Archives of gerontology and geriatrics最新文献

Allostatic load-intrinsic capacity phenotypes and adverse ageing outcomes in middle-aged and older Chinese adults. 中国中老年人的适应负荷、内在能力表型和不良衰老结局。

IF 3.8

Archives of gerontology and geriatrics Pub Date : 2026-10-13 DOI: 10.1016/j.archger.2026.106451

Xinying Feng, Jichen Dai, Feng Chen, Zhuoying Wang, Bing Wang, Peifeng Liu

{"title":"Allostatic load-intrinsic capacity phenotypes and adverse ageing outcomes in middle-aged and older Chinese adults.","authors":"Xinying Feng, Jichen Dai, Feng Chen, Zhuoying Wang, Bing Wang, Peifeng Liu","doi":"10.1016/j.archger.2026.106451","DOIUrl":"https://doi.org/10.1016/j.archger.2026.106451","url":null,"abstract":"Background: Allostatic load (AL) reflects multisystem physiological dysregulation, whereas intrinsic capacity (IC) reflects functional reserve. We examined whether cross-classification of AL and IC identified distinct risk profiles for adverse ageing outcomes.Methods: Among 11,190 otherwise eligible participants, 8695 had sufficient AL and IC information for the non-fatal analyses, and all-cause mortality was analysed in a baseline risk set of 8973. AL was calculated from 11 biomarkers, and IC was operationalised as a proxy-based, prorated 0-9 score across five domains. Discrete-time logistic models with participant-level robust standard errors were fitted to 2011-2018 person-period data.Results: Both low-IC phenotypes were associated with higher odds of functional limitation and hospitalisation compared with the low AL + high IC reference phenotype. The high AL + low IC phenotype had the largest point estimates for activities of daily living (ADL)/instrumental activities of daily living (IADL) limitation (OR 1.87, 95% CI 1.63-2.15), ADL limitation (OR 2.83, 2.37-3.40), and hospitalisation (OR 1.74, 1.52-1.99). For mortality, high AL + low IC had the largest estimate (OR 2.30, 1.74-3.04) and high AL + high IC was also associated with higher mortality (OR 1.84, 1.38-2.46). Multiplicative interactions were not statistically significant. Positive additive interaction on the odds-ratio scale was observed only for ADL limitation (RERI 0.414, 95% CI 0.012-0.804).Conclusion: Joint AL-IC classification identified distinct, outcome-specific risk profiles. Low IC was the more consistent risk dimension for functional limitation and hospitalisation; mortality was associated with the high-AL phenotypes. Incremental predictive performance and clinical utility were not evaluated.","PeriodicalId":93880,"journal":{"name":"Archives of gerontology and geriatrics","volume":"152 ","pages":"106451"},"PeriodicalIF":3.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise training and mitochondrial remodeling in aging skeletal muscle: A translational systematic review and meta-analysis. 运动训练和老化骨骼肌的线粒体重塑：一项转化系统综述和荟萃分析。

IF 3.8

Archives of gerontology and geriatrics Pub Date : 2026-09-30 DOI: 10.1016/j.archger.2026.106435

Farhan Yousaf, Sean Kao, Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee

{"title":"Exercise training and mitochondrial remodeling in aging skeletal muscle: A translational systematic review and meta-analysis.","authors":"Farhan Yousaf, Sean Kao, Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee","doi":"10.1016/j.archger.2026.106435","DOIUrl":"https://doi.org/10.1016/j.archger.2026.106435","url":null,"abstract":"Aging skeletal muscle shows impaired mitochondrial function, altered redox regulation, disrupted fusion-fission balance, and reduced mitochondrial turnover. This translational systematic synthesis and meta-analysis evaluated whether exercise training remodels mitochondrial and functional outcomes in aging muscle. PubMed, EMBASE, and Web of Science were searched to June 26, 2026 following PRISMA 2020. Twenty-eight studies involving aged exercise groups compared to sedentary groups were included. Outcomes covered oxidative stress, mitochondrial dynamics, mitophagy, mitochondrial biogenesis/function, skeletal muscle morphology, and physiological performance. Random-effects meta-analysis showed a significant improvement in VO₂max/VO₂peak after exercise training (SMD = 0.46, p < 0.001; I² = 0%), whereas pooled changes in citrate synthase (SMD = 0.18, p = 0.450) and BMI (SMD = -0.09, p = 0.557) were not significant. The directional synthesis showed that mitochondrial biogenesis and function were consistently responsive across species, particularly for OXPHOS proteins, mitochondrial volume density, ATPmax, and SIRT1/SIRT3 signaling. Human and rodent studies assessed different, only partly overlapping mitophagy and mitochondrial dynamics markers. Therefore, differences in pathway responsiveness across species cannot be separated from differences in which markers were measured. Exercise training and lifelong physical activity were associated with changes in mitochondrial biogenesis, dynamics, mitophagy-related signaling, and muscle function in aging skeletal muscle. The observed patterns varied by training protocol and study design, but indirect comparisons and heterogeneous outcome measures preclude conclusions about the superiority of any modality. Human and rodent findings should therefore be interpreted as complementary evidence rather than equivalent estimates of biological response.","PeriodicalId":93880,"journal":{"name":"Archives of gerontology and geriatrics","volume":"152 ","pages":"106435"},"PeriodicalIF":3.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of temporal variation in social activity participation on physical frailty among community-dwelling middle-aged and older adults: A longitudinal study with a three-wave survey. 社会活动参与的时间变化对社区中老年人身体虚弱的影响：一项三波调查的纵向研究。

IF 3.8

Archives of gerontology and geriatrics Pub Date : 2025-11-01 Epub Date: 2025-08-05 DOI: 10.1016/j.archger.2025.105979

Yuya Goto, Koji Yamatsu

{"title":"Effect of temporal variation in social activity participation on physical frailty among community-dwelling middle-aged and older adults: A longitudinal study with a three-wave survey.","authors":"Yuya Goto, Koji Yamatsu","doi":"10.1016/j.archger.2025.105979","DOIUrl":"10.1016/j.archger.2025.105979","url":null,"abstract":"An aging population necessitates strategies for extending healthy lifespan, with physical frailty as a key obstacle. Social activity participation is a potential intervention. However, previous studies examining the association between social activity participation and physical frailty have predominantly employed cross-sectional designs with single-wave surveys or longitudinal designs with two-wave surveys, and studies using multi-wave longitudinal designs are limited. Few studies have systematically evaluated the classification of physical frailty in subsequent follow-up assessments while considering temporal variations in social activity participation. Therefore, we studied the effect of temporal variations in social activity on subsequent physical frailty classifications using a three-wave survey. We found that sustained non-participation in sports-based activities significantly increased the risk of Pre-Frailty or Frailty at follow-up compared to sustained participation. Similarly, transitioning from participation to non-participation in culture-based activities increased this risk. These results suggest that maintaining participation in sports activities and avoiding cessation of cultural activities are crucial for preventing frailty. Individuals who consistently avoided sports or stopped cultural activities were more likely to be classified as pre-frail or frail in subsequent assessments.","PeriodicalId":93880,"journal":{"name":"Archives of gerontology and geriatrics","volume":"138 ","pages":"105979"},"PeriodicalIF":3.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Employment outcomes for older adults aged 50-74 by major local industry typology and the health of a place: findings from the ONS Longitudinal Study 2001-2011. 按当地主要行业类型和地方健康状况划分的50-74岁老年人的就业结果：2001-2011年国家统计局纵向研究的结果。

IF 3.8

Archives of gerontology and geriatrics Pub Date : 2025-11-01 Epub Date: 2025-07-28 DOI: 10.1016/j.archger.2025.105973

Nicola Shelton, Paul Norman, Jenny Head, Emily T Murray

{"title":"Employment outcomes for older adults aged 50-74 by major local industry typology and the health of a place: findings from the ONS Longitudinal Study 2001-2011.","authors":"Nicola Shelton, Paul Norman, Jenny Head, Emily T Murray","doi":"10.1016/j.archger.2025.105973","DOIUrl":"10.1016/j.archger.2025.105973","url":null,"abstract":"Objectives: Poor health at the individual and area level has been shown to be associated with earlier labour market exit. This paper builds on work demonstrating that health in a place is associated with higher chances of work exit for older workers even once their own health is taken into account. This paper looks at an additional risk factor for work exit: industrial mix.Study design: Data was drawn from the full 2011 Census and an approximately 1.1 % representative sample from England and Wales, the Office for National Statistics Longitudinal Study from 2001 to 2011.Methods: We analysed people aged 40-64 in paid work in 2001 and measured their employment outcomes in 2011, at ages 50-74. Four industrial landscape clusters were derived by K-means cluster analysis using industry mix for 348 local authorities from 2011 Census. 'Health of a place' was measured using 2001 Census data for the usually resident population aged 50-74 years, the proportion who reported 'fair', 'bad' or 'very bad' self-rated health (as opposed to 'good' or 'very good') was calculated and split into tertiles.Results: Work exit showed industrial landscape and area health inequalities. Older workers in healthy service sector areas in London had the lowest work exit chances with a gradient to those in unhealthy rural areas having the highest chance of work exit.Conclusions: More research is required to investigate why, in areas where the same types of industry dominate, the health of the local population was associated with differing odds of work exit.","PeriodicalId":93880,"journal":{"name":"Archives of gerontology and geriatrics","volume":"138 ","pages":"105973"},"PeriodicalIF":3.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex and gender differences in caregiver burden among family caregivers of persons with dementia: A systematic review and meta-analysis. 痴呆症患者家庭照顾者照顾者负担的性别差异：一项系统回顾和荟萃分析

IF 3.8

Archives of gerontology and geriatrics Pub Date : 2025-11-01 Epub Date: 2025-07-29 DOI: 10.1016/j.archger.2025.105977

Thitinan Duangjina, Thanakrit Jeamjitvibool, Chang Park, Rebecca Raszewski, Valerie Gruss, Cynthia Fritschi

{"title":"Sex and gender differences in caregiver burden among family caregivers of persons with dementia: A systematic review and meta-analysis.","authors":"Thitinan Duangjina, Thanakrit Jeamjitvibool, Chang Park, Rebecca Raszewski, Valerie Gruss, Cynthia Fritschi","doi":"10.1016/j.archger.2025.105977","DOIUrl":"10.1016/j.archger.2025.105977","url":null,"abstract":"Objective: This systematic review and meta-analysis examined sex and gender differences in caregiver burden among family caregivers of persons with dementia and explored variations by region and country income level.Methods: Following PRISMA guidelines, a comprehensive literature search was conducted in four databases (CINAHL, PubMed, EMBASE, and PsycINFO), including studies up to December 2024. Forty-seven studies representing 24 countries were included in the systematic review, with 39 studies (41 effect sizes) included in the meta-analysis. A random-effects model was used to calculate pooled effect sizes (Cohen's d), and subgroup analyses were performed based on region and national income level.Results: Across the 47 studies, 14,919 family caregivers participated, of whom 70 % were women. Most family caregivers were either spouses (44 %) or adult children (43 %). Care recipients were predominantly diagnosed with Alzheimer's disease. Female caregivers reported significantly greater burden than males (Cohen's d= 0.21, 95 % CI: 0.13-0.29, p< 0.001). Subgroup analyses showed higher burden in Asian countries (d= 0.27) compared to Western countries (d= 0.19), though the difference was not statistically significant. High-income countries showed greater disparities (d= 0.21) than middle-income countries (d= 0.16), with no significant difference. High heterogeneity was observed among Western and high-income countries.Conclusion: Female family caregivers experience a higher burden than male caregivers across regions and economic settings. Although regional and income-level subgroup differences were not statistically significant, findings underscore the role of cultural and structural contexts in shaping caregiver burden. Gender-sensitive, context specific interventions are essential to address these disparities.","PeriodicalId":93880,"journal":{"name":"Archives of gerontology and geriatrics","volume":"138 ","pages":"105977"},"PeriodicalIF":3.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory age and its impact on age-related health in older Chinese adults 中国老年人的炎症年龄及其对老年健康的影响

Archives of gerontology and geriatrics Pub Date : 2024-05-01 DOI: 10.1016/j.archger.2024.105476

Rui Zhen Wang, W. Zhang, Chao Qiang Jiang, Feng Zhu, Y. Jin, Lin Xu

引用次数: 0

Integrating Transcriptomic and Proteomic Data for a Comprehensive Molecular Perspective on the Association between Sarcopenia and Osteoporosis 整合转录组和蛋白质组数据，从分子角度全面透视 "肌肉疏松症 "与 "骨质疏松症 "之间的关联

Archives of gerontology and geriatrics Pub Date : 2024-05-01 DOI: 10.1016/j.archger.2024.105486

Jincheng Chen, Jie Xu, Lingyun Gou, Yong Zhu, Weihua Zhong, Hai Guo, Yujuan Du

引用次数: 0

A Science-Based Review of the World's Best-Selling Book on Aging. 对世界上最畅销的老龄问题书籍的科学评论。

Archives of gerontology and geriatrics Pub Date : 2023-01-01 Epub Date: 2022-09-26 DOI: 10.1016/j.archger.2022.104825

Charles Brenner