Forensic genomics最新文献

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Interview with Brett Williams, CEO of Verogen 对Verogen公司首席执行官布雷特·威廉姆斯的采访
Forensic genomics Pub Date : 2021-06-01 DOI: 10.1089/forensic.2021.29003.dm
D. Mittelman
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引用次数: 0
Is the FBI's Criminal Justice Database, CODIS, Approaching Its Expiration Date? 联邦调查局的刑事司法数据库CODIS即将到期吗?
Forensic genomics Pub Date : 2021-06-01 DOI: 10.1089/forensic.2021.29002.rk
R. Khan
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引用次数: 1
Introducing Forensic Genomics 法医基因组学介绍
Forensic genomics Pub Date : 2020-09-17 DOI: 10.1089/FORENSIC.2020.29001.MIT
D. Mittelman
{"title":"Introducing Forensic Genomics","authors":"D. Mittelman","doi":"10.1089/FORENSIC.2020.29001.MIT","DOIUrl":"https://doi.org/10.1089/FORENSIC.2020.29001.MIT","url":null,"abstract":"For the first time in decades, we are witnessing a revolution in forensic DNA testing that promises to bring closure to the tragic number of cold cases currently stalled at some point in the investigative process. There are hundreds of thousands of cold cases in the United States alone. The National Institute of Justice calls it a silent mass disaster. Cold cases in the United States and worldwide continue to accumulate, the vast majority of which will not be solved using traditional forensic DNA testing frameworks. One such framework is the Combined DNA Index System (CODIS), a Federal Bureau of Investigation program that supports DNA databases and infrastructure for using these databases to search unknown DNAs against a catalog of known felons. While CODIS will remain a critical and irreplaceable component of forensic DNA testing in the foreseeable future, countless solvable cases remain unsolved due to the simple fact that CODIS was designed from the start—when DNA testing was in its infancy—to identify those individuals who had already been identified by other methods. While effective in tracking repeat crime by convicted criminals, CODIS is ineffective for cases such as unidentified remains, as many of them are victims and not criminals. Of course, CODIS will not reveal the identification of all criminals either. Many perpetrators of crimes have yet to have be caught, and even those who are caught (and even convicted) can accidently be missing from CODIS. In the past few years, incredible advances in forensic genetic testing have transformed what forensic professionals can learn from DNA left at crime scenes. A growing number of seemingly ‘‘unsolvable’’ cases are now being closed—most notably the capture of the Golden State Killer in April 2018. Testing was pivotal in finding the killer and ensuring his life sentence, delivered in August 2020. These newer DNA testing methods, of which there are many, rely on ‘‘reading’’ tens to hundreds of thousands of DNA markers across the genome. In comparison, a full DNA profile for CODIS contains just 20 core markers— or 20 sites on the human genome. When a CODIS profile is entered into CODIS, a match can be made to someone already in the database. In some states, CODIS can be used to search immediate family relationships, such as parent–offspring, with a technique called ‘‘familial DNA testing.’’ However, to detect the sorts of distant genetic relationships used to catch the Golden State Killer, a much richer genomic profile is needed, comprising as many as hundreds of thousands of DNA markers. Measuring these markers requires new methods typically unavailable at laboratories that offer conventional CODIS testing. The foundation for these new methods comes from consumer, research, and medical DNA testing applications over the past decade. As this cutting-edge technology is new for most criminal investigations, there are not many resources available to guide investigators and forensic professionals throu","PeriodicalId":93434,"journal":{"name":"Forensic genomics","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84303349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Heating Up Cold Cases: An Interview with Bruce Budowle on Human Identification 悬案升温:布鲁斯·巴道尔对人类身份识别的访谈
Forensic genomics Pub Date : 2020-09-17 DOI: 10.1089/forensic.2020.29000.int
David Mittelman Interview by
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引用次数: 1
The Family Perspective 家庭视角
Forensic genomics Pub Date : 2020-09-17 DOI: 10.1089/FORENSIC.2020.0002
W. Thomas
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引用次数: 0
Cold Cases Heat up with New Forensic DNA Methods 新的法医DNA方法使悬案升温
Forensic genomics Pub Date : 2020-09-01 DOI: 10.1089/gen.40.09.05
Catherine Shaffer
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引用次数: 1
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