Biochimica et biophysica acta. Reviews on cancer最新文献

RNF43 and ZNRF3: Versatile regulators at the membrane and their role in cancer. RNF43 和 ZNRF3：膜上的多功能调节器及其在癌症中的作用。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-15 DOI: 10.1016/j.bbcan.2024.189217

Shanshan Li, Jiahui Niu, Ron Smits

引用次数: 0

Epstein Barr virus: A cellular hijacker in cancer. Epstein Barr 病毒：癌症中的细胞劫持者

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-14 DOI: 10.1016/j.bbcan.2024.189218

Moyed Alsaadawe, Bakeel A Radman, Jingyi Long, Mohenned Alsaadawi, Weiyi Fang, Xiaoming Lyu

{"title":"Epstein Barr virus: A cellular hijacker in cancer.","authors":"Moyed Alsaadawe, Bakeel A Radman, Jingyi Long, Mohenned Alsaadawi, Weiyi Fang, Xiaoming Lyu","doi":"10.1016/j.bbcan.2024.189218","DOIUrl":"https://doi.org/10.1016/j.bbcan.2024.189218","url":null,"abstract":"Numerous studies have demonstrated the importance of the Epstein-Barr Virus (EBV), which was initially identified in 1964 while studying Burkitt's lymphoma, in the development of a number of cancers, including nasopharyngeal carcinoma, Hodgkin's lymphoma, Burkitt's lymphoma, and EBV-associated gastric carcinoma. Gammaherpesvirus EBV is extremely common; by adulthood, over 90 % of people worldwide have been infected. Usually, the virus causes a permanent latent infection in B cells, epithelial cells, and NK/T cells. It then contributes to oncogenesis by inhibiting apoptosis and promoting unchecked cell proliferation through its latent proteins, which include EBNA-1, LMP1, and LMP2A. Tumor progression further accelerated by EBV's capacity to transition between latent and lytic phases, especially in cases of nasopharyngeal carcinoma. Although our understanding of the molecular underpinnings of EBV has advanced, there are still difficulties in identifying latent infections and creating targeted therapeutics. To tackle EBV-associated malignancies, current research efforts are concentrated on developing vaccines, developing better diagnostic tools, and developing targeted treatments. In order to improve treatment approaches and lower the incidence of EBV-related cancers worldwide, more research into the relationship between EBV and immune evasion and cancer formation is necessary.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythroid progenitor cell modulates cancer immunity: Insights and implications. 红细胞祖细胞调节癌症免疫：启示与影响

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-14 DOI: 10.1016/j.bbcan.2024.189209

Wen-Tao Mo, Cong-Fa Huang, Zhi-Jun Sun

{"title":"Erythroid progenitor cell modulates cancer immunity: Insights and implications.","authors":"Wen-Tao Mo, Cong-Fa Huang, Zhi-Jun Sun","doi":"10.1016/j.bbcan.2024.189209","DOIUrl":"https://doi.org/10.1016/j.bbcan.2024.189209","url":null,"abstract":"The emergence of immunotherapies such as immune checkpoint blockade (ICB) has markedly enhanced cancer treatment outcomes for numerous patients. Nevertheless, the effectiveness of immunotherapy demonstrates substantial variation across different cancer types and individual patients. The immunosuppressive characteristics of the tumor microenvironment (TME) play a crucial role in contributing to this variation. Typically, people focus on cells with immunosuppressive functions in the TME, such as tumor-associated macrophages (TAMs), but research on TAMs alone cannot fully explain the complex structure and composition of the TME. Recent studies have reported that tumors can induce erythroid progenitor cells (EPCs) to exert immunosuppressive functions, not only acting within the TME but also secreting artemin in the spleen to promote tumor progression. In this review, we summarize the recent research on EPCs and tumors in recent years. We elucidate the mechanisms by which EPCs exert immunosuppressive functions in tumor-bearing conditions. In this review, we further propose potential therapeutic strategies targeting EPCs and emphasize the importance of in-depth exploration of the mechanisms by which EPCs regulate tumors and the immune system, as well as the significant clinical value of developing corresponding drugs.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of TGF-β and vice versa in cancers - A review on recent developments. 癌症中 TGF-β 和 TGF-β 的表观遗传调控--最新进展综述。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-14 DOI: 10.1016/j.bbcan.2024.189219

Ankit Naik, Noopur Thakur

{"title":"Epigenetic regulation of TGF-β and vice versa in cancers - A review on recent developments.","authors":"Ankit Naik, Noopur Thakur","doi":"10.1016/j.bbcan.2024.189219","DOIUrl":"https://doi.org/10.1016/j.bbcan.2024.189219","url":null,"abstract":"This review explores the complex relationship between epigenetic mechanisms and Transforming Growth Factor-beta (TGF-β) signalling pathways in the field of cancer research. The study provides an overview of the latest advancements in understanding the crucial functions of epigenetic alterations, such as DNA methylation, histone modifications, and chromatin remodeling, in significantly impacting the TGF-β signalling pathway. The dynamic epigenetic modifications are essential in determining the behaviour of cancer cells, impacting the interactions with the tumor microenvironment, and affecting the overall process of carcinogenesis. Significant attention is given to Breast cancer, Lung cancer, Liver cancer, Prostate cancer, and Pancreatic cancer. Research has revealed intricate regulatory networks in these cancers, involving long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and histone post-translational modifications. These networks are closely connected to TGF-β signalling. Both findings highlight the significant interaction between epigenetic regulation and TGF-β signalling in cancer. They provide valuable insights that can guide the development of new treatment approaches to target both pathways and prevent cancer growth and metastasis.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer. 微生物组和宿主因素在头颈癌发病和治疗中的相互作用。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-12 DOI: 10.1016/j.bbcan.2024.189216

Martina Raudenská, Maria Bugajová, David Kalfeřt, Jan Plzák, Adam Šubrt, Petra Tesařová, Michal Masařík

{"title":"The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer.","authors":"Martina Raudenská, Maria Bugajová, David Kalfeřt, Jan Plzák, Adam Šubrt, Petra Tesařová, Michal Masařík","doi":"10.1016/j.bbcan.2024.189216","DOIUrl":"https://doi.org/10.1016/j.bbcan.2024.189216","url":null,"abstract":"Heterogeneous cancers that lack strong driver mutations with high penetrance, such as head and neck squamous cell carcinoma (HNSCC), present unique challenges to understanding their aetiology due to the complex interactions between genetics and environmental factors. The interplay between lifestyle factors (such as poor oral hygiene, smoking, or alcohol consumption), the oral and gut microbiome, and host genetics appears particularly important in the context of HNSCC. The complex interplay between the gut microbiota and cancer treatment outcomes has also received increasing attention in recent years. This review article describes the bidirectional communication between the host and the oral/gut microbiome, focusing on microbiome-derived metabolites and their impact on systemic immune responses and the modulation of the tumour microenvironment. In addition, we review the role of host lifestyle factors in shaping the composition of the oral/gut microbiota and its impact on cancer progression and therapy. Overall, this review highlights the rationality of considering the oral/gut microbiota as a critical determinant of cancer therapy outcomes and points to therapeutic opportunities offered by targeting the oral/gut microbiota in the management of HNSCC.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence. 泛素-蛋白酶体系统对肿瘤休眠和复发的调控。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1016/j.bbcan.2024.189119

Bashar A Alhasan, Alexey V Morozov, Irina V Guzhova, Boris A Margulis

{"title":"The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence.","authors":"Bashar A Alhasan, Alexey V Morozov, Irina V Guzhova, Boris A Margulis","doi":"10.1016/j.bbcan.2024.189119","DOIUrl":"10.1016/j.bbcan.2024.189119","url":null,"abstract":"Tumor recurrence is a mechanism triggered in sparse populations of cancer cells that usually remain in a quiescent state after strict stress and/or therapeutic factors, which is affected by a variety of autocrine and microenvironmental cues. Despite thorough investigations, the biology of dormant and/or cancer stem cells is still not fully elucidated, as for the mechanisms of their reawakening, while only the major molecular patterns driving the relapse process have been identified to date. These molecular patterns profoundly interfere with the elements of cellular proteostasis systems that support the efficiency of the recurrence process. As a major proteostasis machinery, we review the role of the ubiquitin-proteasome system (UPS) in tumor cell dormancy and reawakening, devoting particular attention to the functions of its components, E3 ligases, deubiquitinating enzymes and proteasomes in cancer recurrence. We demonstrate how UPS components functionally or mechanistically interact with the pivotal proteins implicated in the recurrence program and reveal that modulators of the UPS hold promise to become an efficient adjuvant therapy for eradicating refractory tumor cells to impede tumor relapse.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review exploring the fusion of oncolytic viruses and cancer immunotherapy: An innovative strategy in the realm of cancer treatment. 探讨溶瘤病毒与癌症免疫疗法融合的综述：癌症治疗领域的创新策略。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 Epub Date: 2024-05-14 DOI: 10.1016/j.bbcan.2024.189110

Soumyadeep Chattopadhyay, Rudradeep Hazra, Arijit Mallick, Sakuntala Gayen, Souvik Roy

引用次数: 0

SNARE proteins: Core engines of membrane fusion in cancer. SNARE 蛋白：癌症中膜融合的核心引擎

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 DOI: 10.1016/j.bbcan.2024.189148

Hongyi Liu, Ruiyue Dang, Wei Zhang, Jidong Hong, Xuejun Li

引用次数: 0