CNS & neurological disorders drug targets最新文献_第3页

Identification of Known Flavonoids of Ficus carica L. as Aldose Reductase Inhibitors in Sciatic Nerve of Diabetic Neuropathy-induced Rats through Bioinformatics and Proteomics Analysis. 通过生物信息学和蛋白质组学分析鉴定糖尿病神经病变诱导的大鼠坐骨神经中作为醛糖还原酶抑制剂的已知榕树黄酮类化合物

CNS & neurological disorders drug targets Pub Date : 2025-03-11 DOI: 10.2174/0118715273322121250124065659

Dureshahwar Khan, Hemant D Une, Mubashir Mohammed, Jaiprakash N Sangshetti, Sanjay N Harke, Manoj Damale, Jitendra B Naik

{"title":"Identification of Known Flavonoids of Ficus carica L. as Aldose Reductase Inhibitors in Sciatic Nerve of Diabetic Neuropathy-induced Rats through Bioinformatics and Proteomics Analysis.","authors":"Dureshahwar Khan, Hemant D Une, Mubashir Mohammed, Jaiprakash N Sangshetti, Sanjay N Harke, Manoj Damale, Jitendra B Naik","doi":"10.2174/0118715273322121250124065659","DOIUrl":"https://doi.org/10.2174/0118715273322121250124065659","url":null,"abstract":"Introduction: The polyol pathway is responsible for the metabolism of almost one-third of the total glucose in people with chronic diabetes. Moreover, it causes complications in organs that rely on aldose reductase (AR) as an enzyme. The purpose of this research was to examine the in vitro and in vivo effects of a flavonoid-rich ethyl acetate fraction of a methanolic extract of Ficus carica Lam. leaves (FCEA) on the aldose reductase gene AKR1B1. The complicated relation of AR for target confirmation and analysis of the flavonoids of FCEA, quercetin, kaempferol, and chrysin was explored by building a flavonoid-protein complex network utilizing GeneCards®, String, and Cytoscape Networking.Method: The examination of ADMET was carried out after docking on the active sites of AR. By the binding and scoring abilities, the analysis was carried out. The ADMET characteristics demonstrated that these flavonoids had excellent solubility, absorption, and oral bioavailability, and the results demonstrate that they have potential. An additional in-vivo investigation was conducted on rats using a model induced by streptozotocin (STZ). Hence, upon induction, the rats' sciatic nerves were removed and prepared for an RT-PCR analysis of the AKR1B1 gene.Result: Compared to the diabetic normal group and the metformin group, rats treated with FCEA had lower levels of messenger RNA and AKR1B1 gene expression.Conclusion: This proves that FCEA has effectively blocked AR. It is highly likely to suggest FCEA as a potent aldose reductase inhibitor, as it considerably reduces the mRNA level of AKR1B1 gene expression in the sciatic nerve of sick rats, according to a combined bioinformatics prediction and RT-PCR analysis.","PeriodicalId":93947,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dopamine Depletion in Parkinson's Disease and Therapeutic Options. 帕金森病的多巴胺耗竭和治疗选择。

CNS & neurological disorders drug targets Pub Date : 2025-03-07 DOI: 10.2174/0118715273366223250302092948

Hussaini Adam, Subash C B Gopinath, Tijjani Adam, Evan T Salim, Makram A Fakhri

引用次数: 0

Chlorogenic Acid as a Neuroprotective Agent: Enhancing Plasticity and Promoting Brain Health and Functional Reserve. 绿原酸作为神经保护剂：增强可塑性，促进大脑健康和功能储备。

CNS & neurological disorders drug targets Pub Date : 2025-02-27 DOI: 10.2174/0118715273339375250116042441

Elizabeth Hernández-Echeagaray, Rubén Vázquez-Roque, Julio Cesar Morales-Medina, Francisco M Torres-Cruz, Elibeth Monroy, Gulmaro Galindo-Paredes, Gabriel Gutiérrez-Ospina, Gonzalo Flores

{"title":"Chlorogenic Acid as a Neuroprotective Agent: Enhancing Plasticity and Promoting Brain Health and Functional Reserve.","authors":"Elizabeth Hernández-Echeagaray, Rubén Vázquez-Roque, Julio Cesar Morales-Medina, Francisco M Torres-Cruz, Elibeth Monroy, Gulmaro Galindo-Paredes, Gabriel Gutiérrez-Ospina, Gonzalo Flores","doi":"10.2174/0118715273339375250116042441","DOIUrl":"https://doi.org/10.2174/0118715273339375250116042441","url":null,"abstract":"Introduction: Functional reserve, the process that warrants the brain to have resources to maintain key functions and processes when facing neurodegeneration, may be strengthened in nominally healthy subjects by measures that prompt neural plasticity throughout life.Method: In this work, we administered Chlorogenic Acid (CGA) to evaluate its ability to promote functional morphological plasticity in the frontal cortical-striatal circuit of healthy mice, a pathway exposed constantly to oxidative challenges, excitotoxicity, and neuroinflammation. The magnitude of neural plasticity was estimated by assessing spontaneous motor behavior (open field), the relative magnitude of neuronal activation (number of c-Fos positive neurons), dendritic remodeling (Golgi- Cox impregnation), the availability of Brain-Derived Neurotrophic Factor (BDNF) (semiquantitative Western blotting), and lipid peroxidation (TBARS assay) in CGA- or vehicle-administered C57BL/6 male mice.Results: CGA administration increased c-Fos in the Dorsal striatum (Ds), changed the availability of BDNF and Pro-BDNF in the Frontal Cortex (FC) and DS, induced dendritic remodeling in FC and DS neurons, and reduced FC and DS lipid peroxidation without affecting motor performance or the availability of TrkB receptor isoforms.Conclusion: Our findings suggest that CGA increases functional reserve by promoting neuronal plasticity in healthy male mice. Future research should determine whether these additional resources indeed protect against neurodegeneration.","PeriodicalId":93947,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluoride-induced Neurodevelopmental Toxicity- AMPK as a Possible Target. 氟化物诱导的神经发育毒性——AMPK可能是一个靶点。

CNS & neurological disorders drug targets Pub Date : 2025-02-24 DOI: 10.2174/0118715273300345250206084817

Tejas Ahuja, Farmiza Begum, Fathima Beegum, Gautam Kumar, Nitesh Kumar, Rekha R Shenoy

{"title":"Fluoride-induced Neurodevelopmental Toxicity- AMPK as a Possible Target.","authors":"Tejas Ahuja, Farmiza Begum, Fathima Beegum, Gautam Kumar, Nitesh Kumar, Rekha R Shenoy","doi":"10.2174/0118715273300345250206084817","DOIUrl":"https://doi.org/10.2174/0118715273300345250206084817","url":null,"abstract":"Inorganic fluoride is widely used in dental practices to treat problems like dental caries and prevent bone-related issues. Exposure to excess amounts of fluoride both through drinking water or other sources impairs vital functions of the body and can prove to be toxic, especially for the central nervous system. Sodium fluoride (NaF) crosses the blood-brain barrier in early developmental stages and causes impairments related to learning and memory, anxiety, decreased locomotor ability, and in some cases, depression-like behaviour, especially in children. Major mechanisms involved in this toxicity include reduction in levels of nicotinic and muscarinic receptors, autophagy, and apoptosis in neurons, decreased glucose consumption, inhibition of enzymes involved in the generation of energy and transmission of the synapse, mitochondrial dysfunction, and increased oxidative stress leading to inflammation and neuronal cell death. Out of all these, an increase in oxidative stress was reported to be one of the main mechanisms of fluoride-induced neurotoxicity. Based on these inferences, various natural compounds having antioxidant properties, like curcumin, aloe vera, quercetin, epigallocatechin gallate, etc. have been studied for their protective role in sodium fluoride-induced neurotoxicity. Involvement of other pathways like Nrf2/Keap pathways, SIRT3, etc., have warranted a need for further detailed study to identify other potential therapeutic targets like AMPK to prevent/treat fluoride-induced neurotoxicity. The present review captures fluoride, its role in neurodevelopment, and mechanisms & pathways involved by which fluoride can hurt neurodevelopment & how AMPK can be a possible therapeutic target.","PeriodicalId":93947,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Predisposition and Severity of Eating Disorders- A Review. 遗传易感性和饮食失调的严重程度-综述。

CNS & neurological disorders drug targets Pub Date : 2025-02-21 DOI: 10.2174/0118715273372810250214054917

Md Harun Rashid, Neha Deora, Shashidhar Ravindra Kolur, Suttur S Malini, Priyankar Sen

{"title":"Genetic Predisposition and Severity of Eating Disorders- A Review.","authors":"Md Harun Rashid, Neha Deora, Shashidhar Ravindra Kolur, Suttur S Malini, Priyankar Sen","doi":"10.2174/0118715273372810250214054917","DOIUrl":"https://doi.org/10.2174/0118715273372810250214054917","url":null,"abstract":"Eating disorders (EDs) are multifaceted psychiatric conditions with significant genetic, psychological, and environmental components. This review provides a comprehensive analysis of the genetic underpinnings and key molecular pathways contributing to anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Genetic studies, particularly genome-wide association studies (GWAS), have identified key loci associated with ED susceptibility, with heritability estimates for these disorders ranging between 48% and 74%. Among the critical genes explored, the Agouti-related protein (AGRP), ghrelin (GHRL), and brain-derived neurotrophic factor (BDNF) pathways emerge as pivotal regulators of appetite control, energy balance, and reward systems, offering insights into ED etiology. These pathways are modulated by environmental factors and often dysregulated in individuals with EDs, linking abnormal eating behaviors to disturbances in neurobiological functions. EDs also show a strong association with comorbid psychiatric disorders, such as depression and anxiety, and pose significant physical health risks, including cardiovascular disease and metabolic disturbances. Exploring the intricate genetic and neurobiological mechanisms underlying eating disorders (EDs) paves the way for more effective prevention, early detection, and tailored treatment strategies. This review highlights the potential of utilizing genetic insights to enhance diagnostic and intervention strategies, ultimately leading to better outcomes for individuals impacted by eating disorders.","PeriodicalId":93947,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Internet of Medical Things (IoMT) for Alzheimer Patient's Outcome. 医疗物联网（IoMT）对老年痴呆症患者预后的影响。

CNS & neurological disorders drug targets Pub Date : 2025-02-21 DOI: 10.2174/0118715273371149250218081425

Thangavel Lakshmipriya, Subash C B Gopinath

引用次数: 0

Serotonergic Dynamics in Autism Spectrum Disorder: Unraveling the Intricate Connection. 自闭症谱系障碍的血清素能动力学：揭示复杂的联系。

CNS & neurological disorders drug targets Pub Date : 2025-02-18 DOI: 10.2174/0118715273378214250213114328

Abhishek Chander, Jeetesh Sharma, Shushank Mahajan, Sanchit Dhankhar, Samrat Chauhan, Monika Saini, Sanjana Mehta

引用次数: 0

A Review on Nanotechnology based In Situ Gelling System as a Reliable Weapon for Targeting Alzheimer's Disease via Intranasal Route. 基于纳米技术的原位胶凝系统作为鼻内靶向阿尔茨海默病的可靠武器的研究进展

CNS & neurological disorders drug targets Pub Date : 2025-02-17 DOI: 10.2174/0118715273335978250127070434

Priyanka Deorankar, Vahid Vikram Minglani, Bhupendra G Prajapati, Meenakshi B Patel

{"title":"A Review on Nanotechnology based In Situ Gelling System as a Reliable Weapon for Targeting Alzheimer's Disease via Intranasal Route.","authors":"Priyanka Deorankar, Vahid Vikram Minglani, Bhupendra G Prajapati, Meenakshi B Patel","doi":"10.2174/0118715273335978250127070434","DOIUrl":"https://doi.org/10.2174/0118715273335978250127070434","url":null,"abstract":"A recent World Health Organization report claims that along with the growing world population and emerging life prospects, the prevalence of neurological disorders is also increasing. Out of all neurological disorders, Alzheimer's disease is the most widespread and alarming concern. The disease poses significant therapeutic challenges due to the blood-brain barrier's restrictiveness and the lack of effective drug delivery systems. The olfactory and trigeminal nerves have direct access to the brain, therefore, intranasal drug delivery can be a promising route for the direct delivery of anti-Alzheimer's drugs. Despite this advantage, brain targeting is limited through this route due to mucociliary clearance. Thus, in situ, nanotechnology offers a transformative approach by leveraging the intranasal route to directly target the central nervous system. This comprehensive review discusses recent advancements, mechanisms, and applications of in situ nanotechnology in Alzheimer's disease therapeutics, highlighting its potential to enhance drug delivery efficiency, improve bioavailability, and mitigate the progression of this debilitating condition. The importance of intranasal drug delivery has been emphasized in this review, along with the clear benefits of in situ lipid- based nanotechnology for the efficient delivery of medication in targeting Alzheimer's disease.","PeriodicalId":93947,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Markers and Diagnostics for Diagnosing Cerebral Infarction. 脑梗死诊断的临床指标和诊断方法。

CNS & neurological disorders drug targets Pub Date : 2025-02-14 DOI: 10.2174/0118715273372575250212091813

Thangavel Lakshmipriya, Subash C B Gopinath

引用次数: 0

Abnormality of Voltage-Gated Sodium Channels in Disease Development of the Nervous System. A Review Article. 电压门控钠通道在神经系统疾病发展中的异常。一篇评论文章。

CNS & neurological disorders drug targets Pub Date : 2025-02-11 DOI: 10.2174/0118715273347470250126185122

Bakhtawar Khan, Muhammad Khalid Iqbal, Hamid Khan, Mustafa Kiyani, Shahid Bashir, Li Shao

{"title":"Abnormality of Voltage-Gated Sodium Channels in Disease Development of the Nervous System. A Review Article.","authors":"Bakhtawar Khan, Muhammad Khalid Iqbal, Hamid Khan, Mustafa Kiyani, Shahid Bashir, Li Shao","doi":"10.2174/0118715273347470250126185122","DOIUrl":"https://doi.org/10.2174/0118715273347470250126185122","url":null,"abstract":"Sodium channels are necessary for electrical activity in modules of the nervous system. When such channels fail to work properly, it may cause different neurological diseases. This review will discuss how particular mutation in these channels leads to different diseases. Positive alterations can lead to such diseases as epilepsy, or any muscle disorder due to over activation of neurons. Conversely, loss-of-function mutations may cause heart diseases and problems regarding motor and mental activity since neurons are not functioning well because of lost machinery. The review would discuss over familiar channelopathies such as genetic epilepsies, the familial hemiplegic migraine, and Para myotonia congenital and relatively new interrelations with the complex ailments including Alzheimer's, Parkinson's and multiple sclerosis. Thus, knowledge of these mechanisms is important in designing specific therapeutic approaches. There is a rationale for altering the sodium channel activity in the treatment of these neurological disorders by drugs or indeed genetic methods. Thus, the review is undertaken to provide clear distinctions and discuss the issues related to sodium channel mutations for the potential development of individualized medicine. The review also gives information on the function and general distribution of voltage-gated sodium channels (VGSCs), how their activity is controlled, and what their structure is like. The purpose therefore is to draw understanding over the apparently multifaceted functions exerted by VGSCs in the nervous system relative to several diseases. This knowledge is imperative in the attempt to produce treatments for these disabling disorders.","PeriodicalId":93947,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0