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Lactylation and Methylation: Dual Epigenetic Codes and Potential Therapeutic Targets in Myocardial Aging. 乳酸化和甲基化：心肌老化的双重表观遗传密码和潜在治疗靶点。
IF 12.4
Ageing research reviews Pub Date : 2025-07-30 DOI: 10.1016/j.arr.2025.102849
Qian-Qian Niu, Yu-Ting Xi, Ya-Qi Guo, Zheng-Ji Piao, Chun-Rui Zhang, Tian-Yao Li, Dan-Jie Li, Peng Li, Ya-Ling Yin, Vuanghao Lim, Nik Nur Syazni Nik Mohamed Kamal
{"title":"Lactylation and Methylation: Dual Epigenetic Codes and Potential Therapeutic Targets in Myocardial Aging.","authors":"Qian-Qian Niu, Yu-Ting Xi, Ya-Qi Guo, Zheng-Ji Piao, Chun-Rui Zhang, Tian-Yao Li, Dan-Jie Li, Peng Li, Ya-Ling Yin, Vuanghao Lim, Nik Nur Syazni Nik Mohamed Kamal","doi":"10.1016/j.arr.2025.102849","DOIUrl":"https://doi.org/10.1016/j.arr.2025.102849","url":null,"abstract":"<p><p>Combating aging has become a central challenge in the life sciences, and myocardial aging, as a fundamental pathological process underlying the development and progression of various cardiovascular diseases, has become a key area in anti-aging research. In recent years, lactylation and methylation, two metabolism-dependent epigenetic modifications, have garnered increasing attention in the context of myocardial aging. Lactylation, mediated by lactate accumulation due to metabolic dysregulation, modifies lysine residues on both histone and non-histone proteins, thereby participating in the regulation of gene transcription, metabolic homeostasis, and inflammatory responses. In parallel, methylation affects gene expression, metabolic remodeling, and mitochondrial function through DNA, RNA, and histone modifications. This review systematically summarizes the regulatory mechanisms of lactylation and methylation in myocardial aging, with a particular focus on their interplay in histone and non-histone protein modification, metabolic regulation, and signaling pathway integration. Furthermore, we evaluate the potential of these reversible modifications as early epigenetic biomarkers and discuss multilayered intervention strategies targeting both lactylation and methylation. Such strategies highlight their translational potential in delaying myocardial aging and mitigating cardiovascular disease. Precisely modulating lactylation and methylation may offer novel theoretical frameworks and therapeutic targets for the prevention and treatment of myocardial aging.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102849"},"PeriodicalIF":12.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of antidiabetic medications on the relationship between type 2 diabetes mellitus and cognitive impairment. 降糖药物对2型糖尿病与认知功能障碍关系的影响。
Ageing research reviews Pub Date : 2025-07-12 DOI: 10.1016/j.arr.2025.102834
Annalisa Cozza, Chiara Chinigò, Elvira Filicetti, Giada Ida Greco, Rosamaria Lappano, Cinzia Marinaro, Lucia Muglia, Luca Soraci, Andrea Corsonello, Fabrizia Lattanzio, Mara Volpentesta
{"title":"Effects of antidiabetic medications on the relationship between type 2 diabetes mellitus and cognitive impairment.","authors":"Annalisa Cozza, Chiara Chinigò, Elvira Filicetti, Giada Ida Greco, Rosamaria Lappano, Cinzia Marinaro, Lucia Muglia, Luca Soraci, Andrea Corsonello, Fabrizia Lattanzio, Mara Volpentesta","doi":"10.1016/j.arr.2025.102834","DOIUrl":"https://doi.org/10.1016/j.arr.2025.102834","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM)-related cognitive impairment (CI) has garnered increasing attention in recent research and is emerging as a highly relevant area of study. T2DM is a chronic and globally prevalent condition characterized by insulin resistance, hyperglycemia, oxidative stress, neuroinflammation, and cerebrovascular dysfunction, factors that collectively contribute to cognitive decline. Notably, T2DM is strongly associated with neurodegenerative conditions, ranging from mild cognitive impairment (MCI) to dementia. This review explores the potential neuroprotective effects of various antidiabetic drugs, including insulin-sensitizing agents (metformin and pioglitazone), sodium-glucose co-transporter 2 inhibitors (SGLT2is), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and dipeptidyl peptidase-4 inhibitors (DPP-4is). These medications exert their effects through multiple mechanisms, such as reducing neuroinflammation and oxidative stress, decreasing Aβ accumulation and apoptosis, enhancing cerebral glucose metabolism, and promoting neuroplasticity, processes directly implicated in the interplay between T2DM and cognitive decline. The review highlights the therapeutic potential of these agents in mitigating CI and supporting brain health in individuals with T2DM. However, given the conflicting nature of current clinical evidence, further research is needed to clarify their cognitive benefits, elucidate underlying mechanisms of action, and assess their long-term effects on cognitive outcomes in this population.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102834"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editor's Note to "Biological constraint, evolutionary spandrels and antagonistic pleiotropy". “生物约束、进化障碍和拮抗多效性”的编者注。
Ageing research reviews Pub Date : 2025-06-05 DOI: 10.1016/j.arr.2025.102798
{"title":"Editor's Note to \"Biological constraint, evolutionary spandrels and antagonistic pleiotropy\".","authors":"","doi":"10.1016/j.arr.2025.102798","DOIUrl":"https://doi.org/10.1016/j.arr.2025.102798","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102798"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WITHDRAWN: Biomarker Detection and Therapy of Parkinson's and Alzheimer's disease using upconversion based approach: A Comprehensive Review. 基于上转换方法的帕金森病和阿尔茨海默病的生物标志物检测和治疗：综合综述
Ageing research reviews Pub Date : 2025-01-07 DOI: 10.1016/j.arr.2025.102656
Kabirdas B Ghorpade, Shivanshu Agrawal, Ujwal Havelikar
{"title":"WITHDRAWN: Biomarker Detection and Therapy of Parkinson's and Alzheimer's disease using upconversion based approach: A Comprehensive Review.","authors":"Kabirdas B Ghorpade, Shivanshu Agrawal, Ujwal Havelikar","doi":"10.1016/j.arr.2025.102656","DOIUrl":"10.1016/j.arr.2025.102656","url":null,"abstract":"<p><p>This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies/article-withdrawal.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102656"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress in Alzheimer's disease and bone-brain axis. 阿尔茨海默病和骨脑轴的研究进展。
Ageing research reviews Pub Date : 2024-07-01 Epub Date: 2024-05-15 DOI: 10.1016/j.arr.2024.102341
Fan Zhang, Wei Zhang
{"title":"Research progress in Alzheimer's disease and bone-brain axis.","authors":"Fan Zhang, Wei Zhang","doi":"10.1016/j.arr.2024.102341","DOIUrl":"10.1016/j.arr.2024.102341","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common type of cognitive impairment. AD is closely related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms of epidemiology and pathogenesis. Brain and bone tissues can regulate each other in different manners through bone-brain axis. This article reviews the research progress of the relationship between AD and orthopedic diseases, bone-brain axis mechanisms of AD, and AD therapy by targeting bone-brain axis, in order to deepen the understanding of bone-brain communication, promote early diagnosis and explore new therapy for AD patients.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":" ","pages":"102341"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reelin links Apolipoprotein E4, Tau, and Amyloid-β in Alzheimer's disease. Reelin 将阿尔茨海默病中的载脂蛋白 E4、Tau 和淀粉样蛋白-β联系起来。
Ageing research reviews Pub Date : 2024-05-14 DOI: 10.1016/j.arr.2024.102339
Ling Xiao Yi, Li Zeng, Qing Wang, Eng King Tan, Zhi Dong Zhou
{"title":"Reelin links Apolipoprotein E4, Tau, and Amyloid-β in Alzheimer's disease.","authors":"Ling Xiao Yi, Li Zeng, Qing Wang, Eng King Tan, Zhi Dong Zhou","doi":"10.1016/j.arr.2024.102339","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102339","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the cerebral cortex and hippocampus, and is characterised by progressive cognitive decline and memory loss. A recent report of a patient carrying a novel gain-of-function variant of RELN (H3447R, termed RELN-COLBOS) who developed resilience against presenilin-linked autosomal-dominant AD (ADAD) has generated enormous interest. The RELN-COLBOS variant enhances interactions with the apolipoprotein E receptor 2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR), which are associated with delayed AD onset and progression. These findings were validated in a transgenic mouse model. Reelin is involved in neurodevelopment, neurogenesis, and neuronal plasticity. The evidence accumulated thus far has demonstrated that the Reelin pathway links apolipoprotein E4 (ApoE4), amyloid-β (Aβ), and tubulin-associated unit (Tau), which are key proteins that have been implicated in AD pathogenesis. Reelin and key components of the Reelin pathway have been highlighted as potential therapeutic targets and biomarkers for AD.</p>","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"98 ","pages":"102339"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation 利用后生物制剂治疗神经退行性疾病的新途径：临床转化的突破与瓶颈
Ageing research reviews Pub Date : 2024-02-16 DOI: 10.1016/j.arr.2024.102236
Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, S. Vishwas, N. K. Pandey, Gaurav Gupta, K. Paudel, H. Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia C. Zacconi, Terezinha de Jesus Andreoli Pinto, M. Dhanasekaran, M. Gulati, Kamal Dua, Sachin Kumar Singh
{"title":"Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation","authors":"Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, S. Vishwas, N. K. Pandey, Gaurav Gupta, K. Paudel, H. Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia C. Zacconi, Terezinha de Jesus Andreoli Pinto, M. Dhanasekaran, M. Gulati, Kamal Dua, Sachin Kumar Singh","doi":"10.1016/j.arr.2024.102236","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102236","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"285 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFICACY OF DEPRESCRIBING ON HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS WITH META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS 取消处方对健康结果的影响：对随机对照试验进行荟萃分析的系统综述
Ageing research reviews Pub Date : 2024-02-16 DOI: 10.1016/j.arr.2024.102237
Nicola Veronese, Umberto Gallo, Virginia Boccardi, J. Demurtas, Alberto Michielon, Xhoajda Taci, Giulia Zanchetta, Sophia Campbell, Marco Chiumente, Francesca Venturini, Alberto Pilotto
{"title":"EFFICACY OF DEPRESCRIBING ON HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS WITH META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS","authors":"Nicola Veronese, Umberto Gallo, Virginia Boccardi, J. Demurtas, Alberto Michielon, Xhoajda Taci, Giulia Zanchetta, Sophia Campbell, Marco Chiumente, Francesca Venturini, Alberto Pilotto","doi":"10.1016/j.arr.2024.102237","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102237","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"336 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role and Mechanism of RNA-binding Proteins in Bone Metabolism and Osteoporosis RNA 结合蛋白在骨代谢和骨质疏松症中的作用和机制
Ageing research reviews Pub Date : 2024-02-16 DOI: 10.1016/j.arr.2024.102234
Jiaqiang Wu, Liyan Niu, Kangping Yang, Jingdong Xu, Deju Zhang, J. Ling, Panpan Xia, Yuting Wu, Xiao Liu, Jianping Liu, Jing Zhang, Peng Yu
{"title":"The Role and Mechanism of RNA-binding Proteins in Bone Metabolism and Osteoporosis","authors":"Jiaqiang Wu, Liyan Niu, Kangping Yang, Jingdong Xu, Deju Zhang, J. Ling, Panpan Xia, Yuting Wu, Xiao Liu, Jianping Liu, Jing Zhang, Peng Yu","doi":"10.1016/j.arr.2024.102234","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102234","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"19 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139773842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic regulations of cellular senescence in osteoporosis 骨质疏松症中细胞衰老的表观遗传调控
Ageing research reviews Pub Date : 2024-02-16 DOI: 10.1016/j.arr.2024.102235
Shaochuan Huo, Xinzheng Tang, Weijian Chen, Donghao Gan, Hai Guo, Qing Yao, Rongdong Liao, Tingting Huang, Junxian Wu, Junxing Yang, Guozhi Xiao, Xia Han
{"title":"Epigenetic regulations of cellular senescence in osteoporosis","authors":"Shaochuan Huo, Xinzheng Tang, Weijian Chen, Donghao Gan, Hai Guo, Qing Yao, Rongdong Liao, Tingting Huang, Junxian Wu, Junxing Yang, Guozhi Xiao, Xia Han","doi":"10.1016/j.arr.2024.102235","DOIUrl":"https://doi.org/10.1016/j.arr.2024.102235","url":null,"abstract":"","PeriodicalId":93862,"journal":{"name":"Ageing research reviews","volume":"321 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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