Cell stem cellPub Date : 2026-06-04Epub Date: 2026-05-26DOI: 10.1016/j.stem.2026.04.023
Yunrui Lu, Hui Ni, Jian Shen, Shuang Wu, Shiyu Zhu, Chang Liu, Sheng'an Su, Hong Ma, Bin Zhou, Meixiang Xiang, Yao Xie
{"title":"Smooth muscle cells transiently acquire a CD34<sup>+</sup> progenitor state upon injury to drive pathological vascular remodeling.","authors":"Yunrui Lu, Hui Ni, Jian Shen, Shuang Wu, Shiyu Zhu, Chang Liu, Sheng'an Su, Hong Ma, Bin Zhou, Meixiang Xiang, Yao Xie","doi":"10.1016/j.stem.2026.04.023","DOIUrl":"10.1016/j.stem.2026.04.023","url":null,"abstract":"<p><p>Neointimal hyperplasia, a key pathological feature of many cardiovascular diseases, is driven by vascular smooth muscle cells (SMCs), yet the role of specific SMC subtypes remains unclear. This study identifies a smooth muscle-derived transient progenitor cell (STPC) population, marked by CD34 expression, which emerges after artery injury. These STPCs exhibit high proliferative capacity and generate the majority of neointimal SMCs. Genetic ablation of STPCs significantly reduces neointimal SMC accumulation and attenuates hyperplasia. Mechanistically, SMC-specific knockdown of DCLK1 markedly suppresses STPC generation and mitigates pathological remodeling. These findings establish STPCs as a critical progenitor population responsible for neointimal hyperplasia, identifying them as a novel therapeutic target for vascular diseases.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":" ","pages":"964-981.e5"},"PeriodicalIF":20.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-06-04DOI: 10.1016/j.stem.2026.05.003
W Todd Farmer, Juan Song
{"title":"Beyond replacement: Immature neurons as resilience partners in the aging hippocampus.","authors":"W Todd Farmer, Juan Song","doi":"10.1016/j.stem.2026.05.003","DOIUrl":"10.1016/j.stem.2026.05.003","url":null,"abstract":"<p><p>Whether new neurons contribute to human cognition in old age remains debated. Recently in Cell Stem Cell, Tosoni et al.<sup>1</sup> show that immature-neuron transcriptional programs persist in the aged dentate gyrus and that their molecular state, not simply their abundance, tracks Alzheimer's pathology and cognitive resilience.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"33 6","pages":"898-900"},"PeriodicalIF":20.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-06-04DOI: 10.1016/j.stem.2026.05.002
Pierre Val
{"title":"Human adrenal cortex organoids unlock new frontiers in development, disease, and regenerative therapy.","authors":"Pierre Val","doi":"10.1016/j.stem.2026.05.002","DOIUrl":"10.1016/j.stem.2026.05.002","url":null,"abstract":"<p><p>Recent studies by Mayama et al.<sup>1</sup> and Akkerman et al.<sup>2</sup> established human adrenal cortex organoids that recapitulate fetal and adult adrenal development, offering unprecedented insight into differentiation pathways and allowing disease modeling. Though challenges like immature phenotypes and immune rejection will need addressing, they offer great potential for cell-based therapies.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"33 6","pages":"895-897"},"PeriodicalIF":20.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-06-04Epub Date: 2026-05-15DOI: 10.1016/j.stem.2026.04.018
Tongdong Zhang, Lei Fan, Feibai Yao, Ge Li, Guotong Lin, Yi Yang, Fenglin Qian, Chencheng Liu, Qi Tang, Wendi Wang, Chunfang Xu, Xiaoliang Xu, Yu Chang, Wen Yang, Jiangdong Gong, Yutong Wang, Shichao Huang, Renchu Guan, Lin Lin, Qing Jing, Zhaohua Yang, Tingrui Pan, Xin Cheng, Lei Song, Meirong Du, Zhe Luo, An Zeng
{"title":"Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems.","authors":"Tongdong Zhang, Lei Fan, Feibai Yao, Ge Li, Guotong Lin, Yi Yang, Fenglin Qian, Chencheng Liu, Qi Tang, Wendi Wang, Chunfang Xu, Xiaoliang Xu, Yu Chang, Wen Yang, Jiangdong Gong, Yutong Wang, Shichao Huang, Renchu Guan, Lin Lin, Qing Jing, Zhaohua Yang, Tingrui Pan, Xin Cheng, Lei Song, Meirong Du, Zhe Luo, An Zeng","doi":"10.1016/j.stem.2026.04.018","DOIUrl":"10.1016/j.stem.2026.04.018","url":null,"abstract":"<p><p>Heart rhythm and contraction are initiated by electrical impulses generated by the sinoatrial node (SAN) and modulated by intrinsic cardiac neural inputs. Despite its physiological importance, human in vitro systems that recapitulate neural-SAN interactions are lacking. Here, we develop SAN-plexus assembloids by integrating human pluripotent stem cell-derived SAN organoids (SANOs) with cardiac ganglionated plexus organoids (CGPOs), together with atrial-like cardiac organoids, to model pacemaker-to-atrial conduction in a tri-assembloid system. This platform exhibits molecular, structural, and electrophysiological features of human pacemaker activity and enables functional interrogation of neural control over SAN automaticity, including disease-associated conduction dysfunction. By integrating spatial transcriptomics of human SAN tissue with assembloid-based functional analyses, we identify a neuron-to-pacemaker signaling program in which CGPO-derived prosaposin engages the SAN-enriched receptor GPR37 to promote pacemaker maturation. Together, this work establishes SAN-plexus assembloids as a human platform for studying intrinsic neuro-cardiac interactions in pacemaker development and disease.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":" ","pages":"945-963.e11"},"PeriodicalIF":20.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-06-04DOI: 10.1016/j.stem.2026.04.022
Xi Zhao, Li Zhuang, Boyi Gan
{"title":"Ketone bodies as guardians of leukemic stemness through ferroptosis suppression.","authors":"Xi Zhao, Li Zhuang, Boyi Gan","doi":"10.1016/j.stem.2026.04.022","DOIUrl":"10.1016/j.stem.2026.04.022","url":null,"abstract":"<p><p>Leukemia stem cells exploit cell-intrinsic ketogenesis to suppress ferroptosis and sustain disease propagation. In this issue, Han et al.<sup>1</sup> uncover a β-hydroxybutyrate-epigenetic-lipid remodeling axis that protects stemness by restraining ferroptosis, revealing a metabolic vulnerability with therapeutic potential.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"33 6","pages":"901-903"},"PeriodicalIF":20.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-06-04Epub Date: 2026-05-13DOI: 10.1016/j.stem.2026.04.014
Lei Lei, Masako M Kaufmann, Jessica Lao, Gudrun Thoulass, Sandra Ammann, Hui Xiao, Manuel Rhiel, Viviane Dettmer-Monaco, Julian Grünewald, Geoffroy Andrieux, Jamal Alzubi, Bret R Miller, Kristoffer Weißert, Linda Gräßel, Christoph Schell, Anna L Illert, J Keith Joung, Melanie Boerries, Tatjana I Cornu, Stephan Ehl, Miriam Erlacher, Peter Aichele, Toni Cathomen
{"title":"Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene editing for genetic hyperinflammation.","authors":"Lei Lei, Masako M Kaufmann, Jessica Lao, Gudrun Thoulass, Sandra Ammann, Hui Xiao, Manuel Rhiel, Viviane Dettmer-Monaco, Julian Grünewald, Geoffroy Andrieux, Jamal Alzubi, Bret R Miller, Kristoffer Weißert, Linda Gräßel, Christoph Schell, Anna L Illert, J Keith Joung, Melanie Boerries, Tatjana I Cornu, Stephan Ehl, Miriam Erlacher, Peter Aichele, Toni Cathomen","doi":"10.1016/j.stem.2026.04.014","DOIUrl":"10.1016/j.stem.2026.04.014","url":null,"abstract":"<p><p>Base editors enable precise correction of point mutations without requiring DNA double-strand breaks, yet platform- and cell type-specific genotoxicities remain incompletely characterized. Here, we applied cytosine base editing (CBE) to disrupt a cryptic splice-site mutation in the Unc13d locus of Jinx mice, a model of familial hemophagocytic lymphohistiocytosis type 3 (FHL3). Efficient editing (62%-89%) in fibroblasts, T cells, and hematopoietic stem cells (HSCs) restored Unc13d splicing, reconstituted cytotoxic T cell function, and protected mice from virus-triggered hyperinflammation after transplantation of edited HSCs. Comparative genotoxicity profiling revealed distinct platform- and cell type-specific patterns: hyperactive CBE induced broader off-target activity and more structural variants than CRISPR-Cas9. Although off-target sequence edits persisted, the stability of CBE-induced chromosomal translocations differed between cell types. These findings establish base editing as a therapeutic strategy for a genetically predisposed hyperinflammatory syndrome and underscore the importance of context-specific safety profiling to guide the clinical translation of genome editors.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":" ","pages":"930-944.e5"},"PeriodicalIF":20.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13188852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression.","authors":"Xue Han, Kexin Wang, Weiwei Ma, Songqi Zhu, Jingjing Guan, Xiaobin Tian, Zhuangzhuang Zhao, Linjia Jiang","doi":"10.1016/j.stem.2026.04.013","DOIUrl":"10.1016/j.stem.2026.04.013","url":null,"abstract":"<p><p>Hepatic ketogenesis generates ketone bodies as an alternative energy source during carbohydrate restriction or ketogenic diets, yet its role in non-hepatic cell types remains poorly defined. Here, we show that leukemic stem cells (LSCs) in acute myeloid leukemia (AML) exhibit elevated ketogenesis, driven by fatty acid oxidation (FAO), to produce β-hydroxybutyrate (BHB). LSCs express high levels of 3-hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase 2 (HMGCS2), the rate-limiting enzyme in ketogenesis, compared with blast cells and normal hematopoietic stem cells (HSCs). Deletion of Hmgcs2 in AML cells markedly decreases BHB levels, disrupts LSC function, and impairs leukemia progression in both mouse and human AML models while largely sparing normal hematopoiesis. Mechanistically, BHB suppresses ferroptosis by limiting pro-ferroptotic phospholipid remodeling through epigenetic regulation of fatty acid desaturase 2 (FADS2). Together, these findings identify autonomous ketogenesis as a critical metabolic program that protects LSCs from ferroptotic cell death and sustains leukemia progression.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":" ","pages":"1016-1030.e6"},"PeriodicalIF":20.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-06-04Epub Date: 2026-05-22DOI: 10.1016/j.stem.2026.04.017
Zhenyu Zhang, Alison K Carlisle, Hamish P Carter, Joshua R Lowe, Menekse Mutlu-Smith, Wendy Lee, Odette Leiter, Shilong Zhang, Annie Harding, Muhammed Syed, David Brici, Rupert W Overall, Nicole Rund, Christina Steinhauer, Daniel G Blackmore, Scott Ayton, Ashley I Bush, Ming Chen, Gerd Kempermann, Sheng-Tao Hou, Tara L Walker
{"title":"Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory across aging.","authors":"Zhenyu Zhang, Alison K Carlisle, Hamish P Carter, Joshua R Lowe, Menekse Mutlu-Smith, Wendy Lee, Odette Leiter, Shilong Zhang, Annie Harding, Muhammed Syed, David Brici, Rupert W Overall, Nicole Rund, Christina Steinhauer, Daniel G Blackmore, Scott Ayton, Ashley I Bush, Ming Chen, Gerd Kempermann, Sheng-Tao Hou, Tara L Walker","doi":"10.1016/j.stem.2026.04.017","DOIUrl":"10.1016/j.stem.2026.04.017","url":null,"abstract":"<p><p>Adult hippocampal neurogenesis declines with age, but the stress pathways that shape neural precursor cell (NPC) survival and lineage progression remain incompletely understood. Here, we tested whether ferroptosis-related vulnerability contributes to the regulation of hippocampal NPCs and their progeny. Using in vitro assays, transcriptomic analyses, and in vivo genetic and pharmacologic perturbations, we find that NPCs show features consistent with elevated susceptibility to ferroptotic stress relative to more differentiated hippocampal populations. Reducing glutathione peroxidase 4 (GPX4) or increasing ferroptotic stress impairs neurogenesis-associated cellular and behavioral phenotypes, whereas pathway modulation improves selected outcomes in aged animals. These effects were context dependent, with distinct consequences across age and behavioral paradigms. Together, the findings support a model in which ferroptosis-related susceptibility contributes to the regulation of adult hippocampal neurogenesis and cognition.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":" ","pages":"1031-1046.e8"},"PeriodicalIF":20.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-06-04Epub Date: 2026-05-07DOI: 10.1016/j.stem.2026.04.012
Alexander Waclawiczek, Aino-Maija Leppä, Simon Renders, Ines Bergerweiss, Karolin Stumpf, Barbara Betz, Susanna Gabrowski, Frank Y Huang, Maria-Eleni Lalioti, Bendix Hempel, Markus Sohn, Heikki Kuusanmäki, Vera Thiel, Julia M Unglaub, Rabia Shahswar, Sarah Richter, Maike Janssen, Darja Karpova, Elisa Donato, Halvard Bonig, Christoph Röllig, Simon Raffel, Michael Heuser, Michael Hundemer, Mika Kontro, Ann-Kathrin Eisfeld, Tim Sauer, Nina Cabezas-Wallscheid, Carsten Müller-Tidow, Andreas Trumpp
{"title":"Leukemic stem cell subtypes determine venetoclax resistance and therapeutic vulnerabilities in AML.","authors":"Alexander Waclawiczek, Aino-Maija Leppä, Simon Renders, Ines Bergerweiss, Karolin Stumpf, Barbara Betz, Susanna Gabrowski, Frank Y Huang, Maria-Eleni Lalioti, Bendix Hempel, Markus Sohn, Heikki Kuusanmäki, Vera Thiel, Julia M Unglaub, Rabia Shahswar, Sarah Richter, Maike Janssen, Darja Karpova, Elisa Donato, Halvard Bonig, Christoph Röllig, Simon Raffel, Michael Heuser, Michael Hundemer, Mika Kontro, Ann-Kathrin Eisfeld, Tim Sauer, Nina Cabezas-Wallscheid, Carsten Müller-Tidow, Andreas Trumpp","doi":"10.1016/j.stem.2026.04.012","DOIUrl":"10.1016/j.stem.2026.04.012","url":null,"abstract":"<p><p>The BCL-2 inhibitor venetoclax has transformed the treatment of acute myeloid leukemia (AML), but relapse due to resistance of leukemic stem cells (LSCs) remains a major challenge. By molecular and functional profiling of LSCs from >150 patients, we identify four LSC subtypes. These mirror distinct hematopoietic lineage stages, which determine the expression ratio between the venetoclax target BCL-2 and resistance-inducing proteins MCL-1 and BCL-xL (MAC-score). Longitudinal analyses reveal that venetoclax resistance mostly arises in LSCs through plasticity toward a megakaryocytic/erythroid-progenitor (MEP)-LSC state that switches survival dependency from BCL-2 to BCL-xL. In rare cases, mature monocytic/dendritic (MoDe)-LSCs, found within LAMP5<sup>+</sup> monocytic AMLs, drive venetoclax resistance. LSC subtyping improves genetic risk stratification and provides subtype-specific therapies: venetoclax-resistant MEP-LSCs respond to BCL-xL inhibitors, whereas MoDe-LSCs are sensitive to MEK1/2 inhibition. Our findings reveal four distinct LSC types with unique vulnerabilities and propose biomarker-guided treatment strategies that complement genetic profiling to overcome venetoclax resistance.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":" ","pages":"982-999.e8"},"PeriodicalIF":20.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147858005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell stem cellPub Date : 2026-06-04Epub Date: 2026-04-30DOI: 10.1016/j.stem.2026.04.006
Haruko Kunitomi, Aye Myat Khaine, Radia Jamee, Vanessa Arreola, Mariselle Lancero, Amba Raychaudhuri, Samuel Perli, Yoshiko Sato, Mio Iwasaki, Pedro Ruivo, Kiichiro Tomoda, Mari Mito, Yuichi Shichino, Shintaro Iwasaki, Shinya Yamanaka
{"title":"eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation.","authors":"Haruko Kunitomi, Aye Myat Khaine, Radia Jamee, Vanessa Arreola, Mariselle Lancero, Amba Raychaudhuri, Samuel Perli, Yoshiko Sato, Mio Iwasaki, Pedro Ruivo, Kiichiro Tomoda, Mari Mito, Yuichi Shichino, Shintaro Iwasaki, Shinya Yamanaka","doi":"10.1016/j.stem.2026.04.006","DOIUrl":"10.1016/j.stem.2026.04.006","url":null,"abstract":"<p><p>eIF4G2 (DAP5/NAT1) is a non-canonical translation initiation factor, but its role in homeostasis is unclear. Using inducible Eif4g2 knockout mice and intestinal organoids, we show that eIF4G2 loss collapses Lgr5<sup>+</sup> intestinal stem cell (ISC) and secretory maturation programs while preserving villus architecture. Transcriptomic and single-nucleus multiome analyses reveal a durable fetal-like/regenerative state with YAP-TEAD activation and regenerative absorptive cells. Ribosome profiling identifies selective translation-efficiency loss among chromatin regulators, especially the KAT3 coactivators CREBBP and EP300, resulting in reduced KAT3 abundance and global histone acetylation; chemical KAT3 inhibition phenocopies this state. CUT&Tag and assay for transposase-accessible chromatin sequencing (ATAC-seq) demonstrate that reduced eIF4G2-KAT3 output drives locus-selective enhancer remodeling, with loss of adult ISC/Wnt-Notch elements and activation of TEAD-enriched fetal loci, without inflammatory or integrated stress response programs driving the transition. Fetal intestinal spheroids remain viable despite similar biochemical defects, highlighting a stage-specific requirement for translational buffering in maintaining adult identity.</p>","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":" ","pages":"1000-1015.e11"},"PeriodicalIF":20.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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