Biomolecular and Health Science Journal最新文献_第2页

Health Index for Tuberculosis Patients on Family Ability Based on Self-Care 基于自我照顾的结核患者家庭能力健康指数

Biomolecular and Health Science Journal Pub Date : 2022-04-28 DOI: 10.20473/bhsj.v5i1.30913

Suprajitno Suprajitno, Sri Mugianti, Abdulateef Al-Hadeethi

{"title":"Health Index for Tuberculosis Patients on Family Ability Based on Self-Care","authors":"Suprajitno Suprajitno, Sri Mugianti, Abdulateef Al-Hadeethi","doi":"10.20473/bhsj.v5i1.30913","DOIUrl":"https://doi.org/10.20473/bhsj.v5i1.30913","url":null,"abstract":"Introduction: The health index of a patient of tuberculosis can be calculated using variables obtained from the indicators that were developed based on the sufferer and family's behaviors while preventing the disease based on the nursing theory of self-care. It is expected that a family must be able to treat infected members at home properly using technical treatment. Therefore, this study aims to construct a health index formula for tuberculosis patients.Methods: A cross-sectional design was used and further divided into two phases. The first is focus group discussions, which were carried out between tuberculosis treatment holders, Puskesmas nurses, and researchers to develop measurement instrument indicators. A survey was performed in the second phase for patients who were registered and treated in Public Health Center at Blitar, East Java, Indonesia. The 141 responses obtained were selected using a simple random sampling technique. The data were collected using a questionnaire developed from the focus group discussions and then analyzed using factor analysis.Results: A Goodness of Fit Index (GFI) value of 0.98 was recorded along with composite value reliability of 53%. The formula of Health index obtained from the analysis was (0.238* Home environment) + (0.226* Family prevention efforts) – (0.659* Coughing habits of patients) + (0.250* Impact of treatment). The index was then calculated in four categories, namely low, enough, good, very good.Conclusion: So, the health index formula of tuberculosis patients is illustrated as Health Index=0.238*X1+0.226*X2-0.659*X3+0.250*X4.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87744650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potential Effect Of Sweet Potato (Ipomoea Batatas L.) Extract On Total Cholesterol And Low-Density Lipoprotein (LDL) In Hypercholesterol-Model Wistar Rat (Rattus Norvegicus) 甘薯对人体的潜在影响高胆固醇模型褐家鼠(Rattus Norvegicus)总胆固醇和低密度脂蛋白(LDL)的变化

Biomolecular and Health Science Journal Pub Date : 2022-04-28 DOI: 10.20473/bhsj.v5i1.31689

M. Setiawan, Dzikrulloh Abdi, S. K. Zatalini, Kevin Muliawan Soetanto

{"title":"The Potential Effect Of Sweet Potato (Ipomoea Batatas L.) Extract On Total Cholesterol And Low-Density Lipoprotein (LDL) In Hypercholesterol-Model Wistar Rat (Rattus Norvegicus)","authors":"M. Setiawan, Dzikrulloh Abdi, S. K. Zatalini, Kevin Muliawan Soetanto","doi":"10.20473/bhsj.v5i1.31689","DOIUrl":"https://doi.org/10.20473/bhsj.v5i1.31689","url":null,"abstract":"Introduction: CHD has high development among 86% in the world with the prevalence in urban (0.6%) than rural (0.4 %) areas. Atherosclerosis is an inflammatory response in blood vessels due to hypercholesterolemia and oxidized LDL. LDL and total cholesterol levels can be reduced by anthocyanins compounds, which are contained in purple sweet potato (Ipomoea batatas L.) This study aimed to determine the effectiveness of purple sweet potato extract in reducing total cholesterol and LDL. Methods: This study was a post-test-only control group experimental design. Twenty-five Wistar rats were divided into five groups: normal control, negative control, and three treatment groups fed by purple sweet potato extract doses of 66.67, 133.33, and 266.67 mg/kg BW/day. Results: Based on the statistical analysis there were significant differences between the treatment group and control groups. The highest dose of purple sweet potato extract (266.67 mg/kg BW/day) has an optimal effect in decreasing total cholesterol and LDL levels. Conclusion: Purple sweet potato extract (266.67 mg/kg BW/day) can reduce total cholesterol and LDL levels of Wistar Rats.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79900489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diagnostic and Management Problems of a Patient with Severe Life-Threatening Acute Hypocalcemia: A Case Report 1例严重危及生命的急性低钙血症的诊断和治疗问题

Biomolecular and Health Science Journal Pub Date : 2022-04-28 DOI: 10.20473/bhsj.v5i1.34295

Arvin Wiranata Lianto, Birgita Maria Ratu Rosari Bas, R. D. Adiwinoto, Libriansyah Libriansyah

{"title":"Diagnostic and Management Problems of a Patient with Severe Life-Threatening Acute Hypocalcemia: A Case Report","authors":"Arvin Wiranata Lianto, Birgita Maria Ratu Rosari Bas, R. D. Adiwinoto, Libriansyah Libriansyah","doi":"10.20473/bhsj.v5i1.34295","DOIUrl":"https://doi.org/10.20473/bhsj.v5i1.34295","url":null,"abstract":"Hypocalcemia is a common electrolyte disorder. Acute hypocalcemia is a life-threatening condition that needs prompt evaluation and management. We present a case of a 54-year-old woman presented to emergency room with muscle spasm and involuntary movement. Upon physical examination, the patient was disoriented and the Trousseau’s sign was bilaterally positive when the cuff was inflated. Blood test revealed severe hypocalcemia with albumin-corrected serum total calcium levels 1.77 mg/dL. Following extensive diagnostic workups, there were no alternative explanations other than vitamin D deficiency. Despite aggressive intravenous (IV) calcium correction and high-dose vitamin D supplementation the calcium levels gradually decreased and neurological symptoms relapsed. The use of phenytoin to treat neurological symptoms decreased calcium levels further. The patient was eventually discharged with oral calcium and calcitriol supplementation with minimal symptoms. This case highlights the importance of thorough diagnostic workups and judicious use of anticonvulsant drugs in hypocalcemia for optimal treatment outcome.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91512447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effect and Mechanism of Sucrose Consumption to Liver Disease – A Systematic Literature Review 蔗糖摄入对肝脏疾病的影响及其机制——系统文献综述

Biomolecular and Health Science Journal Pub Date : 2022-04-28 DOI: 10.20473/bhsj.v5i1.35160

Sim Hellene Anjani Sigma

{"title":"The Effect and Mechanism of Sucrose Consumption to Liver Disease – A Systematic Literature Review","authors":"Sim Hellene Anjani Sigma","doi":"10.20473/bhsj.v5i1.35160","DOIUrl":"https://doi.org/10.20473/bhsj.v5i1.35160","url":null,"abstract":"Introduction: One liver disease caused by excessive fat in the liver, called non-alcoholic liver disease (NAFLD), commonly occurs with obesity, diabetes, and other disorders. NAFLD is also associated with hepatic insulin resistance, steatosis, non-alcoholic steatohepatitis (NASH), and cirrhosis. Sucrose consumption has increased recently, and known can promotes NAFLD and will accelerate NAFLD development. This study aimed to discuss the effect and mechanism of sucrose intake on liver disease using a systematic literature review.\u0000Methods: The author identified the articles from 6 online search engines, including PubMed, Science Direct, Sinta, Garuda, Google Scholar, and EBSCOHost. A total of 2271 retrieved articles were obtained from combined search strings in Indonesian and English from the search through online search engines. Excluded articles include title not relevant, duplicate articles, not open access, secondary study or review articles, research objective not appropriate, abstract not suitable, and the results/findings not relevant to the aims of this paper.\u0000Results: A final of twenty-three articles were retrieved using the Mendeley reference manager. Studies included were published studies, types of experimental and observational studies, and their specific findings of sucrose effects on liver disease. Results reveal that most research was primarily conducted experimentally and in case-control study types on male rats.\u0000Conclusion: The most common disease related to sucrose is NAFLD, fibrosis/cirrhosis with the indication of NASH, obesity, insulin resistance (IR), triglycerides (TG), hepatic steatosis, hepatocyte ballooning, and weight gain, which we will discuss further in this review.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76445658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Protective Effect of Lemongrass Extract ( Cymbopogon nardus) on Spermatozoa Cells Induced by Lead Acetate 柠檬草提取物对醋酸铅诱导的精子细胞的保护作用

Biomolecular and Health Science Journal Pub Date : 2022-04-28 DOI: 10.20473/bhsj.v5i1.31450

Putri Ayu Ika Setiyowati, Rofiatun Solekha, Dwi Dianita Irawan, R. Rosalina, Karin Alifia Rachmadani, Angella Ananda Saputra

{"title":"Protective Effect of Lemongrass Extract ( Cymbopogon nardus) on Spermatozoa Cells Induced by Lead Acetate","authors":"Putri Ayu Ika Setiyowati, Rofiatun Solekha, Dwi Dianita Irawan, R. Rosalina, Karin Alifia Rachmadani, Angella Ananda Saputra","doi":"10.20473/bhsj.v5i1.31450","DOIUrl":"https://doi.org/10.20473/bhsj.v5i1.31450","url":null,"abstract":"Introduction: Male infertility can be caused by many factors. One of which is environmental pollution such as lead acetate. Lead acetate exposure can increase Reactive Oxygen Species (ROS), affecting spermatozoa quality. Natural antioxidants and flavonoid on Lemongrass (C. nardus) have a great potential for protecting the male reproductive system. This study aimed to analyze the effect of giving various dosages of C. nardus extract on the sperm quality of mice. Methods: The Balb/C male mice were divided into five equal groups. The negative control group was injected with 0.01 ml Na-CMC 0.5% within 40 days, and the positive control group was injected with 0.01 ml lead acetate 7 mg/kg BW within 5 days, the treatment groups were injected by 0.01 ml lead acetate 7 mg/kg body weight within 5 days and continuously injected by 0.01 ml of C. nardus extract with various dosage 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW within 35 days. At the end of the experiment, mice were sacrificed, and sperm suspensions were collected from cauda epididymal to measure the morphology, concentration, and motility.Results: The results showed that giving C. nardus extract could repair morphology, concentration, and motility of spermatozoa with significantly different (p<0.05). The 25 mg/kg BW dose has a good protective effect. Conclusion: The C. nardus extract can repair the decreasing sperm quality caused by lead acetate exposure.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84552542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Renorrhaphy of Unilateral Grade V Blunt Renal Injury: Case Report 单侧V级钝性肾损伤的再修补术1例

Biomolecular and Health Science Journal Pub Date : 2022-04-28 DOI: 10.20473/bhsj.v5i1.31053

Achmad Romy Syahrial Rozidi, Budi Suwarno, Ogi Bahaurini Gumilar, Shaohong Lai

引用次数: 0

Quality of Life of Chronic Hepatitis B Patients Consuming Nucleoside Analog: A Case-Control Clinical Study in Indonesia 慢性乙型肝炎患者服用核苷类似物的生活质量:印度尼西亚的一项病例对照临床研究

Biomolecular and Health Science Journal Pub Date : 2022-04-28 DOI: 10.20473/bhsj.v5i1.31409

N. Putri, R. H. Aswin, Izzatul Fithriyah, U. Maimunah, M. Miftahussurur, Y. Yamaoka

{"title":"Quality of Life of Chronic Hepatitis B Patients Consuming Nucleoside Analog: A Case-Control Clinical Study in Indonesia","authors":"N. Putri, R. H. Aswin, Izzatul Fithriyah, U. Maimunah, M. Miftahussurur, Y. Yamaoka","doi":"10.20473/bhsj.v5i1.31409","DOIUrl":"https://doi.org/10.20473/bhsj.v5i1.31409","url":null,"abstract":"Introduction: Chronic hepatitis B raises serious concern due to its high morbidity, such as cirrhosis and hepatocellular carcinoma, and mortality from 267 per 100,000 person-years. Up to now, medical therapy that successfully eradicates the hepatitis B virus is not available. Therapy is given in the long term for suppressing viral replication and disease progression. Nucleoside analog (NA) is a medication that is consumed orally once a day for years. Previous studies showed that patients who were treated with NA had a different quality of life (QoL) compared to naïve patients. This research aimed to analyze the QoL of chronic hepatitis B patients who consumed NA by comparing it with naïve patients at Dr. Soetomo General Academic Hospital Surabaya. Methods: Subjects were recruited consecutively from chronic hepatitis B patients at Dr. Soetomo General Academic Hospital Surabaya during 9 February – 31 May 2021. Data about sociodemographic characteristics, hepatitis B therapy history, and QoL were gained by using the SF-36 questionnaire and medical records. Subjects were divided into NA and naïve groups which responses underwent an analytical comparison. Results: NA group had significantly higher QoL in a physical component score (PCS) and mental component score (MCS), with physical functioning (PF), role limitations due to physical health (RP), role limitations due to emotional problems (RM), energy/fatigue (VT), emotional well-being (MH), social functioning (SF), and general health perception (GH) subscales having p<0.05Conclusion: The QoL of patients who were treated with NA was significantly higher than that of naïve patients in terms of physical and mental components.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76821119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Breeding Preference and Bionomics of Anopheles spp. at the Malarial Endemic Area, Runut Village, East Nusa Tenggara Province, Indonesia 印度尼西亚东努沙登加拉省Runut村疟疾流行区按蚊孳生偏好及生物学研究

Biomolecular and Health Science Journal Pub Date : 2022-04-28 DOI: 10.20473/bhsj.v5i1.35278

Gery Morales Munthe, David Nugraha, Gabriel Pedro Mudjianto, Etik Ainun, Rohmah, Zukhaila Salma, Lynda Rossyanti, Fitriah, S. Pusarawati, B. Utomo, S. Basuki, H. Uemura

{"title":"Breeding Preference and Bionomics of Anopheles spp. at the Malarial Endemic Area, Runut Village, East Nusa Tenggara Province, Indonesia","authors":"Gery Morales Munthe, David Nugraha, Gabriel Pedro Mudjianto, Etik Ainun, Rohmah, Zukhaila Salma, Lynda Rossyanti, Fitriah, S. Pusarawati, B. Utomo, S. Basuki, H. Uemura","doi":"10.20473/bhsj.v5i1.35278","DOIUrl":"https://doi.org/10.20473/bhsj.v5i1.35278","url":null,"abstract":"Introduction: Anopheles mosquito is transmitting malaria, one of the health problems in Indonesia. Understanding Anopheles mosquito behaviour and its breeding preference is one of the crucial keys to prevent malaria transmission. This study aimed to identify the breeding place distribution and bionomics of Anopheles spp. in Runut village, Sikka district, East Nusa Tenggara. Methods: A descriptive observational study was conducted in Runut village, Waigete sub- district, in April 2018. Anopheles spp. larvae were collected in 7 suspected breeding places consisting of 2 rice fields, 3 fish ponds, and 2 puddles. Mosquitos behaviour was observed using bed-net traps located inside and outside the house from 7.15 PM to 1.15 AM after obtaining informed consent. Mosquito collection using bed-net trap were performed for 40 minutes then followed by resting mosquito collection for 10 minutes. Results: Anopheles spp. larvae were found in most of the suspected aquatic habitats, presenting different densities and together with larvae of the other mosquito species. Relatively high number of Anopheles spp. larvae was obtained from a puddle. Only one female mosquito of Anopheles spp. resting on the wall inside house was found around 00.55 – 01.05 AM and resulted in low mosquito density determination. Conclusion: Anopheles spp. larvae were harbouring in most of the aquatic habitats and one puddle contained moderately abundant larvae of Anopheles in Runut village, Sikka district, East Nusa Tenggara, Indonesia. Even only one Anopheles spp. mosquito was detected inside the house, residents in Runut village should regular use insecticide-treated bed nets and continuous observation of mosquito breeding places especially puddles to prevent malaria and other mosquito-borne diseases.","PeriodicalId":9324,"journal":{"name":"Biomolecular and Health Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74916069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The correlation of fibronectin and vimentin expression on anthracycline-based neoadjuvant chemotherapy response in stage IIIA and luminal subtype IIIB breast cancer 纤连蛋白和波形蛋白表达与IIIA期和IIIB亚型乳腺癌蒽环类新辅助化疗反应的相关性

Biomolecular and Health Science Journal Pub Date : 2022-01-01 DOI: 10.4103/bhsj.bhsj_25_22

Feri Nugroho, Bachtiar M Budianto, D. Suprabawati

引用次数: 1

Biomolecular and Health Science Journal Pub Date : 2022-01-01 DOI: 10.4103/bhsj.bhsj_20_22

T. Adianti, TusyNovita Dwi Wardani, R. Wulandari

引用次数: 0