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Canadian journal of diabetes最新文献

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IDENTIFICATION OF PLAKOGLOBIN AS A NOVEL POSITIVE REGULATOR OF ADIPOGENESIS 血小板红蛋白作为一种新的脂肪生成积极调节因子的鉴定
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.229
F. Abou Azar, S. Yuen, S. Del Veliz, Y. Mugabo, F. Paré, G. Lavoie, P. Roux, W. Shou, G. Lim
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引用次数: 0
SYSTEMIC INHIBITION OF BRANCHED CHAIN AMINOTRANSFERASE 2 (BCAT2), BUT NOT MUSCLE-SPECIFIC DELETION OF BCAT2, ENHANCES GLUCOSE HOMEOSTASIS IN OBESE AND INSULIN-RESISTANT MICE 支链转氨酶2 (bcat2)的系统性抑制，而不是肌肉特异性的bcat2缺失，增强了肥胖和胰岛素抵抗小鼠的葡萄糖稳态
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.237
A. Abdualkader, H. Mechchate, G. Lopaschuk, R. Al Batran
{"title":"SYSTEMIC INHIBITION OF BRANCHED CHAIN AMINOTRANSFERASE 2 (BCAT2), BUT NOT MUSCLE-SPECIFIC DELETION OF BCAT2, ENHANCES GLUCOSE HOMEOSTASIS IN OBESE AND INSULIN-RESISTANT MICE","authors":"A. Abdualkader, H. Mechchate, G. Lopaschuk, R. Al Batran","doi":"10.1016/j.jcjd.2023.10.237","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.237","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"41 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135409996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE USE OF HSTNI AS AN INDEPENDENT RISK FACTOR IN A LARGE CANADIAN COHORT: NEW INSIGHTS IN CARDIOVASCULAR RISK ASSESSMENT 在一个大型加拿大队列中，hstni作为一个独立的危险因素:心血管风险评估的新见解
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.375
D. Esau, A. Beth
{"title":"THE USE OF HSTNI AS AN INDEPENDENT RISK FACTOR IN A LARGE CANADIAN COHORT: NEW INSIGHTS IN CARDIOVASCULAR RISK ASSESSMENT","authors":"D. Esau, A. Beth","doi":"10.1016/j.jcjd.2023.10.375","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.375","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"38 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135410028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AN INCREASED RATIO OF EICOSAPENTAENOIC ACID (EPA) TO ARACHIDONIC ACID (EPA/AA) REDUCED INFLAMMATORY CHANGES IN VASCULAR ENDOTHELIUM 增加二十碳五烯酸(epa)与花生四烯酸(epa / aa)的比值可减少血管内皮的炎症变化
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.146
S. Sherratt, P. Libby, D. Bhatt, P. Mason
{"title":"AN INCREASED RATIO OF EICOSAPENTAENOIC ACID (EPA) TO ARACHIDONIC ACID (EPA/AA) REDUCED INFLAMMATORY CHANGES IN VASCULAR ENDOTHELIUM","authors":"S. Sherratt, P. Libby, D. Bhatt, P. Mason","doi":"10.1016/j.jcjd.2023.10.146","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.146","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"36 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135410041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A GLYCOSYLATED HEMOGLOBIN ABOVE 6% IS ASSOCIATED WITH A HIGH RISK OF DEVELOPING CYSTIC FIBROSIS–RELATED DIABETES AND A LOWER PROBABILITY OF WEIGHT GAIN IN BOTH ADULTS AND CHILDREN WITH CYSTIC FIBROSIS 糖化血红蛋白高于6%与囊性纤维化相关糖尿病的高风险相关，并且囊性纤维化成人和儿童体重增加的可能性较低
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.179
K. Potter, F. Racine, A. Bonhoure, V. Boudreau, N. Bélanger, A. Coriati, A. Shohoudi, A. Lavoie, P. Senior, G. Mailhot, R. Rabasa-Lhoret
{"title":"A GLYCOSYLATED HEMOGLOBIN ABOVE 6% IS ASSOCIATED WITH A HIGH RISK OF DEVELOPING CYSTIC FIBROSIS–RELATED DIABETES AND A LOWER PROBABILITY OF WEIGHT GAIN IN BOTH ADULTS AND CHILDREN WITH CYSTIC FIBROSIS","authors":"K. Potter, F. Racine, A. Bonhoure, V. Boudreau, N. Bélanger, A. Coriati, A. Shohoudi, A. Lavoie, P. Senior, G. Mailhot, R. Rabasa-Lhoret","doi":"10.1016/j.jcjd.2023.10.179","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.179","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"36 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135410045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMPACT OF ONCE-WEEKLY SUBCUTANEOUS SEMAGLUTIDE 2.4 MG ON METABOLIC SYNDROME IN THE 2-YEAR, RANDOMIZED CONTROLLED STEP 5 TRIAL 在为期2年的随机对照第5步试验中，每周一次皮下注射西马鲁肽2.4 mg对代谢综合征的影响
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.250
M. Azar, R. Batterham, M. Bhatta, T. Holst-Hansen, K. Kandler, G. Rigas, T. Garvey
{"title":"IMPACT OF ONCE-WEEKLY SUBCUTANEOUS SEMAGLUTIDE 2.4 MG ON METABOLIC SYNDROME IN THE 2-YEAR, RANDOMIZED CONTROLLED STEP 5 TRIAL","authors":"M. Azar, R. Batterham, M. Bhatta, T. Holst-Hansen, K. Kandler, G. Rigas, T. Garvey","doi":"10.1016/j.jcjd.2023.10.250","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.250","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TREATMENT WITH APELIN AND ANALOGUES IMPROVES WOUND HEALING IN DIABETIC MICE 用apelin和类似物治疗可改善糖尿病小鼠的伤口愈合
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.379
S. Robillard, P. Boudreault, P. Geraldes
{"title":"TREATMENT WITH APELIN AND ANALOGUES IMPROVES WOUND HEALING IN DIABETIC MICE","authors":"S. Robillard, P. Boudreault, P. Geraldes","doi":"10.1016/j.jcjd.2023.10.379","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.379","url":null,"abstract":"People with diabetes are uniquely susceptible to diabetic foot ulceration (DFU) and lower extremity amputation (LEA). Indeed, patients with diabetes are more vulnerable to injuries creating hard-to-heal or non-healing wounds and increasing the risk of infection and amputation. Although the complex pathophysiology leading to DFU involves the synergistic effect of multiple mechanical, biological and molecular processes, diabetes impairs the angiogenic process while preventing delivery of oxygen, nutrients and immune proper response to fight the infection. Interestingly, our laboratory has shown that stimulation of the apelinergic system with pyr-apelin-13 (pyr-ape-13) or pyr-ELABELA-32 (pyr-ELA-32) improved blood flow reperfusion in diabetic mice following hind limb ischemia. Our objective is to evaluate the potential therapeutic effect of apelinergic system in a diabetic wound healing model.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
POPULATION HEALTH VALUE OF BEING IN TARGET: RESULTS FROM THE CANADIAN MULTI-MORBIDITY MODEL FOR TYPE 2 DIABETES 目标人群健康价值:来自加拿大2型糖尿病多发病模型的结果
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.342
I. Sobotka, L. Cipriano, D. Coyle, B. Shah
{"title":"POPULATION HEALTH VALUE OF BEING IN TARGET: RESULTS FROM THE CANADIAN MULTI-MORBIDITY MODEL FOR TYPE 2 DIABETES","authors":"I. Sobotka, L. Cipriano, D. Coyle, B. Shah","doi":"10.1016/j.jcjd.2023.10.342","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.342","url":null,"abstract":"Diabetes affects nearly 10% of Canadians, and can lead to many diabetes-related complications. Novel therapies purport to both improve control of diabetes and reduce the risk of these complications. Microsimulation modelling allows for the synthesis of multiple data sources for comparative effectiveness analysis related to a variety of correlated outcomes. However, existing type 2 diabetes models often use data that are decades old, are derived using non-representative clinical trial populations, or do not fully model vascular risk.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PARACRINE FACTORS REGULATE INTRACELLULAR TRAFFICKING OF GLUCAGON IN PANCREATIC ALPHA CELLS 旁分泌因子调节胰高血糖素在胰腺细胞内的转运
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.339
N. Chang, S. Dhanvantari, H. Madahey
{"title":"PARACRINE FACTORS REGULATE INTRACELLULAR TRAFFICKING OF GLUCAGON IN PANCREATIC ALPHA CELLS","authors":"N. Chang, S. Dhanvantari, H. Madahey","doi":"10.1016/j.jcjd.2023.10.339","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.339","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE IMPACT OF GASTROINTESTINAL SURGERIES ON PEAK PLASMA ANTI-XA DIRECT ORAL ANTICOAGULANT LEVELS: A RETROSPECTIVE COHORT 胃肠道手术对血浆抗xa直接口服抗凝血药水平峰值的影响:一项回顾性队列研究
Canadian journal of diabetes Pub Date : 2023-11-01 DOI: 10.1016/j.jcjd.2023.10.372
M. Huroy, R. Selby, S. Sutradhar, J. Abdulrehman
{"title":"THE IMPACT OF GASTROINTESTINAL SURGERIES ON PEAK PLASMA ANTI-XA DIRECT ORAL ANTICOAGULANT LEVELS: A RETROSPECTIVE COHORT","authors":"M. Huroy, R. Selby, S. Sutradhar, J. Abdulrehman","doi":"10.1016/j.jcjd.2023.10.372","DOIUrl":"https://doi.org/10.1016/j.jcjd.2023.10.372","url":null,"abstract":"","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"323 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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