Current neurovascular research最新文献

{"title":"Blood-brain Barrier Dysfunction in Parkinson's Disease: Mechanisms and Emerging Therapeutic Strategies.","authors":"Gursimran Singh, Khadga Raj Aran","doi":"10.2174/0115672026434365260113100943","DOIUrl":"10.2174/0115672026434365260113100943","url":null,"abstract":"<p><strong>Introduction: </strong>PD is a progressive neurodegenerative disorder, which is associated with the deterioration of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in motor and non-motor symptoms. Pathogenesis includes alpha-synuclein aggregation and Lewy bodies, neuroinflammation, and oxidative stress. The breakdown of the blood-brain barrier (BBB) via tight junctions and disturbed transporter activity has been identified as a factor in the evolution of PD.</p><p><strong>Methods: </strong>The review is a synthesis of evidence provided by preclinical and clinical studies that examine the connection between BBB dysfunction and the pathogenesis of PD. PubMed, Web of Science, and Google Scholar were used to source the literature, and studies that show BBB permeability, α-synuclein pathology, and therapeutic interventions of BBB integrity were used as a limiting factor.</p><p><strong>Results: </strong>Evidence indicates that the activation of BBB damage by disruptive activity allows the intrusion of neurotoxic factors and inflammatory agents in the central nervous system to worsen the degeneration of dopaminergic neurons. The changes in endothelial tight junction proteins, transporters, and immune cell infiltrations have remained consistent in PD models. Preclinical treatments, including neuroprotective therapeutics, anti-inflammatory medications, and treatments that alter the BBB permeability to be used in delivering drugs to specific brain locations, have demonstrated positive outcomes in the survival of neurons and motor activity.</p><p><strong>Discussion: </strong>BBB dysfunction in PD appears to be an outcome and a cause of neurodegeneration, which forms a vicious cycle with neuroinflammation and α-synuclein deposition. Modifying permeability by targeting BBB repair pathways and selecting particular mechanisms to enhance permeability are promising disease-modifying therapies.</p><p><strong>Conclusion: </strong>BBB integrity is a very important but under-investigated element of PD pathogenesis. Understanding its interplay with neuroinflammation and protein aggregation may yield novel therapeutic targets and improve drug delivery approaches in PD management.</p>","PeriodicalId":93965,"journal":{"name":"Current neurovascular research","volume":" ","pages":"20-37"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Evoked Potentials in Symptomatic and Asymptomatic Carotid Artery Stenosis.","authors":"Yıldız Arslan, Ayse Ceren Ozturk, Seda Karaca Adıyeke, Resat Duman","doi":"10.2174/0115672026449721260306035143","DOIUrl":"10.2174/0115672026449721260306035143","url":null,"abstract":"<p><strong>Introduction: </strong>Carotid artery stenosis is a major risk factor for ischemic stroke; however, functional impairment varies depending on the efficiency of collateral circulation. Visual Evoked Potentials (VEPs) provide a non-invasive means of assessing visual pathway integrity. Beyond the degree of anatomical stenosis, metabolic factors may also influence collateral function. This study aimed to evaluate the relationship between VEP responses, biochemical markers, and symptomatic status in patients with moderate to severe İnternal Carotid Artery (ICA) stenosis.</p><p><strong>Materials and methods: </strong>A total of 80 patients (40 symptomatic, 40 asymptomatic) with cervical ICA stenosis (50-70% or >70%) confirmed by CT angiography were prospectively enrolled. All patients underwent ophthalmological examination and pattern-reversal VEP testing. Abnormal VEP was defined as a P100 latency >110 ms, an interocular latency difference >10 ms, or an amplitude <5 μV. Laboratory parameters, including HDL and HbA1c, were also analyzed.</p><p><strong>Results: </strong>VEP latencies did not significantly differ between symptomatic and asymptomatic groups or between moderate and severe stenosis subgroups, indicating preserved visual pathway function. However, HDL levels were significantly higher in asymptomatic patients (p =0.033), while HbA1c levels were elevated in those with >70% stenosis (p =0.011). These findings suggest that metabolic status contributes to the preservation or impairment of collateral circulation, independent of stenosis severity.</p><p><strong>Discussion: </strong>Our results demonstrate that VEP latencies remained comparable across symptomatic and carotid stenosis subgroups, suggesting preserved visual pathway function despite carotid narrowing. In contrast, higher HDL in asymptomatic patients and elevated HbA1c in severe stenosis indicate a metabolic influence on collateral efficiency. These findings highlight that vascular risk factors and metabolic status may be as critical as anatomical stenosis in determining functional outcomes.</p><p><strong>Conclusion: </strong>Cervical carotid stenosis severity alone does not predict functional compromise. Integrating VEP assessment with metabolic profiling-particularly HDL and HbA1c levels-may enhance risk stratification, offering a more comprehensive and individualized evaluation, especially in asymptomatic patients. This novel perspective links biochemical markers to electrophysiological integrity and collateral efficiency in ICA stenosis.</p>","PeriodicalId":93965,"journal":{"name":"Current neurovascular research","volume":" ","pages":"271-278"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurosyphilis and Parkinsonism: Overlapping Pathophysiology and Emerging Therapeutic Insights.","authors":"Shruti, Zuber Khan, Mustak Ahamed, Sidharth Mehan, Mumtaz, Abdul Rahim, Injamamul Haque, Sumedha Gupta, Aysha Bano","doi":"10.2174/0115672026455328260209113932","DOIUrl":"10.2174/0115672026455328260209113932","url":null,"abstract":"<p><strong>Introduction: </strong>Neurosyphilis, caused by Treponema pallidum, is a complex neurological condition arising from untreated syphilis and can present with diverse manifestations, including Parkinsonism-like motor dysfunction. Its pathophysiology involves Blood-Brain Barrier (BBB) disruption, dopaminergic neuronal loss, and neuroinflammatory cascades that resemble mechanisms seen in idiopathic Parkinson's Disease (PD).</p><p><strong>Methods: </strong>A literature review from PubMed, ScienceDirect, Scopus, and Google Scholar (2014- 2025) explored studies on neurosyphilis, dopaminergic degeneration, BBB dysfunction, neuroinflammation, diagnostics, and treatments, including antibiotics, neuroprotective agents, nanocarriers, and vaccines. A narrative synthesis was conducted due to the variation in study designs.</p><p><strong>Results: </strong>The decreased BBB permeability, extracellular matrix degradation, TLR activation, reactive microglia, and neuronal cell death are mechanisms linking syphilis and idiopathic PD. Neurologists differentiate between neurosyphilis and idiopathic PD through neuroimaging and cerebrospinal fluid analysis (CSF). Treatment for neurosyphilis primarily involves penicillin, with alternatives such as ceftriaxone and doxycycline. Emerging evidence suggests that β-lactam antibiotics and nanoparticle systems targeting neuroinflammatory pathways may offer neuroprotective effects.</p><p><strong>Discussion: </strong>These findings exhibit considerable mechanistic overlap between neurosyphilis and PD, particularly concerning BBB dysfunction, dopaminergic neurodegeneration, and neuroinflammation. These common pathways lead to symptoms similar to those of PD and complicate clinical manifestation. Neuroimaging and CSF analyses are still very important for making an accurate diagnosis. Further study is needed to clarify disease mechanisms and to evaluate novel therapeutic approaches.</p><p><strong>Conclusion: </strong>Neurosyphilis may present with Parkinsonian features due to PD-like neurodegenerative mechanisms. Early diagnosis and timely antimicrobial therapy are crucial to prevent irreversible neurological damage, while emerging neuroprotective strategies warrant further investigation.</p>","PeriodicalId":93965,"journal":{"name":"Current neurovascular research","volume":" ","pages":"231-246"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspartame and Neurotoxicity: Quantitative Insights from Biomarker and Dose-response Analysis.","authors":"Arbind Kumar Choudhary, Nishant Singh","doi":"10.2174/0115672026438031260114120352","DOIUrl":"10.2174/0115672026438031260114120352","url":null,"abstract":"<p><strong>Introduction: </strong>Aspartame, a widely consumed artificial sweetener, raises concerns regarding its potential neurotoxic effects mediated through oxidative stress pathways. This systematic review and meta-analysis quantified the relationship between aspartame exposure and oxidative stress biomarkers that affect learning and memory.</p><p><strong>Methods: </strong>A comprehensive systematic review was conducted following the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searches were performed across multiple databases, including PubMed, MEDLINE, and Google Scholar, for studies published between 2015 and 2025. The review included studies that investigated the effects of aspartame exposure on learning and memory, as well as oxidative stress measurements. A random-effects meta-analysis was performed using the DerSimonian-Laird method, with effect sizes calculated as Cohen's d. This was followed by a dose-response meta-regression analysis. The risk of bias was rigorously assessed using the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) criteria.</p><p><strong>Results: </strong>From an initial pool of 264 records, 10 studies met the predefined inclusion criteria. Meta-analysis revealed significant increases in reactive oxygen species (ROS) (pooled effect size: 2.140, 95% CI: 1.514-2.767) and malondialdehyde (MDA) (1.773, 95% CI: 1.230-2.317). Concurrently, significant decreases were observed in glutathione (GSH) (-1.809, 95% CI: -2.339 to -1.279) and superoxide dismutase (SOD) (-1.438, 95% CI: -1.915 to -0.962). All observed effects were highly significant (p <0.001) and exhibited large effect sizes. Dose-response metaregression analysis demonstrated excellent log-linear relationships (R2 > 0.92) across all biomarkers and predicted large oxidative effects (Cohen's d > 1.2) across all evaluated biomarkers.</p><p><strong>Discussion: </strong>This study evidence that aspartame exposure results in oxidative stress in a dosedependent fashion. ROS has been established as the most sensitive bio-signature of the early occurrence of these effects in the body. These data indicate that aspartame may be an important environmental factor for the development of oxidative stress in the brain, and current safety standards may not be sufficient to avoid biochemical effects, based on our experimental conditions.</p><p><strong>Conclusion: </strong>This is a very clear aspartame dose-dependent relationship in describing a toxic effect of aspartame. The results underscore the urgent necessity of re-evaluating the established daily intake of aspartame for humans to a more realistic, decreased value in order to approach or reach only theoretical risk levels.</p>","PeriodicalId":93965,"journal":{"name":"Current neurovascular research","volume":" ","pages":"135-147"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Notice to \"MiR-34a Inhibits Spinal Cord Injury and Blocks Spinal Cord Neuron Apoptosis by Activating Phatidylinositol 3-kinase (PI3K)/AKT Pathway Through Targeting CD47\".","authors":"Liao Qi, Ming Jiang-Hua, Hu Ge-Liang, Chen Qing, Li Ya-Ming","doi":"10.2174/1567202623999260101101230","DOIUrl":"https://doi.org/10.2174/1567202623999260101101230","url":null,"abstract":"<p><p>This article has been retracted at the request of the author(s) from the journal Current Neurovascular Research. The authors informed the journal after publication that the animal experiments reported in the study were conducted without prior approval from the institutional Animal Ethics Committee, and that the required ethical approval documentation had not been obtained at the time of submission. In fact, at the time of submission, the author(s) declared that the required permission was obtained before proceeding for publication. The publisher cannot decide which statement of authors(s) is correct. The author(s) acknowledged that this omission occurred due to inexperience and an unintended oversight during the submission process. Following publication, concerns were raised by the authors' colleagues, the institutional ethics committee, and the relevant Science and Education department regarding the absence of formal ethical approval. In view of these concerns, the authors formally requested retraction of the article and expressed their apologies to the journal and its readership. As adherence to ethical standards for animal research is mandatory for publication, the Publisher has decided to retract the article in order to maintain the integrity of the scientific record. The publisher apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure, or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication, the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.</p>","PeriodicalId":93965,"journal":{"name":"Current neurovascular research","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Factors for In-stent Restenosis After Cerebrovascular Stent Implantation among Ischemic Stroke Patients.","authors":"Shiliang Xia, JIaxing You, Delong Wang, Xueyu Mao, Shidong Wei, Yunhe Luo, Zhengbao Zhu, Faqing Long, Jin Zheng","doi":"10.2174/0115672026444898260127051641","DOIUrl":"10.2174/0115672026444898260127051641","url":null,"abstract":"<p><strong>Introduction: </strong>In-stent restenosis (ISR) critically impacts the efficacy of cerebrovascular stent implantation. We investigated the influence of clinical factors on the ISR.</p><p><strong>Methods: </strong>A total of 251 patients with ischemic stroke undergoing cerebrovascular stenting from November 2014 to March 2020 were recruited. The primary outcome was ISR within 12 months. Predictors were selected using the least absolute shrinkage and selection operator regression and logistic regression to build a nomogram. Model discriminative ability, calibration, and clinical utility were evaluated via the area under receiver operating characteristic curves (AUC), calibration plots, and decision curve analysis.</p><p><strong>Results: </strong>Multivariate analysis identified coronary artery disease (OR, 3.35; 95% CI, 1.26-9.21; P=0.016), neutrophil-to-lymphocyte ratio (NLR, OR, 1.84; 95% CI, 1.50-2.37; P<0.001), and residual stenosis (OR, 1.08; 95% CI, 1.02-1.15; P=0.012) as independent risk factors for ISR. Hypertension, coronary artery disease, NLR, and residual stenosis were incorporated into the nomogram model. The model demonstrated an AUC of 0.862 (95% CI 0.783-0.929) upon internal validation. Subgroup analyses revealed no statistically significant heterogeneity stratified by age, gender, and stenosis location (all P≥0.1).</p><p><strong>Discussion: </strong>Hypertension and NLR were potential predictive factors for in-stent restenosis after cerebrovascular stent implantation. In addition, patients with vertebral artery stenosis had a higher risk of in-stent restenosis than those with internal carotid artery stenosis.</p><p><strong>Conclusion: </strong>Coronary artery disease, NLR, and residual stenosis were potential predictive factors for ISR after cerebrovascular stent implantation. The developed nomogram helps in identifying patients at high risk for ISR.</p>","PeriodicalId":93965,"journal":{"name":"Current neurovascular research","volume":" ","pages":"101-109"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Machine Learning Models for Functional Recovery Following Endovascular Thrombectomy in Patients with Acute Vertebrobasilar Artery Occlusion.","authors":"Ruicheng Zhang, Menglu Zhang, Xingyue Wang, Bo Zhou, Qingtao Xie, Shiqin Ju, Yu Feng, Yanbo Cheng","doi":"10.2174/0115672026420610260121074852","DOIUrl":"10.2174/0115672026420610260121074852","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to develop machine learning prediction models to identify high-risk populations with Vertebrobasilar Artery Occlusion (VBAO) who are likely to experience poor prognosis after Endovascular Thrombectomy (EVT), thereby informing clinical decision-making.</p><p><strong>Methods: </strong>A retrospective cohort of 204 patients with acute VBAO undergoing EVT at the Department of Neurology, Affiliated Hospital of Xuzhou Medical University (January 2020- October 2024) was analyzed. Multimodal data, including medical history, clinical symptoms, laboratory parameters, hemodynamic indices, and procedural details, were collected. For missing data, Multiple Imputation (MI) was performed to reduce information bias. Patients were stratified into favorable (modified Rankin Scale [mRS] ≤2) and poor prognosis (mRS >2) groups based on 90-day outcomes. Seven machine learning models-logistic regression, random forest, gradient boosting, XGBoost, LightGBM, CatBoost, and AdaBoost-were constructed and evaluated using five-fold cross-validation. Model performance metrics and predictor importance were analyzed.</p><p><strong>Results: </strong>Among 204 patients, the random forest model demonstrated the highest performance (AUC = 0.9648, 95% CI: 0.9356-0.9941), significantly outperforming traditional LR (AUC = 0.76, p < 0.01). Key predictors included Hypertension (HTN), Type 2 Diabetes Mellitus (T2DM), Heart Rate (HR), National Institutes of Health Stroke Scale (NIHSS) score, operation time, Blood Glucose (BG), and albumin. SHapley Additive exPlanations (SHAP) analysis identified BG as the most influential predictor, accounting for 31.2% of the model's predictive power. Decision Curve Analysis (DCA) confirmed clinical utility at a threshold probability of 0.1, supporting its application in guiding preventive or therapeutic interventions.</p><p><strong>Discussion: </strong>The random forest model's superiority lies in its ability to capture non-linear variable interactions, overcoming LR's limitations. BG and systemic inflammatory indices (SIRI, NLR) highlight the role of metabolic-inflammatory crosstalk in prognosis. The model integrates easily accessible data (avoiding over-reliance on imaging) and offers SHAP-based interpretability, but is limited by single-center design, small sample size, and lack of external validationissues to address in future multicenter studies.</p><p><strong>Conclusion: </strong>This machine learning model provides a precise decision-support tool for preoperative risk stratification in VBAO patients, offering significant clinical value for optimizing post- EVT neurological outcomes.</p>","PeriodicalId":93965,"journal":{"name":"Current neurovascular research","volume":" ","pages":"174-186"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific Relationship between Serum Uric Acid to Serum Creatinine Ratio and Prognosis after Cerebral Venous Sinus Thrombosis.","authors":"Kai Liu, Mengmeng Zhang, Jiawei Zhao, Qinqin Dai, Huazheng Li, Yuan Gao, Shen Li, Yuming Xu, Bo Song","doi":"10.2174/0115672026422057260331053637","DOIUrl":"10.2174/0115672026422057260331053637","url":null,"abstract":"<p><strong>Introduction: </strong>Serum Uric Acid to Serum Creatinine Ratio (SUA/SCr) is a new indicator for evaluating renal function and has been found to be associated with multiple prognostic outcomes. This study explores the association between SUA/SCr and prognosis in patients with Cerebral Venous Sinus Thrombosis (CVST).</p><p><strong>Methods: </strong>Retrospectively analyze the patients with CVST admitted to the First Affiliated Hospital of Zhengzhou University from January 2011 to October 2023. The modified Rankin Scale (mRS) is used to evaluate the functional outcomes of the patients. Multivariate logistic regression analysis is adopted to assess the relationship between SUA/SCr and the functional outcomes after CVST.</p><p><strong>Results: </strong>Male patients had higher levels of SUA and SCr than females. Multivariate logistic regression analysis showed that each 1 μ mol/L increase in SUA/SCr levels was linked to lower risks of poor prognosis (OR 0.781, 95% CI 0.621 - 0.982, P = 0.034) and mortality (OR 0.647, 95% CI 0.468 - 0.895, P = 0.009) for females. When categorized by SUA/SCr quartiles, compared with the lowest quartile of SUA/SCr, the highest and the second highest quartiles of SUA/SCr were associated with a 0.344-fold (0.107 - 1.101) and 0.837-fold (0.366 - 1.914) lower risk of poor prognosis, as well as a 0.076-fold (0.009 - 0.658) and 0.510-fold (0.192 - 1.356) lower risk of mortality in females.</p><p><strong>Discussion: </strong>SUA/SCr levels may be a predictor of adverse clinical outcomes and mortality in patients with CVST, and this protective association is gender-specific.</p><p><strong>Conclusion: </strong>Higher SUA/SCr levels were associated with better prognosis in females.</p>","PeriodicalId":93965,"journal":{"name":"Current neurovascular research","volume":" ","pages":"264-270"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Molecular Mechanisms and Key Genes of Early Deterioration of Parenchymal Lesions in Cerebral Venous Sinus Thrombosis.","authors":"Gengyu Cen, Jiaxin Li, Jun Wang, Ya Chen, Zhijian Liang","doi":"10.2174/0115672026438053260120052902","DOIUrl":"10.2174/0115672026438053260120052902","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral Venous Sinus Thrombosis (CVST) is a disease with a low incidence rate but is prone to progression and Early Deterioration of Parenchymal Lesions (EDPL), leading to severe neurological impairment. Exploring the potential molecular mechanisms and key genes of EDPL to achieve early clinical intervention and treatment is of vital importance. This study aims to investigate the potential molecular mechanisms and key genes of EDPL in CVST.</p><p><strong>Methods: </strong>The CVST patients were prospectively recruited, and their peripheral venous blood was collected. The gene expression matrices of three EDPL patients and three non-EDPL patients were obtained by transcriptome sequencing technology, differentially expressed genes were analyzed, a competing endogenous RNA (ceRNA) network for lncRNA-miRNA-mRNA was constructed, and the target genes of the ceRNA network were subjected to GO and KEGG analyses. The Hub genes of differentially expressed mRNAs (DEmRNAs) were screened using Cytoscape. Subsequently, the key genes were obtained by intersecting the Hub genes with the target genes.</p><p><strong>Results: </strong>In the present study, 172 differentially expressed lncRNAs (DElncRNAs, 145 upregulated and 27 down-regulated) and 107 DEmRNAs (53 up-regulated and 54 down-regulated) were obtained between the EDPL group and the non-EDPL group. We constructed a ceRNA network of EDPL containing 75 DElncRNAs, 34 miRNAs, and 46 DEmRNAs, and explored the functional enrichment of the target genes in the ceRNA network. It was shown that the target genes were mainly concentrated in the focal adhesion and the ECM-receptor interaction. Subsequently, the target genes of the ceRNA network were intersected with the Hub genes, and four key genes (RELN, CAV1, CCNB1, NME1-NME2) were screened.</p><p><strong>Discussion: </strong>This study constructed the ceRNA regulatory network of EDPL to analyze the potential mechanisms and screen key genes, but there are still certain limitations, such as a small sample size and a lack of in vivo and in vitro experimental verification. Large-scale, multicenter, and prospective studies are needed to further verify these results.</p><p><strong>Conclusion: </strong>It was shown that focal adhesion and ECM-receptor interaction may be involved in the mechanisms of EDPL, and RELN, CAV1, CCNB1, and NME1-NME2 may be promising intervention targets for EDPL.</p>","PeriodicalId":93965,"journal":{"name":"Current neurovascular research","volume":" ","pages":"212-222"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Liver Function Parameters as Potential Predictors o f Hemorrhagic Transformation in Acute Ischemic Stroke Patients with Successful Recanalization after Endovascular Treatment: A Retrospective Cohort Study.","authors":"Kai Wang, Di Luan","doi":"10.2174/0115672026437827260114072913","DOIUrl":"10.2174/0115672026437827260114072913","url":null,"abstract":"<p><strong>Introduction: </strong>Acute ischemic stroke (AIS) is a leading global cause of death/ disability; endovascular thrombectomy (EVT) treats large vessel occlusion, but postrecanalization hemorrhagic transformation (HT) raises mortality/poor outcomes. Established HT risk factors lack specificity, and the perioperative liver function parameters' predictive role is underexplored. This study investigated their association in AIS patients with successful EVT recanalization.</p><p><strong>Materials and methods: </strong>Retrospective single-center cohort included AIS patients with EVT success [modified Thrombolysis in Cerebral Infarction (mTICI) 2b/3], aged ≥18, AIS confirmed by CT/MRI, and pre-/24h post-op liver tests.</p><p><strong>Exclusions: </strong>non-AIS, intra-arterial thrombolysis, failed recanalization, and missing liver data.</p><p><strong>Variables: </strong>demographics, National Institutes of Health Stroke Scale (NIHSS)/ modified Rankin Scale (mRS), liver parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT)]. Univariate/multivariate logistic regression (IBM SPSS 23) analyzed CT-confirmed HT.</p><p><strong>Results: </strong>Of 178 initial patients, 138 were included (85 non-HT, 53 HT). Univariate: preoperative AST/ALT ratio (OR = 2.547, p = 0.020) was significantly correlated with HT. Multivariate: postoperative AST (OR = 1.427, p = 0.012) and bidirectional GGT (pre-op elevation reduced HT: OR = 0.850, p = 0.010; post-op elevation increased HT: OR = 1.215, p = 0.009) were independent predictors. Model efficacy: Area under the curve (AUC) = 0.869, 84.1% correct prediction.</p><p><strong>Conclusion: </strong>Perioperative AST and GGT are novel HT predictors. Postoperative AST elevation and dynamic GGT changes highlight the value of routine liver monitoring. Future research needs mechanistic validation and multicenter studies.</p>","PeriodicalId":93965,"journal":{"name":"Current neurovascular research","volume":" ","pages":"48-60"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}