Drug and alcohol dependence最新文献

{"title":"Opioid misuse and opioid use disorder by sexual identity in U.S. adults: Findings from the 2021-2022 NSDUH.","authors":"Megan S Schuler, Bradley D Stein","doi":"10.1016/j.drugalcdep.2026.113398","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2026.113398","url":null,"abstract":"<p><strong>Background: </strong>Sexual minority adults experience elevated rates of substance use, yet recent national data on opioid misuse, opioid use disorder (OUD), and heroin-related perceptions by sexual identity and age remain limited.</p><p><strong>Methods: </strong>We used pooled 2021-2022 National Survey on Drug Use and Health (NSDUH) data among heterosexual, gay/lesbian, and bisexual adults (n = 90,066; gay men n = 1312; bisexual men n = 1835; lesbian/gay women n = 1428; bisexual women n = 6389). Survey-weighted logistic regression models, stratified by sex and adjusted for sociodemographic characteristics, estimated adjusted odds of lifetime opioid misuse, lifetime heroin use, past-year opioid misuse, past-year OUD, perceived heroin risk, and perceived heroin access by sexual identity. Age-stratified models estimated disparities in lifetime and past-year opioid misuse across adulthood.</p><p><strong>Results: </strong>Bisexual women had more than twice the adjusted odds of all four opioid outcomes relative to heterosexual women (aORs=2.30-2.96), with disparities in opioid misuse evident across all age groups. Lesbian/gay women had elevated adjusted odds of lifetime opioid misuse and heroin use only. Bisexual men had higher adjusted odds of lifetime opioid misuse (aOR=2.02 [1.59-2.57]) and past-year opioid misuse (aOR=1.95 [1.38-2.76]); gay men had no significant adjusted disparities. Bisexual men and women had lower adjusted odds of perceiving great risk from trying heroin; bisexual women also had higher odds of perceived heroin access.</p><p><strong>Conclusions: </strong>Sexual identity disparities in opioid misuse and OUD persist in national data, with particularly elevated prevalence among bisexual women. Bisexual adults may benefit from age-inclusive opioid screening and harm-reduction messaging responsive to their lower perceived heroin risk.</p>","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"288 ","pages":"113398"},"PeriodicalIF":3.6,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study.","authors":"Joao P De Aquino, Gabriel P A Costa, Julio C Nunes, Justin Hudak, Madeleine Odette, Eric L Garland","doi":"10.1016/j.drugalcdep.2025.112812","DOIUrl":"10.1016/j.drugalcdep.2025.112812","url":null,"abstract":"<p><strong>Background: </strong>With evolving legislation and attitudes towards cannabis in the United States, individuals receiving long-term opioid therapy (LTOT) for chronic pain increasingly use cannabis intending to relieve pain and reduce opioid consumption. Although they might also use cannabis to compensate for emotion dysregulation, the role of emotion regulation capacity in this population's patterns of cannabis use has not been investigated. This study examined whether deficits in emotion regulation capacity, an endophenotype assessed via psychophysiological measures, are associated with more frequent cannabis use among individuals receiving LTOT for chronic pain.</p><p><strong>Methods: </strong>We analyzed data from 104 participants (mean age=51.12 years; 68.35 % female; 88.46 % White) receiving LTOT for chronic pain. Cannabis use frequency was quantified by days of use over 90 days. Emotion regulation capacity was indexed using skin conductance response (SCR) and corrugator electromyography (fEMG) during passive viewing or cognitive reappraisal of negative stimuli. Pain severity was assessed using the Brief Pain Inventory.</p><p><strong>Results: </strong>Smaller reductions in SCR (β=-0.018, p < 0.001) and corrugator fEMG (β=-9.59, p < 0.001) difference scores, signifying weaker emotion regulation capacity, were associated with more days of cannabis use. Pain severity was not significantly associated with cannabis use frequency (β=0.026, p = 0.370).</p><p><strong>Conclusions: </strong>These findings suggest that impaired emotion regulation capacity might be a more critical endophenotype associated with frequent cannabis use than pain severity and support the notion that cannabis use might primarily modulate affective processes in this population. These results highlight the potential for targeted emotion regulation interventions to address heavy cannabis use among pain patients receiving LTOT.</p>","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"275 ","pages":"112812"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal effects of interoceptive awareness training as an adjunct to medication treatment for opioid use disorder: A randomized clinical trial of Mindful Awareness in Body-oriented Therapy.","authors":"Cynthia J Price, Kenneth C Pike, Joseph O Merrill","doi":"10.1016/j.drugalcdep.2025.112813","DOIUrl":"10.1016/j.drugalcdep.2025.112813","url":null,"abstract":"<p><strong>Background and objective: </strong>Medication for opioid use disorder (MOUD) treatment outcomes can be limited by co-occurring mental and physical conditions, and new adjunctive interventions are needed to improve treatment. Mindful Awareness in Body-oriented Therapy (MABT) teaches interoceptive awareness skills to promote well-being. This study evaluated the longitudinal effects of MABT as an adjunct to MOUD treatment.</p><p><strong>Methods: </strong>Patients stable on MOUD recruited from six community clinics were randomly assigned to MABT+MOUD or MOUD. Five assessments delivered over one year (N = 303) examined abstinence from non-prescribed opioid and overall substance use (primary outcomes), and secondary outcomes of mental and physical health distress, interoceptive and mindfulness skills, and opioid craving. An intent-to-treat approach to examine change across time involved generalized estimating equations and linear mixed multilevel models.</p><p><strong>Results: </strong>This sample demonstrated high percent days abstinence from non-prescribed opioids and other substances, resulting in no statistical between-group differences over time. Significant overall longitudinal effects for MABT+MOUD vs. MOUD were evident on secondary outcomes of physical symptom frequency, and interoceptive awareness. In addition, significant baseline to 12 month between-group improvements were evident on PTSD symptoms, emotion regulation difficulties, and mindfulness skills.</p><p><strong>Conclusions: </strong>While stable on MOUD, this sample had high levels of chronic pain and mental health distress. The results highlight improved longitudinal health outcomes in response to MABT critical to support recovery on MOUD. The MABT completion rate and maintained use of MABT skills over 12 months demonstrates MABT implementation feasibility and positive intervention response as an adjunct to MOUD treatment. PREREGISTRATION CLINICALTRIALS.GOV: NCT04082637.</p>","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"275 ","pages":"112813"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning with conviction: Exploring the relationship between criminal legal system involvement and substance use and recovery outcomes for students in collegiate recovery programs","authors":"Noel Vest, Justin S. Bell, Alexa Nieder, Rebecca Smith, Thomas Bannard, Sarah Tragesser, Patrick Hibbard, Danielle Dick","doi":"10.1016/j.drugalcdep.2024.111127","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2024.111127","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"59 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139874183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loci on Chromosome 20 Interact with rs16969968 to Influence Cigarettes per Day in European Ancestry Individuals","authors":"Pamela N Romero Villela, Luke M. Evans, T. Palviainen, Richard Border, Jaakko Kaprio, Rohan H.C. Palmer, Matthew C. Keller, M. Ehringer","doi":"10.1016/j.drugalcdep.2024.111126","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2024.111126","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139886610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotine Use Among Reservation-area American Indian Adolescents Compared With a National Sample","authors":"M. Crabtree, Linda R. Stanley, Richard A. Miech, R. Swaim","doi":"10.1016/j.drugalcdep.2024.111124","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2024.111124","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"209 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139825249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring patterns of alcohol use and alcohol use disorder among Asian Americans with a finer lens","authors":"Haitao Zhang, W. J. Ruan, S. Chou, T. Saha, Amy Z. Fan, Boji Huang, Aaron M. White","doi":"10.1016/j.drugalcdep.2024.111120","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2024.111120","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"16 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139882756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis between CDT in serum and Ethyl glucuronide in hair to define the best reliable tool for the diagnosis of alcohol abuse","authors":"Alice Cerioni, Erika Buratti, Gianmario Mietti, Isabella Lima Arrais Ribeiro, M. Cippitelli, Giovanna Tassoni, Mariano Cingolani, R. Froldi, R. Scendoni","doi":"10.1016/j.drugalcdep.2024.111128","DOIUrl":"https://doi.org/10.1016/j.drugalcdep.2024.111128","url":null,"abstract":"","PeriodicalId":93983,"journal":{"name":"Drug and alcohol dependence","volume":"40 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139829728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}