancer. While newer regimens (NIAGRA, KEYNOTE-B15/905) achieve impressive pathological complete response rates, the survival benefits from these trials were built on consolidative surgery, with a 88% cystectomy rate bladder preservation. Clinical complete response agrees with true pathological complete response only about half the time, meaning current restaging tools cannot reliably identify who is truly disease-free. Bladder preservation trials using systemic therapy alone (RETAIN-1/2, HCRN GU 16-257) have shown concerning rates of recurrence and metastasis even with biomarker selection. Trimodal approaches incorporating radiation (IMMUNOPRESERVE, INDIBLADE) are promising but remain early-phase. Until validated biomarkers and prospective trials prove otherwise, cystectomy should remain part of the curative-intent treatment paradigm.</p>","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148274270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-06-17DOI: 10.1016/j.eururo.2026.05.018
David Zekan, Andres Correa
{"title":"Re: Standardizing Time-to-Event Reporting in Single-arm BCG-unresponsive Registration Trials: A Case for Kaplan-Meier.","authors":"David Zekan, Andres Correa","doi":"10.1016/j.eururo.2026.05.018","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.05.018","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148274343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-06-16DOI: 10.1016/j.eururo.2026.05.023
Sekinat Yusuf, Aishah Azam, Inesh Sood, Hasan Al-Sattar, Vinod Mullassery, Sola Adeleke
{"title":"Re: Stereotactic Body Radiation Therapy for Oligoprogressive Disease in Androgen-suppressed Prostate Cancer: Primary Endpoint Analysis of the TRAP Trial.","authors":"Sekinat Yusuf, Aishah Azam, Inesh Sood, Hasan Al-Sattar, Vinod Mullassery, Sola Adeleke","doi":"10.1016/j.eururo.2026.05.023","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.05.023","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-06-16DOI: 10.1016/j.eururo.2026.05.025
Hongzhi Ma, Qionghui Zhou
{"title":"Re: Pembrolizumab in Combination with Gemcitabine and Concurrent Hypofractionated Radiation Therapy as Bladder-sparing Treatment for Muscle-invasive Urothelial Cancer of the Bladder: A Multicenter Phase 2 Trial.","authors":"Hongzhi Ma, Qionghui Zhou","doi":"10.1016/j.eururo.2026.05.025","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.05.025","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-06-06DOI: 10.1016/j.eururo.2026.05.008
Amar U Kishan, Giulio Francolini, Declan G Murphy, Renu S Eapen, Paul Sargos, Giulia Marvaso, Piet Ost, Neha Vapiwala
{"title":"A Multidisciplinary Approach to Prevention and Treatment of Late Genitourinary Adverse Events After Radiotherapy for Prostate Cancer.","authors":"Amar U Kishan, Giulio Francolini, Declan G Murphy, Renu S Eapen, Paul Sargos, Giulia Marvaso, Piet Ost, Neha Vapiwala","doi":"10.1016/j.eururo.2026.05.008","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.05.008","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European urologyPub Date : 2026-05-13DOI: 10.1016/j.eururo.2026.04.026
Javier de Nicolás-Hernández, Carlos Valdivia, Alicia Arenas, Miguel A Zaballos, Mercedes Robledo, Cristina Rodríguez-Antona
{"title":"Expanding Bevacizumab-Erlotinib Therapy Through Fumarate Hydratase Deficiency Screening and Drug Target Pathway Analysis in Papillary Morphology Metastatic Renal Cell Carcinoma.","authors":"Javier de Nicolás-Hernández, Carlos Valdivia, Alicia Arenas, Miguel A Zaballos, Mercedes Robledo, Cristina Rodríguez-Antona","doi":"10.1016/j.eururo.2026.04.026","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.04.026","url":null,"abstract":"","PeriodicalId":94000,"journal":{"name":"European urology","volume":" ","pages":""},"PeriodicalIF":25.2,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}