Biochimica et biophysica acta. Reviews on cancer最新文献

Comprehensive insights into human papillomavirus and cervical cancer: Pathophysiology, screening, and vaccination strategies.

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-09-28 DOI: 10.1016/j.bbcan.2024.189192

Ying Liu, Hao Ai

引用次数: 0

The tumor microenvironment's gambit: Exosomal pawns on the board of head and neck cancer.

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-09-27 DOI: 10.1016/j.bbcan.2024.189189

Solmaz Mohamadi, Parisa Mehrasa, Bahareh Mehramuz, Sepehr Kobravi, Mohammad Taghizadieh, Arash Salmaninejad, Mobina Bayat, Javid Sadri Nahand

{"title":"The tumor microenvironment's gambit: Exosomal pawns on the board of head and neck cancer.","authors":"Solmaz Mohamadi, Parisa Mehrasa, Bahareh Mehramuz, Sepehr Kobravi, Mohammad Taghizadieh, Arash Salmaninejad, Mobina Bayat, Javid Sadri Nahand","doi":"10.1016/j.bbcan.2024.189189","DOIUrl":"https://doi.org/10.1016/j.bbcan.2024.189189","url":null,"abstract":"The tumor microenvironment (TME) harbors a hidden universe of interactions that profoundly shape the behavior of head and neck cancers (HNCs). HNCs are not merely localized afflictions; they constitute a pressing global health crisis that impacts millions, frequently resulting in severe prognoses due to late-stage diagnosis and intrinsic resistance to conventional therapies. In this intricate interplay, cancer cells function as strategic players, adeptly manipulating their microenvironment to foster proliferation, evade immune detection, and withstand therapeutic interventions. Central to this dynamic play are exosomes, the enigmatic pawns of cellular communication, carrying vital messages across the board. This review elucidates the multifaceted roles of exosomes within the TME, highlighting their capacity to transmit critical signals that not only promote tumor progression but also modulate immune responses, ultimately playing a crucial role in the evolving narrative of HNC. Our insights aim to catalyze further research and exploration into exosome-targeted therapies, potentially transforming the landscape of HNC treatment and improving clinical outcomes in this formidable battle against cancer.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The metabolic crosstalk of cancer-associated fibroblasts and tumor cells: Recent advances and future perspectives.

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-09-26 DOI: 10.1016/j.bbcan.2024.189190

Bing Xia, Liqing Qiu, Jing Yue, Jingxing Si, Hongfang Zhang

{"title":"The metabolic crosstalk of cancer-associated fibroblasts and tumor cells: Recent advances and future perspectives.","authors":"Bing Xia, Liqing Qiu, Jing Yue, Jingxing Si, Hongfang Zhang","doi":"10.1016/j.bbcan.2024.189190","DOIUrl":"https://doi.org/10.1016/j.bbcan.2024.189190","url":null,"abstract":"Tumor cells grow in a microenvironment with a lack of nutrients and oxygen. Cancer-associated fibroblasts (CAFs) as one major component of tumor microenvironment have strong ability to survive under stressful conditions through metabolic remodelling. Furthermore, CAFs are educated by tumor cells and help them adapt to the hostile microenvironment through their metabolic communication. By inducing catabolism, CAFs release nutrients into the microenvironment which are taken up by tumor cells to satisfy their metabolic requirements. Furthermore, CAFs can recycle toxic metabolic wastes produced by cancer cells into energetic substances, allowing cancer cells to undergo biosynthesis. Their metabolic crosstalk also enhances CAFs' pro-tumor phenotype and reshape the microenvironment facilitating tumor cells' metastasis and immune escape. In this review, we have analyzed the effect and mechanisms of metabolic crosstalk between tumor cells and CAFs. We also analyzed the future perspectives in this area from the points of CAFs heterogeneity, spatial metabonomics and patient-derived tumor organoids (PDOs). These information may deepen the knowledge of tumor metabolism regulated by CAFs and provide novel insights into the development of metabolism-based anti-cancer strategies.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination therapies with Wnt signaling inhibition: A better choice for prostate cancer treatment.

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-09-25 DOI: 10.1016/j.bbcan.2024.189186

Yifan Hou, Zhenhua Zhao, Pan Li, Yujia Cao, Yi Zhang, Changsheng Guo, Xiaobo Nie, Junqing Hou

{"title":"Combination therapies with Wnt signaling inhibition: A better choice for prostate cancer treatment.","authors":"Yifan Hou, Zhenhua Zhao, Pan Li, Yujia Cao, Yi Zhang, Changsheng Guo, Xiaobo Nie, Junqing Hou","doi":"10.1016/j.bbcan.2024.189186","DOIUrl":"https://doi.org/10.1016/j.bbcan.2024.189186","url":null,"abstract":"The intractability and high mortality rate of castration-resistant prostate cancer (CRPC) remain the most challenging problems in the field of prostate cancer (PCa). Emerging evidence has shown that the dysregulation of Wnt signaling pathways, which are highly conserved cascades that regulate embryonic development and maintain tissue homeostasis, is involved in various stages of PCa occurrence and progression. In this review, we systemically discuss the mechanisms by which the androgen receptor (AR) signaling pathway and Wnt signaling pathways participate in the occurrence of PCa and its progression to CRPC. Specifically, we elaborate on how Wnt signaling pathways induce the malignant transformation of prostate cells, promote the malignant progression of PCa and establish an immunosuppressive prostate tumor microenvironment through interaction with the AR pathway or in an AR-independent manner. We also discuss how Wnt signaling pathways enhances the stemness characteristics of prostate cancer stem cells (PCSCs) to induce the occurrence and metastasis of CPPC. Additionally, we discuss the latest progress in the use of different types of drugs that inhibit the Wnt signaling pathways in the treatment of PCa. We believe that the combination of Wnt signaling-based drugs with endocrine and other therapies is necessary and may enhance the clinical efficacy in the treatment of all types of PCa.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting DNA damage response in pancreatic ductal adenocarcinoma: A review of preclinical and clinical evidence.

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-09-24 DOI: 10.1016/j.bbcan.2024.189185

Fatemeh Moosavi, Bahareh Hassani, Somayeh Nazari, Luciano Saso, Omidreza Firuzi

引用次数: 0

The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence. 泛素-蛋白酶体系统对肿瘤休眠和复发的调控。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1016/j.bbcan.2024.189119

Bashar A Alhasan, Alexey V Morozov, Irina V Guzhova, Boris A Margulis

{"title":"The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence.","authors":"Bashar A Alhasan, Alexey V Morozov, Irina V Guzhova, Boris A Margulis","doi":"10.1016/j.bbcan.2024.189119","DOIUrl":"10.1016/j.bbcan.2024.189119","url":null,"abstract":"Tumor recurrence is a mechanism triggered in sparse populations of cancer cells that usually remain in a quiescent state after strict stress and/or therapeutic factors, which is affected by a variety of autocrine and microenvironmental cues. Despite thorough investigations, the biology of dormant and/or cancer stem cells is still not fully elucidated, as for the mechanisms of their reawakening, while only the major molecular patterns driving the relapse process have been identified to date. These molecular patterns profoundly interfere with the elements of cellular proteostasis systems that support the efficiency of the recurrence process. As a major proteostasis machinery, we review the role of the ubiquitin-proteasome system (UPS) in tumor cell dormancy and reawakening, devoting particular attention to the functions of its components, E3 ligases, deubiquitinating enzymes and proteasomes in cancer recurrence. We demonstrate how UPS components functionally or mechanistically interact with the pivotal proteins implicated in the recurrence program and reveal that modulators of the UPS hold promise to become an efficient adjuvant therapy for eradicating refractory tumor cells to impede tumor relapse.","PeriodicalId":93897,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review exploring the fusion of oncolytic viruses and cancer immunotherapy: An innovative strategy in the realm of cancer treatment. 探讨溶瘤病毒与癌症免疫疗法融合的综述：癌症治疗领域的创新策略。

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 Epub Date: 2024-05-14 DOI: 10.1016/j.bbcan.2024.189110

Soumyadeep Chattopadhyay, Rudradeep Hazra, Arijit Mallick, Sakuntala Gayen, Souvik Roy

引用次数: 0

SNARE proteins: Core engines of membrane fusion in cancer. SNARE 蛋白：癌症中膜融合的核心引擎

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-01 DOI: 10.1016/j.bbcan.2024.189148

Hongyi Liu, Ruiyue Dang, Wei Zhang, Jidong Hong, Xuejun Li

引用次数: 0