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Conserved Biological Processes in Partial Cellular Reprogramming: Relevance to Aging and Rejuvenation.
Ageing research reviews Pub Date : 2025-03-21 DOI: 10.1016/j.arr.2025.102737
Roberto A Avelar, Daniel Palmer, Anton Y Kulaga, Georg Fuellen
{"title":"Conserved Biological Processes in Partial Cellular Reprogramming: Relevance to Aging and Rejuvenation.","authors":"Roberto A Avelar, Daniel Palmer, Anton Y Kulaga, Georg Fuellen","doi":"10.1016/j.arr.2025.102737","DOIUrl":"https://doi.org/10.1016/j.arr.2025.102737","url":null,"abstract":"<p><p>Partial or transient cellular reprogramming is defined by the limited induction of pluripotency factors without full dedifferentiation of cells to a pluripotent state. Comparing in vitro and in vivo mouse studies, and in vitro studies in humans, supported by visualizations of data interconnections, we show consistent patterns in how such reprogramming modulates key biological processes. Generally, partial reprogramming drives dynamic chromatin remodelling, involving histone modifications that regulate accessibility and facilitate pluripotency gene activation while silencing somatic identity. These changes are accompanied by modifications in stress response programs, such as inflammation, autophagy, and cellular senescence, as well as improved mitochondrial activity and dysregulation of extracellular matrix pathways. We also underscore the challenges in evaluating complex processes like aging and cellular senescence, given the variability in biomarkers used across studies. Overall, we highlight biological processes consistently influenced by reprogramming while noting that some effects are context-dependent, varying according to cell type, species, sex, recovery time, and the reprogramming method employed. These insights inform future research and potential therapeutic applications in aging and regenerative medicine.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102737"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeted Partial Reprogramming as a Novel Therapeutic Strategy for Age-Related Decline.
Ageing research reviews Pub Date : 2025-03-15 DOI: 10.1016/j.arr.2025.102731
Eli Adashi, Max Rose
{"title":"Targeted Partial Reprogramming as a Novel Therapeutic Strategy for Age-Related Decline.","authors":"Eli Adashi, Max Rose","doi":"10.1016/j.arr.2025.102731","DOIUrl":"https://doi.org/10.1016/j.arr.2025.102731","url":null,"abstract":"<p><p>Cellular reprogramming has emerged as a promising strategy for the amelioration of age-associated cellular phenotypes. In-vivo reprogramming approaches, however, have been limited by a lack of specificity and oncogenic risk. Recent breakthroughs have addressed these limitations, constituting a significant progression toward the development of safe and effective therapeutics for age-related pathologies.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102731"},"PeriodicalIF":0.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WITHDRAWN: Biomarker Detection and Therapy of Parkinson's and Alzheimer's disease using upconversion based approach: A Comprehensive Review. 基于上转换方法的帕金森病和阿尔茨海默病的生物标志物检测和治疗：综合综述
Ageing research reviews Pub Date : 2025-01-07 DOI: 10.1016/j.arr.2025.102656
Kabirdas B Ghorpade, Shivanshu Agrawal, Ujwal Havelikar
{"title":"WITHDRAWN: Biomarker Detection and Therapy of Parkinson's and Alzheimer's disease using upconversion based approach: A Comprehensive Review.","authors":"Kabirdas B Ghorpade, Shivanshu Agrawal, Ujwal Havelikar","doi":"10.1016/j.arr.2025.102656","DOIUrl":"10.1016/j.arr.2025.102656","url":null,"abstract":"<p><p>This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies/article-withdrawal.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102656"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress in Alzheimer's disease and bone-brain axis. 阿尔茨海默病和骨脑轴的研究进展。
Ageing research reviews Pub Date : 2024-07-01 Epub Date: 2024-05-15 DOI: 10.1016/j.arr.2024.102341
Fan Zhang, Wei Zhang
{"title":"Research progress in Alzheimer's disease and bone-brain axis.","authors":"Fan Zhang, Wei Zhang","doi":"10.1016/j.arr.2024.102341","DOIUrl":"10.1016/j.arr.2024.102341","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common type of cognitive impairment. AD is closely related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms of epidemiology and pathogenesis. Brain and bone tissues can regulate each other in different manners through bone-brain axis. This article reviews the research progress of the relationship between AD and orthopedic diseases, bone-brain axis mechanisms of AD, and AD therapy by targeting bone-brain axis, in order to deepen the understanding of bone-brain communication, promote early diagnosis and explore new therapy for AD patients.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102341"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reelin links Apolipoprotein E4, Tau, and Amyloid-β in Alzheimer's disease. Reelin 将阿尔茨海默病中的载脂蛋白 E4、Tau 和淀粉样蛋白-β联系起来。
Ageing research reviews Pub Date : 2024-05-14 DOI: 10.1016/j.arr.2024.102339
Ling Xiao Yi, Li Zeng, Qing Wang, Eng King Tan, Zhi Dong Zhou
{"title":"Reelin links Apolipoprotein E4, Tau, and Amyloid-β in Alzheimer's disease.","authors":"Ling Xiao Yi, Li Zeng, Qing Wang, Eng King Tan, Zhi Dong Zhou","doi":"10.1016/j.arr.2024.102339","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102339","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the cerebral cortex and hippocampus, and is characterised by progressive cognitive decline and memory loss. A recent report of a patient carrying a novel gain-of-function variant of RELN (H3447R, termed RELN-COLBOS) who developed resilience against presenilin-linked autosomal-dominant AD (ADAD) has generated enormous interest. The RELN-COLBOS variant enhances interactions with the apolipoprotein E receptor 2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR), which are associated with delayed AD onset and progression. These findings were validated in a transgenic mouse model. Reelin is involved in neurodevelopment, neurogenesis, and neuronal plasticity. The evidence accumulated thus far has demonstrated that the Reelin pathway links apolipoprotein E4 (ApoE4), amyloid-β (Aβ), and tubulin-associated unit (Tau), which are key proteins that have been implicated in AD pathogenesis. Reelin and key components of the Reelin pathway have been highlighted as potential therapeutic targets and biomarkers for AD.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"98 ","pages":"102339"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation 利用后生物制剂治疗神经退行性疾病的新途径：临床转化的突破与瓶颈
Ageing research reviews Pub Date : 2024-02-16 DOI: 10.1016/j.arr.2024.102236
Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, S. Vishwas, N. K. Pandey, Gaurav Gupta, K. Paudel, H. Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia C. Zacconi, Terezinha de Jesus Andreoli Pinto, M. Dhanasekaran, M. Gulati, Kamal Dua, Sachin Kumar Singh
{"title":"Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation","authors":"Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, S. Vishwas, N. K. Pandey, Gaurav Gupta, K. Paudel, H. Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia C. Zacconi, Terezinha de Jesus Andreoli Pinto, M. Dhanasekaran, M. Gulati, Kamal Dua, Sachin Kumar Singh","doi":"10.1016/j.arr.2024.102236","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102236","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"285 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFICACY OF DEPRESCRIBING ON HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS WITH META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS 取消处方对健康结果的影响：对随机对照试验进行荟萃分析的系统综述
Ageing research reviews Pub Date : 2024-02-16 DOI: 10.1016/j.arr.2024.102237
Nicola Veronese, Umberto Gallo, Virginia Boccardi, J. Demurtas, Alberto Michielon, Xhoajda Taci, Giulia Zanchetta, Sophia Campbell, Marco Chiumente, Francesca Venturini, Alberto Pilotto
{"title":"EFFICACY OF DEPRESCRIBING ON HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS WITH META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS","authors":"Nicola Veronese, Umberto Gallo, Virginia Boccardi, J. Demurtas, Alberto Michielon, Xhoajda Taci, Giulia Zanchetta, Sophia Campbell, Marco Chiumente, Francesca Venturini, Alberto Pilotto","doi":"10.1016/j.arr.2024.102237","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102237","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"336 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role and Mechanism of RNA-binding Proteins in Bone Metabolism and Osteoporosis RNA 结合蛋白在骨代谢和骨质疏松症中的作用和机制
Ageing research reviews Pub Date : 2024-02-16 DOI: 10.1016/j.arr.2024.102234
Jiaqiang Wu, Liyan Niu, Kangping Yang, Jingdong Xu, Deju Zhang, J. Ling, Panpan Xia, Yuting Wu, Xiao Liu, Jianping Liu, Jing Zhang, Peng Yu
{"title":"The Role and Mechanism of RNA-binding Proteins in Bone Metabolism and Osteoporosis","authors":"Jiaqiang Wu, Liyan Niu, Kangping Yang, Jingdong Xu, Deju Zhang, J. Ling, Panpan Xia, Yuting Wu, Xiao Liu, Jianping Liu, Jing Zhang, Peng Yu","doi":"10.1016/j.arr.2024.102234","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102234","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"19 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139773842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic regulations of cellular senescence in osteoporosis 骨质疏松症中细胞衰老的表观遗传调控
Ageing research reviews Pub Date : 2024-02-16 DOI: 10.1016/j.arr.2024.102235
Shaochuan Huo, Xinzheng Tang, Weijian Chen, Donghao Gan, Hai Guo, Qing Yao, Rongdong Liao, Tingting Huang, Junxian Wu, Junxing Yang, Guozhi Xiao, Xia Han
{"title":"Epigenetic regulations of cellular senescence in osteoporosis","authors":"Shaochuan Huo, Xinzheng Tang, Weijian Chen, Donghao Gan, Hai Guo, Qing Yao, Rongdong Liao, Tingting Huang, Junxian Wu, Junxing Yang, Guozhi Xiao, Xia Han","doi":"10.1016/j.arr.2024.102235","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102235","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"321 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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