Journal of endocrinological science最新文献_第2页

Commentary: Emerging role of GIP and related gut hormones in fertility and PCOS 评论:GIP和相关肠道激素在生育和多囊卵巢综合征中的新作用

Journal of endocrinological science Pub Date : 2020-07-15 DOI: 10.29245/2767-5157/2020/1.1109

D. Khan, R. C. Moffett

{"title":"Commentary: Emerging role of GIP and related gut hormones in fertility and PCOS","authors":"D. Khan, R. C. Moffett","doi":"10.29245/2767-5157/2020/1.1109","DOIUrl":"https://doi.org/10.29245/2767-5157/2020/1.1109","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with infertility which affects one in ten women in the United Kingdom. Women with PCOS are typified by insulin resistance, gestational diabetes and obesity. Therefore, a close association between reproductive function and nutrition is postulated. However, regulatory pathways common to energy and reproductive function have received little attention. Recent research shows rapid amelioration of infertility, PCOS and type 2 diabetes following Roux-en-Y bariatric surgery (RYGB). This occurs prior to weight loss suggesting involvement of gut derived factors. Therefore, gut hormones emerge as key players in the regulation of both energy homeostasis and possibly reproductive function. Alteration of gut peptide levels including GLP-1, GIP, PYY, ghrelin, NPY and neurotensin post-bariatric surgery suggest a plausible mechanism behind beneficial effects of RYGB. Furthermore, expression of gut peptide receptors within the reproductive axis strengthen the idea of involvement of these hormones in the remission of fertility post-surgery. The present commentary discusses the role of these important gut peptides and their receptors in the regulation of female reproductive system in the light of a recent article published by our laboratory. Understanding the functional relationship between the gut and reproductive axis will help us to identify novel and less invasive alternatives to bariatric surgeries for reproductive and related metabolic disorders.","PeriodicalId":93655,"journal":{"name":"Journal of endocrinological science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43190599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Adherence to Mediterranean Diet and Nutritional Status: Impact on Clinical Outcomes in Hospitalized Elderly Patients 坚持地中海饮食和营养状况:对住院老年患者临床结果的影响

Journal of endocrinological science Pub Date : 2020-05-27 DOI: 10.29245/2767-5157/2020/1.1108

A. L. Buglio, F. Bellanti, G. Vendemiale

引用次数: 1

Remarkable Improvement in Plaque Psoriasis with a 4 week Short Course Liraglutide Therapy in an Obese Type 2 DM Patient 利拉鲁肽4周短程治疗肥胖2型糖尿病患者斑块状银屑病疗效显著改善

Journal of endocrinological science Pub Date : 2020-04-15 DOI: 10.29245/2767-5157/2020/1.1106

S. Ramakrishnan, Mohammed Yousuf Khan, Anantharaman Ramakrishnan, Shanmugasundar Gopal, Rohit S. Warrier

引用次数: 0

Thyroid Nodules in Children and Adolescents: Mini-review 儿童和青少年甲状腺结节：小型综述

Journal of endocrinological science Pub Date : 2020-03-29 DOI: 10.29245/2767-5157/2020/1.1110

Catherine E. Kerr, Sarah D. Hackman, Gary L. Francis

引用次数: 10

Hydroxychloroquine (HCQS) for glycaemic control: a remarkable turnaround in a patient with Type 2 DM 羟氯喹(HCQS)用于血糖控制:2型糖尿病患者的显著转变

Journal of endocrinological science Pub Date : 2020-03-02 DOI: 10.29245/2767-5157/2020/1.1104

S. Ramakrishnan, Anantharaman Ramakrishnan, Rohit S. Warrier, Shanmugasundar Gopal

引用次数: 0

A Study of Blood Pressure in Relation to the Light/Dark Variations of the Cardiac Hormone Atrial Natriuretic Peptide and the Pineal Hormone Melatonin in Adult and Old Population 成年和老年人血压与心脏激素、心钠肽和松果体激素褪黑激素明暗变化关系的研究

Journal of endocrinological science Pub Date : 2019-08-01 DOI: 10.29245/2767-5157/2019/1.1103

P. Lissoni

{"title":"A Study of Blood Pressure in Relation to the Light/Dark Variations of the Cardiac Hormone Atrial Natriuretic Peptide and the Pineal Hormone Melatonin in Adult and Old Population","authors":"P. Lissoni","doi":"10.29245/2767-5157/2019/1.1103","DOIUrl":"https://doi.org/10.29245/2767-5157/2019/1.1103","url":null,"abstract":"Several clinical studies have shown that blood pressure (BP) declines during the night in the healthy subjects, and that BP circadian rhythm tends to disappear with age. The mechanisms responsible for BP circadian rhythm and its aging-dependent loss need to be further understood. At present, it is already known that the two main hormones provided by hypotensive activity, consisting of the cardiac hormone atrial natriuretic peptide (ANP) and the pineal indole hormone melatonin (MLT), are mainly produced during the night, whereas hypertensive hormones, such as cortisol, are mainly produced during the early period of light phase. Then, the circadian variations of BP would be the consequence of changes in the neuroendocrine system. On this basis, a preliminary study was performed to establish which relation may exist among BP, ANP and MLT rhythms in the healthy subjects. The study included 20 65-year younger, and 20 65-year older healthy subjects. In 65-year younger subjects, both systolic and diastolic BP mean values significantly decreased during the night, whereas no significant difference occurred in the 65-older ones, because of BP values decreased in the night only in 13/20 (65) subjects. In addition, within the 65-year older group, both ANP and MLT night mean values were significantly higher in subjects with BP rhythm than in those, who had no BP daily variations. These preliminary results would suggest that age-dependent loss in the circadian rhythm of BP may be caused by the concomitant loss in the circadian secretion of at least two major hypotensive hormones, such as ANP and MLT.","PeriodicalId":93655,"journal":{"name":"Journal of endocrinological science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45526524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0