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A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. 一种在阿尔茨海默病小鼠模型中恢复小胶质细胞Trem2功能的细胞治疗方法。
Cell stem cell Pub Date : 2023-10-05 DOI: 10.1016/j.stem.2023.08.011
Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Wernig
{"title":"A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease.","authors":"Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Wernig","doi":"10.1016/j.stem.2023.08.011","DOIUrl":"https://doi.org/10.1016/j.stem.2023.08.011","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"30 10","pages":"1392"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Human embryo models made from pluripotent stem cells are not synthetic; they aren't embryos, either. 由多能干细胞制成的人类胚胎模型不是合成的；它们也不是胚胎。
Cell stem cell Pub Date : 2023-10-05 DOI: 10.1016/j.stem.2023.09.006
Hannah L Landecker, Amander T Clark
{"title":"Human embryo models made from pluripotent stem cells are not synthetic; they aren't embryos, either.","authors":"Hannah L Landecker, Amander T Clark","doi":"10.1016/j.stem.2023.09.006","DOIUrl":"10.1016/j.stem.2023.09.006","url":null,"abstract":"<p><p>Embryo models are potentially highly impactful for human health research because their development recapitulates otherwise inaccessible events in a poorly understood area of biology, the first few weeks of human life. Casual reference to these models as \"synthetic embryos\" is misleading and should be approached with care and deliberation.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"30 10","pages":"1290-1293"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10927377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41142652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson's disease, STEM-PD. 用于治疗帕金森病的人类胚胎干细胞衍生产品的临床前质量、安全性和疗效。
Cell stem cell Pub Date : 2023-10-05 DOI: 10.1016/j.stem.2023.08.014
Agnete Kirkeby, Jenny Nelander, Deirdre B Hoban, Nina Rogelius, Hjálmar Bjartmarz, Petter Storm, Alessandro Fiorenzano, Andrew F Adler, Shelby Vale, Janitha Mudannayake, Yu Zhang, Tiago Cardoso, Bengt Mattsson, Anne M Landau, Andreas N Glud, Jens C Sørensen, Thea P Lillethorup, Mark Lowdell, Carla Carvalho, Owen Bain, Trinette van Vliet, Olle Lindvall, Anders Björklund, Bronwen Harry, Emma Cutting, Håkan Widner, Gesine Paul, Roger A Barker, Malin Parmar
{"title":"Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson's disease, STEM-PD.","authors":"Agnete Kirkeby, Jenny Nelander, Deirdre B Hoban, Nina Rogelius, Hjálmar Bjartmarz, Petter Storm, Alessandro Fiorenzano, Andrew F Adler, Shelby Vale, Janitha Mudannayake, Yu Zhang, Tiago Cardoso, Bengt Mattsson, Anne M Landau, Andreas N Glud, Jens C Sørensen, Thea P Lillethorup, Mark Lowdell, Carla Carvalho, Owen Bain, Trinette van Vliet, Olle Lindvall, Anders Björklund, Bronwen Harry, Emma Cutting, Håkan Widner, Gesine Paul, Roger A Barker, Malin Parmar","doi":"10.1016/j.stem.2023.08.014","DOIUrl":"10.1016/j.stem.2023.08.014","url":null,"abstract":"<p><p>Cell replacement therapies for Parkinson's disease (PD) based on transplantation of pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we present quality, safety, and efficacy data supporting the first-in-human STEM-PD phase I/IIa clinical trial along with the trial design. The STEM-PD product was manufactured under GMP and quality tested in vitro and in vivo to meet regulatory requirements. Importantly, no adverse effects were observed upon testing of the product in a 39-week rat GLP safety study for toxicity, tumorigenicity, and biodistribution, and a non-GLP efficacy study confirmed that the transplanted cells mediated full functional recovery in a pre-clinical rat model of PD. We further observed highly comparable efficacy results between two different GMP batches, verifying that the product can be serially manufactured. A fully in vivo-tested batch of STEM-PD is now being used in a clinical trial of 8 patients with moderate PD, initiated in 2022.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"30 10","pages":"1299-1314.e9"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41170336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fishing for "complements" with vascular organoid models of microvascular disease. 寻找微血管疾病血管类器官模型的“补品”。
Cell stem cell Pub Date : 2023-10-05 DOI: 10.1016/j.stem.2023.09.004
Sean X Gu, Timur O Yarovinsky, John Hwa
{"title":"Fishing for \"complements\" with vascular organoid models of microvascular disease.","authors":"Sean X Gu, Timur O Yarovinsky, John Hwa","doi":"10.1016/j.stem.2023.09.004","DOIUrl":"10.1016/j.stem.2023.09.004","url":null,"abstract":"<p><p>In this issue of Cell Stem Cell, Kawakami et al. develop a SARS-CoV-2 infection-competent, progenitor-derived, human vascular organoid model and uncover a role for complement factor D (CFD) in mediating microvascular immunothrombosis. This model may be applied to conditions where microvascular disease plays a major pathogenic role.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"30 10","pages":"1285-1286"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anniversary reflections: Inspiring discoveries and the future of the field. 周年纪念：鼓舞人心的发现和该领域的未来。
Cell stem cell Pub Date : 2022-06-02 DOI: 10.1016/j.stem.2022.05.005
Madeline Lancaster, Samantha A Morris, Takanori Takebe, Li Qian, Shaorong Gao, Meritxell Huch
{"title":"Anniversary reflections: Inspiring discoveries and the future of the field.","authors":"Madeline Lancaster, Samantha A Morris, Takanori Takebe, Li Qian, Shaorong Gao, Meritxell Huch","doi":"10.1016/j.stem.2022.05.005","DOIUrl":"10.1016/j.stem.2022.05.005","url":null,"abstract":"<p><p>Cell Stem Cell was launched in 2007, and this year marks its 15<sup>th</sup> anniversary. To recognize this occasion, we asked six advisory board members to reflect on inspiring discoveries reported in Cell Stem Cell and how these breakthroughs connect to their vision for the future of the field.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"29 6 1","pages":"879-881"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49305210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells. 由胚胎干细胞组装的人类胚胎模型的体外附着和对称性破坏。
Cell stem cell Pub Date : 2022-06-01 DOI: 10.1016/j.stem.2022.05.001
M. Simunovic, E. Siggia, A. Brivanlou
{"title":"In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells.","authors":"M. Simunovic, E. Siggia, A. Brivanlou","doi":"10.1016/j.stem.2022.05.001","DOIUrl":"https://doi.org/10.1016/j.stem.2022.05.001","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"29 6 1","pages":"962-972.e4"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48052953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
The spatiotemporal program of zonal liver regeneration following acute injury. 急性损伤后肝分区再生的时空程序。
Cell stem cell Pub Date : 2022-06-01 DOI: 10.1016/j.stem.2022.04.008
S. Ben-Moshe, Tamar Veg, R. Manco, S. Dan, Delfina Papinutti, A. Lifshitz, Aleksandra A. Kolodziejczyk, K. Bahar Halpern, E. Elinav, S. Itzkovitz
{"title":"The spatiotemporal program of zonal liver regeneration following acute injury.","authors":"S. Ben-Moshe, Tamar Veg, R. Manco, S. Dan, Delfina Papinutti, A. Lifshitz, Aleksandra A. Kolodziejczyk, K. Bahar Halpern, E. Elinav, S. Itzkovitz","doi":"10.1016/j.stem.2022.04.008","DOIUrl":"https://doi.org/10.1016/j.stem.2022.04.008","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"29 6 1","pages":"973-989.e10"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48202486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis. 用微器官球扩展精确肿瘤学工具包，用于早期癌症诊断。
Cell stem cell Pub Date : 2022-06-01 DOI: 10.1016/j.stem.2022.05.002
J. Vandana, Lauretta A. Lacko, Shuibing Chen
{"title":"Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis.","authors":"J. Vandana, Lauretta A. Lacko, Shuibing Chen","doi":"10.1016/j.stem.2022.05.002","DOIUrl":"https://doi.org/10.1016/j.stem.2022.05.002","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"29 6 1","pages":"873-875"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45983845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anniversary reflections: ISSCR presidents on 20 years of progress. 周年反思:ISSCR主席回顾20年的进步。
Cell stem cell Pub Date : 2022-06-01 DOI: 10.1016/j.stem.2022.05.003
M. Little, Sean Morrison, J. Rossant, Deepak Srivastava, G. Daley
{"title":"Anniversary reflections: ISSCR presidents on 20 years of progress.","authors":"M. Little, Sean Morrison, J. Rossant, Deepak Srivastava, G. Daley","doi":"10.1016/j.stem.2022.05.003","DOIUrl":"https://doi.org/10.1016/j.stem.2022.05.003","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"29 6 1","pages":"876-878"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41386077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A human embryo model cracks symmetry breaking. 一个人类胚胎模型打破了对称性。
Cell stem cell Pub Date : 2022-06-01 DOI: 10.1016/j.stem.2022.05.009
Thorsten E. Boroviak
{"title":"A human embryo model cracks symmetry breaking.","authors":"Thorsten E. Boroviak","doi":"10.1016/j.stem.2022.05.009","DOIUrl":"https://doi.org/10.1016/j.stem.2022.05.009","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"29 6 1","pages":"869-870"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44423014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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