Teresa Obrero-Sojo, Ma José Jiménez-Moral, Fátima Guerrero, Ma Encarnación Rodríguez-Ortiz, Ana Isabel Torralbo, Karen Valdés-Díaz, Raquel Ma García-Sáez, Antonio Rivas-Domínguez, Daniel Jurado-Montoya, Fernando Leiva-Cepas, Ma Victoria Pendón-Ruiz de Mier, Cristian Rodelo-Haad, Griet Glorieux, Mariano Rodríguez, Sagrario Soriano-Cabrera, Juan Rafael Muñoz-Castañeda
{"title":"Corrigendum to \"Ceftriaxone administration reduces vascular calcification associated with experimental models of chronic kidney disease.\" [Biomed. Pharmacother. 197 (2026), 119131].","authors":"Teresa Obrero-Sojo, Ma José Jiménez-Moral, Fátima Guerrero, Ma Encarnación Rodríguez-Ortiz, Ana Isabel Torralbo, Karen Valdés-Díaz, Raquel Ma García-Sáez, Antonio Rivas-Domínguez, Daniel Jurado-Montoya, Fernando Leiva-Cepas, Ma Victoria Pendón-Ruiz de Mier, Cristian Rodelo-Haad, Griet Glorieux, Mariano Rodríguez, Sagrario Soriano-Cabrera, Juan Rafael Muñoz-Castañeda","doi":"10.1016/j.biopha.2026.119339","DOIUrl":"10.1016/j.biopha.2026.119339","url":null,"abstract":"","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":" ","pages":"119339"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mennatallah A Gowayed, Norhan S El-Sayed, Noura A Matar, Elham A Afify, Samar O El-Ganainy
{"title":"Retraction notice to \"The α7 nAChR allosteric modulator PNU-120596 amends neuroinflammatory and motor consequences of parkinsonism in rats: Role of JAK2/NF-κB/GSk3β/ TNF-α pathway\" [Biomedicine & Pharmacotherapy 148 (2022) 112776].","authors":"Mennatallah A Gowayed, Norhan S El-Sayed, Noura A Matar, Elham A Afify, Samar O El-Ganainy","doi":"10.1016/j.biopha.2026.119234","DOIUrl":"10.1016/j.biopha.2026.119234","url":null,"abstract":"","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":" ","pages":"119234"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sameh Saber, Eslam E Abd El-Fattah, Amir Mohamed Abdelhamid, Ahmed A E Mourad, Manal Ali Mahrous Hamouda, Amr Elrabat, Sahar Zakaria, Amira A Haleem, Sherin Z Mohamed, Rehab Mohamed Elgharabawy, Nesreen Elsayed Morsy, Noura El Adle Khalaf, Osama A Mohammed, Waleed Barakat El-Bahouty, Sally Abdallah Mostafa, Rasha Abdelhady, Omneya Galal, Zeinab H ElSaid, Galal Yahya, Ahmed Shata, Mahmoud E Youssef
{"title":"Retraction notice to \"Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling\" [Biomedicine & Pharmacotherapy 158 (2023) 114196].","authors":"Sameh Saber, Eslam E Abd El-Fattah, Amir Mohamed Abdelhamid, Ahmed A E Mourad, Manal Ali Mahrous Hamouda, Amr Elrabat, Sahar Zakaria, Amira A Haleem, Sherin Z Mohamed, Rehab Mohamed Elgharabawy, Nesreen Elsayed Morsy, Noura El Adle Khalaf, Osama A Mohammed, Waleed Barakat El-Bahouty, Sally Abdallah Mostafa, Rasha Abdelhady, Omneya Galal, Zeinab H ElSaid, Galal Yahya, Ahmed Shata, Mahmoud E Youssef","doi":"10.1016/j.biopha.2026.119233","DOIUrl":"10.1016/j.biopha.2026.119233","url":null,"abstract":"","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":" ","pages":"119233"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manzar Alam, Summya Rashid, Kisa Fatima, Mohd Adnan, Alaa Shafie, Mohammad Salman Akhtar, A H Ganie, Sayed M Eldin, Asimul Islam, Ilyas Khan, Md Imtaiyaz Hassan
{"title":"Retraction notice to \"Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits\" [Biomedicine & Pharmacotherapy 163 (2023) 114710].","authors":"Manzar Alam, Summya Rashid, Kisa Fatima, Mohd Adnan, Alaa Shafie, Mohammad Salman Akhtar, A H Ganie, Sayed M Eldin, Asimul Islam, Ilyas Khan, Md Imtaiyaz Hassan","doi":"10.1016/j.biopha.2026.119310","DOIUrl":"10.1016/j.biopha.2026.119310","url":null,"abstract":"","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":" ","pages":"119310"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ASPP-092, a Curcuma comosa diarylheptanoid, inhibits the adipogenic differentiation of human bone marrow-derived mesenchymal stem cells via activation of TGF-β/SMAD2/3 signaling.","authors":"Nareerat Sutjarit, Klodthida Yanukun, Kanit Bhukhai, Nithi Asavapanumas, Sarun Rangketkarn, Umnuaychoke Thongsa-Ad, Waraluck Chaichompoo, Apichart Suksamrarn, Sunhapas Soodvilai, Duangrat Tantikanlayaporn","doi":"10.1016/j.biopha.2025.118884","DOIUrl":"10.1016/j.biopha.2025.118884","url":null,"abstract":"<p><p>Excessive bone marrow adipose tissue (BMAT) is a key contributor to postmenopausal osteoporosis. It is associated with bone marrow-derived mesenchymal stem cells (BM-MSCs), which favor differentiation into adipocytes, thereby compromising osteoblast and bone formation. In addition, BMAT secretes anti-osteogenic factors that exacerbate bone loss. In this study, we investigated the effects of ASPP-092, a diarylheptanoid compound isolated from Curcuma comosa, on BM-MSC differentiation. ASPP-092 inhibited adipogenic differentiation and lipid accumulation by downregulating key adipogenic transcription factors and enzymes, including peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer-binding protein alpha (C/EBPα), sterol regulatory element-binding protein 1 (SREBP1), lipoprotein lipase (LPL), and fatty acid-binding protein 4 (FABP4). ASPP-092 also reduced the secretion of pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) while increasing anti-inflammatory interleukin-10 (IL-10) and adipokines such as leptin, adiponectin, and resistin. Transcriptomic analysis revealed upregulation of genes involved in the transforming growth factor-beta (TGF-β), Hippo, and Wnt/beta-catenin signaling pathways. Pharmacological inhibition of TGF-β/SMAD2/3 signaling abolished the anti-adipogenic effects of ASPP-092. These findings identify a novel mechanism by which ASPP-092 suppresses BMAT formation and supports its potential as an anti-osteoporotic agent.</p>","PeriodicalId":93904,"journal":{"name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","volume":"193 ","pages":"118884"},"PeriodicalIF":7.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}