Annals of behavioral neuroscience最新文献_第2页

Dose-Response Relationship of EAE Clinical Severity in a MOG35-55 Mouse Model: A Pilot Study MOG35-55小鼠模型EAE临床严重程度的剂量反应关系：一项初步研究

Annals of behavioral neuroscience Pub Date : 2018-11-20 DOI: 10.18314/ABNE.V1I1.1263

G. Metz, D. Bettenson, S. Babatunde, C. Gustafson, R. Chan

{"title":"Dose-Response Relationship of EAE Clinical Severity in a MOG35-55 Mouse Model: A Pilot Study","authors":"G. Metz, D. Bettenson, S. Babatunde, C. Gustafson, R. Chan","doi":"10.18314/ABNE.V1I1.1263","DOIUrl":"https://doi.org/10.18314/ABNE.V1I1.1263","url":null,"abstract":"Experimental autoimmune encephalomyelitis (EAE) is a common animal model of multiple sclerosis (MS) which mimics the autoimmune, demyelinating, and inflammatory hallmarks of this human disorder. To better understand the severity of the symptoms in relation to the antigen in EAE, we explored the dose-symptom relationship between the quantity of MOG35-55 and clinical symptoms in a C57/BL6 mouse pilot study. To isolate the impact of MOG35-55 we developed an EAE model that does not require the additional application of pertussis toxin. Mice were treated with either 50µg, 100µg, or 150µg of MOG35-55 emulsified in complete Freund’s adjuvant. Following induction, the mice were assessed for clinical symptoms daily, and tested weekly for gross and fine motor impairments, mechanical allodynia, and anxiety-like behaviours. The time course of sensorimotor function loss was characterized by multiphasic disease progression. Findings also suggested an inverted U-shape dose-response relationship with a medium dosage of 100 µl MOG35-55 dosage aggravating symptom severity in induced animals. Outcomes measured by a clinical score correlated with performance on motor and nociceptive sensitivity tasks. As the disease progressed, fine and gross motor impairments and nociceptive sensitivity diminished and impairments persisted beyond 8 weeks. This study indicates that mild to moderate EAE can be induced in the absence of use of pertussis toxin. The progression suggests a spontaneously multiphasic disease course, which may have attractive implications for clinically relevant animal models.","PeriodicalId":93258,"journal":{"name":"Annals of behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45295263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Parent-Teacher Concordance for DSM V Diagnosis of Attention-Deficit/Hyperactivity Disorder in a Community Based Sample in Nigeria 尼日利亚社区样本中注意缺陷/多动障碍DSM V诊断的家长-教师一致性

Annals of behavioral neuroscience Pub Date : 2018-11-14 DOI: 10.18314/ABNE.V1I1.1197

O. Oke, S. Oseni, E. Adejuyigbe, S. Mosaku

引用次数: 0

The Phylogenetic Background of Neurotransmitters in the Unicellular Organism Tetrahymena Pyriformis Pyriformis四膜虫神经递质的系统发育背景

Annals of behavioral neuroscience Pub Date : 2018-10-29 DOI: 10.18314/ABNE.V1I1.1229

Andria Tziakouri, E. Lajkó, L. Köhidai

{"title":"The Phylogenetic Background of Neurotransmitters in the Unicellular Organism Tetrahymena Pyriformis","authors":"Andria Tziakouri, E. Lajkó, L. Köhidai","doi":"10.18314/ABNE.V1I1.1229","DOIUrl":"https://doi.org/10.18314/ABNE.V1I1.1229","url":null,"abstract":"The Human Central Nervous System (CNS) is governed by electrochemical networks forming a delicate interplay between the different regions of the brain. The objective of the present experiment is to investigate the phylogenetic background of this electrochemical network by creating a comparable binary and ternary interplay of interactions between different neurotransmitters (noradrenaline, histamine, serotonin, acetylcholine, glutamate, and dopamine) in the unicellular eukaryote Tetrahymena pyriformis. Tetrahymena – as a protozoon – has no nervous system; however, it has been shown that it has not only the ability to store, synthesize and secrete biogenic amines but it also bears binding sites for the corresponding receptors of some of these molecules. The chemotactic responsiveness elicited by the neurotransmitters was examined in Tetrahymena cells, using a modified version of Leick’s two-chamber capillary chemotaxis assay with 20-minute incubation times. The concentration course of each neurotransmitter was determined and the concentration eliciting the strongest effect was further used to examine the chemotactic response of the neurotransmitters when used in pairs and in groups of three. Adequate cellular responses (chemoattractant and chemorepellent) were detected in both cases when the neurotransmitters were used alone and in combinations. A pattern detected in these responses was related to the neurotransmitters’ physicochemical characteristics (XlogP, TPSA). These provide evidence that the chief regulatory molecules of the CNS can be identified even in lower, eukaryotic unicellular levels of phylogeny and possibly alter the basic functions of these organisms. In summary, our results support the theory that any evolved nervous system-like interplay could stem from a common origin. Therefore, identifying the “ancient” function of a molecule or its receptor effect can open new windows in the advancement of therapeutic interventions.","PeriodicalId":93258,"journal":{"name":"Annals of behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42860234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Walker vs. Wheelchair User: Expected Gains from Lower Extremity Eccentric Resistance Training after Incomplete Spinal Cord Injury 助行器与轮椅使用者:不完全脊髓损伤后下肢偏心阻力训练的预期收益

Annals of behavioral neuroscience Pub Date : 2018-10-16 DOI: 10.18314/ABNE.V1I1.1273

W. Stone, S. Stevens

{"title":"Walker vs. Wheelchair User: Expected Gains from Lower Extremity Eccentric Resistance Training after Incomplete Spinal Cord Injury","authors":"W. Stone, S. Stevens","doi":"10.18314/ABNE.V1I1.1273","DOIUrl":"https://doi.org/10.18314/ABNE.V1I1.1273","url":null,"abstract":"Individuals post Incomplete Spinal Cord Injury (iSCI) experience mitigated physical function relative to the degree of injury. Prolonged therapeutic interventions may include strengthening of the affected musculature below the lesion. Eccentric resistance training has shown to positively impact strength and function inferior to the iSCI. It has yet to be determined if the severity of injury impacts sensitivity to such exercise interventions. A 12-week lower extremity, eccentrically-biased resistance training program was implemented in a mixed sample of walkers (n = 4) and wheelchair users (n = 7) with iSCI. Strength, walking speed, mobility, and daily step activity were analyzed using multiple 1 way ANOVAs with percent improvement from pre- to post-test as the dependent variable and community traversing style as the independent-between factors. Traversing style made no impact on strength gained (eccentric and isometric) nor increase in daily step activity (p > 0.05). Chair users experienced greater improvement in walking speed (p = 0.03) and mobility (p = 0.025) when compared to the walkers, respectively. These preliminary data may represent a ceiling effect for community ambulators in respect to walking function without formal gait training. Alternatively, those using chairs may attain walking improvement in the absence of structured walking therapy. Further support is provided for implementation of lower extremity exercise training regardless of severity of iSCI as the trajectory of improvement in strength and step activity was similar between groups.","PeriodicalId":93258,"journal":{"name":"Annals of behavioral neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67530444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adolescent Sports-Related Concussion: US Healthcare Access, Finance, and Delivery 青少年运动相关脑震荡：美国医疗保健准入、金融和分娩

Annals of behavioral neuroscience Pub Date : 2018-10-11 DOI: 10.18314/abne.v1i1.1292

D. Younger

引用次数: 0

Spirituality, Universal Love and Sustainable Behaviour 灵性，博爱和可持续行为

Annals of behavioral neuroscience Pub Date : 2018-09-28 DOI: 10.18314/ABNE.V1I1.1240

R. Ulluwishewa

引用次数: 4

Symmetrical Central Tegmental Tract Hyperintensity on T2-weighted Images in Pediatrics: A Systematic Review 对称中央被盖束在儿科t2加权图像上的高强度:一个系统的回顾

Annals of behavioral neuroscience Pub Date : 2018-09-27 DOI: 10.18314/ABNE.V1I1.1259

C. Mallio, J. Goethem, T. Bondt, L. Hauwe, B. Zobel, C. Quattrocchi, P. Parizel

{"title":"Symmetrical Central Tegmental Tract Hyperintensity on T2-weighted Images in Pediatrics: A Systematic Review","authors":"C. Mallio, J. Goethem, T. Bondt, L. Hauwe, B. Zobel, C. Quattrocchi, P. Parizel","doi":"10.18314/ABNE.V1I1.1259","DOIUrl":"https://doi.org/10.18314/ABNE.V1I1.1259","url":null,"abstract":"AbstractPurpose: The aim of the present study is to provide a systematic literature review of the current evidence about the Central Tegmental Tract Hyperintensity (CTTH).Methods: The literature search was performed on December 2017 using Medline PubMed, Google Scholar and Cochrane Central databases. Statistical analysis was performed using Kolmogorov-Smirnov, chi-square and the Mann-Whitney U tests.Results: Twenty publications were included. Of these, 11 were retrospective studies and 9 were case reports. In total, CTTH was reported in 226 cases. The age parameter showed a significantly non-Gaussian distribution (KS test; p-value < 0.001). The median age was 1,83 years (range: 7 days – 21 years; P25 = 1.00 year, P75 = 3.00 years; IQR = 2 years). The two most common clinical conditions associated to CTTH were cerebral palsy (51 cases; 22.6%) and glutaric aciduria type 1 (50 cases; 22.10%). CTTH was often found in the absence of other concomitant brain MRI abnormalities (32 cases; 21.8%).Conclusions: CTTH is an uncommon neuroimaging finding that is mainly related to the acquisitionimprovement of a physiologicalmotor developmental process. The finding is influenced by hypoxic ischemic and toxic?metabolic factors. Data regarding DWI and follow-up are largely unreported and deserve to be further explored.","PeriodicalId":93258,"journal":{"name":"Annals of behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42602309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Group Cognitive Behavioural Therapy Improves Quality of Life of Multiple Sclerosis Patients and Delays Disease Progression: A Multi-Centre Controlled Trial 群体认知行为疗法改善多发性硬化症患者的生活质量并延缓疾病进展:一项多中心对照试验

Annals of behavioral neuroscience Pub Date : 2018-09-17 DOI: 10.18314/abne.v1i1.1200

R. Devy, P. Lehert, M. Genty

{"title":"A Group Cognitive Behavioural Therapy Improves Quality of Life of Multiple Sclerosis Patients and Delays Disease Progression: A Multi-Centre Controlled Trial","authors":"R. Devy, P. Lehert, M. Genty","doi":"10.18314/abne.v1i1.1200","DOIUrl":"https://doi.org/10.18314/abne.v1i1.1200","url":null,"abstract":"Background: Multiple Sclerosis (MS) affects quality of life (QoL). Pharmacological treatments demonstrated benefits on clinical endpoints without improving QoL. We evaluated the effects of a group Cognitive Behavioural Therapy (CBT) on QoL disease progression. Methods: One-year multi-centre controlled multivariate-matched study was organised on Relapsing-Remitting MS (RRMS) patients with Expanded Disability Status Scale (EDSS) < 4, MS duration < 2 years, treated by interferon I? in 11 French centres. For each new patient, the two best-matching patients for age, gender, EDSS, mood, illness duration baseline variables were selected in the other centres. The self-filled Two Lives Scale (TLS)-QoL10 was used at months (M) 0-3-6-9-12-15; the post-baseline mean QoL was the endpoint. We compared CBT + I? to I? alone. The effect of disease progression on QoL was evaluated by modelling, for each visit, the effect of EDSS on QoL at later visits.Results: 19 + 32 patients were recruited. Compared to placebo, improvements of 1.10 (95%CI [0.31-1.89], p = 0.009) and 1.43*** [0.72, 2.15] were observed in the CBT group on QoL and coping scales, respectively. Coping explained 81%*** [57, 100] of the effect of CBT on QoL. QoL was negatively affected by disease progression (0.95*** [-1.21; 0.63]), whereas EDSS was influenced by QoL values (-0.10*** [-0.14; -0.06]).Conclusions: We observed a clinically significant beneficial effect of CBT on QoL, the effect of CBT essentially explained by an increase of coping, a positive influence of QoL on disease progression. QoL is both the most important target for patients and a factor of slowing disease progression.","PeriodicalId":93258,"journal":{"name":"Annals of behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42024252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Neurocosmological Neurotheology Organized Around Reissner’s Fiber 围绕Reissner纤维组织的神经宇宙学神经神学

Annals of behavioral neuroscience Pub Date : 2018-09-07 DOI: 10.18314/abne.v1i1.1213

L. Wile

{"title":"A Neurocosmological Neurotheology Organized Around Reissner’s Fiber","authors":"L. Wile","doi":"10.18314/abne.v1i1.1213","DOIUrl":"https://doi.org/10.18314/abne.v1i1.1213","url":null,"abstract":"Neurotheology is the study of the neurobiological correlates of religious experiences. A key problem for this nascent field is that interpretations of religious experiences range from a regression to the oceanic oneness of the womb to supersensory apprehensions of transcendent realities. Identifying appropriate subjects is therefore problematic. Correlating the complex array of neurobiological data obtained from neuroimaging, genetic analysis and lab tests with such elusive “religious experiences” offers little hope of scientific rigor. This paper proposes a new approach. Mystical traditions have consistently described a “subtle anatomy” organized around a circuit running through the center of the spine that connects the human and the divine. If descriptions of this circuit are based on actual interoceptions, then it corresponds to a little-known, epigenetically suppressed structure that ensheathes the central axis of the central nervous system; Reissner’s fiber (RF). Rather than identifying subjects based on self-reporting and correlating their experiences with an array of neurobiological data, this new approach would regenerate the fiber, measure its activity and explore possible correlations with religious experiences.","PeriodicalId":93258,"journal":{"name":"Annals of behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47691708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Dialogic Learning on Students’ Attention and Academic Achievement 对话学习对学生注意力和学习成绩的影响

Annals of behavioral neuroscience Pub Date : 2018-08-01 DOI: 10.18314/abne.v1i1.1215

A. Nouri, F. Esmaeilli, Saman Seifpour, M. Talkhabi, A. Khorami

引用次数: 2