Biochimica et biophysica acta. Reviews on cancer最新文献_第2页

STAT3 axis in cancer and cancer stem cells: From oncogenesis to targeted therapies. STAT3轴在癌症和癌症干细胞：从肿瘤发生到靶向治疗。

IF 8.3

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-29 DOI: 10.1016/j.bbcan.2025.189461

Deepika Godugu, Rameswari Chilamakuri, Saurabh Agarwal

{"title":"STAT3 axis in cancer and cancer stem cells: From oncogenesis to targeted therapies.","authors":"Deepika Godugu, Rameswari Chilamakuri, Saurabh Agarwal","doi":"10.1016/j.bbcan.2025.189461","DOIUrl":"https://doi.org/10.1016/j.bbcan.2025.189461","url":null,"abstract":"The signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that is essential in regulating cellular homeostasis. Aberrant and persistent activation of STAT3 triggers the oncogenic progression of multiple cancers. STAT3 can be activated by both canonical and non-canonical pathways, leading to its nuclear translocation and regulation of the transcription of multiple target genes to promote tumor cell proliferation, drug resistance, differentiation, inflammation, immune evasion, and angiogenesis. Persistent activation of STAT3 correlates with the poor prognosis of cancer patients. Notably, STAT3 plays a crucial role in the maintenance of cancer stem cells (CSCs), contributing to disease relapse, metastasis, and poor clinical outcomes. Given its multifaceted role in tumor biology, STAT3 is an attractive target for therapeutic intervention. Various small molecules, peptides, and natural compounds targeting STAT3 are currently under different stages of preclinical and clinical evaluation. Despite promising advances, challenges such as drug resistance, selectivity, and toxicity remain obstacles in the development of effective STAT3-targeted therapies. This review provides a comprehensive overview of STAT3 structure, activation mechanisms, and its functional role in tumor biology and CSC maintenance. We also highlight current progress in STAT3-targeted therapeutic strategies, including agents in clinical trials, and discuss the future potential of STAT3 inhibition in precision oncology.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":" ","pages":"189461"},"PeriodicalIF":8.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

E-cadherin: A potential biomarker in cancer and a therapeutic target. e -钙粘蛋白：一种潜在的癌症生物标志物和治疗靶点。

IF 8.3

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-26 DOI: 10.1016/j.bbcan.2025.189466

Puja Kumari, Sagarika Dash, Dibyendu Samanta

{"title":"E-cadherin: A potential biomarker in cancer and a therapeutic target.","authors":"Puja Kumari, Sagarika Dash, Dibyendu Samanta","doi":"10.1016/j.bbcan.2025.189466","DOIUrl":"10.1016/j.bbcan.2025.189466","url":null,"abstract":"Tumorigenesis is a complex, multifaceted process that deregulates normal cellular functions, including cell growth, proliferation, and apoptosis. The primary factors driving tumorigenesis include the activation of oncogenes, inhibition of tumor suppressor genes, and the disruption of cell-cell contact. E-cadherin, a critical component of adherens junctions, plays an integral role in cell adhesion, maintaining tissue integrity, and contributing to developmental processes. E-cadherin facilitates the regulation of proliferation through contact inhibition under physiological conditions, acting as a tumor suppressor, and the alterations in E-cadherin expression are a major driving force in the development of various cancers. However, ongoing research has revealed the significance of E-cadherin in cancer progression, emphasizing its functional duality in tumorigenesis. This review summarizes E-cadherin's diverse and complex functions in various cancers, the underlying molecular mechanisms, and its role as a potential cancer biomarker across different cancer types. Further, we highlight numerous therapeutic strategies designed to target E-cadherin expression to treat various cancers.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":" ","pages":"189466"},"PeriodicalIF":8.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence. 泛素-蛋白酶体系统对肿瘤休眠和复发的调控。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1016/j.bbcan.2024.189119

Bashar A Alhasan, Alexey V Morozov, Irina V Guzhova, Boris A Margulis

{"title":"The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence.","authors":"Bashar A Alhasan, Alexey V Morozov, Irina V Guzhova, Boris A Margulis","doi":"10.1016/j.bbcan.2024.189119","DOIUrl":"10.1016/j.bbcan.2024.189119","url":null,"abstract":"Tumor recurrence is a mechanism triggered in sparse populations of cancer cells that usually remain in a quiescent state after strict stress and/or therapeutic factors, which is affected by a variety of autocrine and microenvironmental cues. Despite thorough investigations, the biology of dormant and/or cancer stem cells is still not fully elucidated, as for the mechanisms of their reawakening, while only the major molecular patterns driving the relapse process have been identified to date. These molecular patterns profoundly interfere with the elements of cellular proteostasis systems that support the efficiency of the recurrence process. As a major proteostasis machinery, we review the role of the ubiquitin-proteasome system (UPS) in tumor cell dormancy and reawakening, devoting particular attention to the functions of its components, E3 ligases, deubiquitinating enzymes and proteasomes in cancer recurrence. We demonstrate how UPS components functionally or mechanistically interact with the pivotal proteins implicated in the recurrence program and reveal that modulators of the UPS hold promise to become an efficient adjuvant therapy for eradicating refractory tumor cells to impede tumor relapse.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":" ","pages":"189119"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review exploring the fusion of oncolytic viruses and cancer immunotherapy: An innovative strategy in the realm of cancer treatment. 探讨溶瘤病毒与癌症免疫疗法融合的综述：癌症治疗领域的创新策略。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 Epub Date: 2024-05-14 DOI: 10.1016/j.bbcan.2024.189110

Soumyadeep Chattopadhyay, Rudradeep Hazra, Arijit Mallick, Sakuntala Gayen, Souvik Roy

引用次数: 0

SNARE proteins: Core engines of membrane fusion in cancer. SNARE 蛋白：癌症中膜融合的核心引擎

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 DOI: 10.1016/j.bbcan.2024.189148

Hongyi Liu, Ruiyue Dang, Wei Zhang, Jidong Hong, Xuejun Li

引用次数: 0