Nutraceuticals最新文献_第7页

Study of the Antioxidant Potential of UV-Treated Vegetables 紫外线处理蔬菜抗氧化能力的研究

Nutraceuticals Pub Date : 2022-10-14 DOI: 10.3390/nutraceuticals2040022

S. Ivanova, A. Prosekov

引用次数: 0

Development of Quercetin-DHA Ester-Based Pectin Conjugates as New Functional Supplement: Effects on Cell Viability and Migration 槲皮素- dha酯基果胶缀合物的新功能补充:对细胞活力和迁移的影响

Nutraceuticals Pub Date : 2022-10-11 DOI: 10.3390/nutraceuticals2040021

G. Carullo, U. G. Spizzirri, R. Malivindi, V. Rago, Marisa Francesca Motta, D. Lofaro, D. Restuccia, F. Aiello

{"title":"Development of Quercetin-DHA Ester-Based Pectin Conjugates as New Functional Supplement: Effects on Cell Viability and Migration","authors":"G. Carullo, U. G. Spizzirri, R. Malivindi, V. Rago, Marisa Francesca Motta, D. Lofaro, D. Restuccia, F. Aiello","doi":"10.3390/nutraceuticals2040021","DOIUrl":"https://doi.org/10.3390/nutraceuticals2040021","url":null,"abstract":"A quercetin derivative with remarkable biological performance was successfully synthesized by chemical modification of the flavonoid with docosahexaenoic acid to synthesize 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate (3), deeply characterized by NMR spetroscopy. Modified quercetin and pectin were involved in a grafting process by an ecofriendly radical procedure able to preserve the biological features of the quercetin derivative. Antioxidant performances of the conjugate were evaluated both in term of total phenolic amount and scavenger activity in organic and aqueous environments. Additionally, in vitro acute oral toxicity was also tested against Caco-2 cells and 3T3 fibroblasts, confirming that pectin conjugate does not have any effect on cell viability at the dietary use concentrations. Finally, in vitro experiments highlighted the ability of the conjugate to counteract the migratory properties of Caco-2 and HepG2 cells, indicating its feature in the reduction of the migration of tumour cells. These data showed that the covalent binding of the quercetin derivative to the pectin chain represents a very interesting strategy to improve the bioavailability of the quercetin, representing an effective means of protecting and to transporting polyphenol molecules.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46473978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Nutritional Supplements and Lipedema: Scientific and Rational Use 营养补充剂与唇水肿的科学合理使用

Nutraceuticals Pub Date : 2022-10-03 DOI: 10.3390/nutraceuticals2040020

Roberto Cannataro, E. Cione

引用次数: 0

Plant Seed Mucilage—Great Potential for Sticky Matter 植物种子粘液——极具潜力的粘性物质

Nutraceuticals Pub Date : 2022-09-26 DOI: 10.3390/nutraceuticals2040019

Matúš Kučka, K. Ražná, Ľubomír Harenčár, Terézia Kolarovičová

{"title":"Plant Seed Mucilage—Great Potential for Sticky Matter","authors":"Matúš Kučka, K. Ražná, Ľubomír Harenčár, Terézia Kolarovičová","doi":"10.3390/nutraceuticals2040019","DOIUrl":"https://doi.org/10.3390/nutraceuticals2040019","url":null,"abstract":"Some seeds of flowering plants can differentiate their seed coat epidermis into the specialized cell layer producing a hydrophilic mucilage with several ecological functions, such as seed hydration, protection, spatial fixation, stimulation of metabolic activity and development of seed. Due to the species- and genotype-dependent variabilities in the chemical composition of mucilage, mucilage does not display the same functional properties and its role depends on the respective species and environment. Mucilaginous substances, depending on their composition, exhibit many preventive and curative effects for human and animal health, which has significant potential in the agricultural, food, cosmetic and pharmaceutical industries. This paper summarizes the ecological, biological, and functional properties of mucilaginous plant substances and highlights their significant nutritional potential in terms of the development of functional foods, and nutraceuticals and dietary supplements. A paragraph describing the gene regulation of seed mucilage synthesis is included, and some recommendations for the direction of further research on mucilaginous substances are outlined.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42374724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antiproliferative Effect of Plant-Derived Bioactive Compounds Endowed with Antioxidant Activity on Breast Cancer Cells 具有抗氧化活性的植物衍生生物活性化合物对乳腺癌症细胞的抗增殖作用

Nutraceuticals Pub Date : 2022-09-17 DOI: 10.3390/nutraceuticals2030018

Valeria Consoli, V. Sorrenti, Ilaria Burò, M. Modica, L. Vanella

引用次数: 1

A Comprehensive and Comparative Metabolomic Study of Two Nutraceutical-Containing Plants; Moringa oleifera and Solanum lycopersicum: A Review 两种含营养药物的植物的综合比较代谢组学研究；辣木和番茄：综述

Nutraceuticals Pub Date : 2022-09-16 DOI: 10.3390/nutraceuticals2030017

T. Mokgehle, D. Ndou, N. Madala, N. Tavengwa

引用次数: 0

Evaluation of the In Vitro Bioactivities’ Profiles of Brewers’ Spent Grain Protein and Hydrolysates with and without Cellulase Pretreatment 纤维素酶预处理和非纤维素酶预处理啤酒糟蛋白和水解物的体外生物活性评价

Nutraceuticals Pub Date : 2022-09-08 DOI: 10.3390/nutraceuticals2030016

Jiao Zhang, Ariane Perez-Gavilan, A. C. Neves

{"title":"Evaluation of the In Vitro Bioactivities’ Profiles of Brewers’ Spent Grain Protein and Hydrolysates with and without Cellulase Pretreatment","authors":"Jiao Zhang, Ariane Perez-Gavilan, A. C. Neves","doi":"10.3390/nutraceuticals2030016","DOIUrl":"https://doi.org/10.3390/nutraceuticals2030016","url":null,"abstract":"Brewer’s spent grain is the residue left after the separation of wort during the beer-brewing process. Although this by-product has been reported to have a high protein content, it is normally treated as waste. This work aims to isolate bioactive hydrolysates from BSG, and then explore their bioactivities. Two groups (A and B) of BSG were subjected to protein extraction using the alkaline extraction method at pH 12, where group A was pre-treated with cellulase, while group B was not pre-treated and was directly extracted. The final isolate yielded 50.18 ± 1.22% recovery of the BSGP from group A and 66.41 ± 0.37% recovery from group B. RP-HPLC profiles showed that the extracted BSGPs are mainly hydrophilic proteins. The proteins extracted by the two methods were hydrolyzed enzymatically using Alcalase and α-chymotrypsin. The hydrolysates obtained displayed blood pressure regulation activity and antioxidant properties, when assayed with angiotensin-converting enzyme assay, 2,2-diphenyl-picryl-hydrazyl assay, and ferric antioxidant power assay. It can be concluded that it is possible to extract good quality proteins from BSG and this by-product presents potential as a source for the extraction of a variety of proteins that might be of interest to the food industries.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47791182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Apple Puree as a Natural Fructose Source Provides an Effective Alternative to Artificial Fructose Sources for Fuelling Endurance Cycling Performance in Males 苹果浆作为一种天然果糖来源，为提高雄性耐力循环性能提供了一种替代人工果糖来源的有效方法

Nutraceuticals Pub Date : 2022-08-22 DOI: 10.3390/nutraceuticals2030015

Kirsty M. Reynolds, Loris A. Juett, James Cobb, C. Hulston, S. Mears, L. James

{"title":"Apple Puree as a Natural Fructose Source Provides an Effective Alternative to Artificial Fructose Sources for Fuelling Endurance Cycling Performance in Males","authors":"Kirsty M. Reynolds, Loris A. Juett, James Cobb, C. Hulston, S. Mears, L. James","doi":"10.3390/nutraceuticals2030015","DOIUrl":"https://doi.org/10.3390/nutraceuticals2030015","url":null,"abstract":"Carbohydrate consumption during exercise enhances endurance performance. A food-focused approach may offer an alternative, ‘healthier’ approach given the potential health concerns associated with artificial fructose sources, but food-based carbohydrate sources may increase gastrointestinal (GI) symptoms. This study compared the cycling performance and GI comfort of two different fructose sources (fruit and artificial) ingested during exercise. Nine trained male cyclists (age 24 ± 7 years; VO2peak 65 ± 6 mL/kg/min) completed a familiarisation and two experimental trials (60 g/h carbohydrate, 120 min at 55% Wmax and ~15 min time trial). In the two experimental trials, carbohydrate was ingested in a 2:1 glucose-to-fructose ratio, with fructose provided as artificial crystalline fructose (GLU/FRU) or natural apple puree (APPLE PUREE) and maltodextrin added to provide sufficient glucose. Time trial (TT) performance was not different between trials (GLU/FRU 792 ± 68 s, APPLE PUREE 800 ± 65 s; p = 0.313). No GI symptoms were significantly different between trials (p ≥ 0.085). Heart rate, blood glucose/lactate concentrations, and RPE were not different between trials, but all, excluding blood glucose concentration, increased from rest to exercise and further increased post-TT. Apple puree as a natural fructose source provides an alternative to artificial fructose sources without influencing cycling performance or GI symptoms.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43177540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Food Antioxidants and Aging: Theory, Current Evidence and Perspectives 食品抗氧化剂与衰老：理论、现有证据和展望

Nutraceuticals Pub Date : 2022-08-03 DOI: 10.3390/nutraceuticals2030014

Taiki Miyazawa, Chizumi Abe, G. Burdeos, Akira Matsumoto, Masako Toda

引用次数: 7

Anti-Allergic Effect of Aqueous Extract of Coriander (Coriandrum sativum L.) Leaf in RBL-2H3 Cells and Cedar Pollinosis Model Mice 芫荽水提物的抗过敏作用RBL-2H3细胞与雪松授粉模型小鼠叶片的关系

Nutraceuticals Pub Date : 2022-07-26 DOI: 10.3390/nutraceuticals2030013

Yurika Kitamura, K. Nishi, M. Ishida, S. Nishimoto, T. Sugahara

{"title":"Anti-Allergic Effect of Aqueous Extract of Coriander (Coriandrum sativum L.) Leaf in RBL-2H3 Cells and Cedar Pollinosis Model Mice","authors":"Yurika Kitamura, K. Nishi, M. Ishida, S. Nishimoto, T. Sugahara","doi":"10.3390/nutraceuticals2030013","DOIUrl":"https://doi.org/10.3390/nutraceuticals2030013","url":null,"abstract":"Coriander (Coriandrum sativum L.) is classified in the Apiaceae family and used as an herb. Coriander leaf has been reported to possess various health functions. Here, we report the anti-allergic effect of aqueous coriander leaf extract (ACLE). ACLE with 1.0 mg/mL or higher concentration significantly inhibited degranulation of RBL-2H3 cells in a concentration-dependent manner with no cytotoxicity. ACLE suppressed the increase in the intracellular Ca2+ concentration in response to antigen-specific stimulation. Immunoblot analysis demonstrated that ACLE significantly downregulates phosphorylation of phosphatidylinositol 3-kinase and tends to downregulate phosphorylation of Syk kinase in the signaling pathways activated by antigen-mediated stimulation. Oral administration of ACLE did not alter the sneezing frequency of pollinosis model mice stimulated with cedar pollen, but significantly reduced the serum IgE level. Our data show anti-allergic effects of coriander leaf in both cultured cells and pollinosis mice. These results suggest that coriander leaf has the potential to be a functional foodstuff with anti-allergy effects.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47808310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3