Clinical hematology international最新文献_第4页

Standing on the Shoulders of the Giants: Dr. Alain Fischer. 站在巨人队的肩膀上：阿兰·菲舍尔博士。

Clinical hematology international Pub Date : 2023-09-16 eCollection Date: 2023-01-01 DOI: 10.46989/001c.87882

Mohamad Mohty, Alain Fischer

引用次数: 0

Racial Disparities in Plasma Cell Leukemia Outcomes Among Hospitalized Patients in the United States. 美国住院患者浆细胞白血病结局的种族差异。

Clinical hematology international Pub Date : 2023-09-08 eCollection Date: 2023-01-01 DOI: 10.46989/001c.87755

Cindy Wu, Deepa Dongarwar, Samer Al Hadidi

{"title":"Racial Disparities in Plasma Cell Leukemia Outcomes Among Hospitalized Patients in the United States.","authors":"Cindy Wu, Deepa Dongarwar, Samer Al Hadidi","doi":"10.46989/001c.87755","DOIUrl":"https://doi.org/10.46989/001c.87755","url":null,"abstract":"<p><p>Plasma cell leukemia (PCL) is a rare, aggressive subtype of multiple myeloma (MM) with a poor prognosis. Prior studies have shown that racial disparities affect MM patients in various ways, which may affect patients' outcomes. In this study, we aimed to investigate racial differences in hospitalization outcomes for PCL using Nationwide Inpatient Sample data. Overall, hospitalization rates for PCL tended to decrease over the past decade. Among hospitalized patients with a primary diagnosis of PCL, there was no statistically significant association between race/ethnicity and hospitalization rates, between NH-White patients and NH-Black patients (OR 1.94; 95%CI 0.3-3.54, p 0.95), and Hispanic patients (OR 0.47; 95% CI 0.05-4.23, p 0.5). Additionally, there was no significant association between race/ethnicity and inpatient mortality. The overall lower incidence of PCL, more significant disease burden, and poor prognosis across all groups may contribute to our findings. With increasing evidence that PCL is cytogenetically distinct from MM, more investigation into biological and sociodemographic factors that affect healthcare utilization and treatment outcomes should be carried out.</p>","PeriodicalId":93942,"journal":{"name":"Clinical hematology international","volume":"5 4","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/20/chi_2023_5_4_87755.PMC10515655.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incorporation of Ruxolitinib in the Management of Refractory/Relapsed Hodgkin Lymphoma: Where Do We Stand? Ruxolitinib在难治性/复发性霍奇金淋巴瘤治疗中的应用：我们的立场？

Clinical hematology international Pub Date : 2023-08-28 eCollection Date: 2023-01-01 DOI: 10.46989/001c.87501

Ahmed H Al Sharie, Balqis M Abu Mousa, Ahmad O Alomari

引用次数: 0

Racial Differences in Spinal Cord Compression Related Hospitalizations in Patients with Multiple Myeloma 多发性骨髓瘤患者脊髓压迫相关住院治疗的种族差异

Clinical hematology international Pub Date : 2023-02-03 DOI: 10.46989/001c.87569

Samer Al Hadidi, Deepa Dongarwar, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, John D. Shaughnessy, Frits van Rhee

引用次数: 0

Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation 造血干细胞移植后单核细胞重建和肠道菌群组成

Clinical hematology international Pub Date : 2019-09-20 DOI: 10.1101/777268

S. Morjaria, Allen W. Zhang, Sohn G. Kim, J. Peled, Simone Becattini, E. Littmann, E. Pamer, M. Perales, Michael C. Abt

{"title":"Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation","authors":"S. Morjaria, Allen W. Zhang, Sohn G. Kim, J. Peled, Simone Becattini, E. Littmann, E. Pamer, M. Perales, Michael C. Abt","doi":"10.1101/777268","DOIUrl":"https://doi.org/10.1101/777268","url":null,"abstract":"Monocytes are an essential cellular component of the innate immune system that support the host’s effectivenss to combat a range of infectious pathogens. Hemopoietic cell transplantation (HCT) results in transient monocyte depletion, but the factors that regulate recovery of monocyte populations are not fully understood. In this study, we investigated whether the composition of the gastrointestinal microbiota is associated with the recovery of monocyte homeostasis after HCT. Methods We performed a single-center, prospective, pilot study of 18 recipients of either autologous or allogeneic HCT. Serial blood and stool samples were collected from each patient during their HCT hospitalization. Analysis of the gut microbiota was done using 16S rRNA gene sequencing and flow cytometric analysis was used to characterize the phenotypic composition of monocyte populations. Results Dynamic fluctuations in monocyte reconstitution occurred after HCT and large differences were observed in monocyte frequency among patients over time. Recovery of absolute monocyte counts and monocyte subsets showed significant variability across the heterogeneous transplant types and conditioning intensities; no relationship to the microbiota composition was observed in this small cohort. Conclusion A relationship between the microbiota composition and monocyte homeostasis could not be firmly established in this pilot study.","PeriodicalId":93942,"journal":{"name":"Clinical hematology international","volume":"4 1","pages":"156 - 164"},"PeriodicalIF":0.0,"publicationDate":"2019-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73184002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5