Research and advances in pharmacy and life sciences最新文献

Role of Lipids in Biological System 脂类在生物系统中的作用

Research and advances in pharmacy and life sciences Pub Date : 2022-11-17 DOI: 10.46610/rapls.2022.v04i02.005

Twinkle Gautam, Rashi Rai, Abhinav K. Srivastava

引用次数: 0

Validation and Development of Metformin obtained from the Extraction of Bougainvillea California Gold Flowers by UV Spectrophotometry, TLC and FTIR 紫外分光光度法、薄层色谱法和红外光谱法对九重葛加州金花提取物二甲双胍含量的验证与研究

Research and advances in pharmacy and life sciences Pub Date : 2022-08-02 DOI: 10.46610/rapls.2022.v04i02.002

Sunitha N., P. Paul, M. a, Sravya D., S. P., Jaswanth V., L. Y., M. S

{"title":"Validation and Development of Metformin obtained from the Extraction of Bougainvillea California Gold Flowers by UV Spectrophotometry, TLC and FTIR","authors":"Sunitha N., P. Paul, M. a, Sravya D., S. P., Jaswanth V., L. Y., M. S","doi":"10.46610/rapls.2022.v04i02.002","DOIUrl":"https://doi.org/10.46610/rapls.2022.v04i02.002","url":null,"abstract":"The project was considered to validate and develop an accurate, simple and precise, UV-Visible spectrophotometric, Thin Layer Chromatography (TLC) and Fourier transform Infrared Spectroscopy (FTIR) method for the estimation of Metformin present in extract of Bougainvillea California Gold flowers by using distilled water as solvent at a wavelength of 232 nm. The linearity of the metformin is 10-50 μg/ml with y = 0.0011x - 0.0006 as the regression equation r2 value was 0.9977. Recovery values for Metformin present in Bougainvillea California Gold flowers extract powder is found to 98.45% - 99.16%. The RSD % of intraday precision and intraday precision is 16.67 % and 61.53% respectively. LOQ and LOD values are 0.26 μg/ml and 0.0.08μg/mL respectively. The robustness %RSD values method was 64.38 – 64.66. Rf value of the extract was found to be 0.586 with 60:40 (methanol and water) in TLC. IR interpretation of both bougainvillea California gold flowers extract and Meformin were found to be similar. So the method was simple, precise, exact and economical. This method could be applicable for quantitative determination of the metformin in Bougainvillea California gold flowers extract.","PeriodicalId":93497,"journal":{"name":"Research and advances in pharmacy and life sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80937570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ring Chromosomes and Associated Disorders: A Review 环染色体及其相关疾病:综述

Research and advances in pharmacy and life sciences Pub Date : 2022-03-05 DOI: 10.46610/rapls.2022.v04i01.001

U. P. Singh, Anubha Gupta, Rajeev Kumar, Abhinav K. Srivastava

{"title":"Ring Chromosomes and Associated Disorders: A Review","authors":"U. P. Singh, Anubha Gupta, Rajeev Kumar, Abhinav K. Srivastava","doi":"10.46610/rapls.2022.v04i01.001","DOIUrl":"https://doi.org/10.46610/rapls.2022.v04i01.001","url":null,"abstract":"Ring chromosomes are formed due to rejoining or breaking in either one or both the chromosome arms. Any chromosome can form such structure and thus a specific ring chromosome will have an altogether distinct size and inherited content. Of intrigue are ring chromosomes 14 and X that have a remarkable relationship with epilepsy and seizure beginning in early years of life. Phenotypic characteristics associated with ring chromosomes are very much disparate and this may be due to any deletion caused by ring arrangement. Other reason may be the imbalances occurred due to ring instability. Extreme deficiency of development without major deformity is a very usual observation in the carrier of the ring chromosomes. Such phenotypic expressions are termed as \"ring disorder\" and they are strictly related with mitotic instability and ring behavior and does not dependent on the chromosome engaged. In case of ring chromosomes, it is not possible to exactly correlate genotype-phenotype because all the determining factors mostly variegate depending on the magnitude of deletion during ring development. Also, ring instability and the level of mosaicism add extra degree of pleomorphism. In spite of the fact that ring chromosomes generally emerge as de-novo events, filial transmission of rings from carrier to progeny is portrayed and pre-birth diagnosis for any pregnancies should be appraised.","PeriodicalId":93497,"journal":{"name":"Research and advances in pharmacy and life sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83805660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alkaloid Cytotoxic Test on Ethanol Extract from Itchy Leaves (Laportea decumana (Roxb.) Wedd.) 发痒叶乙醇提取物生物碱细胞毒试验Wedd)。

Research and advances in pharmacy and life sciences Pub Date : 2021-06-30 DOI: 10.46610/rapls.2021.v03i02.001

Septiani Mangiwa

引用次数: 0

The Sojourn Drain Effects on Tissue Healing in Postoperative Patients in Abdominal Surgeries: A Correlation of Prophylactic Antibiotic Administration and Complications 留置引流对腹部手术患者术后组织愈合的影响:预防性抗生素使用与并发症的相关性

Research and advances in pharmacy and life sciences Pub Date : 2021-04-15 DOI: 10.46610/RAPLS.2021.V03I01.003

R. Sethi, G. F. Avetisyan, Sanobar Shariff, Burhan Kantawala

引用次数: 0

An Approach to Improving Clinical Morale: Targeting a Positive Culture. 提高临床士气的方法：以积极文化为目标。

Research and advances in pharmacy and life sciences Pub Date : 2021-01-01

Jonathan Willman, Brandon Lucke-Wold

引用次数: 0