Biochimica et biophysica acta. Reviews on cancer最新文献

Decoding the key hallmarks of chemoresistance: A proteomic tale from breast cancer research. 解读化疗耐药的关键特征：乳腺癌研究中的蛋白质组学故事。

IF 8.3

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-30 DOI: 10.1016/j.bbcan.2025.189404

Praneeta Pradip Bhavsar, Bhargab Kalita, Khushman Taunk, Srikanth Rapole

{"title":"Decoding the key hallmarks of chemoresistance: A proteomic tale from breast cancer research.","authors":"Praneeta Pradip Bhavsar, Bhargab Kalita, Khushman Taunk, Srikanth Rapole","doi":"10.1016/j.bbcan.2025.189404","DOIUrl":"https://doi.org/10.1016/j.bbcan.2025.189404","url":null,"abstract":"Chemoresistance denotes the intricate, multifactorial molecular mechanisms by which malignant cells subvert the cytotoxicity of chemotherapeutic agents, thereby impeding therapeutic efficacy. This phenomenon is orchestrated through a confluence of processes, which we propose as the major hallmarks of chemoresistance in cancer. Dysregulation of drug transporters, activation of pro-survival pathways, cancer stem cell driven proliferation, DNA damage and repair mechanisms, evasion of apoptosis, autophagy induction, secretion of extracellular vesicles, and metabolic reprogramming represents the major mechanisms of chemoresistance in cancer. Breast cancer is one of the most common and aggressive types of cancer, with significant challenges in treatment due to its heterogeneity. Despite progress in various treatment regimens, chemoresistance continues to be a significant challenge in the effective management of breast cancer. In this context, high-throughput proteomic methodologies, which quantitatively assess proteome-wide alterations and explore post-translational modifications, can provide an unbiased framework for unraveling the molecular intricacies of chemotherapy resistance. This article comprehensively reviews the application of advanced proteomic techniques in elucidating the pathophysiological mechanisms of chemoresistance in breast carcer. Additionally, it highlights promising protein signatures uncovered via proteomic tools, as well as therapeutic strategies targeting chemoresistant hallmarks to overcome drug resistance in breast cancer. By leveraging proteomic technologies, we move closer to more effective and personalized therapeutic interventions for chemoresistant breast cancer.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":" ","pages":"189404"},"PeriodicalIF":8.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Taurine and cancer: Biological properties and multifaceted roles in cancer progression. 牛磺酸与癌症：生物学特性和癌症进展中的多方面作用。

IF 8.3

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-29 DOI: 10.1016/j.bbcan.2025.189403

Rong Liu, Xinze Li, Zhenyu Hua, ZhiTong Liu, ZhengYue Wang, Xiang Li

{"title":"Taurine and cancer: Biological properties and multifaceted roles in cancer progression.","authors":"Rong Liu, Xinze Li, Zhenyu Hua, ZhiTong Liu, ZhengYue Wang, Xiang Li","doi":"10.1016/j.bbcan.2025.189403","DOIUrl":"https://doi.org/10.1016/j.bbcan.2025.189403","url":null,"abstract":"Cancer remains one of the leading causes of mortality worldwide and poses a major threat to global health. Recent insights into the tumor microenvironment (TME) have highlighted the pivotal role of amino acid metabolism-one of the three core metabolic pathways-in driving tumor proliferation, metastasis, and resistance to therapy. Taurine, a conditionally essential amino acid abundantly present in various tissues, does not participate in protein synthesis but exhibits multiple biological functions, including antioxidant, anti-inflammatory, and cytoprotective effects. These properties are increasingly recognized as relevant in both physiological regulation and pathological conditions such as cancer. Emerging evidence suggests that taurine modulates tumor growth and progression through diverse mechanisms, including regulation of immune responses, redox homeostasis, cellular metabolism, and the TME. This review summarizes the multifaceted roles of taurine in tumorigenesis and its potential applications in cancer therapy, providing new perspectives for targeted intervention.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":" ","pages":"189403"},"PeriodicalIF":8.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anoikis and NETosis in colorectal cancer liver metastasis: the relationship and perspectives. 结直肠癌肝转移中的异常与NETosis：关系及展望。

IF 8.3

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-29 DOI: 10.1016/j.bbcan.2025.189401

Ruoyu Zhang, Yunfei Tan, Dedi Jiang, Dewei Kong, Mei Liu, Jianwei Liang, Aiwen Wu, Liming Wang

{"title":"Anoikis and NETosis in colorectal cancer liver metastasis: the relationship and perspectives.","authors":"Ruoyu Zhang, Yunfei Tan, Dedi Jiang, Dewei Kong, Mei Liu, Jianwei Liang, Aiwen Wu, Liming Wang","doi":"10.1016/j.bbcan.2025.189401","DOIUrl":"https://doi.org/10.1016/j.bbcan.2025.189401","url":null,"abstract":"Colorectal cancer (CRC) is a leading cause of cancer-related mortality, with metastatic spread being the primary reason for fatalities. Anoikis, a form of programmed cell death triggered by cell detachment from the extracellular matrix (ECM), and NETosis, a neutrophil cell death mode releasing extracellular traps (NETs), play critical roles in CRC liver metastasis (CRCLM). This review explores the mechanisms of anoikis and NETosis, their interplay, and genetic underpinnings in CRCLM. Anoikis resistance in CRC cells allows survival during metastasis in the initial stage, while NETs promote tumor progression by facilitating immune evasion, ECM remodeling, and angiogenesis. Meanwhile, through bioinformatics analysis and summary, we elaborated on the relationship between anoikis and NETosis as well as the potential interaction mechanisms, exploring the connecting links between them. The crosstalk between these processes is analyzed, highlighting shared signaling pathways (e.g., PI3K/AKT, MAPK, EMT) and potential biomarkers (e.g., MUC13, GLI2, SIRT6, FASN). Therapeutic strategies targeting anoikis and NETosis, including inhibitors of integrins, EGFR, and NET components (e.g., DNase I, CXCR2 antagonists), inhibitors of autophagy (e.g., CQ, HCQ, azithromycin) are discussed. This comprehensive analysis advances understanding of CRCLM pathogenesis and provides novel perspectives for targeted interventions.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":" ","pages":"189401"},"PeriodicalIF":8.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence. 泛素-蛋白酶体系统对肿瘤休眠和复发的调控。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1016/j.bbcan.2024.189119

Bashar A Alhasan, Alexey V Morozov, Irina V Guzhova, Boris A Margulis

{"title":"The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence.","authors":"Bashar A Alhasan, Alexey V Morozov, Irina V Guzhova, Boris A Margulis","doi":"10.1016/j.bbcan.2024.189119","DOIUrl":"10.1016/j.bbcan.2024.189119","url":null,"abstract":"Tumor recurrence is a mechanism triggered in sparse populations of cancer cells that usually remain in a quiescent state after strict stress and/or therapeutic factors, which is affected by a variety of autocrine and microenvironmental cues. Despite thorough investigations, the biology of dormant and/or cancer stem cells is still not fully elucidated, as for the mechanisms of their reawakening, while only the major molecular patterns driving the relapse process have been identified to date. These molecular patterns profoundly interfere with the elements of cellular proteostasis systems that support the efficiency of the recurrence process. As a major proteostasis machinery, we review the role of the ubiquitin-proteasome system (UPS) in tumor cell dormancy and reawakening, devoting particular attention to the functions of its components, E3 ligases, deubiquitinating enzymes and proteasomes in cancer recurrence. We demonstrate how UPS components functionally or mechanistically interact with the pivotal proteins implicated in the recurrence program and reveal that modulators of the UPS hold promise to become an efficient adjuvant therapy for eradicating refractory tumor cells to impede tumor relapse.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":" ","pages":"189119"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review exploring the fusion of oncolytic viruses and cancer immunotherapy: An innovative strategy in the realm of cancer treatment. 探讨溶瘤病毒与癌症免疫疗法融合的综述：癌症治疗领域的创新策略。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 Epub Date: 2024-05-14 DOI: 10.1016/j.bbcan.2024.189110

Soumyadeep Chattopadhyay, Rudradeep Hazra, Arijit Mallick, Sakuntala Gayen, Souvik Roy

引用次数: 0

SNARE proteins: Core engines of membrane fusion in cancer. SNARE 蛋白：癌症中膜融合的核心引擎

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 DOI: 10.1016/j.bbcan.2024.189148

Hongyi Liu, Ruiyue Dang, Wei Zhang, Jidong Hong, Xuejun Li

引用次数: 0