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DNA and RNA nanotechnology最新文献

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DNA Nanotechnology: From Structure to Functionality DNA纳米技术:从结构到功能
DNA and RNA nanotechnology Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-54806-3
Wai-Yeung Wong, Jie Chen, Jinglin Fu, Xiaoyi Fu, Guoliang Ke, Megan E. Kizer, Yuhan Kong, Hua Kuang, Feng Li, Xiao Hua Liang, Huajie Liu, Yizhen Liu, Hong‐min Meng, Brian Minevich, Sung Won Oh, Lixia Shi, Yun Tan, Leilei Tian, Fuan Wang, G. Wang, Lihua Wang, Maggie Wang, Zhicheng Wang, Zixiang Wei, Xuemei Xu, Chunhai Fan, Yonggang Ke, Ying Zhu, Jiliang Liu
{"title":"DNA Nanotechnology: From Structure to Functionality","authors":"Wai-Yeung Wong, Jie Chen, Jinglin Fu, Xiaoyi Fu, Guoliang Ke, Megan E. Kizer, Yuhan Kong, Hua Kuang, Feng Li, Xiao Hua Liang, Huajie Liu, Yizhen Liu, Hong‐min Meng, Brian Minevich, Sung Won Oh, Lixia Shi, Yun Tan, Leilei Tian, Fuan Wang, G. Wang, Lihua Wang, Maggie Wang, Zhicheng Wang, Zixiang Wei, Xuemei Xu, Chunhai Fan, Yonggang Ke, Ying Zhu, Jiliang Liu","doi":"10.1007/978-3-030-54806-3","DOIUrl":"https://doi.org/10.1007/978-3-030-54806-3","url":null,"abstract":"","PeriodicalId":93282,"journal":{"name":"DNA and RNA nanotechnology","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81714267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functionalized non-viral cationic vectors for effective siRNA induced cancer therapy. 用于有效 siRNA 诱导的癌症治疗的功能化非病毒阳离子载体。
DNA and RNA nanotechnology Pub Date : 2017-05-01 Epub Date: 2017-05-27 DOI: 10.1515/rnan-2017-0001
Kshitij Gupta, Anu Puri, Bruce A Shapiro
{"title":"Functionalized non-viral cationic vectors for effective siRNA induced cancer therapy.","authors":"Kshitij Gupta, Anu Puri, Bruce A Shapiro","doi":"10.1515/rnan-2017-0001","DOIUrl":"10.1515/rnan-2017-0001","url":null,"abstract":"<p><p>RNA interference (RNAi) has been regarded as a vital asset in the field of therapeutics as it has the capability to silence various disease causing genes including those that cause cancer. Small non-coding RNA molecules such as short interfering RNAs (siRNAs) are one of the extensively studied RNAi inducers for gene modulations. However, the delivery of RNAi inducers including siRNAs is compromised due to the barriers imposed by the biological system such as degradation by nucleases, rapid clearance, high anionic charge, immunogenicity and off-target effects. Viral vectors, in general exhibit high transfection efficiencies but are expensive and likely to confer immunological and safety issues. Therefore, non-viral cationic vectors (NVCVs) have received considerable attention to not only address these issues but also for developing efficacious siRNA delivery vectors. In this review, we will first discuss the historical development of various NVCVs and then will discuss functionalized NVCVs with linkers that provide stability, as well as respond to the cancer cell environment and with cancer cell receptor specific ligands to explicitly target them for improved siRNA efficacy. Multifunctional NVCVs (MNVCVs) that employ multiple synergistically working components to aid siRNA delivery efficacy are also discussed.</p>","PeriodicalId":93282,"journal":{"name":"DNA and RNA nanotechnology","volume":"4 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39255103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blink and you’ll miss it: a new biosensing strategy with nucleic acids 眨眼就会错过：一种新的核酸生物传感策略
DNA and RNA nanotechnology Pub Date : 2017-01-28 DOI: 10.1515/rnan-2017-0002
Sameer Sajja, B. Roark, Morgan Chandler, Marcus Jones
{"title":"Blink and you’ll miss it: a new biosensing strategy with nucleic acids","authors":"Sameer Sajja, B. Roark, Morgan Chandler, Marcus Jones","doi":"10.1515/rnan-2017-0002","DOIUrl":"https://doi.org/10.1515/rnan-2017-0002","url":null,"abstract":"Abstract Fluorescent biosensors typically use energy or electron transfer to modulate the emission from a fluorophore. This requirement often makes it difficult to change the biosensor to make it selective to a difference target. In this research highlight we describe a recently reported strategy that relies, for the first time, on fluorescence blinking from nucleic acid-coupled quantum dots to report the presence of a target molecule. This strategy produces a decoupled biosensor, whose fluorescence output is not directly modulated by interaction with the target. The resulting biosensor can be readily modified to sense any target that can be selectively bound to nucleic acids and is therefore much more widely applicable than the vast majority of fluorescent sensors that have been reported.","PeriodicalId":93282,"journal":{"name":"DNA and RNA nanotechnology","volume":"4 1","pages":"21 - 23"},"PeriodicalIF":0.0,"publicationDate":"2017-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/rnan-2017-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43568016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of Multiple Functionalities Through Interacting Nanoparticles 通过相互作用纳米颗粒激活多种功能
DNA and RNA nanotechnology Pub Date : 2017-01-26 DOI: 10.1515/rnan-2017-0003
Morgan Chandler, J. Halman, Emil F Khisamutdinov
{"title":"Activation of Multiple Functionalities Through Interacting Nanoparticles","authors":"Morgan Chandler, J. Halman, Emil F Khisamutdinov","doi":"10.1515/rnan-2017-0003","DOIUrl":"https://doi.org/10.1515/rnan-2017-0003","url":null,"abstract":"Abstract Nucleic acids are biocompatible, robust, and highly versatile polymers that can be used to design fine-tunable and dynamically responsive nanostructures. In this report, we focus our attention to recently introduced concepts of interdependent, cognate nucleic acid nanoparticles assembly that take advantage of dynamic interactions and consequent shape-switching to trigger the activation of multiple functionalities. Particularly, we discuss re-association of thermodynamically driven complementary nanocubes (“cube” and complementary “anti-cube”) into functional duplexes that do not require toehold interactions or extensive computational design, bringing a new perspective for utility of nucleic acid nanoparticles as a drug carriers, biosensors, and templates for the formation of siRNA duplexes.","PeriodicalId":93282,"journal":{"name":"DNA and RNA nanotechnology","volume":"4 1","pages":"24 - 26"},"PeriodicalIF":0.0,"publicationDate":"2017-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/rnan-2017-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43200826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-assembled DNA/RNA nanoparticles as a new generation of therapeutic nucleic acids: immunological compatibility and other translational considerations 自组装DNA/RNA纳米颗粒作为新一代治疗性核酸:免疫相容性和其他翻译考虑
DNA and RNA nanotechnology Pub Date : 2016-06-08 DOI: 10.1515/rnan-2016-0001
M. Dobrovolskaia
{"title":"Self-assembled DNA/RNA nanoparticles as a new generation of therapeutic nucleic acids: immunological compatibility and other translational considerations","authors":"M. Dobrovolskaia","doi":"10.1515/rnan-2016-0001","DOIUrl":"https://doi.org/10.1515/rnan-2016-0001","url":null,"abstract":"Abstract Therapeutic nucleic acids (TNAs) are rapidly being embraced as effective interventions in a variety of genetic disorders, cancers, and viral/microbial infections, as well as for use in improving vaccine efficacy. Many traditional nucleotide-based formulations have been approved for clinical use, while various macromolecular nucleic acids are in different phases of preclinical and clinical development. Various nanotechnology carriers, including but not limited to liposomes, emulsions, dendrimers, and polyplexes, are considered for their improved delivery and reduced toxicity compared to traditional TNAs. Moreover, a new generation of TNAs has recently emerged and is represented by DNA/RNA nanoparticles formed by the self-assembly of DNA, RNA, or hybrid DNA-RNA oligonucleotides into 1D, 2D, and 3D structures of different shapes. In this mini-review, I will discuss immunocompatibility and other translational aspects in the development of this new class of promising nucleic acid therapeutics.","PeriodicalId":93282,"journal":{"name":"DNA and RNA nanotechnology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/rnan-2016-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66983040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Self-assembly of large RNA structures: learning from DNA nanotechnology 大RNA结构的自组装:从DNA纳米技术中学习
DNA and RNA nanotechnology Pub Date : 2016-02-02 DOI: 10.1515/rnan-2015-0002
J. M. Stewart, Elisa Franco
{"title":"Self-assembly of large RNA structures: learning from DNA nanotechnology","authors":"J. M. Stewart, Elisa Franco","doi":"10.1515/rnan-2015-0002","DOIUrl":"https://doi.org/10.1515/rnan-2015-0002","url":null,"abstract":"Abstract Nucleic acid nanotechnology offers many methods to build self-assembled structures using RNA and DNA. These scaffolds are valuable in multiple applications, such as sensing, drug delivery and nanofabrication. Although RNA and DNA are similar molecules, they also have unique chemical and structural properties. RNA is generally less stable than DNA, but it folds into a variety of tertiary motifs that can be used to produce complex and functional nanostructures. Another advantage of using RNA over DNA is its ability to be encoded into genes and to be expressed in vivo. Here we review existing approaches for the self-assembly of RNA and DNA nanostructures and specifically methods to assemble large RNA structures. We describe de novo design approaches used in DNA nanotechnology that can be ported to RNA. Lastly, we discuss some of the challenges yet to be solved to build micron-scale, multi stranded RNA scaffolds.","PeriodicalId":93282,"journal":{"name":"DNA and RNA nanotechnology","volume":"2 1","pages":"23 - 35"},"PeriodicalIF":0.0,"publicationDate":"2016-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/rnan-2015-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66982523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Aptamer guided delivery of nucleic acid-based nanoparticles 核酸基纳米粒子的适体引导递送
DNA and RNA nanotechnology Pub Date : 2016-01-21 DOI: 10.1515/rnan-2015-0005
M. Panigaj, J. Reiser
{"title":"Aptamer guided delivery of nucleic acid-based nanoparticles","authors":"M. Panigaj, J. Reiser","doi":"10.1515/rnan-2015-0005","DOIUrl":"https://doi.org/10.1515/rnan-2015-0005","url":null,"abstract":"Abstract Targeted delivery of bioactive compounds is a key part of successful therapies. In this context, nucleic acid and protein-based aptamers have been shown to bind therapeutically relevant targets including receptors. In the last decade, nucleic acid-based therapeutics coupled to aptamers have emerged as a viable strategy for cell specific delivery. Additionally, recent developments in nucleic acid nanotechnology offer an abundance of possibilities to rationally design aptamer targeted RNA or DNA nanoparticles involving combinatorial use of various intrinsic functionalities. Although a host of issues including stability, safety and intracellular trafficking remain to be addressed, aptamers as simple functional chimeras or as parts of multifunctional self-assembled RNA/DNA nanostructures hold great potential for clinical applications.","PeriodicalId":93282,"journal":{"name":"DNA and RNA nanotechnology","volume":"2 1","pages":"42 - 52"},"PeriodicalIF":0.0,"publicationDate":"2016-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/rnan-2015-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66982377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Meeting Report: 2016 RNA Nanotechnology Conference ‒ Fusion Conferences Limited 会议报告:2016 RNA纳米技术会议- Fusion会议有限公司
DNA and RNA nanotechnology Pub Date : 2016-01-05 DOI: 10.1515/rnan-2016-0004
Farzin Haque, K. Afonin
{"title":"Meeting Report: 2016 RNA Nanotechnology Conference ‒ Fusion Conferences Limited","authors":"Farzin Haque, K. Afonin","doi":"10.1515/rnan-2016-0004","DOIUrl":"https://doi.org/10.1515/rnan-2016-0004","url":null,"abstract":"","PeriodicalId":93282,"journal":{"name":"DNA and RNA nanotechnology","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66983099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Non-viral Vector Mediated RNA Interference Technology for Central Nerve System Injury. 非病毒载体介导的RNA干扰技术治疗中枢神经系统损伤。
DNA and RNA nanotechnology Pub Date : 2016-01-01 Epub Date: 2016-08-25 DOI: 10.1515/rnan-2016-0003
Christian Macks, Jeoung Soo Lee
{"title":"Non-viral Vector Mediated RNA Interference Technology for Central Nerve System Injury.","authors":"Christian Macks,&nbsp;Jeoung Soo Lee","doi":"10.1515/rnan-2016-0003","DOIUrl":"https://doi.org/10.1515/rnan-2016-0003","url":null,"abstract":"<p><p>Neuronal axons damaged by traumatic injury are unable to spontaneously regenerate in the mammalian adult central nervous system (CNS), causing permanent motor, sensory, and cognitive deficits. Regenerative failure in the adult CNS results from a complex pathology presenting multiple barriers, both the presence of growth inhibitors in the extrinsic microenvironment and intrinsic deficiencies in neuronal biochemistry, to axonal regeneration and functional recovery. There are many strategies for axonal regeneration after CNS injury including antagonism of growth-inhibitory molecules and their receptors, manipulation of cyclic nucleotide levels, and delivery of growth-promoting stimuli through cell transplantation and neurotrophic factor delivery. While all these approaches have achieved varying degrees of improvement in plasticity, regeneration, and function, there is no clinically effective therapy for CNS injury. RNA interference technology offers strategies for improving regeneration by overcoming the aspects of the injured CNS environment that inhibit neurite growth. This occurs through the knockdown of growth-inhibitory molecules and their receptors. In this review, we discuss the current state of RNAi strategies for the treatment of CNS injury based on non-viral vector mediated delivery.</p>","PeriodicalId":93282,"journal":{"name":"DNA and RNA nanotechnology","volume":"3 1","pages":"14-22"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/rnan-2016-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39774945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
RNA Toehold Interactions Initiate Conditional Gene Silencing. RNA Toehold 相互作用引发条件基因沉默
DNA and RNA nanotechnology Pub Date : 2016-01-01 DOI: 10.1515/rnan-2016-0002
Paul Zakrevsky, Eckart Bindewald, Bruce A Shapiro
{"title":"RNA Toehold Interactions Initiate Conditional Gene Silencing.","authors":"Paul Zakrevsky, Eckart Bindewald, Bruce A Shapiro","doi":"10.1515/rnan-2016-0002","DOIUrl":"10.1515/rnan-2016-0002","url":null,"abstract":"","PeriodicalId":93282,"journal":{"name":"DNA and RNA nanotechnology","volume":"3 1","pages":"11-13"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/c3/nihms-1723203.PMC8302070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39221243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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