Nutraceuticals最新文献_第9页

Anti-Inflammatory and Neuroprotective Effect of the Anti-Obesity Dietary Supplement Dekosilhue® in an In Vitro Model of Neuroinflammation 抗肥胖膳食补充剂Dekosilhue®在神经炎症体外模型中的抗炎和神经保护作用

Nutraceuticals Pub Date : 2022-02-08 DOI: 10.3390/nutraceuticals2010002

V. Borgonetti, L. Cenci, N. Galeotti

{"title":"Anti-Inflammatory and Neuroprotective Effect of the Anti-Obesity Dietary Supplement Dekosilhue® in an In Vitro Model of Neuroinflammation","authors":"V. Borgonetti, L. Cenci, N. Galeotti","doi":"10.3390/nutraceuticals2010002","DOIUrl":"https://doi.org/10.3390/nutraceuticals2010002","url":null,"abstract":"Obesity is now recognized as a global health problem and has reached epidemic proportions, affecting both developed and developing countries. This condition is associated with an increased incidence in central nervous system (CNS) disorders. The intake of foods or supplements with anti-inflammatory activity could potentially lead to a lower impact of obesity on the functionality of CNS. Therefore, in this work we tested the effect of a dietary supplement, DEKOSILHUE® (DSK), containing polyphenols enriched herbal extracts and successfully used for improving the control of body weight, in an in vitro inflammatory model. LPS-stimulated immortalized microglia BV2 cells have been used as a model of neuroinflammation. The stimulation with LPS increased the release and activation of several neuroinflammatory mediators, such as IKB⍺, HDAC-1, and IL-1ß. DSK reduced the levels and the activation of all these pro-inflammatory markers. In addition, DSK increased the expression of the anti-inflammatory cytokine IL-10, promoting an anti-inflammatory response. Finally, we showed that the anti-inflammatory effect of DSK can prevent the neurotoxicity related to microglia hyperactivation. In conclusion, DSK could potentially help in controlling neuroinflammation CNS, reducing microglia pro-inflammatory activation.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47884002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulation of Rosemary Extracts through Spray-Drying Encapsulation or Emulsification 喷雾干燥包埋或乳化制备迷迭香提取物

Nutraceuticals Pub Date : 2022-01-20 DOI: 10.3390/nutraceuticals2010001

Lamprini-Danai Kanakidi, Dimitrios Tsimogiannis, Sotirios N. Kiokias, V. Oreopoulou

{"title":"Formulation of Rosemary Extracts through Spray-Drying Encapsulation or Emulsification","authors":"Lamprini-Danai Kanakidi, Dimitrios Tsimogiannis, Sotirios N. Kiokias, V. Oreopoulou","doi":"10.3390/nutraceuticals2010001","DOIUrl":"https://doi.org/10.3390/nutraceuticals2010001","url":null,"abstract":"Natural, plant-derived antioxidants can be used to prolong the shelf life of food or cosmetics, or as health-promoting additives. Although their extraction from plants has been extensively studied, purification and formulation processes need further research to allow their exploitation. In the present work, rosemary extracts were obtained by successive extractions with acetone and water or single extraction by either an acetone:water or ethanol:water mixture. The extracts were analyzed by HPLC-DAD, and rosmarinic acid, carnosic acid, carnosol, and several flavonoids were identified and quantified. The extracts obtained by water or aqueous mixtures of organic solvents were encapsulated in maltodextrin combined with gum arabic with a high encapsulation yield (90–100%) and efficiency (97%) for rosmarinic acid and flavonoids. The acetone extract, rich in carnosic acid, was transformed to oil solution and either encapsulated or formulated in emulsion. The shelf life of encapsulated products was tested over a period of six months, and the results showed high retention of rosmarinic acid (88%) and lower of flavonoids (54–80%). Carnosic acid presented lower retention either encapsulated in solid powder (65–70% after one month at ambient temperature) or in emulsion (48% after 20 days of storage at 15 °C), while it was partially transformed to carnosol.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47607219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Genotoxicity and Carcinogenicity of Medicinal Herbs and Their Nanoparticles 中草药及其纳米粒子的遗传毒性和致癌性

Nutraceuticals Pub Date : 2021-11-18 DOI: 10.3390/nutraceuticals1010005

Sameer H. Qari, A. Alrefaei, Ahmed Ashour, M. Soliman

{"title":"Genotoxicity and Carcinogenicity of Medicinal Herbs and Their Nanoparticles","authors":"Sameer H. Qari, A. Alrefaei, Ahmed Ashour, M. Soliman","doi":"10.3390/nutraceuticals1010005","DOIUrl":"https://doi.org/10.3390/nutraceuticals1010005","url":null,"abstract":"Medicinal plants (MPs) account for 70–80% of use in primary care around the world, and this percentage indicates that the number of MP users is high; thus, it is necessary to focus studies on medicinal herbs to ensure their proper use. In addition, MPs have strong genotoxic effects, as some types of MPs can cause DNA damage. Any substance that raises the risk of cancer or a tumor in an organism is called a carcinogen. There are many genotoxic and carcinogenic substances in the environment that can directly or indirectly affect genetic material. There are also nanoparticles (NPs) derived from MPs. Carbon-based NPs contain many nanoscale materials, such as fullerenes and carbon nanotubes, as well as metals such as gold (Au), silver (Ag), and aluminum (Al). Unfortunately, few studies are concerned with the carcinogenicity of NPs from MPs, whereas many researchers are interested in genotoxic assessment. For this reason, there is an urgent need for more studies into the safety of MPs and NPs. Therefore, this study reviewed the genotoxicity and carcinogenicity of MPs and their derived NPs. We also emphasized the need for strict regulation and monitoring of MP usage.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46764462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Friends or Foes? Cytotoxicity, HPTLC and NMR Analyses of Some Important Naturally Occurring Hydroxyanthraquinones 朋友还是敌人?一些重要的天然羟基蒽醌类化合物的细胞毒性、HPTLC和NMR分析

Nutraceuticals Pub Date : 2021-10-18 DOI: 10.3390/nutraceuticals1010004

Bassam S. M. Al Kazman, J. Prieto

{"title":"Friends or Foes? Cytotoxicity, HPTLC and NMR Analyses of Some Important Naturally Occurring Hydroxyanthraquinones","authors":"Bassam S. M. Al Kazman, J. Prieto","doi":"10.3390/nutraceuticals1010004","DOIUrl":"https://doi.org/10.3390/nutraceuticals1010004","url":null,"abstract":"Hydroxyanthraquinones from plants have been used as both medicinal active ingredients and adulterants in slimming food supplements. Although sensible doses of certain natural hydroxyanthraquinones for laxative effects are generally safe in the short term, chronic intake has been related to tumorigenic, carcinogenic, and genotoxic effects. However, an increasing number of researchers are reporting the antiproliferative properties of the same ingredients in cancer cells, pointing towards a potential nutraceutical value for cancer prevention. Previous studies have evaluated anthraquinones’ anti-proliferative activity against various tumour cell lines and bioavailability in Caco-2 cells. However, there are scarce data about both their cytotoxicity in the later cell line and long-term stability. Therefore, this study will check the purity of several ‘aged’ samples using mutually complementary analytical techniques such as HPTLC and NMR assays as well as evaluate the anti-proliferative activity of the purest of these samples using the Caco-2 cell line. The chromatographic and spectroscopic analyses confirmed the long-term stability of those compounds, and their cytotoxic activity resulted in chrysazin (15 µg/mL) > catenarin (27.29 µg/mL) > rhein (49.55 µg/mL) > helminthosporin (52.91 µg/mL) > aloe-emodin (55.34 µg/mL). Our succinct review of the cytotoxicity of these compounds afforded two results: that this is the first clear report for catenarin being active in colon cancer cells and that this class of compounds needs to be better studied to clearly evaluate their benefit/risk profile in regard to both new chemo preventative nutraceuticals and anticancer therapies.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44266030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Publisher’s Note: Nutraceuticals Is Launched 发行商注:Nutraceuticals上市

Nutraceuticals Pub Date : 2021-09-17 DOI: 10.3390/nutraceuticals1010003

Shu-Kun Lin

引用次数: 0

Effects of Zembrin® (Sceletium tortuosum) Supplementation on Mood, Soreness, and Performance Following Unaccustomed Resistance Exercise: A Pilot Study Zembrin®（Sceletium tortuosum）补充剂对不习惯阻力运动后情绪、疼痛和表现的影响：一项初步研究

Nutraceuticals Pub Date : 2021-09-16 DOI: 10.3390/nutraceuticals1010002

Angela C. Berry, H. Langley, R. Rogers, Courteney L. Benjamin, Tyler D. Williams, C. Ballmann

{"title":"Effects of Zembrin® (Sceletium tortuosum) Supplementation on Mood, Soreness, and Performance Following Unaccustomed Resistance Exercise: A Pilot Study","authors":"Angela C. Berry, H. Langley, R. Rogers, Courteney L. Benjamin, Tyler D. Williams, C. Ballmann","doi":"10.3390/nutraceuticals1010002","DOIUrl":"https://doi.org/10.3390/nutraceuticals1010002","url":null,"abstract":"The purpose of this study was to investigate acute Zembrin® (Sceletium tortuosum) supplementation on muscle soreness, markers of muscle damage, mood, and exercise performance following unaccustomed resistance exercise. Untrained females (n = 16) were divided into two groups with a different three-day treatment regimen: (1) placebo (PL) and (2) Zembrin® (ZEM). During the initial visit, baseline perceived soreness, range of motion (ROM), mood state (profile of mood states (POMS) questionnaire), and plasma lactate dehydrogenase concentrations (LDH) were measured followed by the performance of an eccentric bicep curl protocol with their non-dominant arm. The total repetitions and rate of perceived exertion (RPE) were recorded throughout the exercise. The participants then supplemented with the corresponding treatment immediately following, the subsequent day, and 30 min prior to completing a 48 h follow-up visit. For the 48 h visit, all procedures were repeated and comparisons were drawn for perceived soreness, ROM, LDH, mood scores, total repetitions, and RPE. The findings indicate that short-term ZEM supplementation resulted in lower perceived soreness (p = 0.020) and a greater preservation of ROM (p = 0.028) at 48 h versus the PL group. Mood worsened from the baseline to 48 h regardless of the treatment (p = 0.043) but the decrements were exacerbated in the PL group compared with the ZEM group (p < 0.001). LDH levels (p = 0.019) and RPE (p = 0.008) were higher and total repetitions were lower (p < 0.001) at 48 h irrespective of the treatment. Although short-term dietary enrichment with ZEM did not alter the exercise performance or biomarkers of muscle damage, the current results suggest ZEM supplementation may be effective in reducing the markers of soreness and preserve mood following unaccustomed eccentric exercise.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49079158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Update on Nutraceuticals 营养药品最新消息

Nutraceuticals Pub Date : 2021-09-16 DOI: 10.3390/nutraceuticals1010001

L. Tesoriere

引用次数: 1

Genomic and proteomic mechanisms and models in toxicity and safety evaluation of nutraceuticals 营养药品毒性和安全性评价的基因组和蛋白质组学机制和模型

Nutraceuticals Pub Date : 2021-01-01 DOI: 10.1016/B978-0-12-821038-3.00021-5

Christina R. Wilson-Frank

引用次数: 0

German chamomile 德国洋甘菊

Nutraceuticals Pub Date : 2021-01-01 DOI: 10.1016/b978-0-12-821038-3.00044-6

R. Kolanos, S. Stice