Ageing research reviews最新文献_第2页

Lactylation modification in cardio-cerebral diseases: A state-of-the-art review.

Ageing research reviews Pub Date : 2024-12-06 DOI: 10.1016/j.arr.2024.102631

Zi Liao, Bei Chen, Tong Yang, Wenli Zhang, Zhigang Mei

{"title":"Lactylation modification in cardio-cerebral diseases: A state-of-the-art review.","authors":"Zi Liao, Bei Chen, Tong Yang, Wenli Zhang, Zhigang Mei","doi":"10.1016/j.arr.2024.102631","DOIUrl":"10.1016/j.arr.2024.102631","url":null,"abstract":"Cardio-cerebral diseases (CCDs), encompassing conditions such as coronary heart disease, myocardial infarction, stroke, Alzheimer's disease, et al., represent a significant threat to human health and well-being. These diseases are often characterized by metabolic abnormalities and remodeling in the process of pathology. Glycolysis and hypoxia-induced lactate accumulation play critical roles in cellular energy dynamics and metabolic imbalances in CCDs. Lactylation, a post-translational modification driven by excessive lactate accumulation, occurs in both histone and non-histone proteins. It has been implicated in regulating protein function across various pathological processes in CCDs, including inflammation, angiogenesis, lipid metabolism dysregulation, and fibrosis. Targeting key proteins involved in lactylation, as well as the enzymes regulating this modification, holds promise as a therapeutic strategy to modulate disease progression by addressing these pathological mechanisms. This review provides a holistic picture of the types of lactylation and the associated modifying enzymes, highlights the roles of lactylation in different pathological processes, and synthesizes the latest clinical evidence and preclinical studies in a comprehensive view. We aim to emphasize the potential of lactylation as an innovative therapeutic target for preventing and treating CCD-related conditions.","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102631"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The activation of microglia by the complement system in neurodegenerative diseases.

Ageing research reviews Pub Date : 2024-12-06 DOI: 10.1016/j.arr.2024.102636

He Zhao, Yayun Lv, Jiasen Xu, Xiaoyu Song, Qi Wang, Xiaoyu Zhai, Xiaohui Ma, Jingjing Qiu, Limei Cui, Yan Sun

{"title":"The activation of microglia by the complement system in neurodegenerative diseases.","authors":"He Zhao, Yayun Lv, Jiasen Xu, Xiaoyu Song, Qi Wang, Xiaoyu Zhai, Xiaohui Ma, Jingjing Qiu, Limei Cui, Yan Sun","doi":"10.1016/j.arr.2024.102636","DOIUrl":"10.1016/j.arr.2024.102636","url":null,"abstract":"Neurodegenerative diseases (NDDs) are a group of neurological disorders characterized by the progressive loss of neuronal structure and function, leading to cognitive and behavioral impairments. Despite significant research advancements, there is currently no definitive cure for NDDs. With global aging on the rise, the burden of these diseases is becoming increasingly severe, highlighting the urgency of understanding their pathogenesis and developing effective therapeutic strategies. Microglia, specialized macrophages in the central nervous system, play a dual role in maintaining neural homeostasis. They are involved in clearing cellular debris and apoptotic cells, but in their activated state, they release inflammatory factors that contribute significantly to neuroinflammation. The complement system (CS), a critical component of the innate immune system, assists in clearing damaged cells and proteins. However, excessive or uncontrolled activation of the CS can lead to chronic neuroinflammation, exacerbating neuronal damage. This review aims to explore the roles of microglia and the CS in the progression of NDDs, with a specific focus on the mechanisms through which the CS activates microglia by modulating mitochondrial function. Understanding these interactions may provide insights into potential therapeutic targets for mitigating neuroinflammation and slowing neurodegeneration.","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102636"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations.

Ageing research reviews Pub Date : 2024-12-06 DOI: 10.1016/j.arr.2024.102634

Emilia Zawieja, Agata Chmurzynska

{"title":"Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations.","authors":"Emilia Zawieja, Agata Chmurzynska","doi":"10.1016/j.arr.2024.102634","DOIUrl":"10.1016/j.arr.2024.102634","url":null,"abstract":"The rapid aging of the global population necessitates addressing age-related conditions through innovative strategies. Nutritional supplements have emerged as potential interventions for preventing or slowing age-related changes, with betaine being a promising candidate. This systematic review aims to provide a comprehensive analysis of current literature on the impact of betaine on the aging process. Specifically, we summarize the mechanisms through which betaine is proposed to affect aging, we integrate existing findings, we identify gaps in the literature, and we discuss practical implications for promoting healthy aging. Evidence suggests that betaine may counteract aging-related changes in methylation potential by increasing concentration of S-adenosylmethionine, a key methyl donor. Additionally, betaine reduces homocysteine concentrations, potentially mitigating vascular, neurodegenerative, and oxidative damage. Betaine has also been shown to enhance mitochondrial function, to reduce oxidative stress, and to attenuate inflammation. It may serve as a preventive agent against sarcopenia by promoting anabolic signaling pathways and improving muscle strength in younger adults. Betaine may also exert an effect on bone remodeling and adipose tissue metabolism, with animal studies indicating enhanced fat oxidation and reduced fat synthesis. Although certain limited studies have suggested betaine's potential in mitigating age-related neurodegenerative diseases, the currently available evidence does not establish a clear link between dietary betaine intake and the incidence of cardiovascular diseases or type-2 diabetes. In conclusion, emerging evidence highlights the potential of betaine in attenuating age-related changes. However, further research is required to elucidate the efficacy and safety of betaine supplementation in older populations.","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102634"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications.

Ageing research reviews Pub Date : 2024-12-05 DOI: 10.1016/j.arr.2024.102629

Lili Zhu, Yiyang Liu, Kangkai Wang, Nian Wang

{"title":"Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications.","authors":"Lili Zhu, Yiyang Liu, Kangkai Wang, Nian Wang","doi":"10.1016/j.arr.2024.102629","DOIUrl":"10.1016/j.arr.2024.102629","url":null,"abstract":"Acute myocardial infarction (AMI), primarily caused by coronary atherosclerosis, initiates a series of events that culminate in the obstruction of coronary arteries, resulting in severe myocardial ischemia and hypoxia. The subsequent myocardial ischemia/reperfusion (I/R) injury further aggravates cardiac damage, leading to a decline in heart function and the risk of life-threatening complications. The complex interplay of multiple regulated cell death (RCD) pathways plays a pivotal role in the pathogenesis of AMI. Each RCD pathway is orchestrated by a symphony of molecular regulatory mechanisms, highlighting the dynamic changes and critical roles of key effector molecules. Strategic disruption or inhibition of these molecular targets offers a tantalizing prospect for mitigating or even averting the onset of RCD, thereby limiting the extensive loss of cardiomyocytes and the progression of detrimental myocardial fibrosis. This review systematically summarizes the mechanisms underlying various forms of RCD, provides an in-depth exploration of the pathogenesis of AMI through the lens of RCD, and highlights a range of promising therapeutic targets that hold the potential to revolutionize the management of AMI.","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102629"},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation Requirements for AI-based Intervention-Evaluation in Aging and Longevity Research and Practice.

Ageing research reviews Pub Date : 2024-12-04 DOI: 10.1016/j.arr.2024.102617

Georg Fuellen, Anton Kulaga, Sebastian Lobentanzer, Maximilian Unfried, Roberto A Avelar, Daniel Palmer, Brian K Kennedy

引用次数: 0

Hallmarks of aging: A user's guide for comparative biologists.

Ageing research reviews Pub Date : 2024-12-04 DOI: 10.1016/j.arr.2024.102616

Peggy R Biga, Jingyue E Duan, Tristan E Young, Jamie R Marks, Anne Bronikowski, Louis P Decena, Eric C Randolph, Ananya G Pavuluri, Guangsheng Li, Yifei Fang, Gerald S Wilkinson, Gunjan Singh, Nathan T Nigrin, Erica N Larschan, Andrew J Lonski, Nicole C Riddle

{"title":"Hallmarks of aging: A user's guide for comparative biologists.","authors":"Peggy R Biga, Jingyue E Duan, Tristan E Young, Jamie R Marks, Anne Bronikowski, Louis P Decena, Eric C Randolph, Ananya G Pavuluri, Guangsheng Li, Yifei Fang, Gerald S Wilkinson, Gunjan Singh, Nathan T Nigrin, Erica N Larschan, Andrew J Lonski, Nicole C Riddle","doi":"10.1016/j.arr.2024.102616","DOIUrl":"10.1016/j.arr.2024.102616","url":null,"abstract":"Since the first description of a set of characteristics of aging as so-called hallmarks or pillars in 2013/2014, these characteristics have served as guideposts for the research in aging biology. They have been examined in a range of contexts, across tissues, in response to disease conditions or environmental factors, and served as a benchmark for various anti-aging interventions. While the hallmarks of aging were intended to capture generalizable characteristics of aging, they are derived mostly from studies of rodents and humans. Comparative studies of aging including species from across the animal tree of life have great promise to reveal new insights into the mechanistic foundations of aging, as there is a great diversity in lifespan and age-associated physiological changes. However, it is unclear how well the defined hallmarks of aging apply across diverse species. Here, we review each of the twelve hallmarks of aging defined by Lopez-Otin in 2023 with respect to the availability of data from diverse species. We evaluate the current methods used to assess these hallmarks for their potential to be adapted for comparative studies. Not unexpectedly, we find that the data supporting the described hallmarks of aging are restricted mostly to humans and a few model systems and that no data are available for many animal clades. Similarly, not all hallmarks can be easily assessed in diverse species. However, for at least half of the hallmarks, there are methods available today that can be employed to fill this gap in knowledge, suggesting that these studies can be prioritized while methods are developed for comparative study of the remaining hallmarks.","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102616"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monoclonal therapy with lecanemab in the treatment of mild Alzheimer's disease: A systematic review and meta-analysis.

Ageing research reviews Pub Date : 2024-12-03 DOI: 10.1016/j.arr.2024.102620

Nelson Arroyo-Pacheco, Shayury Sarmiento-Blanco, Guillermo Vergara-Cadavid, Maryarena Castro-Leones, Neyder Contreras-Puentes

{"title":"Monoclonal therapy with lecanemab in the treatment of mild Alzheimer's disease: A systematic review and meta-analysis.","authors":"Nelson Arroyo-Pacheco, Shayury Sarmiento-Blanco, Guillermo Vergara-Cadavid, Maryarena Castro-Leones, Neyder Contreras-Puentes","doi":"10.1016/j.arr.2024.102620","DOIUrl":"10.1016/j.arr.2024.102620","url":null,"abstract":"Alzheimer's disease, a progressive neurodegenerative pathology, is characterized by the accumulation of Amyloid-β plaques in the brain. Lecanemab (BAN2401), a humanized IgG1 monoclonal antibody, binds with high affinity to Amyloid-β protofibrils. It is the first monoclonal antibody for Alzheimer's disease to receive full FDA approval. This systematic review, conducted meticulously, examines the current use and safety of Lecanemab in treating Alzheimer's disease. We screened literature from databases such as PubMed Central, PubMed (MedLine), ScienceDirect, Scopus, Web of Science, and Wolters Kluwer for randomized controlled trials testing Lecanemab for cognitive decline in patients with mild cognitive impairment due to Alzheimer's disease. Outcomes measured included CDR-SB, ADCOMS, ADAS-Cog, and Amyloid burden on PET in centiloids. Likewise, reports were analyzed for adverse events associated with ARIA-A and ARIA-H. Five papers were included in the systematic review and three in the meta-analysis. The meta-analysis showed that Lecanemab slowed the progression of cognitive impairment as measured by CDR-SB, ADCOMS, and ADASCog, and significantly reduced Amyloid burden on PET in centiloids. However, Lecanemab was associated with an increased risk of ARIA-E and ARIA-H. Lecanemab has demonstrated efficacy in slowing cognitive impairment progression in Alzheimer's disease as measured by ADCOMS, ADAS-Cog, and CDR-SB. However, it is associated with an increased risk of ARIA-E and ARIA-H, particularly in ApoE4 carriers.","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102620"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The senotherapeutic potential of phytochemicals for age-related intestinal disease.

Ageing research reviews Pub Date : 2024-12-03 DOI: 10.1016/j.arr.2024.102619

Célia Maria Costa, Sílvia Santos Pedrosa, James L Kirkland, Flávio Reis, Ana Raquel Madureira

{"title":"The senotherapeutic potential of phytochemicals for age-related intestinal disease.","authors":"Célia Maria Costa, Sílvia Santos Pedrosa, James L Kirkland, Flávio Reis, Ana Raquel Madureira","doi":"10.1016/j.arr.2024.102619","DOIUrl":"10.1016/j.arr.2024.102619","url":null,"abstract":"During the last few decades, life expectancy has increased worldwide along with the prevalence of several age-related diseases. Among aging pathways, cellular senescence and chronic inflammation (or \"inflammaging\") appear to be connected to gut homeostasis and dysbiosis of the microbiome. Cellular senescence is a state of essentially irreversible cell cycle arrest that occurs in response to stress. Although senescent cells (SC) remain metabolically active, they do not proliferate and can secrete inflammatory and other factors comprising the senescence-associated secretory phenotype (SASP). Accumulation of SCs has been linked to onset of several age-related diseases, in the brain, bones, the gastrointestinal tract, and other organs and tissues. The gut microbiome undergoes substantial changes with aging and is tightly interconnected with either successful (healthy) aging or disease. Senotherapeutic drugs are compounds that can clear senescent cells or modulate the release of SASP factors and hence attenuate the impact of the senescence-associated pro-inflammatory state. Phytochemicals, phenolic compounds and terpenes, which have antioxidant and anti-inflammatory activities, could also be senotherapeutic given their ability to act upon senescence-linked cellular pathways. The aim of this review is to dissect links among the gut microbiome, cellular senescence, inflammaging, and disease, as well as to explore phytochemicals as potential senotherapeutics, focusing on their interactions with gut microbiota. Coordinated targeting of these inter-related processes might unveil new strategies for promoting healthy aging.","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102619"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview on the impact of viral pathogens on Alzheimer's disease.

Ageing research reviews Pub Date : 2024-12-02 DOI: 10.1016/j.arr.2024.102615

Melika AmeliMojarad, Mandana AmeliMojarad, Xiaonan Cui

{"title":"An overview on the impact of viral pathogens on Alzheimer's disease.","authors":"Melika AmeliMojarad, Mandana AmeliMojarad, Xiaonan Cui","doi":"10.1016/j.arr.2024.102615","DOIUrl":"10.1016/j.arr.2024.102615","url":null,"abstract":"Alzheimer's disease (AD) is the most common type of dementia which affects over than 60 million cases worldwide with higher incidence in low and middle-income countries by 2030. Based on the multifactorial nature of AD different risk factors are linked to the condition considering the brain's β-amyloid plaques (Aβ) and neurofibrillary tangles (NFTs) as its primary hallmarks. Lately, viral photogenes specially after recent SARS-CoV-2 pandemic has gained a lot of attention in promoting the neurodegenerative disorder such as AD based on their capacity to increase the permeability of the blood-brain barrier, dysregulation of immune responses, and the impact on Aβ processing and phosphorylation of tau proteins. Therefore, in this review, we summarized the important association of viral pathogens and their mechanism by which they contribute with AD formation and development. AN OVERVIEW OF THE ROLES OF VIRAL PATHOGENS IN AD: According to this figure, viruses can infect neurons directly by modulating the BBB, transferring from endothelial cells to glial cells and then to neurons, increasing the Aβ deposition, and affecting the tau protein phosphorylation or indirectly through the virus's entrance and pathogenicity that can be accelerated by genetic and epigenetic factors, as well as chronic neuroinflammation caused by activated microglia and astrocytes.","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102615"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicle-packed microRNAs profiling in Alzheimer's disease: The molecular intermediary between pathology and diagnosis.

Ageing research reviews Pub Date : 2024-12-01 DOI: 10.1016/j.arr.2024.102614

Sandila Arif, Talal Jamil Qazi, Zhenzhen Quan, Junjun Ni, Zhaohan Li, Yunjie Qiu, Hong Qing

引用次数: 0