Ageing research reviews最新文献

{"title":"The Therapeutic Potential of Adiponectin and Extracellular Vesicles for Promoting Improved Healthspan.","authors":"Yubin Lei, Hye Kyoung Sung, Dylan Burger, Gary Sweeney","doi":"10.1016/j.arr.2025.102823","DOIUrl":"https://doi.org/10.1016/j.arr.2025.102823","url":null,"abstract":"<p><p>The gradual decline in physiological functions that comes with aging contributes to a range of chronic diseases, such as Alzheimer's, type 2 diabetes, heart failure, and osteoarthritis. Significant advancements in human longevity due to socioeconomic development have resulted in a foreseeable and substantial strain on the global healthcare system. In fact, there is now a shift in research focus towards enhancing healthspan. As a result, the development of improved therapies for various chronic diseases is essential to enhance healthspan in the aging population. Adiponectin, mainly produced in adipose tissue, is found at elevated levels in the blood of healthy centenarians. In contrast, lower circulating levels of adiponectin are inversely associated with the occurrence and severity of several age-related complications. Adiponectin plays a crucial role in promoting beneficial effects on key biological processes associated with aging-related diseases, contributing to improved healthspan and lifespan in preclinical models. In recent years, extracellular vesicles (EVs) have garnered significant research interest due to their crucial role in both local paracrine signaling and systemic inter-organ communication. They are now widely recognized for their potential as valuable diagnostic and therapeutic tools. In this review, we summarize current knowledge on the pathophysiological roles of adiponectin and EVs in aging, emphasizing their combined therapeutic potential in age-related diseases. Additionally, we explore the emerging evidence of crosstalk between adiponectin and EVs, underscoring their potential for developing improved strategies to promote healthy aging and longevity.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102823"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Effectiveness and Implementation of Digital Health Interventions for Older Adults with Cognitive Frailty: A Systematic Review and Meta-Analysis.","authors":"Yanyan Li, Meijun Liu, Jieru Yang, Qinqin Liu, Wendie Zhou, Jiaqi Yu, Xue Wang, Cuili Wang","doi":"10.1016/j.arr.2025.102819","DOIUrl":"https://doi.org/10.1016/j.arr.2025.102819","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness and implementation of digital health interventions compared with control group for older adults with cognitive frailty.</p><p><strong>Methods: </strong>We conducted a systematic review of randomized controlled trials (RCTs) and non-randomized studies of interventions (NRSIs), searching ten electronic databases and grey literature sources from their inception to 17 March 2024, with an update performed on 15 March 2025. The standardized mean difference (SMD) with 95% CIs was calculated. The methodological quality was assessed by the Cochrane RoB2 and ROBINS-I.</p><p><strong>Results: </strong>Eleven RCTs and two NRSIs with a total of 1059 participants were included. The meta-analysis showed that the digital health intervention among older adults with cognitive frailty significantly increased global cognitive function (SMD = 0.57, 95%CI = 0.32, 0.83, P < 0.001), executive function (SMD = -0.54, 95%CI =-0.99, -0.09, P = 0.02) and physical domain of quality of life (PCS) (SMD = 0.30, 95%CI = 0.06, 0.55, P = 0.01), and decreased frailty (SMD = -0.41, 95%CI = -0.81, -0.01, P = 0.04), depressive symptom (SMD =-0.41, 95%CI =-0.73, -0.08, P =0.01). RoB2 assessment revealed that six studies were rated as high risk and four as low risk, with one having some concerns. Additionally, two studies were assessed as having moderate risk using the ROBINS-I tool.</p><p><strong>Conclusions: </strong>Digital health interventions targeting older adults with cognitive frailty have demonstrated effectiveness in improving cognitive function, mental health, and PCS, while also reducing frailty. Further high-quality research is warranted to bolster the evidence in these fields in the future.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102819"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of microRNAs in the pathophysiology of the aging eye.","authors":"Mohammadsaber Tamaddon, Mohammadreza Fazel, Delsuz Rezaee, Mohammad Amin Khalilzad, Jamal Majidpoor, Hamid Ahmadieh, Mohammad-Davood Fattahi, Kosar Namakin, Fatemeh Suri, Sajad Najafi","doi":"10.1016/j.arr.2025.102805","DOIUrl":"https://doi.org/10.1016/j.arr.2025.102805","url":null,"abstract":"<p><p>The human eye is a complex organ integral to visual perception, comprising multiple structures, including the retina, cornea, and lens. Vision loss affects over 2.2 billion individuals globally, with conditions such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy responsible for a majority of visual-impairing conditions. Recent research highlights the critical roles of microRNAs (miRNAs)-small non-coding RNAs involved in post-transcriptional gene regulation-in ocular physiology and pathophysiology. miRNAs regulate gene expression by binding to target mRNA, modulating processes such as cell growth, apoptosis, and differentiation. Dysregulation of miRNAs has been implicated in several age-related ocular disorders like retinopathy, glaucoma and age-related macular degeneration, thereby disrupting cellular homeostasis and promoting disease progression. Experimental evidence, primarily from murine models, reveals that miRNAs regulate photoreceptor differentiation, retinal development, and the survival of postmitotic retinal cells. Additionally, miRNA dysregulation offers potential diagnostic and therapeutic insights. This study explores the roles of miRNAs in ocular pathophysiology, emphasizing their involvement in the maintenance of retinal cell integrity and visual system homeostasis. Furthermore, the significance of miRNAs in the pathogenesis of various human ophthalmic diseases associated with advancing age is delved.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102805"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Note to \"Biological constraint, evolutionary spandrels and antagonistic pleiotropy\".","authors":"","doi":"10.1016/j.arr.2025.102798","DOIUrl":"https://doi.org/10.1016/j.arr.2025.102798","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102798"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of community-based interventions on healthy older adults' physical health, psychological wellbeing, and social connections: A systematic review.","authors":"Shaimaa Elhag, Malwina A Niechcial, Lauren Potter, Alan J Gow","doi":"10.1016/j.arr.2025.102784","DOIUrl":"https://doi.org/10.1016/j.arr.2025.102784","url":null,"abstract":"<p><strong>Background: </strong>Given trends towards greater life expectancy, there is an increasing need to promote healthy ageing and add quality and value to older adults' lives, however the evidence regarding the effects on overall health and wellbeing has not been synthesised. Active lifestyles may provide diverse health and wellbeing benefits for older adults in terms of maintaining or improving their physical, psychological, and social functions. This systematic review evaluates whether and how different types of interventions within community-based settings could benefit specific aspects of older adults' health and wellbeing.</p><p><strong>Methods: </strong>PubMed, PsycINFO, Scopus and Web of Science were systematically searched in January 2022 for experimental studies (including randomised controlled trials, non-randomised controlled trials, and quasi-experimental studies) exploring health and wellbeing benefits of community-based activities in older adults. A total of 12,707 sources were identified through database searches with 183 retained for full screening. Final inclusion was based on the following eligibility criteria: (1) participants were generally healthy and predominantly independent community-dwelling older adults aged 60 and above; (2) interventions were based in real-world settings, e.g., dance, art and technology classes, etc. held in publicly-accessible facilities; (3) pre-/post-interventions assessed at least one outcome in physical health, psychological wellbeing or social connections; (4) control groups were used, including passive and active control groups or groups that received a different type of intervention; (5) experimental studies followed a quantitative research design. Study quality was systematically assessed, and a comprehensive narrative synthesis of the findings was conducted.</p><p><strong>Results: </strong>Of the 183 studies screened, 56 were included in the final review. Among the 33 predominantly physical interventions, 31 demonstrated positive effects. Of the 16 predominantly mental interventions, 14 reported benefits. All seven predominantly social interventions reported positive effects.</p><p><strong>Discussion: </strong>The benefits of real-world interventions were reported across a range of outcomes, particularly in terms of reducing depression or anxiety, or improving physical functioning, sleep quality and social participation. However, heterogeneity in interventions, sample design, duration and dosage suggest that more research is needed to support the effects of duration and dosage of intervention exposure. As real-world interventions more closely resemble the way in which older people engage in activities, evidence of their effectiveness in promoting health and wellbeing should inform preventative healthcare provision and policymaking.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102784"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Biomarker Detection and Therapy of Parkinson's and Alzheimer's disease using upconversion based approach: A Comprehensive Review.","authors":"Kabirdas B Ghorpade, Shivanshu Agrawal, Ujwal Havelikar","doi":"10.1016/j.arr.2025.102656","DOIUrl":"10.1016/j.arr.2025.102656","url":null,"abstract":"<p><p>This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies/article-withdrawal.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102656"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress in Alzheimer's disease and bone-brain axis.","authors":"Fan Zhang, Wei Zhang","doi":"10.1016/j.arr.2024.102341","DOIUrl":"10.1016/j.arr.2024.102341","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common type of cognitive impairment. AD is closely related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms of epidemiology and pathogenesis. Brain and bone tissues can regulate each other in different manners through bone-brain axis. This article reviews the research progress of the relationship between AD and orthopedic diseases, bone-brain axis mechanisms of AD, and AD therapy by targeting bone-brain axis, in order to deepen the understanding of bone-brain communication, promote early diagnosis and explore new therapy for AD patients.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102341"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reelin links Apolipoprotein E4, Tau, and Amyloid-β in Alzheimer's disease.","authors":"Ling Xiao Yi, Li Zeng, Qing Wang, Eng King Tan, Zhi Dong Zhou","doi":"10.1016/j.arr.2024.102339","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102339","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the cerebral cortex and hippocampus, and is characterised by progressive cognitive decline and memory loss. A recent report of a patient carrying a novel gain-of-function variant of RELN (H3447R, termed RELN-COLBOS) who developed resilience against presenilin-linked autosomal-dominant AD (ADAD) has generated enormous interest. The RELN-COLBOS variant enhances interactions with the apolipoprotein E receptor 2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR), which are associated with delayed AD onset and progression. These findings were validated in a transgenic mouse model. Reelin is involved in neurodevelopment, neurogenesis, and neuronal plasticity. The evidence accumulated thus far has demonstrated that the Reelin pathway links apolipoprotein E4 (ApoE4), amyloid-β (Aβ), and tubulin-associated unit (Tau), which are key proteins that have been implicated in AD pathogenesis. Reelin and key components of the Reelin pathway have been highlighted as potential therapeutic targets and biomarkers for AD.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"98 ","pages":"102339"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation","authors":"Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, S. Vishwas, N. K. Pandey, Gaurav Gupta, K. Paudel, H. Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia C. Zacconi, Terezinha de Jesus Andreoli Pinto, M. Dhanasekaran, M. Gulati, Kamal Dua, Sachin Kumar Singh","doi":"10.1016/j.arr.2024.102236","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102236","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"285 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY OF DEPRESCRIBING ON HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS WITH META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS","authors":"Nicola Veronese, Umberto Gallo, Virginia Boccardi, J. Demurtas, Alberto Michielon, Xhoajda Taci, Giulia Zanchetta, Sophia Campbell, Marco Chiumente, Francesca Venturini, Alberto Pilotto","doi":"10.1016/j.arr.2024.102237","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102237","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"336 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}