Genetic Predisposition and Severity of Eating Disorders- A Review.

Abstract

Eating disorders (EDs) are multifaceted psychiatric conditions with significant genetic, psychological, and environmental components. This review provides a comprehensive analysis of the genetic underpinnings and key molecular pathways contributing to anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Genetic studies, particularly genome-wide association studies (GWAS), have identified key loci associated with ED susceptibility, with heritability estimates for these disorders ranging between 48% and 74%. Among the critical genes explored, the Agouti-related protein (AGRP), ghrelin (GHRL), and brain-derived neurotrophic factor (BDNF) pathways emerge as pivotal regulators of appetite control, energy balance, and reward systems, offering insights into ED etiology. These pathways are modulated by environmental factors and often dysregulated in individuals with EDs, linking abnormal eating behaviors to disturbances in neurobiological functions. EDs also show a strong association with comorbid psychiatric disorders, such as depression and anxiety, and pose significant physical health risks, including cardiovascular disease and metabolic disturbances. Exploring the intricate genetic and neurobiological mechanisms underlying eating disorders (EDs) paves the way for more effective prevention, early detection, and tailored treatment strategies. This review highlights the potential of utilizing genetic insights to enhance diagnostic and intervention strategies, ultimately leading to better outcomes for individuals impacted by eating disorders.