Trends in medical research最新文献_第7页

Response of Cellular Elements to Frequent Blood Donations among Male Subjects in Calabar, Nigeria 细胞因子对尼日利亚卡拉巴尔男性受试者频繁献血的反应

Trends in medical research Pub Date : 2016-01-01 DOI: 10.3923/TMR.2016.11.19

D. Okpokam, I. Okafor, J. Akpotuzor, V. U. Nna, O. Okpokam, E. Osim, E. A. Usanga

{"title":"Response of Cellular Elements to Frequent Blood Donations among Male Subjects in Calabar, Nigeria","authors":"D. Okpokam, I. Okafor, J. Akpotuzor, V. U. Nna, O. Okpokam, E. Osim, E. A. Usanga","doi":"10.3923/TMR.2016.11.19","DOIUrl":"https://doi.org/10.3923/TMR.2016.11.19","url":null,"abstract":"Abuse of blood donation is common in Calabar and Nigeria. Research on blood donors has focused on the erythrocyte and iron-related parameters, without considering the other cell lines of the donors. This study examined the effect of frequent blood donations on leucocytes and thrombocytes. One hundred and eighty four subjects aged 18-35 years were used for this study. The subjects were divided into 5 groups thus; 35 (19%) control group, 32 (17.4%) of first time donors, 35 (19%) of second time donors, 41 (22.3%) of third time donors and 41 (22.3%) of fourth time donors. Their full blood counts were evaluated using complete automated cell counter and values obtained were statistically analyzed. Results showed that 63% of the donors were commercial blood donors. Haematocrit (Hct) of first (41.9±0.66%), second (40.1±0.47%), third (39.1±0.54%) and fourth (33.3±0.56%) time male donors decreased progressively as number of times of donation increased, compared with control (43.9±0.55%). Total White Blood Cell (WBC) count significantly (p<0.001) decreased in first, third and fourth time donors, compared with control. Monocytes, granulocytes and platelet counts decreased progressively with repeated blood donations. Lymphocytes increased progressively following repeated blood donations. We therefore, conclude that, serial blood donation decreases Hct, WBC (monocyte and granulocyte) and platelet counts in males and increases lymphocyte count.","PeriodicalId":93827,"journal":{"name":"Trends in medical research","volume":"44 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90333725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Incidence of substance abuse among cab-drivers involved in non fatal accidents 非致命事故中出租车司机药物滥用的发生率

Trends in medical research Pub Date : 2016-01-01 DOI: 10.3923/TMR.2016.20.27

M. Aglan, A. Adawi

{"title":"Incidence of substance abuse among cab-drivers involved in non fatal accidents","authors":"M. Aglan, A. Adawi","doi":"10.3923/TMR.2016.20.27","DOIUrl":"https://doi.org/10.3923/TMR.2016.20.27","url":null,"abstract":"Road Traffic Injuries (RTIs) represent a major global health problem. Substance abuse is a major contributing factor for such injuries. The current study aimed to investigate the problem of substance misuse among cab-drivers involved in non-fatal accidents. This cross-sectional study carried out at Al-Azhar University Hospitals (Cairo, Al-Hussein and Bab El-Sharia Hospitals), during the period from August 2012 to August 2014. All cab-drivers who were admitted to the emergency department with non-fatal motor car trauma were asked to participate. We identified 80 eligible drivers, 20 of them refused to participate. Thus, the final included cases were 60 drivers. Positive cases were 32 with an incidence rate of 53.3%. All were males. Socio-demographic factors were documented and urine samples were drawn to screen for abused substances (e.g., opiate, methamphetamine, tetrahydrocannabinol, barbiturates, benzodiazepines and tramadol). The most common abused substance was cannabis (THC) (90.6%), then tramadol in 59.4%, barbiturates in 34.4%, opiates in 28.1%, benzodiazepines in 25% and finally methamphetamine in 21.9%. In addition, 90.6% abused two or more substances concomitantly and 9.4% had a single substance. This study highlighted the magnitude of substance abuse in cab-driver. The most common abused drug was cannabis and the least was methamphetamine. The majority of cases (90.6%) abused more than one substance.","PeriodicalId":93827,"journal":{"name":"Trends in medical research","volume":"79 1","pages":"20-27"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88387959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Protective Effect of Coenzyme Q10 on Methamphetamine-Induced Neurotoxicity in the Mouse Brain 辅酶Q10对甲基苯丙胺致小鼠脑神经毒性的保护作用

Trends in medical research Pub Date : 2016-01-01 DOI: 10.3923/TMR.2016.1.10

H. N. Thanh, H. Minh, L. V. Duc, Tung Bui Thanh

引用次数: 6

Prolonged Aminoglycoside Treatment for Pelvic Inflammatory Disease Associated Ovarian Carcinoma 延长氨基糖苷治疗盆腔炎相关卵巢癌

Trends in medical research Pub Date : 2016-01-01 DOI: 10.3923/TMR.2016.49.53

S. Shanmughap, Arumugam Lency, S. Kavitha, K. Natarajase

{"title":"Prolonged Aminoglycoside Treatment for Pelvic Inflammatory Disease Associated Ovarian Carcinoma","authors":"S. Shanmughap, Arumugam Lency, S. Kavitha, K. Natarajase","doi":"10.3923/TMR.2016.49.53","DOIUrl":"https://doi.org/10.3923/TMR.2016.49.53","url":null,"abstract":"Pelvic actinomycosis constitutes one of the curiosities of gynecology. In this present investigation the presence of actinomycetes infection among Intrauterine device (IUD) users and its correlation correlated with the development of Pelvic Inflammatory Disease (PID) and ovarian carcinoma was studied. Endocervical swabs were obtained from ovarian carcinoma, IUD users, non-users and processed to isolate actinomycetes on actinomycetes isolation agar. The isolation rate was found to be increased among IUD users who were clinically diagnosed to have PID (52.9%) followed by ovarian carcinoma cases who were prior users of IUD (44.4%). Compared to healthy non-IUD users, IUD users with PID experienced a 158 fold statistically significant increased risk of actinomycetes infection (OR = 158.63, 95% CI = 17.84, 161.11) followed by ovarian carcinoma patients with IUDs (OR = 112.80, 95% CI = 10.59, 120.02). The isolates showed high resistance against penicillin, clindamycin and erythromycin and low resistance against tetracycline, linezolid and gentamycin. The use of IUDs facilitates the colonization by actinomycetes which in turn lead to PID and pelvic actinomycosis. Further the pelvic actinomycosis simulates pelvic malignancies. If chronic actinomycetes infection are encountered, the patients should be given long term therapy with aminoglycoside antibiotics and if a pelvic mass is evident aggressive and prolonged antibiotic therapy with surgical intervention is required.","PeriodicalId":93827,"journal":{"name":"Trends in medical research","volume":"9 1","pages":"49-53"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89537402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of the Desert Truffle Terfezia claveryi to Cure Trachoma Disease with Special Emphasis on its Antibacterial Bioactivity 沙漠松露治疗沙眼病的疗效及抑菌活性研究

Trends in medical research Pub Date : 2016-01-01 DOI: 10.3923/TMR.2016.28.34

M. S. Alhussaini, A. M. Saadabi, Kamal Hashim, Abdullah A. Al Ghanayem

{"title":"Efficacy of the Desert Truffle Terfezia claveryi to Cure Trachoma Disease with Special Emphasis on its Antibacterial Bioactivity","authors":"M. S. Alhussaini, A. M. Saadabi, Kamal Hashim, Abdullah A. Al Ghanayem","doi":"10.3923/TMR.2016.28.34","DOIUrl":"https://doi.org/10.3923/TMR.2016.28.34","url":null,"abstract":"The aim of the present study was to apply natural drops of truffle (Terfezia claveryi) to patients diagnosed with trachoma for curing the disease and inhibiting the chlamydial bacteria and explore the potential for the development of new treatment modalities compared to currently used antibiotics. Results showed that the truffle juice was very effective against trachoma in the third phase of the disease. There was clear reduction of symptoms in patients with cortisone compounds in the form of drops plus truffle juice drops. There were also complete healing of the conjunctiva and healing of the keratitis. Partial curing was observed when cortisone plus cream of chloramphenicol was added included healing of trachoma without any change of fibrosis in the conjunctiva. In the treatment of trachoma with cortisone drops and cream plus truffle juice, complete of healing was observed but continued swelling in the capillaries with no fibrosis occurred. It was clearly noticed that in all of the treatments, there was a noticeable reduction in fibrosis of the affected site in the eye. It was also concluded that truffle juice seems to prevent fibrosis of trachoma by a large extent. On the other hand, the use of chemical antibiotic or cortisone-based compounds produced several side effects. Though these chemicals reduced the toxins caused by trachoma thereby reducing the enlargement of the cells. We can therefore clearly recommend adding truffle juice to the traditional treatment for trachoma at all stages.","PeriodicalId":93827,"journal":{"name":"Trends in medical research","volume":"6 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79268585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of Basal Gonadotropins, Prolactin and Anthropometry as Predictive Markers of Ovarian Response in Patients Seeking Assisted Reproduction 基础促性腺激素、催乳素和人体测量作为辅助生殖患者卵巢反应的预测指标的作用

Trends in medical research Pub Date : 2015-04-01 DOI: 10.3923/TMR.2015.75.86

R. Ngala, M. B. Yakass, K. Addo, E. Hiadzi

{"title":"Effect of Basal Gonadotropins, Prolactin and Anthropometry as Predictive Markers of Ovarian Response in Patients Seeking Assisted Reproduction","authors":"R. Ngala, M. B. Yakass, K. Addo, E. Hiadzi","doi":"10.3923/TMR.2015.75.86","DOIUrl":"https://doi.org/10.3923/TMR.2015.75.86","url":null,"abstract":"Assisted reproduction is expensive, time-consuming and stressful for patients. The accurate determination of ovarian reserve is important for this procedure. Basal hormonal levels may help to predict ovarian reserve after stimulation. The aim of this study was to assess basal hormonal markers; Luteinizing Hormones (LH), Follicle stimulating (FSH), prolactin and anthropometric indices as predictive markers of ovarian response in patients seeking assisted reproduction. A total of 104 subjects were recruited at the Lister Hospital Fertility Centre in Accra-Ghana for this study. Anthropometric parameters: Body Mass Index (BMI) and Waist-to-Hip Ratio (WHR) were measured. Lifestyle features; exercise and smoking patterns were assessed from a questionnaire. Blood samples were drawn on second day of their menstrual cycle in the month prior to the in vitro fertilization (IVF) procedure and basal luteinizing hormones, FSH and prolactin assayed by ELISA method. Subjects who yielded four or less oocytes were classified as poor responders whereas those who yielded more than 4 oocytes were termed as normal responders. Basal FSH and age (12.9±0.51 IU LG and 40±0.54 years) were significantly (p<0.01) higher in poor responders than normal responders 9.7±0.61 IU LG and 36±0.42 years, respectively. Increasing age, (42.44±0.47 years), high basal FSH (13.41±0.91 IU LG) and high FSH/LH ratio (2.74±0.64) significantly but negatively correlated with retrieved oocyte (7.28±2.03) and ovarian capacity (8.44±1.16) when compared to low age (28.08±0.65 years), normal FSH (7.64±1.21 IU LG) and FSH/LH (1.23±0.16) with retrieved oocyte (20.31±3.30) and ovarian capacity (20.92±2.63), respectively. Subjects engaged in moderate to high forms of exercise recorded a normal response. Number of retrieved oocytes and ovarian capacity were negatively correlated to WHR and BMI. Basal FSH and FSH/LH ratio better predicted response of subjects after ovarian stimulation. Obesity negatively impacted on ovarian response.","PeriodicalId":93827,"journal":{"name":"Trends in medical research","volume":"133 1","pages":"75-86"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79796984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Variations in Blood Parameters of High Salt Loaded Rats Following Administration of Moringa oleifera Leaf Extract 辣木叶提取物对高盐负荷大鼠血液参数的影响

Trends in medical research Pub Date : 2015-04-01 DOI: 10.3923/TMR.2015.97.105

O. Ofem, E. Ani, A. N. Archibong, J. M. Ufford

{"title":"Variations in Blood Parameters of High Salt Loaded Rats Following Administration of Moringa oleifera Leaf Extract","authors":"O. Ofem, E. Ani, A. N. Archibong, J. M. Ufford","doi":"10.3923/TMR.2015.97.105","DOIUrl":"https://doi.org/10.3923/TMR.2015.97.105","url":null,"abstract":"High salt loading is associated with myriad deleterious effects including alterations in blood parameters, cardiovascular risk and sudden death. This study explored the impact of Moringa oleifera on some blood parameters in high salt loaded rats. Twenty four male albino Wistar rats were assigned into 4 groups of 6 rats each. They were fed on either control diet, high salt diet (8% NaCl diet+1% NaCl drinking water) and/or Moringa extract (600 mg kgG b.wt. orally, once daily) ad libitum for 6 weeks. Blood samples were obtained via cardiac puncture for full blood count measurement using automated blood counter. Results revealed that the high salt fed untreated rats had significant increases in their total WBC, RBC, platelet counts, PCV, lymphocytes, P-LCR, MPV and PDW. These increases were reversed to near control levels by Moringa. Also, Moringa reversed lowered, MCHC platelet and neutrophil counts in high salt loaded rats. Values obtained for control group include: RBC (7.02±0.16×10 cell μLG), total WBC (8.08±0.80×10 cell μLG), PCV (40.30±1.14%), platelet count (673.17±18.89×10 cell μLG), RDW-SD (35.70±0.32 fL). In conclusion, Moringa oleifera extract prevents changes in total WBC, RBC count, packed cell volume (hematocrit), platelet count, lymphocytes, neutrophils, MPV, P-LCR and PDW in high salt fed rats, these parameters are determinants of the blood volume, hemostasis and the tendencies to excessive bleeding, cardiovascular diseases, hypertension and sudden death.","PeriodicalId":93827,"journal":{"name":"Trends in medical research","volume":"23 1","pages":"97-105"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82502909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Surveillance for Antibiotic Resistance in Nigeria: Challenges and Possible Solutions 尼日利亚抗生素耐药性监测:挑战和可能的解决办法

Trends in medical research Pub Date : 2015-04-01 DOI: 10.3923/TMR.2015.106.113

I. Nasir, Adamu Babyo, A. Emeribe, N. Sani

{"title":"Surveillance for Antibiotic Resistance in Nigeria: Challenges and Possible Solutions","authors":"I. Nasir, Adamu Babyo, A. Emeribe, N. Sani","doi":"10.3923/TMR.2015.106.113","DOIUrl":"https://doi.org/10.3923/TMR.2015.106.113","url":null,"abstract":"There is no doubt that antibiotics have saved the human race from a lot of suffering due to bacterial disease burden. Without these drugs, millions of people would have succumbed to infectious diseases. Regrettably, antibiotic resistance (ABR) threatens the effective treatment of these pathogens. The incidence of ABR and the emergence of multidrug-resistance bacteria are on the increase and has been considered a major public health issue. In view of this, we conducted this review of relevant published articles using extensive literature search made through PubMed, Google scholar, Scopus and HINARI on the emergence and spread of ABR, challenges and possible solutions to ABR surveillance especially in Nigeria. Findings from our review revealed that surveillance for ABR in pulmonary tuberculosis was the only system in good function in Nigeria. Regrettably, most hospitals have poor ABR systems for other bacteria. This setback was found to be linked to multifactorial reasons. Urgent and coordinated action is required at all levels to ensure preservation of these life-saving drugs for future utility. Detection of resistance and monitoring its spread requires appropriate laboratory-based surveillance. In addition, there is need to sustain the efficiency of diagnostic laboratories, improved surveillance, better regulation and education of the public, clinicians/prescribers in the appropriate use of antibiotics.","PeriodicalId":93827,"journal":{"name":"Trends in medical research","volume":"1 1","pages":"106-113"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86426688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Knowledge and Social Distance Towards Mental Disorders in an Inner-City Population: Case of University Students in Cameroon 市中心人群对精神障碍的知识和社会距离:喀麦隆大学生的案例

Trends in medical research Pub Date : 2015-04-01 DOI: 10.3923/TMR.2015.87.96

N. Blaise

{"title":"Knowledge and Social Distance Towards Mental Disorders in an Inner-City Population: Case of University Students in Cameroon","authors":"N. Blaise","doi":"10.3923/TMR.2015.87.96","DOIUrl":"https://doi.org/10.3923/TMR.2015.87.96","url":null,"abstract":"Mental disorders are widely recognized as a major contributor to the global burden of disease worldwide. They often constitute a double jeopardy for those affected because of stigmatization by members of the community. The purpose of this study is to explore knowledge and social distance of mental disorders among students from Cameroonian universities who reside in urban areas, as mental health among university students represents an important and growing public health concern for which epidemiological data are needed. A cross-sectional survey was conducted from October 2014 to march 2015 among 680 students from six universities. A self-administered questionnaire exploring knowledge and social distance within students was formulated. Questions were based on basic demographic information, opinions about stigmas, myths and knowledge of mental health. Data was analyzed using descriptive and inferential statistics to investigate the relationship between the participant’s field of study, their beliefs and perceptions about mental disorders and the participants’ length of stay in urban settings. Of 680 students surveyed, 453 have already heard about mental diseases and 227 know someone who has suffered or who is suffering from mental illness. Among them, 53.2% are attending social/human sciences studies whereas 26.9 and 19.9% are attending, respectively life sciences and applied sciences studies. Most of the respondents (71.0%) have been living in urban areas for at least five years. Recognition of common mental disorders in the studied population is poor (42.6%) and 39.5% believe that mental illness can be treated. Though respondents are university students, knowledge of mental illnesses is poor and their negative perceptions and attitudes towards individual with mental disorders suggest opportunities to address mental health issues (increase mental health literacy) in this important group of populations. Keys words: Mental diseases, knowledge, social distance, university students, urban settings,","PeriodicalId":93827,"journal":{"name":"Trends in medical research","volume":"139 1","pages":"87-96"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87543986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Sildenafil Citrate and Tramadol Administered Separately and in Combination Affects Basal Metabolic Rate, Triiodothyronine (T3) and Cortisol Levels in Albino Wistar Rats 枸橼酸西地那非和曲马多单独或联合给药对白化Wistar大鼠基础代谢率、三碘甲状腺原氨酸(T3)和皮质醇水平的影响

Trends in medical research Pub Date : 2015-03-01 DOI: 10.3923/TMR.2015.51.62

V. Oka, A. L. Udefa, V. U. Nna, D. Owu

{"title":"Sildenafil Citrate and Tramadol Administered Separately and in Combination Affects Basal Metabolic Rate, Triiodothyronine (T3) and Cortisol Levels in Albino Wistar Rats","authors":"V. Oka, A. L. Udefa, V. U. Nna, D. Owu","doi":"10.3923/TMR.2015.51.62","DOIUrl":"https://doi.org/10.3923/TMR.2015.51.62","url":null,"abstract":"Studies have reported abuse of medications used in treating erectile dysfunction and premature ejaculation, with several adults taking far above recommended doses. A variety of negative effects (including exhaustion) have been associated with the use of these drugs. This study therefore assessed the effects of separate administration of sildenafil citrate, tramadol and their combination on Basal Metabolic Rate (BMR) in relation to body weight, T3 and cortisol levels in rats. Twenty male albino Wistar rats weighing 150-180 g were randomly assigned into 4 groups (n = 5) thus: control (0.2 mL normal saline), sildenafil-treated (10 mg kgG1), tramadol-treated (20 mg kgG1) and sildenafil+tramadol-treated (10 and 20 mg kgG1, respectively) groups. The different drugs were administered orally, every 2 days, for 3 weeks, after one week acclimatization period. The body weight and BMR were measured weekly and serum concentrations of T3 and cortisol were measured at the end of 21 days of treatment. Tramadol significantly (p<0.05) reduced mean food intake, compared with control. Sildenafil and sildenafil+tramadol-treated groups had significantly (p<0.001, p<0.05) lower body weight change, compared with control. Sildenafl-treated group had a lower change in BMR, significantly (p<0.05) different from control and sildenafil+tramadoltreated groups. Serum T3 concentration was significantly (p<0.001) increased in tramadol and sildenafil+tramadol-treated groups, compared with control and sildenafil treated groups. Serum cortisol concentration was significantly (p<0.001) reduced in all treated groups, compared with control. Sildenafil citrate decreased body weight, BMR, serum T3 and cortisol concentrations, while tramadol increased BMR and serum T3 concentration, but decreased serum cortisol concentration and body weight. A combination of these drugs seems to act in a pattern similar to tramadol. This probably explains the feeling of exhaustion reported by users of these drugs.","PeriodicalId":93827,"journal":{"name":"Trends in medical research","volume":"10 1","pages":"51-62"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88585031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14