Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft最新文献

{"title":"The effect of two different abutment designs on marginal bone loss: a pilot randomised controlled clinical trial.","authors":"B Xie, I Gloßner, T Mundt, F Heinemann, I Dörsam","doi":"10.1016/j.aanat.2026.152850","DOIUrl":"https://doi.org/10.1016/j.aanat.2026.152850","url":null,"abstract":"<p><strong>Objective: </strong>A new implant system allows the use of both platform and conical abutments within the same implant design. The aim of this pilot clinical study was to preliminarily describe the marginal bone behaviour associated with these abutment connection designs.</p><p><strong>Method: </strong>A randomized controlled clinical study was initiated to evaluate conical and platform abutments. After successful osseointegration, platform and conical abutments were randomly applied to the implant. Then, all patients were scheduled for clinical follow-up appointments at 6, 12, and 24 months, after the placement of the final restorations. The probing depth and marginal bone level of each implant were measured.</p><p><strong>Results: </strong>A total of 33 patients with 86 dental implants were followed over the 2-year period. At all-time points, the probing depth and marginal bone level of the 45 (52,3%) conical abutment was lower than that of the 41(47.7%) platform abutments. The probing depth in the anterior region is consistently greater than that in the posterior region, while marginal bone level is typically greater in the posterior region compared to the anterior region.</p><p><strong>Conclusions: </strong>The two abutments in this implant system demonstrate good long-term stability across various implant-supported restorations. Notably, the conical abutments are more effective than platform abutments in maintaining the height of peri-implant soft and hard tissues.</p>","PeriodicalId":93872,"journal":{"name":"Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft","volume":" ","pages":"152850"},"PeriodicalIF":1.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sox9 contributes to postnatal opening of the murine parotid papilla.","authors":"Akiho Ezawa, Sayo Sekiya, Hidetomo Hirouchi, Kazunari Higa, Gen Murakami, Toshihide Mizoguchi, Shinichi Abe, Nobuyuki Matsuura, Masahito Yamamoto","doi":"10.1016/j.aanat.2026.152851","DOIUrl":"https://doi.org/10.1016/j.aanat.2026.152851","url":null,"abstract":"<p><p>The parotid papilla is the epithelial outlet through which the parotid duct opens into the oral cavity. Although the papilla is thought to open postnatally, its precise timing and morphogenetic events during the initial opening have not been anatomically defined. Sox9 is essential for salivary gland development; however, its role in parotid papilla formation and opening remains unclear. Here, we (i) determined when and how the parotid papilla opens after birth and (ii) tested whether Sox9 is required for this process. We analyzed C57BL/6J mice at postnatal days (P) 2-6 and Sox9CreER;Sox9^fl/+ mice following tamoxifen administration at P2. In wild-type mice, the parotid papilla opened into the oral cavity at P4. Immediately prior to opening (P2-P3), Sox9-high epithelial cells transiently accumulated within the papillary epithelium and rapidly decreased after opening. In Sox9CreER;Sox9^fl/+ mice, papilla opening was absent at P5 and the papilla itself displayed marked hypoplasia. These findings demonstrate that Sox9 haploinsufficiency disrupts parotid papilla morphogenesis and impairs the formation of a patent salivary duct outlet, thereby providing an anatomical basis for the postnatal opening of the parotid papilla.</p>","PeriodicalId":93872,"journal":{"name":"Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft","volume":" ","pages":"152851"},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How bones learn to listen: In vivo models for investigating mechanosensitivity at bony interfaces in the ageing mouse.","authors":"Jack J Kendall, Gisela A Kuhn, Friederike A Schulte, Ralph Müller","doi":"10.1016/j.aanat.2026.152838","DOIUrl":"10.1016/j.aanat.2026.152838","url":null,"abstract":"<p><p>Beyond the well-documented loss of bone volume, the aged skeletal environment is marked by structural decay and the degenerated network of osteocytes, the bone cells responsible for orchestrating bone formation and resorption. Recent findings point towards the loss of mechanosensitivity and thus the 'deafened' adaptive response to mechanical loading as the driver of decreased bone formation. This imbalance results in a net loss of bone mass and, over time, increases skeletal fragility and fracture incidence. Although the responsiveness of bones to mechanical loading is typically diminished with age, newly formed bone during fracture healing remains responsive to mechanical stimulation. To date, the intrinsic quality of the newly formed bone tissue and the embedded osteocytes remain largely unknown. Given that invasive, longitudinal investigations are restricted in human subjects, mouse models serve as indispensable surrogates for researching changes in tissue mechanosensitivity within the context of ageing and regeneration. Combined with recent advances in quantitative histology-based approaches and time-lapsed three-dimensional high-resolution imaging, these models are well suited to address this knowledge gap and to investigate mechanosensitivity at the periosteal, endosteal, and intracortical interfaces. To this end, this work examines the key structural and cellular hallmarks of aged bone in mice, alongside the in vivo experimental models used to investigate the regenerative potential following fracture and the adaptive response to mechanical loading as vibration therapy. Finally, this review proposes that future therapeutic strategies should harness the regenerative process, together with targeted mechanical loading, to rejuvenate the degenerated osteocyte network. In doing so, bone may once again learn to 'listen' to mechanical vibrations and thereby help restore the functional quality of the ageing skeleton.</p>","PeriodicalId":93872,"journal":{"name":"Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft","volume":" ","pages":"152838"},"PeriodicalIF":1.7,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone-cartilage interfaces: An imaging perspective.","authors":"Frank W Roemer, Ali Guermazi","doi":"10.1016/j.aanat.2026.152830","DOIUrl":"10.1016/j.aanat.2026.152830","url":null,"abstract":"<p><strong>Introduction: </strong>In medical imaging, the bone-cartilage interface refers to the anatomical and radiological boundary between the subchondral bone and overlying hyaline cartilage. Direct visualization of this interface is challenging for multiple reasons, but advances have been made. This perspective focuses on the visualization and clinical relevance of the cartilage-bone interface as visualized by magnetic resonance imaging (MRI), discusses the concept of the meniscal-osteo-chondral unit, introduces cartilage classification systems in the context of this interface and briefly addresses the role of computed tomography (CT) arthrography.</p><p><strong>Main part: </strong>Recent developments in MRI technology including optimization of ultrashort echo time (TE) sequences allow for direct visualization of the osteo-chondral junction. Despite these advances, the clinical relevance of these imaging findings remains incompletely understood to date. The concept of the osteo-chondral-meniscal unit reflects the close anatomical and functional interrelation between different joint tissues at a local level and has implications for disease progression. Cumulative tissue damage on a subregional joint level substantially increases risk for cartilage damage progression. Cartilage delaminations are typically a result of shear forces and are clinically relevant as these may not be fully appreciated during arthroscopy but may require surgical treatment. The International Cartilage Regeneration & Joint Preservation Society (ICRS) cartilage classification system includes damage of the osteochondral interface while most other systems do not include subchondral bone changes. CT arthrography remains the imaging reference standard for assessing surface morphology and detecting subtle surface defects. Despite its strengths, it is likely underutilized in both clinical trials and routine clinical practice.</p><p><strong>Conclusions: </strong>The cartilage-bone interface is best comprehensively evaluated using advanced MRI techniques. The close interrelation between different joint tissues on a subregional joint level must be considered when considering individualized treatment strategies.</p>","PeriodicalId":93872,"journal":{"name":"Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft","volume":" ","pages":"152830"},"PeriodicalIF":1.7,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic composites versus calcium phosphate cements in bone regeneration: a narrative review.","authors":"Oana Bulagea Dima, A. Didilescu, C. Manole, Cornelis Pameijer, Claudiu Călin","doi":"10.1016/j.aanat.2024.152273","DOIUrl":"https://doi.org/10.1016/j.aanat.2024.152273","url":null,"abstract":"","PeriodicalId":93872,"journal":{"name":"Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft","volume":"17 7","pages":"152273"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141051056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of rat vertebrae cortical bone microstructures using confocal Raman microscopy combined to tomography and electron microscopy.","authors":"S.A. Shah, H. Salehi, Vincent Cavaillès, Frédéric Fernandez, F. Cuisinier, P. Collart-Dutilleul, A. Desoutter","doi":"10.2139/ssrn.4397670","DOIUrl":"https://doi.org/10.2139/ssrn.4397670","url":null,"abstract":"BACKGROUND\u0000The rat vertebrae is a good model to study bone regeneration after implantation of biomaterials used to treat bone loss, a major problem in oral and dental surgery. However, the precise characterization of bone microstructures in the rat vertebrae has not been reported. Therefore, the aim of this study was to achieve the complete analysis of such bone, at different scales, in order to have a clear model of healthy bone for comparison with regenerated bone.\u0000\u0000\u0000METHODS\u0000In order to image the cortical bone of rat caudal vertebra, confocal Raman microscopy was combined with high resolution X-ray micro computed tomography (micro-CT), with scanning electron microscopy (SEM) using backscatter electron imaging and with more conventional histology coloration techniques. SEM and Raman microscopy were done in various regions of the cortical bone corresponding to external, middle and internal areas. The spongy bone was imaged in parallel. Micro-CT was performed on the whole vertebra to monitor the network of haversian canals in the cortical bone. Osteonic canals characteristics, and relative chemical composition were analysed in several regions of interest, in cortical and spongy bone. Five rats were included in this study.\u0000\u0000\u0000RESULTS\u0000On micro-CT images, differences in intensity were observed in the cortical bone, substantiated by SEM. Chemical analysis with Raman spectra confirmed the difference in composition between the different regions of the cortical and spongy bone. PCA and k-mean cluster analysis separated these groups, except for the external and middle cortical bone. Peak intensity ratio confirmed these results with a CO3 to ν2 PO4 ratio significantly different for the internal cortical bone. Grayscale images stack extracted from micro-CT showed that global architecture of cortical bone was characterized by a dense and complex network of haversian osteonic canals, starting from the surface towards the vertebrae center. The mean diameter of the canals was 18.4µm (SD 8.6µm) and the mean length was 450µm (SD 152µm). Finally, Raman reconstructed images of the lamellar bone showed an enlargement of the lamellar layer width, both in circumferential lamellar bone and around haversian canals.\u0000\u0000\u0000CONCLUSIONS\u0000Micro-CT and confocal Raman microscopy are good tools to complete classical analysis using optical and electron microscopy. The results and measurements presented in a rat model known for its small inter-individual differences provide the main characteristics of a mature bone. This study will allow the community working on this rat vertebrate model to have a set of characteristics, in particular on the structure of the haversian canals.","PeriodicalId":93872,"journal":{"name":"Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft","volume":"5 1","pages":"152162"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81658095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"yThe influence of censorship laws on Viennese anatomy textbooks from the outgoing 18th Century until after the student revolution of 1848 in Austrian absolutism.","authors":"Sophia Bauer, Leo Maria Schaukal, W. Weninger","doi":"10.2139/ssrn.4330785","DOIUrl":"https://doi.org/10.2139/ssrn.4330785","url":null,"abstract":"INTRODUCTION\u0000Anatomy textbooks´ connection to the rigid censoring laws enacted by Habsburg rulers, was never sufficiently investigated. Using anatomy textbooks written at the University of Vienna, our article aims at investigating the influence of censorship laws on the anatomy textbooks in Vienna between 1786 and 1865.\u0000\u0000\u0000METHODS\u0000In our case study we compared legal text and archival sources (source material A) with seven prefaces of textbooks written by Viennese anatomists (source material B). The prefaces were comparatively investigated by applying the following questions based on source material A: (1) What motives for writing the textbooks were indicated by the anatomists in the prefaces? (2) What legal or other influences were mentioned as motives that point to a connection to the censorship regulations installed? (3) Referring to changing censorship guidelines is there a change in the mentioned audience?\u0000\u0000\u0000RESULTS\u0000Our results are that we found evidence for censorship regulations (source material A) in the prefaces (source material B). Also, the motives for writing those textbooks changed over time because of changing censorship regulations.\u0000\u0000\u0000CONCLUSION\u0000Our findings show that Viennese anatomy textbooks were part of the Austrian censorship laws in the investigated period with a timely correlation between the appointment as professor and the publication of the textbooks and prefaces (indirectly) referring to censorship laws. The academic tradition of writing textbooks arose from this system, when freedom of speech stood in opposition to the absolute Habsburg reign. Thus, when working with historical anatomy textbooks it is important to reflect on their censorship heritage.","PeriodicalId":93872,"journal":{"name":"Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft","volume":"296 1","pages":"152129"},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76304471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior superior alveolar nerves contribute to sensation in the anterior teeth.","authors":"Sanako Makishi, Mikako Tanaka, Taichi Kobayashi, R. Tanaka, Takafumi Hayashi, H. Ohshima","doi":"10.21203/rs.3.rs-123843/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-123843/v1","url":null,"abstract":"BACKGROUND\u0000There is no available data on the occurrence rate of a converged alveolar canal, the detailed three-dimensional (3D) courses of alveolar canals/grooves (ACGs), or the contribution of each superior alveolar nerve to each area in the maxilla. This study aimed to clarify the 3D courses of ACGs, the relationship between ACGs and superior alveolar nerves, and the contribution of posterior superior alveolar nerves (PSANs) using computed tomography (CT) with histological analysis.\u0000\u0000\u0000METHODS\u0000During the gross anatomy course at Niigata University, we investigated nine human cadavers.\u0000\u0000\u0000RESULTS\u0000All anterior and posterior ACGs converged into the common alveolar canal, which contained blood vessels and several nerve bundles surrounded by perineurium, located at the nasal floor near the pyriform aperture. Histometrical analysis clarified that 16.3% of the nerve bundles in this canal were derived from PSANs, and 67% of the bundles were dispersed while they coursed down to the nasal floor. There seems to be no relationship between the density of nerve bundles in the canal and the number of remaining anterior teeth.\u0000\u0000\u0000CONCLUSIONS\u0000Data obtained from observing the detailed 3D courses of anterior and posterior ACGs, and their relationship with superior alveolar nerves, suggest that PSANs partially contribute to the nociception of the anterior teeth.","PeriodicalId":93872,"journal":{"name":"Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft","volume":"28 1","pages":"151784"},"PeriodicalIF":0.0,"publicationDate":"2020-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72710710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual Special Issue \"Human lymph vessels\".","authors":"E. Brenner","doi":"10.1016/j.aanat.2019.151441","DOIUrl":"https://doi.org/10.1016/j.aanat.2019.151441","url":null,"abstract":"","PeriodicalId":93872,"journal":{"name":"Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft","volume":"521 1","pages":"151441"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78856252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related changes of the human retinal vessels: possible involvement of lipid peroxidation.","authors":"T. Nag, M. Maurya, T. Roy","doi":"10.1016/j.aanat.2019.06.007","DOIUrl":"https://doi.org/10.1016/j.aanat.2019.06.007","url":null,"abstract":"","PeriodicalId":93872,"journal":{"name":"Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89398656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}