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A clinical remission study of low-severity alcohol use disorder, treated with nalmefene 纳美芬治疗低度酒精使用障碍的临床缓解研究
SPG biomed Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.59
J. Guardia-Serecigni
{"title":"A clinical remission study of low-severity alcohol use disorder, treated with nalmefene","authors":"J. Guardia-Serecigni","doi":"10.32392/BIOMED.59","DOIUrl":"https://doi.org/10.32392/BIOMED.59","url":null,"abstract":"Background: When someone develops an alcohol use disorder (AUD), their addiction conditioning does not go away simply by refraining from drinking for some weeks or months. On the contrary, due to the deprivation effect, if one day they try to have just one alcoholic drink they will feel a strong and imperative biological necessity to keep drinking very fast, not being able to stop, which will lead to immediate negative consequences.","PeriodicalId":93816,"journal":{"name":"SPG biomed","volume":"427 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78255146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual Therapy with Insulin-Like Growth Factor-I Receptor/Insulin Receptor (IGF1R/IR) and Androgen Receptor (AR) Antagonists Inhibits Triple-Negative Breast Cancer Cell Migration In Vitro 胰岛素样生长因子- 1受体/胰岛素受体(IGF1R/IR)和雄激素受体(AR)拮抗剂的双重治疗抑制三阴性乳腺癌细胞的体外迁移
SPG biomed Pub Date : 2019-01-01 DOI: 10.32392/biomed.69
N. Hamilton, D. Márquez-Garbán, Ben Rogers, David Austin, K. Foos, A. Tong, Diana Adams, J. Vadgama, M. Brecht, R. Pietras
{"title":"Dual Therapy with Insulin-Like Growth Factor-I Receptor/Insulin Receptor (IGF1R/IR) and Androgen Receptor (AR) Antagonists Inhibits Triple-Negative Breast Cancer Cell Migration In Vitro","authors":"N. Hamilton, D. Márquez-Garbán, Ben Rogers, David Austin, K. Foos, A. Tong, Diana Adams, J. Vadgama, M. Brecht, R. Pietras","doi":"10.32392/biomed.69","DOIUrl":"https://doi.org/10.32392/biomed.69","url":null,"abstract":"","PeriodicalId":93816,"journal":{"name":"SPG biomed","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90069749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sexual health and impact of treatments on Colombian women with breast cancer and their sex partners 性健康和治疗对哥伦比亚乳腺癌妇女及其性伴侣的影响
SPG biomed Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.52
Luz Stella Bueno-Robles, Virginia Inés Soto-Lesmes
{"title":"Sexual health and impact of treatments on Colombian women with breast cancer and their sex partners","authors":"Luz Stella Bueno-Robles, Virginia Inés Soto-Lesmes","doi":"10.32392/BIOMED.52","DOIUrl":"https://doi.org/10.32392/BIOMED.52","url":null,"abstract":"Methodology: This was a correlational-type study with cross-sectional design and quantitative approach. The sampling was non-probabilistic and the sample was comprised of 103 couples from five Colombian cities. The women received the Sexual Functioning Questionnaire-Women (SFQ-W); and the version for the sex partners, denominated Sexual Functioning Questionnaire-Men (SFQ-M) by Syrjala KL et al. For the variable Impact of treatments, the study used the subscale Impact of treatments version for women and men by Syrjala KL et al., 2000, with prior informed consent.","PeriodicalId":93816,"journal":{"name":"SPG biomed","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87525214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MYCN overexpression is linked to significant differences in nuclear DNA organization in neuroblastoma MYCN过表达与神经母细胞瘤中细胞核DNA组织的显著差异有关
SPG biomed Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.63.3
A. Rangel-Pozzo, A. Kuzyk, J. Gartner, S. Mai
{"title":"MYCN overexpression is linked to significant differences in nuclear DNA organization in neuroblastoma","authors":"A. Rangel-Pozzo, A. Kuzyk, J. Gartner, S. Mai","doi":"10.32392/BIOMED.63.3","DOIUrl":"https://doi.org/10.32392/BIOMED.63.3","url":null,"abstract":"Neuroblastomas are the most common extracranial cancers in children. They have a complex morphology and heterogeneous clinical course. Amplification of the MYCN oncogene is seen in 50% of high-risk neuroblastomas and is associated with a poor clinical outcome with a higher rate of progression and relapse when compared with tumors without MYCN amplification. MYCN amplification drives genomic instability, dynamic remodeling of chromosomes and changes in nuclear organization. However, understanding of how the chromatin structure responds to MYC overexpression in neuroblastoma is nebulous. In the present study, we examined neuroblastoma samples with and without MYCN amplification as well as in the neuroblastoma cell line SH-EP transfected with MYCN pUHD. Our neuroblastoma cases segregated into one of three prognostic clusters of increasingly poor prognosis. Clusters I and II encompassed tumors with no MYCN amplification, while cluster III included tumors with MYCN amplification. Measurements of both the DNA structure (p<0.001) and structure of the DNA-free space (p < 0.001) showed significant DNA structural alterations associated with MYCN amplification indicating that there is a progressive disruption of nuclear DNA organization with MYCN amplification suggesting that MYCN may play an functional role in determining the nuclear structure in neuroblastoma.","PeriodicalId":93816,"journal":{"name":"SPG biomed","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89304641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Acute Mesenteric Ischemi a (AMI): A surgical perspective 急性肠系膜缺血a (AMI):外科视角
SPG biomed Pub Date : 2019-01-01 DOI: 10.32392/biomed.28.1
Nissar Shaikh, Sayed Ali, Z. Aftab, U. Amara, Arshad H. Chanda, M. Zubair, Jazib Hassan, Ahmed Jalil, M. Nayeemuddin, M. Khan, Inamullah, A. Tharayil, A. Vegesna
{"title":"Acute Mesenteric Ischemi a (AMI): A surgical perspective","authors":"Nissar Shaikh, Sayed Ali, Z. Aftab, U. Amara, Arshad H. Chanda, M. Zubair, Jazib Hassan, Ahmed Jalil, M. Nayeemuddin, M. Khan, Inamullah, A. Tharayil, A. Vegesna","doi":"10.32392/biomed.28.1","DOIUrl":"https://doi.org/10.32392/biomed.28.1","url":null,"abstract":"","PeriodicalId":93816,"journal":{"name":"SPG biomed","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83731138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Immunological and clinical evaluation of Triticum aestivum aeroallergens in asthmatic patients 哮喘患者小麦气敏原的免疫学和临床评价
SPG biomed Pub Date : 2019-01-01 DOI: 10.32392/biomed.45
S. Sara, Ashraf Komal, Malka M. Samra, Muhammad Shahzad, Muhammad Yusuf, M. Athar, M. Basra
{"title":"Immunological and clinical evaluation of Triticum aestivum aeroallergens in asthmatic patients","authors":"S. Sara, Ashraf Komal, Malka M. Samra, Muhammad Shahzad, Muhammad Yusuf, M. Athar, M. Basra","doi":"10.32392/biomed.45","DOIUrl":"https://doi.org/10.32392/biomed.45","url":null,"abstract":"Methods: To characterize the protein fractions in wheat flour, responsible for aeroallergy in the asthmatic patients, twelve out of forty-five asthmatic patients were screened. These patients were sensitive to wheat and suspected of having wheat aero-allergy by their clinical allergic history, positive skin prick test and enzyme-linked immunosorbent assay (ELISA). Total level of protein in water salt soluble wheat extract was estimated through Lowry’s method. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) was used for the separation of protein fractions in wheat and immunoblotting assay was carried out to target the protein fractions responsible for aero-allergy in screened asthmatic patients.","PeriodicalId":93816,"journal":{"name":"SPG biomed","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89322508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of efflux bomb and the transmural potential difference in the permeation of azidothymidine across the small intestine of the rat 外排弹和跨壁电位差对叠氮胸苷在大鼠小肠内渗透的影响
SPG biomed Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.49
V. Amaral, A. Rios, D. Baldo, Juliana Ferreira de Souza, Kessi Crescencio, F. Batain, M. Gremião, T. Alves, M. Chaud
{"title":"The effect of efflux bomb and the transmural potential difference in the permeation of azidothymidine across the small intestine of the rat","authors":"V. Amaral, A. Rios, D. Baldo, Juliana Ferreira de Souza, Kessi Crescencio, F. Batain, M. Gremião, T. Alves, M. Chaud","doi":"10.32392/BIOMED.49","DOIUrl":"https://doi.org/10.32392/BIOMED.49","url":null,"abstract":"","PeriodicalId":93816,"journal":{"name":"SPG biomed","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90459924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Approach to the Cure of HIV using Cord Blood Hematopoietic Cell Transplantation 脐带血造血细胞移植治疗HIV的研究
SPG biomed Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.48.3
L. Petz
{"title":"An Approach to the Cure of HIV using Cord Blood Hematopoietic Cell Transplantation","authors":"L. Petz","doi":"10.32392/BIOMED.48.3","DOIUrl":"https://doi.org/10.32392/BIOMED.48.3","url":null,"abstract":"The cure was reported in the New England Journal of Medicine in 2009 by Dr. Gero Hütter and associates from Germany (1). The patient, Timothy Brown, had acute myeloid leukemia and HIV infection and is now referred to as “The Berlin Patient”. It was well known at that time that HIV-1 enters host cells by binding to a CD4 receptor and then interacting with either CCR5 or the CXC chemokine receptor (CXCR4). Homozygosity for a 32-bp deletion (delta32/delta32; CCR5-/-) in the CCR5 allele results in an inactive CCR5 gene product and consequently confers high resistance against HIV-1 infection. Following transplantation using stem cells from an adult donor who had the CCR5-/mutation, HIV could not be detected in Timothy Brown’s peripheral blood, spinal fluid, lymph nodes, bone marrow, brain or GI mucosa as assessed with RNA and proviral DNA PCR assays. Further, there has been no recurrence of HIV in more than 10 years. Thus, the “Berlin Patient” has had a functional cure if not a sterilizing cure of HIV.","PeriodicalId":93816,"journal":{"name":"SPG biomed","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91368157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somatic Pluripotent Genes in Tissue Repair, Developmental Disease, and Cancer. 组织修复、发育性疾病和癌症中的体细胞多能性基因。
SPG biomed Pub Date : 2018-01-01 Epub Date: 2018-10-28 DOI: 10.32392/biomed.18
Hannah Wollenzien, Ellen Voigt, Michael S Kareta
{"title":"Somatic Pluripotent Genes in Tissue Repair, Developmental Disease, and Cancer.","authors":"Hannah Wollenzien,&nbsp;Ellen Voigt,&nbsp;Michael S Kareta","doi":"10.32392/biomed.18","DOIUrl":"https://doi.org/10.32392/biomed.18","url":null,"abstract":"<p><p>Embryonic stem cells possess the ability to differentiate into all cell types of the body. This pliable developmental state is achieved by the function of a series of pluripotency factors, classically identified as <i>OCT4</i>, <i>SOX2</i>, and <i>NANOG</i>. These pluripotency factors are responsible for activating the larger pluripotency networks and the self-renewal programs which give ES cells their unique characteristics. However, during differentiation pluripotency networks become downregulated as cells achieve greater lineage specification and exit the cell cycle. Typically the repression of pluripotency is viewed as a positive factor to ensure the fidelity of cellular identity by restricting cellular pliancy. Consistent with this view, the expression of pluripotency factors is greatly restricted in somatic cells. However, there are examples whereby cells either maintain or reactivate pluripotency factors to preserve the increased potential for the healing of wounds or tissue homeostasis. Additionally there are many examples where these pluripotency factors become reactivated in a variety of human pathologies, particularly cancer. In this review, we will summarize the somatic repression of pluripotency factors, their role in tissue homeostasis and wound repair, and the human diseases that are associated with pluripotency factor misregulation with an emphasis on their role in the etiology of multiple cancers.</p>","PeriodicalId":93816,"journal":{"name":"SPG biomed","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548517/pdf/nihms-1006621.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40549787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Learning from life-logging data by hybrid HMM: a case study on active states prediction 基于混合HMM的生命测井数据学习:动态状态预测案例研究
SPG biomed Pub Date : 2016-02-20 DOI: 10.2316/P.2016.832-019
Ji Ni, T. Lambrou, Xujiong Ye
{"title":"Learning from life-logging data by hybrid HMM: a case study on active states prediction","authors":"Ji Ni, T. Lambrou, Xujiong Ye","doi":"10.2316/P.2016.832-019","DOIUrl":"https://doi.org/10.2316/P.2016.832-019","url":null,"abstract":"In this paper, we have proposed employing a hybrid classifier-hidden Markov model (HMM) as a supervised learning approach to recognize daily active states from sequential life-logging data collected from wearable sensors. We generate synthetic data from real dataset to cope with noise and incompleteness for training purpose and, in conjunction with HMM, propose using a multiobjective genetic programming (MOGP) classifier in comparison of the support vector machine (SVM) with variant kernels. We demonstrate that the system with either algorithm works effectively to recognize personal active states regarding medical reference. We also illustrate that MOGP yields generally better results than SVM without requiring an ad hoc kernel.","PeriodicalId":93816,"journal":{"name":"SPG biomed","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91398141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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