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Biochimica et biophysica acta. Reviews on cancer最新文献

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A review exploring the fusion of oncolytic viruses and cancer immunotherapy: An innovative strategy in the realm of cancer treatment. 探讨溶瘤病毒与癌症免疫疗法融合的综述：癌症治疗领域的创新策略。
Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 Epub Date: 2024-05-14 DOI: 10.1016/j.bbcan.2024.189110
Soumyadeep Chattopadhyay, Rudradeep Hazra, Arijit Mallick, Sakuntala Gayen, Souvik Roy
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引用次数: 0
SNARE proteins: Core engines of membrane fusion in cancer. SNARE 蛋白：癌症中膜融合的核心引擎
Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 DOI: 10.1016/j.bbcan.2024.189148
Hongyi Liu, Ruiyue Dang, Wei Zhang, Jidong Hong, Xuejun Li
{"title":"SNARE proteins: Core engines of membrane fusion in cancer.","authors":"Hongyi Liu, Ruiyue Dang, Wei Zhang, Jidong Hong, Xuejun Li","doi":"10.1016/j.bbcan.2024.189148","DOIUrl":"https://doi.org/10.1016/j.bbcan.2024.189148","url":null,"abstract":"<p><p>Vesicles are loaded with a variety of cargoes, including membrane proteins, secreted proteins, signaling molecules, and various enzymes, etc. Not surprisingly, vesicle transport is essential for proper cellular life activities including growth, division, movement and cellular communication. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) mediate membrane fusion of vesicles with their target compartments that is fundamental for cargo delivery. Recent studies have shown that multiple SNARE family members are aberrantly expressed in human cancers and actively contribute to malignant proliferation, invasion, metastasis, immune evasion and treatment resistance. Here, the localization and function of SNARE proteins in eukaryotic cells are firstly mapped. Then we summarize the expression and regulation of SNAREs in cancer, and describe their contribution to cancer progression and mechanisms, and finally we propose engineering botulinum toxin as a strategy to target SNAREs for cancer treatment.</p>","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":" ","pages":"189148"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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