Ageing and neurodegenerative diseases最新文献_第3页

Role of MeCP2 in oligodendrocyte lineage cells in Rett syndrome: review and inference MeCP2在Rett综合征少突胶质细胞谱系细胞中的作用:综述和推断

Ageing and neurodegenerative diseases Pub Date : 2023-07-19 DOI: 10.20517/and.2023.13

Zhen Zhang, Peng Li, Yongchang Chen

引用次数: 0

Cannabinoid modulations of pain- and stress-related circuits 大麻素对疼痛和压力相关回路的调节

Ageing and neurodegenerative diseases Pub Date : 2023-01-01 DOI: 10.20517/and.2023.19

Ying Wang, Qingyu Wang, Li Tang, Xia Zhang

{"title":"Cannabinoid modulations of pain- and stress-related circuits","authors":"Ying Wang, Qingyu Wang, Li Tang, Xia Zhang","doi":"10.20517/and.2023.19","DOIUrl":"https://doi.org/10.20517/and.2023.19","url":null,"abstract":"In the past decade, significant advancements have been made in understanding the brain regions and neuronal circuits regulating neurological behaviors. The endocannabinoid (eCB) system, which is ubiquitously distributed in the brain and extensively involved in synaptic modulation, has been believed to play potential roles in neuronal circuit processes and related disorders. Although eCB-based pharmacological studies have made some clinical achievements, they still often encounter conflicting reports or undesired effects due to global manipulation of manifold brain regions and neuronal circuits, which impede the therapeutic application of eCB-based medications. In this review, we are devoted to discussing the versatile forms of eCB-mediated synaptic plasticity and dissecting currently well-studied specific cannabinoid circuits involved in behavioral domains which are closely linked to the organism’s survival and life quality, such as pain perception and stress-related emotion disorders. By gaining new insights into selective cannabinoid control in circuits, we can potentially mitigate the drawbacks of traditional pharmacology and facilitate the development of precision medicine with novel therapeutic strategies and drug discoveries.","PeriodicalId":93251,"journal":{"name":"Ageing and neurodegenerative diseases","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79381757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can alpha-synuclein be both the cause and a consequence of Parkinson's disease? 突触核蛋白是帕金森氏症的病因和结果吗?

Ageing and neurodegenerative diseases Pub Date : 2023-01-01 DOI: 10.20517/and.2023.05

Kang Chen, Yu-jie Guo, P. Lei, D. Finkelstein

引用次数: 1

Amyloid-β-targeted therapies for Alzheimer's disease: currently and in the future 淀粉样蛋白β靶向治疗阿尔茨海默病:目前和未来

Ageing and neurodegenerative diseases Pub Date : 2023-01-01 DOI: 10.20517/and.2023.16

Cai Huimin, Fu Xiaofeng, Quan Shuiyue, Ren Ziye, Chu Changbiao, Jia Longfei

引用次数: 0

Benefits of physical exercise on Alzheimer's disease: an epigenetic view 体育锻炼对阿尔茨海默病的益处:一种表观遗传学观点

Ageing and neurodegenerative diseases Pub Date : 2023-01-01 DOI: 10.20517/and.2022.37

Song Li

引用次数: 0

Newly identified transmembrane protein 106B amyloid fibrils in the human brain: pathogens or by-products? 人脑中新发现的跨膜蛋白106B淀粉样原纤维:病原体还是副产品?

Ageing and neurodegenerative diseases Pub Date : 2023-01-01 DOI: 10.20517/and.2022.30

Yun Fan, Wanbing Zhao, Y. Ni, Yiqi Liu, Yilin Tang, Yimin Sun, Feng-tao Liu, Wenbo Yu, Jianjun Wu, Jian Wang

{"title":"Newly identified transmembrane protein 106B amyloid fibrils in the human brain: pathogens or by-products?","authors":"Yun Fan, Wanbing Zhao, Y. Ni, Yiqi Liu, Yilin Tang, Yimin Sun, Feng-tao Liu, Wenbo Yu, Jianjun Wu, Jian Wang","doi":"10.20517/and.2022.30","DOIUrl":"https://doi.org/10.20517/and.2022.30","url":null,"abstract":"Neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) constitute a spectrum of diseases characterized by the abnormal aggregation of specific amyloid fibrillar proteins; these include β-amyloid (Aβ) and tau in the form of the extracellular Aβ plaques and neuronal neurofibrillary tangles in AD and fibrillar α-synuclein aggregation in the form of Lewy bodies and Lewy neurites in PD. Transmembrane protein 106B (TMEM106B) is a type II transmembrane lysosomal protein that participates in lysosome morphology, localization, acidification, and trafficking; t is involved in the pathogenesis of several NDs, especially frontotemporal lobular degeneration with TAR DNA-binding protein immunoreactive inclusions (FTLD-TDP). Studies from four independent research groups revealed that the luminal domain of TMEM106B (120-254aa) forms amyloid fibrils in several brain regions in patients with a series of NDs and neurologically normal older adults. Given its potentially critical roles in the pathogenesis of NDs and brain aging, this surprising finding has focused attention on TMEM106B and suggested that it is nearly as fundamental as other pathogenic amyloid proteins (e.g., Aβ, tau, α-syn); nevertheless, new questions surrounding TMEM106B must be asked. In this review,we firstly introduce the physiological function of TMEM106B and its involvement in NDs. Then, we elucidate the identification and cryo-electronic microscopic structure of TMEM106B fibrils and analyze the factors that contribute to the polymorphism of TMEM106B fibrils. Finally, the potential pathogenic role of TMEM106B fibrils is discussed, and the future directions for TMEM106 research in NDs are briefly summarized.","PeriodicalId":93251,"journal":{"name":"Ageing and neurodegenerative diseases","volume":"167 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74218973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological complications of COVID-19 and SARS-CoV-2 vaccination: an update COVID-19和SARS-CoV-2疫苗接种的神经系统并发症:最新进展

Ageing and neurodegenerative diseases Pub Date : 2023-01-01 DOI: 10.20517/and.2022.29

Huan-yu Meng, Qinming Zhou, Sheng Chen

{"title":"Neurological complications of COVID-19 and SARS-CoV-2 vaccination: an update","authors":"Huan-yu Meng, Qinming Zhou, Sheng Chen","doi":"10.20517/and.2022.29","DOIUrl":"https://doi.org/10.20517/and.2022.29","url":null,"abstract":"The respiratory infectious disease COVID-19, which emerged in 2019, has affected the world population over a brief period. In 2020, the disease was declared a pandemic by the World Health Organization. Although most COVID-19 patients primarily develop respiratory symptoms, neurological symptoms have been observed. Neurological symptoms are usually mild and non-specific. However, some patients could experience life-threatening neurological symptoms. With the increase in the incidence of COVID-19, the disease spectrum of patients with central and peripheral nervous system involvement has expanded significantly compared to the previous period. Lack of awareness has caused delays in diagnosis and treatment; therefore, updating the disease spectrum of neurological complications of COVID-19 is necessary. After COVID-19 claimed millions of lives, researchers found that some vaccines may induce autoimmune inflammatory responses in the nervous system via molecular mimicry, leading to SARS-CoV-2 vaccine-related neurological deficits. These neurological complications are often ignored by clinicians, delaying diagnosis and treatment; it is essential to study cases of vaccine-associated neurological complications. Therefore, we summarize the neurological complications of COVID-19 and nervous system adverse reactions caused by SARS-CoV-2 vaccines to help clinicians and public health service personnel understand these rare complications. Avoiding delays in diagnosis and treatment would ensure the safety of COVID-19 patients and SARS-CoV-2 vaccine recipients.","PeriodicalId":93251,"journal":{"name":"Ageing and neurodegenerative diseases","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90249941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogen infection in Alzheimer’s disease: pathophysiology and therapeutic strategies 阿尔茨海默病的病原体感染:病理生理学和治疗策略

Ageing and neurodegenerative diseases Pub Date : 2023-01-01 DOI: 10.20517/and.2022.32

Min Xiong, Honglu Yu, Ye Tian, Lanxia Meng, Zhentao Zhang

引用次数: 0

The role of domain alterations in F1Fo-ATPase dysfunction associated to neurodegenerative diseases 结构域改变在与神经退行性疾病相关的f1fo - atp酶功能障碍中的作用

Ageing and neurodegenerative diseases Pub Date : 2023-01-01 DOI: 10.20517/and.2022.28

Miaomiao Zhou, Yuwan Lin, Zhiling Zhang, Yuting Tang, Wenlong Zhang, Hanqun Liu, Guoyou Peng, Jiewen Qiu, Wenyuan Guo, Xiang Chen, P. Xu

引用次数: 1

Repurposing multiples sclerosis disease-modifying drugs for Parkinson's disease 重新利用多发性硬化症治疗帕金森病的药物

Ageing and neurodegenerative diseases Pub Date : 2023-01-01 DOI: 10.20517/and.2023.08

Tingyu Cao, Qiang Liu, Xiaodong Zhu

引用次数: 0