Ageing and neurodegenerative diseases最新文献_第6页

Genome-edited rabbit, a prospective alternative model for neurological diseases 基因组编辑兔，神经系统疾病的潜在替代模型

Ageing and neurodegenerative diseases Pub Date : 2022-01-01 DOI: 10.20517/and.2022.15

Zhongtian Zhang, Yuning Song, L. Lai, Zhanjun Li

引用次数: 1

Interplay among norepinephrine, NOX2, and neuroinflammation: key players in Parkinson’s disease and prime targets for therapies 去甲肾上腺素、NOX2和神经炎症之间的相互作用:帕金森病的关键因素和治疗的主要目标

Ageing and neurodegenerative diseases Pub Date : 2021-08-11 DOI: 10.20517/and.2021.06

Qingshan Wang, Sheng Song, Lulu Jiang, Jau-Shyong Hong

引用次数: 6

Mild cognitive impairment vs. mild cognitive dysfunctions: validation with a nomothetic network approach 轻度认知障碍与轻度认知功能障碍:用神经网络方法验证

Ageing and neurodegenerative diseases Pub Date : 2021-08-09 DOI: 10.20517/and.2021.08

M. Maes, S. Tangwongchai

{"title":"Mild cognitive impairment vs. mild cognitive dysfunctions: validation with a nomothetic network approach","authors":"M. Maes, S. Tangwongchai","doi":"10.20517/and.2021.08","DOIUrl":"https://doi.org/10.20517/and.2021.08","url":null,"abstract":"article: Mild cognitive impairment vs . mild cognitive dysfunctions: validation with a nomothetic network approach. Abstract Aim: No studies have examined whether interactions between the apolipoprotein E4 (ApoE4) allele and peripheral biomarkers, hypertension, and type 2 diabetes mellitus (T2DM) may impact the neurocognitive, behavioral, and social dysfunctions in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD). We aimed to clinically define and biologically validate a subgroup of aMCI subjects who take up an intermediate position between controls and AD patients. age, and education. The OBD index was used to construct three subgroups (normal, medium, and high OBD) with the medium group ( n = 45) showing mild cognitive dysfunctions (MCD) in memory, language, orientation, and ADL. People with MCD show OBD and BIORISK scores that are significantly different from controls and AD. Conclusion: Petersen’s aMCI criteria cannot be validated and should be replaced by the more restrictive, biologically validated MCD class. statistical significance. Two-step cluster analysis was employed to define clusters of patients based on the cognitome and phenome features. Nearest neighbor analysis was employed to classify subjects based on their feature similarities. All statistical analyses were performed using IBM SPSS windows version 25. phenome latent vectors extracted by PLS scores (3k, Euclidian distance, training sample of 70%, and a holdout sample of 30%), and this analysis showed 45.0% misclassifications in both the training and holdout samples with many aMCI subjects being allocated to the normal control class.","PeriodicalId":93251,"journal":{"name":"Ageing and neurodegenerative diseases","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89681597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naive BM-derived stem cells (Neuro-Cells) may modify acute and chronic neurodegenerative disorders by modulating macrophage behaviors 原始脑源性干细胞(神经细胞)可能通过调节巨噬细胞的行为来改变急性和慢性神经退行性疾病

Ageing and neurodegenerative diseases Pub Date : 2021-07-20 DOI: 10.20517/and.2021.04

E. Wolters, T. Strekalova, J. P. Munter, B. Kramer

{"title":"Naive BM-derived stem cells (Neuro-Cells) may modify acute and chronic neurodegenerative disorders by modulating macrophage behaviors","authors":"E. Wolters, T. Strekalova, J. P. Munter, B. Kramer","doi":"10.20517/and.2021.04","DOIUrl":"https://doi.org/10.20517/and.2021.04","url":null,"abstract":"Naive BM-derived stem cells (Neuro-Cells) may modify acute and chronic neurodegenerative disorders by modulating macrophage behaviors. Ageing Neur Abstract In acute traumatic or hypoxic brain and spinal cord lesions, as well as in chronic idiopathic neurodegenerative disorders induced by a genetic/environmental/idiopathic protein misfolding with aggregation, emerging evidence indicates that primary necrosis, as induced by the underlying event, initiates a secondary inflammatory process. In this secondary process, responsible for significant neurological deterioration, a microglia type M1/M2 misbalance plays a major role. Indeed, both acute and chronic neurodegenerative disorders share a common pathway: a M1/M2 misbalance-induced hyperinflammatory process with a lack of response to conventional anti-inflammatory interventions. In recent literature, however, both in preclinical and clinical neurodegenerative conditions, these processes were suggested to be sensitive for interventions with stem cells. Intrathecal interventions with a fresh, not-manipulated (naïve) bone marrow-derived stem cell preparation, after positive selection of pro-inflammatory substances (Neuro-Cells), were found to prevent/reduce secondary necrosis-induced pro-inflammatory and pro-apoptotic processes in both immune-compromised and otherwise healthy experimental animal models. Therefore, it seems justified to further encourage clinical trials applying autologous BM-derived naïve stem cells in patients suffering from those debilitating neurodegenerative conditions.","PeriodicalId":93251,"journal":{"name":"Ageing and neurodegenerative diseases","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91331425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Autophagy in ageing and ageing-related neurodegenerative diseases 衰老和衰老相关神经退行性疾病中的自噬

Ageing and neurodegenerative diseases Pub Date : 2021-07-14 DOI: 10.20517/and.2021.05

C. Karabiyik, Rebecca A. Frake, So Jung Park, Mariana Pavel, D. Rubinsztein

{"title":"Autophagy in ageing and ageing-related neurodegenerative diseases","authors":"C. Karabiyik, Rebecca A. Frake, So Jung Park, Mariana Pavel, D. Rubinsztein","doi":"10.20517/and.2021.05","DOIUrl":"https://doi.org/10.20517/and.2021.05","url":null,"abstract":"Autophagy is a catabolic mechanism that allows cells to deliver cytoplasmic contents to lysosomes for degradation to maintain energy homeostasis and to protect cells against stress. Autophagy has been directly linked to neurodegeneration and ageing by an extensive body of research. It has become evident that disruption of autophagy contributes significantly to age-related pathologies and to the cognitive and motor declines associated with “healthy” ageing. Autophagic dysfunction causes the accumulation of many of the toxic, aggregate-prone proteins that are responsible for neurodegenerative diseases, including mutant huntingtin, alpha-synuclein, tau, and others. Since upregulation of autophagy has been found to reduce levels of such protein species, the therapeutic potential of autophagy induction as a strategy against age-related diseases and a method for modulating longevity has been widely studied. Here we review the evidence supporting a role for autophagy dysfunction in the progression of the age-associated functional decline in the brain and age-related brain pathologies and discuss the available evidence that upregulation of autophagy may be a valuable therapeutic strategy.","PeriodicalId":93251,"journal":{"name":"Ageing and neurodegenerative diseases","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84889494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Diverse midbrain dopaminergic neuron subtypes and implications for complex clinical symptoms of Parkinson's disease. 多种中脑多巴胺能神经元亚型及其对帕金森病复杂临床症状的影响

Ageing and neurodegenerative diseases Pub Date : 2021-01-01 Epub Date: 2021-07-15 DOI: 10.20517/and.2021.07

Kathleen Carmichael, Breanna Sullivan, Elena Lopez, Lixin Sun, Huaibin Cai

{"title":"Diverse midbrain dopaminergic neuron subtypes and implications for complex clinical symptoms of Parkinson's disease.","authors":"Kathleen Carmichael, Breanna Sullivan, Elena Lopez, Lixin Sun, Huaibin Cai","doi":"10.20517/and.2021.07","DOIUrl":"https://doi.org/10.20517/and.2021.07","url":null,"abstract":"Parkinson's disease (PD), the most common degenerative movement disorder, is clinically manifested with various motor and non-motor symptoms. Degeneration of midbrain substantia nigra pas compacta (SNc) dopaminergic neurons (DANs) is generally attributed to the motor syndrome. The underlying neuronal mechanisms of non-motor syndrome are largely unexplored. Besides SNc, midbrain ventral tegmental area (VTA) DANs also produce and release dopamine and modulate movement, reward, motivation, and memory. Degeneration of VTA DANs also occurs in postmortem brains of PD patients, implying an involvement of VTA DANs in PD-associated non-motor symptoms. However, it remains to be established that there is a distinct segregation of different SNc and VTA DAN subtypes in regulating different motor and non-motor functions, and that different DAN subpopulations are differentially affected by normal ageing or PD. Traditionally, the distinction among different DAN subtypes was mainly based on the location of cell bodies and axon terminals. With the recent advance of single cell RNA sequencing technology, DANs can be readily classified based on unique gene expression profiles. A combination of specific anatomic and molecular markers shows great promise to facilitate the identification of DAN subpopulations corresponding to different behavior modules under normal and disease conditions. In this review, we first summarize the recent progress in characterizing genetically, anatomically, and functionally diverse midbrain DAN subtypes. Then, we provide perspectives on how the preclinical research on the connectivity and functionality of DAN subpopulations improves our current understanding of cell-type and circuit specific mechanisms of the disease, which could be critically informative for designing new mechanistic treatments.","PeriodicalId":93251,"journal":{"name":"Ageing and neurodegenerative diseases","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39424372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Olfactory and Gustatory Dysfunctions in Patients With COVID-19 in Wuhan, China 武汉地区新冠肺炎患者嗅觉和味觉功能障碍

Ageing and neurodegenerative diseases Pub Date : 2020-06-01 DOI: 10.21203/rs.3.rs-28370/v1

Li Zou, Tingyan Yu, Yangyang Zhang, Li-xiang Dai, Zhaohui Zhang, Zhentao Zhang

{"title":"Olfactory and Gustatory Dysfunctions in Patients With COVID-19 in Wuhan, China","authors":"Li Zou, Tingyan Yu, Yangyang Zhang, Li-xiang Dai, Zhaohui Zhang, Zhentao Zhang","doi":"10.21203/rs.3.rs-28370/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-28370/v1","url":null,"abstract":"\u0000 Background: The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 isspreading all over the world.The main symptoms of COVID-19 include fever, cough,fatigue, and myalgia. However, there are few reports onolfactoryand gustatory dysfunctions in patients with COVID-19.Objective: To investigate the incidence of olfactory and gustatory dysfunctions in patients with confirmed COVID-19 infection, in Wuhan, China.Methods:In this retrospective study,we collected 81 confirmed cases of COVID-19 from the Renmin Hospital of Wuhan University, from February 2020 to March 2020, and analyzed the demographic characteristics, clinical manifestations (including olfactory and gustatory dysfunctions), laboratory findings,and comorbidities.Results: A total of 81 confirmed COVID-19 patients were enrolledin this study (38 males). The most prevalent symptoms include cough, myalgia, and loss of appetite. On admission, 25 (30.9%) of all patients reported either olfactory dysfunction (OD) or gustatory dysfunction (GD), and 7 (8.6%) reported both OD and GD. 13.6% and 25.9% of allpatients reported OD and GD, respectively. OD and GD were not associated with disease severity. Pearson correlation analysisidentified some factors are positively correlated with OD and GD, including headache or dizziness (r = 0.342, P = 0.002), dark urine (r = 0.256, P = 0.021), IgM titer (r = 0.305, P = 0.01), and diabetes (r = 0.275, P = 0.013). In 81.8% of the cases with OD and 28.6% of the cases with GD, the symptomslasted for at least 1 month after discharge.3.6% of inpatients without OD developed OD after discharge.Conclusion:OD and GDare common in COVID-19.These symptoms appear early during thecourse of disease, and may last for at least 1 month.The incidence of OD and GDisrelated to neurological manifestations, diabetics, and IgM titers.","PeriodicalId":93251,"journal":{"name":"Ageing and neurodegenerative diseases","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72878791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4