Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie最新文献_第8页

Facile engineered macrophages-derived exosomes-functionalized PLGA nanocarrier for targeted delivery of dual drug formulation against neuroinflammation by modulation of microglial polarization in a post-stroke depression rat model. 在中风后抑郁大鼠模型中通过调节小胶质细胞极化靶向递送抗神经炎症的双重药物配方

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Pub Date : 2024-10-01 Epub Date: 2024-09-08 DOI: 10.1016/j.biopha.2024.117263

Zhongyue Lv, Cui Zhao, Xiping Wu, Yinqi Chen, Cheng Zheng, Xiaoling Zhang, Yifei Xu, Lujia Zhu, Haifeng Wang, Guomin Xie, Wu Zheng

{"title":"Facile engineered macrophages-derived exosomes-functionalized PLGA nanocarrier for targeted delivery of dual drug formulation against neuroinflammation by modulation of microglial polarization in a post-stroke depression rat model.","authors":"Zhongyue Lv, Cui Zhao, Xiping Wu, Yinqi Chen, Cheng Zheng, Xiaoling Zhang, Yifei Xu, Lujia Zhu, Haifeng Wang, Guomin Xie, Wu Zheng","doi":"10.1016/j.biopha.2024.117263","DOIUrl":"10.1016/j.biopha.2024.117263","url":null,"abstract":"Post-stroke depression (POSD) is a common difficulty and most predominant emotional syndrome after stroke often consequences in poor outcomes. In the present investigation, we have designed and studied the neurologically active celastrol/minocycline encapsulated with macrophages-derived exosomes functionalized PLGA nanoformulations (CMC-EXPL) to achieve enhanced anti-inflammatory behaviour and anti-depressant like activity in a Rat model of POSD. The animal model of POSD was established through stimulating process with chronic unpredictable mild stress (CUM) stimulations after procedure of middle cerebral artery occlusion (MCAO). Neuronal functions and Anti-inflammation behaviours were observed by histopathological (H&E) examination and Elisa analyses, respectively. The anti-depressive activity of the nanoformulations treated Rat models were evaluated by open-field and sucrose preference test methods. Microglial polarization was evaluated via flow-cytometry and qRT-PCR observations. The observed results exhibited that prepared nanoformulations reduced the POSD-stimulated depressive-like activities in rat models as well alleviated the neuronal damages and inflammatory responses in the cerebral hippocampus. Importantly, prepared CMC-EXPL nanoformulation effectively prevented the M1 pro-inflammatory polarization and indorsed M2 anti-inflammatory polarization, which indicates iNOS and CD86 levels significantly decreased and upsurged Arg-1 and CD206 levels. CMC-EXPL nanoformulation suggestively augmented anti-depressive activities and functional capability and also alleviated brain inflammation in POSD rats, demonstrating its therapeutic potential for POSD therapy.","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":"179 ","pages":"117263"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose oxidase and MnO₂ functionalized liposome for catalytic radiosensitization enhanced synergistic breast cancer therapy. 用于催化放射增敏的葡萄糖氧化酶和 MnO2 功能化脂质体增强了乳腺癌的协同治疗。

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Pub Date : 2024-10-01 Epub Date: 2024-09-08 DOI: 10.1016/j.biopha.2024.117402

Lihua Shao, Dun Liu, Xuexue Liu, Xueyuan Wang, Xian Yang, Runyan Niu, Shaoping Yin, Peipei Xu, Yonghuan Mao, Xiao Du, Lin Yang

{"title":"Glucose oxidase and MnO2 functionalized liposome for catalytic radiosensitization enhanced synergistic breast cancer therapy.","authors":"Lihua Shao, Dun Liu, Xuexue Liu, Xueyuan Wang, Xian Yang, Runyan Niu, Shaoping Yin, Peipei Xu, Yonghuan Mao, Xiao Du, Lin Yang","doi":"10.1016/j.biopha.2024.117402","DOIUrl":"10.1016/j.biopha.2024.117402","url":null,"abstract":"In recent years, the integration of radiotherapy and nanocatalytic medicine has gained widespread attention in the treatment of breast cancer. Herein, the glucose oxidase (GOx) and MnO2 nanoparticles co-modified multifunctional liposome of GOx-MnO2@Lip was constructed for enhanced radiotherapy. Introduction of GOx would not only elevate the glucose consumption to starve the cancer cells, but also increased the endogenous H2O2 level. Meanwhile, high intracellular GSH concentration facilitated the release of Mn2+ to amplify the cytotoxic ·OH through cascade catalytic reactions within the tumor microenvironment, resulting in a favorable tumor suppression rate of 74.45 %. Furthermore, the blood biochemical and blood routine demonstrated that GOx-MnO2@Lip had no obvious toxic side effects. Therefore, this work provided a potential vehicle for synergistic cancer starving therapy, chemodynamic therapy and radiotherapy for improving therapeutic efficacy of breast cancer.","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":"179 ","pages":"117402"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ''Spinosad blocks CHRNA5 mediated EGFR signaling pathway activation to inhibit lung adenocarcinoma proliferation'' [Biomed. Pharma. 177 (2024) 117105]. 对 "Spinosad 阻断 CHRNA5 介导的表皮生长因子受体信号通路激活以抑制肺腺癌增殖"[Biomed. Pharma. 177 (2024) 117105]的更正。

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.1016/j.biopha.2024.117213

Hongling Zou, Yan Chen, Xinping Zhu, Xinyun Zhao, Jili Cao, Yuxin Chen, Ziru Zhang, Yongqiang Zhu, Qun Li, Mingqian Li

引用次数: 0

Corrigendum to "Prenylated xanthones from mangosteen (Garcinia mangostana) target oxidative mitochondrial respiration in cancer cells" Biomed. Pharmacother. 179 (2024) 117365. 更正："山竹果（Garcinia mangostana）中的异戊烯基黄酮具有靶向癌细胞氧化线粒体呼吸的作用" Biomed.Pharmacother.179 (2024) 117365.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Pub Date : 2024-10-01 Epub Date: 2024-09-14 DOI: 10.1016/j.biopha.2024.117441

Menna El Gaafary, Passent M Abdel-Baki, Ali M El-Halawany, Heba M Mohamed, Amira Duweb, Hossam M Abdallah, Gamal A Mohamed, Sabrin R M Ibrahim, Thomas Simmet, Tatiana Syrovets

引用次数: 0

Corrigendum to "Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy" [Biomed. Pharmacother. (2023) 160 114382]. 丹酚酸 A 在糖尿病心肌病中通过 CRYAB 抑制细胞凋亡途径改善线粒体呼吸和心脏功能》[Biomed. Pharmacother. (2023) 160 114382]的更正。

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Pub Date : 2024-10-01 Epub Date: 2024-09-10 DOI: 10.1016/j.biopha.2024.117435

Di-Fei Gong, Shu-Chan Sun, Ran-Ran Wang, Awaguli Dawuti, De-Wen Kong, Rui-Qi Liu, Li-da Du, Shou-Bao Wang, Yang Lu, Tian-Yi Yuan, Guan-Hua Du, Lian-Hua Fang

引用次数: 0

Preparation of photo-controlled release ROS-responsive Ce6/elemene co-loaded liposomes and study on the effect on enhancing apoptosis of NMIBC. 制备光控释放 ROS 响应的 Ce6/elemene 共载脂质体并研究其对增强 NMIBC 细胞凋亡的作用。

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Pub Date : 2024-10-01 Epub Date: 2024-09-08 DOI: 10.1016/j.biopha.2024.117398

Xiulin Zhang, Wei Mei, Dongyan Guo, Jing Sun, Yajun Shi, Xiaofei Zhang, Junbo Zou, Jiangxue Cheng, Fei Luan, Bingtao Zhai, Huan Tian

{"title":"Preparation of photo-controlled release ROS-responsive Ce6/elemene co-loaded liposomes and study on the effect on enhancing apoptosis of NMIBC.","authors":"Xiulin Zhang, Wei Mei, Dongyan Guo, Jing Sun, Yajun Shi, Xiaofei Zhang, Junbo Zou, Jiangxue Cheng, Fei Luan, Bingtao Zhai, Huan Tian","doi":"10.1016/j.biopha.2024.117398","DOIUrl":"10.1016/j.biopha.2024.117398","url":null,"abstract":"At present, chemotherapy combined with photodynamic therapy is exerting satisfactory therapeutic effects in the treatment of tumors. Chlorin e6 (Ce6) is a photosensitizer with high efficiency and low dark toxicity. At the same time, elemene (ELE) contains high-efficiency and low-toxicity anti-cancer active ingredients, which can effectively penetrate tumor tissue and inhibit its recovery and proliferation. Due to the poor water solubility of these two drugs, we prepared ELE/Ce6 co-loaded liposomes (Lipo-ELE/Ce6) to improve their water solubility, thereby enhancing the anti-tumor effect. The characterization of Lipo-ELE/Ce6 showed that Lipo-ELE/Ce6 had suitable encapsulation efficiency (EE), particle size, polydispersity (PDI), zeta potential, and good photo-controlled release properties. In vitro, Lipo-ELE/Ce6 effectively inhibited the growth of T24 cells and induced apoptosis, and more importantly, in vivo experiments showed that Lipo-ELE/Ce6 had significant anti-tumor effects, which was significantly better than free drugs. The above results suggest that Lipo-ELE/Ce6 can significantly enhance the induction of apoptosis of non-muscle invasive bladder cancer (NMIBC) by light-controlled release and ROS response.","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":"179 ","pages":"117398"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrathecal administration of MCRT produced potent antinociception in chronic inflammatory pain models via μ-δ heterodimer with limited side effects. 在慢性炎症性疼痛模型中，鞘内给药 MCRT 可通过 μ-δ 异二聚体产生强效抗镇痛作用，且副作用有限。

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Pub Date : 2024-10-01 Epub Date: 2024-09-08 DOI: 10.1016/j.biopha.2024.117389

Yaofeng Zhao, Zhonghua Zhang, Dingnian Gou, Pengtao Li, Tong Yang, Zhanyu Niu, Jerine Peter Simon, Xuyan Guan, Xinyu Li, Chunbo He, Shouliang Dong

{"title":"Intrathecal administration of MCRT produced potent antinociception in chronic inflammatory pain models via μ-δ heterodimer with limited side effects.","authors":"Yaofeng Zhao, Zhonghua Zhang, Dingnian Gou, Pengtao Li, Tong Yang, Zhanyu Niu, Jerine Peter Simon, Xuyan Guan, Xinyu Li, Chunbo He, Shouliang Dong","doi":"10.1016/j.biopha.2024.117389","DOIUrl":"10.1016/j.biopha.2024.117389","url":null,"abstract":"An important goal in the opioid field is to discover effective analgesic drugs with minimal side effects. MCRT demonstrated potent antinociceptive effects with limited side effects, making it a promising candidate. However, its pharmacological properties and how it minimizes side effects remain unknown. Various mouse pain and opioid side effect models were used to evaluate the antinociceptive properties and safety at the spinal level. The targets of MCRT were identified through cAMP measurement, isolated tissue assays, and pharmacological experiments. Immunofluorescence was employed to visualize protein expression. MCRT displayed distinct antinociceptive effects between acute and chronic inflammatory pain models due to its multifunctional properties at the μ opioid receptor (MOR), µ-δ heterodimer (MDOR), and neuropeptide FF receptor 2 (NPFFR2). Activation of NPFFR2 reduced MOR-mediated antinociception, leading to bell-shaped response curves in acute pain models. However, activation of MDOR produced more effective antinociception in chronic inflammatory pain models. MCRT showed limited tolerance and opioid-induced hyperalgesia in both acute and chronic pain models and did not develop cross-tolerance to morphine. Additionally, MCRT did not exhibit addictive properties, gastrointestinal inhibition, and effects on motor coordination. Mechanistically, peripheral chronic inflammation or repeated administration of morphine and MCRT induced an increase in MDOR in the spinal cord. Chronic administration of MCRT had no apparent effect on microglial activation in the spinal cord. These findings suggest that MCRT is a versatile compound that provides potent antinociception with minimal opioid-related side effects. MDOR could be a promising target for managing chronic inflammatory pain and addressing the opioid crisis.","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":"179 ","pages":"117389"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome analysis reveals the anti-Parkinson's activity of Mangiferin in zebrafish. 转录组分析揭示了芒果苷在斑马鱼体内的抗帕金森病活性。

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Pub Date : 2024-10-01 Epub Date: 2024-09-08 DOI: 10.1016/j.biopha.2024.117387

Fengqing Qin, Ming Zhang, Pei Wang, Ziru Dai, Xi Li, Dongliang Li, Lijun Jing, Cen Qi, Heliang Fan, Mei Qin, Ying Li, Likun Huang, Tianci Wang

{"title":"Transcriptome analysis reveals the anti-Parkinson's activity of Mangiferin in zebrafish.","authors":"Fengqing Qin, Ming Zhang, Pei Wang, Ziru Dai, Xi Li, Dongliang Li, Lijun Jing, Cen Qi, Heliang Fan, Mei Qin, Ying Li, Likun Huang, Tianci Wang","doi":"10.1016/j.biopha.2024.117387","DOIUrl":"10.1016/j.biopha.2024.117387","url":null,"abstract":"As the global population ages, the incidence of Parkinson's Disease (PD) continues to rise, imposing significant social and economic burdens. Mangiferin (MGF), a polyphenolic, bioactive compound has been shown to play a role in the prevention and treatment of PD. This study investigates the neuroprotective effects of MGF in an MPTP-induced zebrafish model of PD through transcriptome analysis. Initially, optimal concentrations for modeling were determined using various MPTP and MGF combinations. The zebrafish were then divided into control, MPTP-treated, and MGF co-treated groups. Subsequent evaluations included hatching rates, mortality rates, growth and development conditions, spontaneous motor abilities, as well as measurements of enzymatic activities of SOD, CAT, and levels of GSH. Ultimately, the therapeutic efficacy of MGF on the PD model in zebrafish was assessed through transcriptome sequencing. The results demonstrated that MPTP treatment induced PD-associated symptoms in zebrafish, while MGF treatment significantly improved the motor abilities and survival rates of the PD model zebrafish, effectively reducing oxidative stress and ameliorating PD symptoms. Transcriptome sequencing further revealed that MGF may mitigate mitochondrial-related oxidative stress in PD zebrafish by modulating the expression of critical genes including lrrk2, vps35, atp13a, dnajc6, and uchl1. Differential gene expression analysis indicated that these genes are primarily involved in vital signaling pathways, such as neuroactive ligand-receptor interaction, and the calcium signaling pathway. In summary, our study provides robust scientific evidence supporting MGF as a potential therapeutic candidate for PD by preserving mitochondrial homeostasis and elucidating its mechanisms of action.","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":"179 ","pages":"117387"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Blocking 5-LO pathway alleviates renal fibrosis by inhibiting the epithelial-mesenchymal transition" [Biomed. Pharmacother. 138 (2021) 1-11]. 对 "通过抑制上皮-间质转化阻断 5-LO 通路减轻肾脏纤维化 "的更正 [Biomed. Pharmacother. 138 (2021) 1-11].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Pub Date : 2024-10-01 Epub Date: 2024-08-27 DOI: 10.1016/j.biopha.2024.117318

Jian Zhou, Rui Li, Qinhui Liu, Jinhang Zhang, Hui Huang, Cuiyuan Huang, Guorong Zhang, Yingnan Zhao, Tong Wu, Qin Tang, Ya Huang, Zijing Zhang, Yanping Li, Jinhan He

引用次数: 0

Metformin inhibits OCT3-mediated serotonin transport in the placenta. 二甲双胍可抑制胎盘中由 OCT3 介导的血清素转运。

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Pub Date : 2024-10-01 Epub Date: 2024-09-08 DOI: 10.1016/j.biopha.2024.117399

Veronika Vachalova, Fiona Kumnova, Tetiana Synova, Kasin Yadunandam Anandam, Cilia Abad, Rona Karahoda, Frantisek Staud

{"title":"Metformin inhibits OCT3-mediated serotonin transport in the placenta.","authors":"Veronika Vachalova, Fiona Kumnova, Tetiana Synova, Kasin Yadunandam Anandam, Cilia Abad, Rona Karahoda, Frantisek Staud","doi":"10.1016/j.biopha.2024.117399","DOIUrl":"10.1016/j.biopha.2024.117399","url":null,"abstract":"Proper fetal development requires tight regulation of serotonin concentrations within the fetoplacental unit. This homeostasis is partly maintained by the placental transporter OCT3/SLC22A3, which takes up serotonin from the fetal circulation. Metformin, an antidiabetic drug commonly used to treat gestational diabetes mellitus, was shown to inhibit OCT3. We, therefore, hypothesized that its use during pregnancy could disrupt placental serotonin homeostasis. This hypothesis was tested using three experimental model systems: primary trophoblast cells isolated from the human term placenta, fresh villous human term placenta fragments, and rat term placenta perfusions. Inhibition of serotonin transport by metformin at three concentrations (1 μM, 10 μM, and 100 μM) was assessed in all three models. The OCT3 inhibitor decynium-22 (100 μM) and paroxetine (100 μM), a dual inhibitor of SERT and OCT3, were used as controls. In primary trophoblasts, paroxetine exhibited the strongest inhibition of serotonin uptake, followed by decynium-22. Metformin showed a concentration-dependent effect, reducing serotonin uptake by up to 57 % at the highest concentration. Its inhibitory effect was less pronounced in fresh villous fragments but remained statistically significant at all concentrations. In the perfused rat placenta, metformin demonstrated a concentration-dependent effect, reducing placental serotonin uptake by 44 % at the highest concentration tested. Our findings across all experimental models show inhibition of placental OCT3 by metformin, resulting in reduced serotonin uptake by the trophoblast. This sheds light on mechanisms that may underpin metformin-mediated effects on fetal development.","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":"179 ","pages":"117399"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0