BMJ (Clinical research ed.)最新文献

{"title":"NHS services in England are told to stop routine prescribing of puberty blockers.","authors":"Adrian O'Dowd","doi":"10.1136/bmj.q660","DOIUrl":"10.1136/bmj.q660","url":null,"abstract":"","PeriodicalId":93911,"journal":{"name":"BMJ (Clinical research ed.)","volume":"384 ","pages":"q660"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less than full time working beyond parenting: the increasing number of doctors going LTFT for wellbeing reasons.","authors":"Erin Dean","doi":"10.1136/bmj.q358","DOIUrl":"10.1136/bmj.q358","url":null,"abstract":"","PeriodicalId":93911,"journal":{"name":"BMJ (Clinical research ed.)","volume":"384 ","pages":"q358"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer trends in the UK.","authors":"Freddie Bray","doi":"10.1136/bmj.q504","DOIUrl":"10.1136/bmj.q504","url":null,"abstract":"","PeriodicalId":93911,"journal":{"name":"BMJ (Clinical research ed.)","volume":"384 ","pages":"q504"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global number of FGM survivors is up 15% since 2016, Unicef reports.","authors":"Owen Dyer","doi":"10.1136/bmj.q636","DOIUrl":"10.1136/bmj.q636","url":null,"abstract":"","PeriodicalId":93911,"journal":{"name":"BMJ (Clinical research ed.)","volume":"384 ","pages":"q636"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical devices: Government vows to tackle ethnic inequities.","authors":"Elisabeth Mahase","doi":"10.1136/bmj.q647","DOIUrl":"10.1136/bmj.q647","url":null,"abstract":"","PeriodicalId":93911,"journal":{"name":"BMJ (Clinical research ed.)","volume":"384 ","pages":"q647"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25 year trends in cancer incidence and mortality among adults aged 35-69 years in the UK, 1993-2018: retrospective secondary analysis.","authors":"Jon Shelton, Ewa Zotow, Lesley Smith, Shane A Johnson, Catherine S Thomson, Amar Ahmad, Lars Murdock, Diana Nagarwalla, David Forman","doi":"10.1136/bmj-2023-076962","DOIUrl":"10.1136/bmj-2023-076962","url":null,"abstract":"<p><strong>Objective: </strong>To examine and interpret trends in UK cancer incidence and mortality for all cancers combined and for the most common cancer sites in adults aged 35-69 years.</p><p><strong>Design: </strong>Retrospective secondary data analysis.</p><p><strong>Data sources: </strong>Cancer registration data, cancer mortality and national population data from the Office for National Statistics, Public Health Wales, Public Health Scotland, Northern Ireland Cancer Registry, NHS England, and the General Register Office for Northern Ireland.</p><p><strong>Setting: </strong>23 cancer sites were included in the analysis in the UK.</p><p><strong>Participants: </strong>Men and women aged 35-69 years diagnosed with or who died from cancer between 1993 to 2018.</p><p><strong>Main outcome measures: </strong>Change in cancer incidence and mortality age standardised rates over time.</p><p><strong>Results: </strong>The number of cancer cases in this age range rose by 57% for men (from 55 014 cases registered in 1993 to 86 297 in 2018) and by 48% for women (60 187 to 88 970) with age standardised rates showing average annual increases of 0.8% in both sexes. The increase in incidence was predominantly driven by increases in prostate (male) and breast (female) cancers. Without these two sites, all cancer trends in age standardised incidence rates were relatively stable. Trends for a small number of less common cancers showed concerning increases in incidence rates, for example, in melanoma skin, liver, oral, and kidney cancers. The number of cancer deaths decreased over the 25 year period, by 20% in men (from 32 878 to 26 322) and 17% in women (28 516 to 23 719); age standardised mortality rates reduced for all cancers combined by 37% in men (-2.0% per year) and 33% in women (-1.6% per year). The largest decreases in mortality were noted for stomach, mesothelioma, and bladder cancers in men and stomach and cervical cancers and non-Hodgkin lymphoma in women. Most incidence and mortality changes were statistically significant even when the size of change was relatively small.</p><p><strong>Conclusions: </strong>Cancer mortality had a substantial reduction during the past 25 years in both men and women aged 35-69 years. This decline is likely a reflection of the successes in cancer prevention (eg, smoking prevention policies and cessation programmes), earlier detection (eg, screening programmes) and improved diagnostic tests, and more effective treatment. By contrast, increased prevalence of non-smoking risk factors are the likely cause of the observed increased incidence for a small number of specific cancers. This analysis also provides a benchmark for the following decade, which will include the impact of covid-19 on cancer incidence and outcomes.</p>","PeriodicalId":93911,"journal":{"name":"BMJ (Clinical research ed.)","volume":"384 ","pages":"e076962"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10935512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wegovy: FDA approves weight loss drug to cut cardiovascular risk.","authors":"Janice Hopkins Tanne","doi":"10.1136/bmj.q642","DOIUrl":"10.1136/bmj.q642","url":null,"abstract":"","PeriodicalId":93911,"journal":{"name":"BMJ (Clinical research ed.)","volume":"384 ","pages":"q642"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NHS staff to receive paid leave following pregnancy loss.","authors":"Abi Rimmer","doi":"10.1136/bmj.q638","DOIUrl":"10.1136/bmj.q638","url":null,"abstract":"","PeriodicalId":93911,"journal":{"name":"BMJ (Clinical research ed.)","volume":"384 ","pages":"q638"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coroner warns of \"multiple failures\" that contributed to child's death from asthma.","authors":"Clare Dyer","doi":"10.1136/bmj.q641","DOIUrl":"10.1136/bmj.q641","url":null,"abstract":"","PeriodicalId":93911,"journal":{"name":"BMJ (Clinical research ed.)","volume":"384 ","pages":"q641"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homelessness is a public health emergency, report warns.","authors":"Jacqui Wise","doi":"10.1136/bmj.q632","DOIUrl":"10.1136/bmj.q632","url":null,"abstract":"","PeriodicalId":93911,"journal":{"name":"BMJ (Clinical research ed.)","volume":"384 ","pages":"q632"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}