发布求助
文献互助 智能选刊 最新文献

Infectious diseases research最新文献

筛选
英文 中文
Oral Versus Intravenous Chemotherapy in COVID-19 Epidemic 2019冠状病毒病流行中的口服与静脉化疗
Infectious diseases research Pub Date : 2021-11-05 DOI: 10.54457/dr.202201001
Bicheng Wang, Boya Xiao
{"title":"Oral Versus Intravenous Chemotherapy in COVID-19 Epidemic","authors":"Bicheng Wang, Boya Xiao","doi":"10.54457/dr.202201001","DOIUrl":"https://doi.org/10.54457/dr.202201001","url":null,"abstract":"The novel coronavirus has a significant impact on the routine clinical practice for cancer patients in China since December 2019. During the epidemic in mainland China, especially Wuhan, the intravenous chemotherapies of cancer patients were considerably delayed. Up to now, cancer patients throughout the world directly encounter similar obstacles. For patients who have the right to choose chemotherapeutic regimens with different administration routes, oral drugs can be considered to be applied. In this mini-review, oral chemotherapeutic drugs were compared with intravenous drugs in seven types of tumors. Accordingly, we intended to provide useful suggestions for clinicians to balance the benefits and risks of oral against intravenous chemotherapies and to choose properly substituted oral chemotherapeutic regimens for cancer patients amid the coronavirus disease 2019 (COVID-19) pandemic.","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72429273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Progress of Adjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma 局部进展期鼻咽癌辅助化疗的临床进展
Infectious diseases research Pub Date : 2021-11-04 DOI: 10.54457/dr.202101001
Boya Xiao, Zhan-jie Zhang, Bohua Kuang, Ru-bo Cao, Bicheng Wang
{"title":"Clinical Progress of Adjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma","authors":"Boya Xiao, Zhan-jie Zhang, Bohua Kuang, Ru-bo Cao, Bicheng Wang","doi":"10.54457/dr.202101001","DOIUrl":"https://doi.org/10.54457/dr.202101001","url":null,"abstract":"Concurrent chemoradiotherapy (CCRT) is the foundational standard-of-care for patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). Adding adjuvant chemotherapy (AC) or induction chemotherapy (IC) to CCRT has been shown to benefit LANPC patients. During recent five years, large numbers of prospective randomized controlled clinical trials have demonstrated the superior efficacy of IC+CCRT than CCRT alone in LANPC patients. However, prospectively designed studies concerned with AC are limited. The efficacy of CCRT+AC in treating LANPC remains unclear. For better understanding and more properly clinical usages of AC, we reviewed the studies of CCRT+AC in the treatments for LANPC patients. In summary, adding AC to CCRT is a feasible therapeutic strategy for patients with EBV positive LANPC.","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89463181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Glioma Nude Mouse Xenograft Model in situ 人胶质瘤裸鼠原位移植模型
Infectious diseases research Pub Date : 2021-11-04 DOI: 10.54457/dr.202101003
Zhijie Wang, Jianglong Kong, Ziteng Chen, Meiru Mao, Jiacheng Li, Hui Yuan, Ya-nan Chang, Kui Chen, Juan Li
{"title":"Human Glioma Nude Mouse Xenograft Model in situ","authors":"Zhijie Wang, Jianglong Kong, Ziteng Chen, Meiru Mao, Jiacheng Li, Hui Yuan, Ya-nan Chang, Kui Chen, Juan Li","doi":"10.54457/dr.202101003","DOIUrl":"https://doi.org/10.54457/dr.202101003","url":null,"abstract":"Backgrounds: Surgery and chemotherapy are difficult because of the specific location of the glioma. The establishment of a suitable in situ model of glioma is the premise of the treatment of glioma. 8 week-old female BALB/c nude mice were chose to establish the glioma model. Methods: For the orthotopic glioma mice model, 1 × 105cells/5 μL U87-MG-Luc or U87-MG cells which were trypsinized and resuspended in sterile PBS were slowly injected into the right corpus striatum (1.8 mm lateral, 0.6 mm anterior to the bregma and 3.0 mm in depth) by a stereotactic fixation device using a mouse adaptor. Results: The othotopic U87 glioma mice model identified by imaging on IVIS Spectrum and magnetic resonance imaging after 2 weeks from surgery. H&E-stained tumor sections in brain of the mice model were also observed. Conclusions: After identification, the glioma mouse xenograft in situ model obtained could be used in the evaluation system of therapeutic drugs or methods.","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76324470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of Toll-like Receptor 3 in Intrauterine Transmission of Hepatitis B Virus in Mothers with High Viral Load toll样受体3在高病毒载量母亲乙型肝炎病毒宫内传播中的作用
Infectious diseases research Pub Date : 2021-11-04 DOI: 10.54457/dr.202101002
Hong Gao, Ling Xu, Xiangying Zhang, Zhihao Fan, Huanhu Zhang, Z. Duan, F. Ren
{"title":"Roles of Toll-like Receptor 3 in Intrauterine Transmission of Hepatitis B Virus in Mothers with High Viral Load","authors":"Hong Gao, Ling Xu, Xiangying Zhang, Zhihao Fan, Huanhu Zhang, Z. Duan, F. Ren","doi":"10.54457/dr.202101002","DOIUrl":"https://doi.org/10.54457/dr.202101002","url":null,"abstract":"Backgrounds: Despite passive and active immunization, perinatal mother-to-infant transmission (MTIT) of hepatitis B virus (HBV) still occurs in women with high levels of viremia. Thus, understanding the mechanisms of MTIT is essential to prevent MTIT. The aims of this study were to clarify the roles of toll-like receptor 3 (TLR3) in the prevention of hepatitis B transmission in mothers with a high viral load. Methods: Placental samples were collected from 87 HBV-positive pregnant women and 25 normal pregnant women. Choriocarcinoma JEG-3 cell lines were exposed to different HBV viral loads to mimic the trophoblast barrier affected by HBV in the placenta. The mRNA and protein expression levels of TLR3 were analyzed by qRT-PCR and western blotting assays in placenta and JEG-3 cells, respectively. Results: In terms of mRNA and protein expression, the expression of TLR3 in the placenta among the control, low viral load, medium viral load and high viral load groups were significantly different, showing significant upregulation in the medium load and high load groups compared with the control; TLR3 expression in the placenta of the HBeAg-positive group was higher than that in the HBeAg-negative group, and TLR3 expression in the placenta of the infant-infected group was lower than that of the infant-noninfected group. Expression of TLR3 was gradually increased in JEG-3 cells exposed to low HBV viral loads or with shortterm HBV exposure and was decreased in JEG-3 cells exposed to high HBV viral loads or with longterm HBV exposure. Conclusions: TLR3 contribute to HBV intrauterine infection in mothers with a high viral load and, importantly, prevents mother-to-infant transmission.","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85019468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The significance of the potential link between thrombocytopenia and NETs in COVID-19 should not be ignored 血小板减少症和NETs在COVID-19中的潜在联系的重要性不应被忽视
Infectious diseases research Pub Date : 2021-01-01 DOI: 10.53388/idr2021o0208001
Xiankun Wang, X. Ren, Liuluan Zhu, Zhihai Chen
{"title":"The significance of the potential link between thrombocytopenia and NETs in COVID-19 should not be ignored","authors":"Xiankun Wang, X. Ren, Liuluan Zhu, Zhihai Chen","doi":"10.53388/idr2021o0208001","DOIUrl":"https://doi.org/10.53388/idr2021o0208001","url":null,"abstract":"","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70809719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of cytisine on smoking cessation in patients with pulmonary tuberculosis 胱氨酸对肺结核患者戒烟的影响
Infectious diseases research Pub Date : 2021-01-01 DOI: 10.53388/tmr2021t0127001
Yan Wang, Yueying Zhang, Wanying Zhang, Guo-wei Zhang
{"title":"The effect of cytisine on smoking cessation in patients with pulmonary tuberculosis","authors":"Yan Wang, Yueying Zhang, Wanying Zhang, Guo-wei Zhang","doi":"10.53388/tmr2021t0127001","DOIUrl":"https://doi.org/10.53388/tmr2021t0127001","url":null,"abstract":"An article by Omara Dogar et al [1]. that was first published in Lancet Global Health in 2020 revealed that current evidence didn’t support the addition of cytisine to brief behavioural support for the treatment of tobacco dependence in patients with tuberculosis. Tuberculosis is one of the most common chronic infectious diseases in the world. An estimated 10 million people suffering from tuberculosis and around 7.1 million new TB cases worldwide were officially notified to national authorities in 2019. Geographically, the majority of TB cases in 2019 were concentrated in Southeast Asia (44%), Africa (25%), the Western Pacific (18%), while the Eastern Mediterranean (8.2%), the Americas (2.9%) and Europe (2.5%) accounted for a smaller proportion. In 2017, about 85% of tuberculosis deaths occurred in Africa and southeast Asia where the prevalence of smoking is high [2]. In 2019, the number of cases of tuberculosis in China was about 775,764, and the death toll was about 2,990. Smoking has gradually become one of the important causes of death from tuberculosis [3]. Smoking seriously affects human health, especially those patients with tuberculosis. The smoke produced by smok-","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70822298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Modelling of the Therapeutic agents for COVID-19 Treatment 新型冠状病毒肺炎治疗剂的分子模型研究
Infectious diseases research Pub Date : 2021-01-01 DOI: 10.53388/idr2020a0927001
A. Ranjbar, S. Torabi, D. Nematollahi, M. Jamshidi, H. Ghasemi
{"title":"Molecular Modelling of the Therapeutic agents for COVID-19 Treatment","authors":"A. Ranjbar, S. Torabi, D. Nematollahi, M. Jamshidi, H. Ghasemi","doi":"10.53388/idr2020a0927001","DOIUrl":"https://doi.org/10.53388/idr2020a0927001","url":null,"abstract":"","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70809063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Role of Darunavir/Cobicisitat for treating COVID-19: initial virological and clinical findings 达那韦/可比西他治疗COVID-19的作用:初步病毒学和临床结果
Infectious diseases research Pub Date : 2021-01-01 DOI: 10.53388/idr2021a0215001
Liping Deng, Tie-long Chen, Yongxi Zhang, Mingqi Luo, S. Gao, Pingzheng Mo, Shi-hui Song, Zhiyong Ma, Xiaoping Chen, Y. Xiong, Hengning Ke, Xinghuan Wang
{"title":"Role of Darunavir/Cobicisitat for treating COVID-19: initial virological and clinical findings","authors":"Liping Deng, Tie-long Chen, Yongxi Zhang, Mingqi Luo, S. Gao, Pingzheng Mo, Shi-hui Song, Zhiyong Ma, Xiaoping Chen, Y. Xiong, Hengning Ke, Xinghuan Wang","doi":"10.53388/idr2021a0215001","DOIUrl":"https://doi.org/10.53388/idr2021a0215001","url":null,"abstract":"","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70808849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of bronchoscopy-guided treatment and oral posaconazole to treat pulmonary mucormycosis: a case report and literature review 支气管镜引导下联合口服泊沙康唑治疗肺毛霉病1例报告并文献复习
Infectious diseases research Pub Date : 2021-01-01 DOI: 10.53388/idr2021a1011015
Pengcheng Zhou, Wei Yu
{"title":"Use of bronchoscopy-guided treatment and oral posaconazole to treat pulmonary mucormycosis: a case report and literature review","authors":"Pengcheng Zhou, Wei Yu","doi":"10.53388/idr2021a1011015","DOIUrl":"https://doi.org/10.53388/idr2021a1011015","url":null,"abstract":"","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70809647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laboratory indicators of death in severe fever with thrombocytopenia syndrome: a meta-analysis and systematic review 重症发热伴血小板减少综合征死亡的实验室指标:荟萃分析和系统回顾
Infectious diseases research Pub Date : 2021-01-01 DOI: 10.53388/idr2021a0816001
X. Ren, Xiankun Wang, Z. Ge, S. Cui, Zhihai Chen
{"title":"Laboratory indicators of death in severe fever with thrombocytopenia syndrome: a meta-analysis and systematic review","authors":"X. Ren, Xiankun Wang, Z. Ge, S. Cui, Zhihai Chen","doi":"10.53388/idr2021a0816001","DOIUrl":"https://doi.org/10.53388/idr2021a0816001","url":null,"abstract":"","PeriodicalId":93445,"journal":{"name":"Infectious diseases research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70809133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信