Annals of the American Thoracic Society最新文献

{"title":"Coming Up for Air: Unraveling the Bestowed Legacy of Hysteria in Medicine.","authors":"Marika Orlov, Gwenyth L Day, Sarah Jolley","doi":"10.1513/AnnalsATS.202408-838IP","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202408-838IP","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Being Born Moderate-to-Late Preterm on Lung Function and Respiratory Morbidity at 9 to 10 Years of Age.","authors":"Cassidy Du Berry, Rheanna M Mainzer, Nicole Westrupp, Tara FitzGerald, Sarath Ranganathan, Lex W Doyle, Liam Welsh, Jeanie L Y Cheong","doi":"10.1513/AnnalsATS.202403-244OC","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202403-244OC","url":null,"abstract":"<p><p><b>Rationale:</b> The effect of moderate-late preterm (MLP; 32 to 36 completed weeks' gestation) birth on childhood respiratory health is unclear. <b>Objectives:</b> To assess the effect of being born MLP, compared with being born at term (≥37 completed weeks' gestation), on lung function and respiratory morbidity at 9-10 years of age. <b>Methods:</b> Prospective cohort of children born MLP or at term at the Royal Women's Hospital, Victoria, Australia. Participants completed pre- and post-bronchodilator spirometry, DL_CO, plethysmography, and multiple breath washout at 9-10 years of age. Parents completed the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Mean differences in z-scores of lung function outcomes and risk ratio (RR) for ISAAC outcomes between those born moderate-late preterm and those born at term were estimated using regression models with adjustment for potential confounding. Multiple imputation was used to handle missing data. <b>Measurements and Main Results:</b> 148 of 201 children born MLP and 120 of 201 term-born controls were assessed at 9-10 years. Compared with controls, children born moderate-late preterm had lower mean z-scores (mean difference, 95% confidence interval) for FEV₁: -0.35, (-0.61, -0.08), FEV₁/FVC: -0.29, (-0.58, -0.01), FEF_25-75%: -0.33, (-0.62, -0.04) and DL_CO: -0.24, (-0.45, -0.03). Participants born MLP had higher risk of experiencing asthma symptoms (RR, 95% CI: 1.52 [1.08, 2.14]). <b>Conclusions:</b> Children born MLP have lower lung function and increased risk of exhibiting asthma symptoms compared with term-born peers at 9-10 years. Such findings at the end of the first decade of life may portend adverse consequences for respiratory health in adulthood.</p>","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There a Role for Lumacaftor/Ivacaftor in Young Children with Cystic Fibrosis?","authors":"Isaac Martin, Hartmut Grasemann","doi":"10.1513/AnnalsATS.202410-1070LE","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202410-1070LE","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not to Be Forgotten, Pulmonary Vascular Effects of Nonmyeloablative Hematopoietic Cell Transplant for Sickle Cell Disease.","authors":"Kelsey Holbert, Dustin R Fraidenburg","doi":"10.1513/AnnalsATS.202411-1188LE","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202411-1188LE","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Holbert and Fraidenburg: Not to Be Forgotten, Pulmonary Vascular Effects of Nonmyeloablative Hematopoietic Cell Transplant for Sickle Cell Disease.","authors":"A Parker Ruhl, Emily M Limerick, Amisha V Barochia, Courtney D Fitzhugh, Matthew M Hsieh","doi":"10.1513/AnnalsATS.202412-1253LE","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202412-1253LE","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keep Your Mouth Shut when Pressured?","authors":"David M Rapoport","doi":"10.1513/AnnalsATS.202501-010ED","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202501-010ED","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Martin and Grasemann: Is There a Role for Lumacaftor/Ivacaftor in Young Children with Cystic Fibrosis?","authors":"Mirjam Stahl, Jobst Röhmel, Mark O Wielpütz, Marcus A Mall","doi":"10.1513/AnnalsATS.202411-1237LE","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202411-1237LE","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Complex Spectrum of Chronic Thromboembolic Pulmonary Disease and the Implications of Hemodynamic Reclassification.","authors":"Michael Risbano","doi":"10.1513/AnnalsATS.202412-1259ED","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202412-1259ED","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Explanatory Mixed-methods Study of \"ICU net benefit\": Triage and Trajectory for Sepsis and Acute Respiratory Failure.","authors":"George L Anesi, Lindsay W Glassman, Erich Dress, M Kit Delgado, Fernando X Barreda, Gabriel J Escobar, Vincent X Liu, Scott D Halpern, Julia E Szymczak","doi":"10.1513/AnnalsATS.202408-806OC","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202408-806OC","url":null,"abstract":"<p><strong>Rationale: </strong>Patients with sepsis and/or acute respiratory failure are at high risk for death or long hospital stays, yet limited evidence exists to guide triage to intensive care units (ICUs) or general medical wards for the majority of these patients who do not initially require life support.</p><p><strong>Objectives: </strong>To identify factors that influence how hospitals triage patients with capacity-sensitive conditions and those factors that may account for observed ICU relative to ward, or ward relative to ICU, benefits for such patients.</p><p><strong>Methods: </strong>We conducted an explanatory sequential mixed-methods study. As part of a 27-hospital, two-health system retrospective cohort study, we calculated hospital-specific measurements of ICU net benefit for patients with sepsis and/or acute respiratory failure. Hospitals among the highest ICU net benefit and lowest ICU net benefit (or highest ward net benefit) from each study health system were selected for in-depth qualitative study. At each hospital interviews were conducted with emergency department (ED), ward, and ICU clinicians and administrators. Interview transcripts were analyzed using flexible coding and the framework method.</p><p><strong>Results: </strong>Interviews were conducted with 118 respondents (46 physicians, 43 nurses, 5 advanced practice providers, and 24 administrators) from four hospitals. Respondents across hospitals agreed that the prediction of patient trajectory is central to triage decisions, but there was variation in opinion across work locations about optimal pre-triage ED interventions in terms of intensity, repetition, clinical reassessment, and observation duration. The main difference observed between high and low ICU net benefit hospitals related to the way respondents working in the ICU and ward described their responses to patients who experience rapid clinical deviations from triage-expected trajectories including sustained lack of critical care needs after admission to the ICU and acute critical care needs after admission to the ward. Hospitals with low ICU net benefit (or high ward net benefit) had particularly robust and proactive rapid response and clinical decompensation surveillance practices for ward-admitted patients.</p><p><strong>Conclusions: </strong>Particularly proactive rapid response programs that deliver on-location critical care may quantitatively increase ward net benefit by bringing ICU benefits without ICU-associated harms to ward patients who become critically ill.</p>","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>CHP2</i> Modifies Chronic <i>Pseudomonas aeruginosa</i> Airway Infection Risk in Cystic Fibrosis.","authors":"Anna V Faino, William W Gordon, Kati Buckingham, Adrienne M Stilp, Rhonda G Pace, Karen S Raraigh, Joseph M Collaco, Yi-Hui Zhou, Hong Dang, Wanda O'Neal, Michael K Knowles, Garry R Cutting, Margaret Rosenfeld, Michael J Bamshad, Ronald L Gibson, Elizabeth E Blue","doi":"10.1513/AnnalsATS.202408-868OC","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202408-868OC","url":null,"abstract":"<p><strong>Rationale: </strong>Chronic <i>Pseudomonas aeruginosa</i> (<i>Pa</i>) airway infection is common and a key contributor to diminished lung function and early mortality in persons with cystic fibrosis (PwCF). Risk factors for chronic <i>Pa</i> among PwCF include cystic fibrosis transmembrane conductance regulator genotype, genetic modifiers, and environmental factors. Intensive antibiotic therapy and highly effective modulators do not eradicate <i>Pa</i> in most adolescents and adults with cystic fibrosis.</p><p><strong>Objective: </strong>To identify new genetic modifiers contributing to the pathophysiology of chronic <i>Pa</i> infection in PwCF.</p><p><strong>Methods: </strong>4,945 participants in the CF Genome Project with whole genome sequencing linked to longitudinal clinical data from the 2017 CF Foundation Patient Registry were used to conduct a time-to-event genome-wide association study using two definitions of chronic <i>Pa</i> infection.</p><p><strong>Main results: </strong>We identified a genome-wide significant association (p=2.2E-8) between delayed onset of chronic <i>Pa</i> infection and rs194810, a common variant near the gene <i>CHP2</i> which encodes calcineurin B homolog protein 2 (minor A allele frequency 43%). Survival curves by rs198410 allele dosage show that PwCF homozygous for the A allele are an average of 3 years older when achieving chronic Pa infection compared to G allele homozygotes.</p><p><strong>Conclusion: </strong>Variants near <i>CHP2</i> are associated with a significant delay in the age of chronic <i>Pa</i> infection in PwCF.</p>","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}