Drug and alcohol dependence最新文献

{"title":"Naltrexone blocks the sleep-disrupting effects of methamphetamine in male rhesus monkeys.","authors":"Patrick G Davis, Victor Nascimento-Rocha, James K Rowlett, Lais F Berro","doi":"10.1016/j.drugalcdep.2025.112911","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2025.112911","url":null,"abstract":"<p><strong>Background: </strong>Methamphetamine has garnered increasing attention due to its escalating recreational use resulting in significant morbidity and mortality. Methamphetamine also significantly alters sleep quality, a finding that has been observed in both human and non-human primates. Naltrexone, an opioid receptor antagonist used in the treatment of opioid and alcohol use disorder, has shown promise as a treatment for methamphetamine use disorder. However, the potential benefits of naltrexone with regards to ameliorating sleep disturbances associated with methamphetamine use are unknown. The aim of the present study was to investigate the acute effects of evening naltrexone administration on the acute sleep-disrupting effects of methamphetamine.</p><p><strong>Methods: </strong>Adult male rhesus macaques (N = 4) were fitted with primate collars to which actigraphy monitors were attached. Vehicle or naltrexone (0.03, 0.1, and 0.3mg/kg, i.m.) were administered in the evening (ZT10.5, 1.5h before \"lights off\") following a morning (ZT4, 4h after \"lights on\") administration of methamphetamine (0.3mg/kg, i.m.).</p><p><strong>Results: </strong>Our findings replicate previous studies showing that methamphetamine significantly impairs sleep-associated measures in male rhesus monkeys, increasing actigraphy-based measures of sleep latency and wake time after sleep onset (WASO), and decreasing sleep efficiency. Evening treatment with naltrexone dose-dependently improved methamphetamine-induced sleep impairment, with the highest dose significantly improving actigraphy-based measures of sleep latency, sleep efficiency, and WASO.</p><p><strong>Conclusions: </strong>These results suggest that naltrexone may be beneficial in the treatment of methamphetamine use disorder through amelioration of sleep disturbances observed with methamphetamine use.</p>","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"112911"},"PeriodicalIF":3.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study.","authors":"Joao P De Aquino, Gabriel P A Costa, Julio C Nunes, Justin Hudak, Madeleine Odette, Eric L Garland","doi":"10.1016/j.drugalcdep.2025.112812","DOIUrl":"10.1016/j.drugalcdep.2025.112812","url":null,"abstract":"<p><strong>Background: </strong>With evolving legislation and attitudes towards cannabis in the United States, individuals receiving long-term opioid therapy (LTOT) for chronic pain increasingly use cannabis intending to relieve pain and reduce opioid consumption. Although they might also use cannabis to compensate for emotion dysregulation, the role of emotion regulation capacity in this population's patterns of cannabis use has not been investigated. This study examined whether deficits in emotion regulation capacity, an endophenotype assessed via psychophysiological measures, are associated with more frequent cannabis use among individuals receiving LTOT for chronic pain.</p><p><strong>Methods: </strong>We analyzed data from 104 participants (mean age=51.12 years; 68.35 % female; 88.46 % White) receiving LTOT for chronic pain. Cannabis use frequency was quantified by days of use over 90 days. Emotion regulation capacity was indexed using skin conductance response (SCR) and corrugator electromyography (fEMG) during passive viewing or cognitive reappraisal of negative stimuli. Pain severity was assessed using the Brief Pain Inventory.</p><p><strong>Results: </strong>Smaller reductions in SCR (β=-0.018, p < 0.001) and corrugator fEMG (β=-9.59, p < 0.001) difference scores, signifying weaker emotion regulation capacity, were associated with more days of cannabis use. Pain severity was not significantly associated with cannabis use frequency (β=0.026, p = 0.370).</p><p><strong>Conclusions: </strong>These findings suggest that impaired emotion regulation capacity might be a more critical endophenotype associated with frequent cannabis use than pain severity and support the notion that cannabis use might primarily modulate affective processes in this population. These results highlight the potential for targeted emotion regulation interventions to address heavy cannabis use among pain patients receiving LTOT.</p>","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"275 ","pages":"112812"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal effects of interoceptive awareness training as an adjunct to medication treatment for opioid use disorder: A randomized clinical trial of Mindful Awareness in Body-oriented Therapy.","authors":"Cynthia J Price, Kenneth C Pike, Joseph O Merrill","doi":"10.1016/j.drugalcdep.2025.112813","DOIUrl":"10.1016/j.drugalcdep.2025.112813","url":null,"abstract":"<p><strong>Background and objective: </strong>Medication for opioid use disorder (MOUD) treatment outcomes can be limited by co-occurring mental and physical conditions, and new adjunctive interventions are needed to improve treatment. Mindful Awareness in Body-oriented Therapy (MABT) teaches interoceptive awareness skills to promote well-being. This study evaluated the longitudinal effects of MABT as an adjunct to MOUD treatment.</p><p><strong>Methods: </strong>Patients stable on MOUD recruited from six community clinics were randomly assigned to MABT+MOUD or MOUD. Five assessments delivered over one year (N = 303) examined abstinence from non-prescribed opioid and overall substance use (primary outcomes), and secondary outcomes of mental and physical health distress, interoceptive and mindfulness skills, and opioid craving. An intent-to-treat approach to examine change across time involved generalized estimating equations and linear mixed multilevel models.</p><p><strong>Results: </strong>This sample demonstrated high percent days abstinence from non-prescribed opioids and other substances, resulting in no statistical between-group differences over time. Significant overall longitudinal effects for MABT+MOUD vs. MOUD were evident on secondary outcomes of physical symptom frequency, and interoceptive awareness. In addition, significant baseline to 12 month between-group improvements were evident on PTSD symptoms, emotion regulation difficulties, and mindfulness skills.</p><p><strong>Conclusions: </strong>While stable on MOUD, this sample had high levels of chronic pain and mental health distress. The results highlight improved longitudinal health outcomes in response to MABT critical to support recovery on MOUD. The MABT completion rate and maintained use of MABT skills over 12 months demonstrates MABT implementation feasibility and positive intervention response as an adjunct to MOUD treatment. PREREGISTRATION CLINICALTRIALS.GOV: NCT04082637.</p>","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"275 ","pages":"112813"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum/Erratum to \"Opioid agonist treatment in transition: A cross-country comparison between Austria, Germany and Switzerland\" [Drug Alcohol Depend. 254 (2024) 111036].","authors":"Tanja Schwarz, Judith Anzenberger, Martin Busch, Gerhard Gmel, Ludwig Kraus, R Michael Krausz, Florian Labhart, Maximilian Meyer, Michael P Schaub, Jean N Westenberg, Alfred Uhl","doi":"10.1016/j.drugalcdep.2025.112887","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2025.112887","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":" ","pages":"112887"},"PeriodicalIF":3.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"The prevalence of fentanyl in New York City's unregulated drug supply as measured through drug checking offered at syringe service programs\" [Drug Alcohol Depend. 268 (2025) 112578].","authors":"Yarelix Estrada, Jeffery Sauer, Leonardo Dominguez, Izza Zaidi, Andrew J Trinidad, Hannah Helmy, Alex Harocopos","doi":"10.1016/j.drugalcdep.2025.112847","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2025.112847","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":" ","pages":"112847"},"PeriodicalIF":3.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of stigmatizing language related to substance use disorders in media: A systematic review.","authors":"Elizabeth K Farkouh, Kiyan Heybati, Annie B Fox, John F Kelly, Jeff Niederdeppe, Wei Zhang","doi":"10.1016/j.drugalcdep.2025.112820","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2025.112820","url":null,"abstract":"<p><strong>Aims: </strong>Substance use disorder (SUD)-related stigma may contribute to delayed help seeking and undertreatment. Stigmatizing language (\"substance abuse,\" \"alcoholic,\" etc.) is a harmful component of stigma that implies moral failing and characterological weakness. Media portrayals of SUDs influence attitudes, public opinion, and support for public policies addressing SUDs. This review examined SUD-related stigmatizing language in print, broadcast, digital, and social media to understand shaping of public attitudes and inform future interventions.</p><p><strong>Methods: </strong>This study was prospectively registered and conducted according to the Cochrane Handbook. Abstracts (n = 515) were identified through systematic searches across Medline, Embase, PyschINFO, Web of Science, and supplemented by hand searching bibliographies of included studies. English-language, peer-reviewed publications that examined stigmatizing language within media channels were included.</p><p><strong>Results: </strong>Thirteen studies focusing on print and digital news (n = 9), video-based (n = 2), and social (n = 4) media were included, of which two examined a combination of media types. With few exceptions, the use of stigmatizing language was frequent across locations and media types. Common terms included \"addict,\" substance/drug \"abuse(r),\" and \"junkie.\" While some studies found changes in stigmatizing language use over time, the direction and magnitude of changes varied by context and media type.</p><p><strong>Conclusions: </strong>Stigmatizing language in media remains prevalent with a few exceptions. Broad-reaching stigma-reducing interventions such as public education and advocacy by medical and public health communities are critically needed. Additional studies are needed to examine other media types, explore differential use of stigmatizing language by substance discussed, and investigate how stigmatizing language influences perceptions of and attitudes toward SUDs.</p>","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":" ","pages":"112820"},"PeriodicalIF":3.6,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning with conviction: Exploring the relationship between criminal legal system involvement and substance use and recovery outcomes for students in collegiate recovery programs","authors":"Noel Vest, Justin S. Bell, Alexa Nieder, Rebecca Smith, Thomas Bannard, Sarah Tragesser, Patrick Hibbard, Danielle Dick","doi":"10.1016/j.drugalcdep.2024.111127","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2024.111127","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"59 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139874183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loci on Chromosome 20 Interact with rs16969968 to Influence Cigarettes per Day in European Ancestry Individuals","authors":"Pamela N Romero Villela, Luke M. Evans, T. Palviainen, Richard Border, Jaakko Kaprio, Rohan H.C. Palmer, Matthew C. Keller, M. Ehringer","doi":"10.1016/j.drugalcdep.2024.111126","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2024.111126","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139886610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotine Use Among Reservation-area American Indian Adolescents Compared With a National Sample","authors":"M. Crabtree, Linda R. Stanley, Richard A. Miech, R. Swaim","doi":"10.1016/j.drugalcdep.2024.111124","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2024.111124","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"209 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139825249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring patterns of alcohol use and alcohol use disorder among Asian Americans with a finer lens","authors":"Haitao Zhang, W. J. Ruan, S. Chou, T. Saha, Amy Z. Fan, Boji Huang, Aaron M. White","doi":"10.1016/j.drugalcdep.2024.111120","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2024.111120","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"16 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139882756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}