Vaccination research : open journal最新文献_第3页

Current Status of Human Immunodeficiency Virus Vaccines 人类免疫缺陷病毒疫苗的现状

Vaccination research : open journal Pub Date : 2016-12-31 DOI: 10.17140/vroj-1-e002

D. Sosa, R. Jayant, A. Kaushik, M. Nair

引用次数: 2

Leading Ebola Vaccine Candidates 领先的埃博拉候选疫苗

Vaccination research : open journal Pub Date : 2016-12-31 DOI: 10.17140/vroj-1-101

V. Pavot

引用次数: 1

Dendritic Cell Maturation is a Critical Step in Dendritic Cell Vaccine Preparation for Cancer Therapy 树突状细胞成熟是制备用于癌症治疗的树突状细胞疫苗的关键步骤

Vaccination research : open journal Pub Date : 2016-12-31 DOI: 10.17140/vroj-1-105

S. Farashi-Bonab, N. Khansari

{"title":"Dendritic Cell Maturation is a Critical Step in Dendritic Cell Vaccine Preparation for Cancer Therapy","authors":"S. Farashi-Bonab, N. Khansari","doi":"10.17140/vroj-1-105","DOIUrl":"https://doi.org/10.17140/vroj-1-105","url":null,"abstract":"Background: Dendritic cell (DC) vaccine is a hopeful approach for cancer treatment. In clinical trials, DC vaccines have produced clinical responses in some cancer patients. However, DC vaccines efficacy is not satisfactory in most types of cancer and more efforts must be done to improve their effectiveness in advanced cancers. Understanding the influence of tumor cells and tumor stromal cells on DCs and the antitumor activity of ex vivo generated DCs in the tumor microenvironment can help to augment antitumor efficiency of ex vivo generated DCs. In a fibrosarcoma tumor model, we explored effects of the tumor microenvironment on the antitumor efficacy of ex vivo generated DCs. Methods: DCs were generated from mouse bone marrow precursor cells in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4). DCs were pulsed with tumor antigens and matured in the presence of tumor necrosis factor-alpha (TNF-α), lipopolysaccharide (LPS), or TNF-α plus LPS. Mature or immature DCs were injected subcutaneously before tumor inoculation or were directly injected into the tumor tissue. Results: Tumor antigen-pulsed DCs matured in the presence of TNF-α plus LPS showed appropriate functionality in vitro, including IL-12 secretion and induction of lymphocyte proliferation. Tumor lysate-loaded DCs matured in the presence of TNF-α did not show appropriate antitumor function in vivo. Injection of antigen-unpulsed mature DCs two days before tumor inoculation resulted in antitumor effects. In contrast, injection of immature DCs directly into the tumor tissue enhanced the tumor growth. Conclusion: These results suggest that tumor cells, tumor stromal cells, or tumor derived factors can influence DCs to have tumor-promoting function. Appropriate maturation induction in ex vivo generated DCs and manipulating the tumor microenvironment before DC vaccination may improve antitumor activity of DC vaccines in cancer patients.","PeriodicalId":93237,"journal":{"name":"Vaccination research : open journal","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83261943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-C Chemokine Receptor Seven (CCR7): Coming of Age In Vaccines. C-C趋化因子受体7 (CCR7):疫苗的成熟

Vaccination research : open journal Pub Date : 2016-04-01

Colin A Bill, Olga B Soto, Charlotte M Vines

引用次数: 0

C-C Chemokine Receptor Seven (CCR7): Coming of Age In Vaccines C-C趋化因子受体7 (CCR7):疫苗的成熟

Vaccination research : open journal Pub Date : 2016-04-01 DOI: 10.17140/vroj-1-102

C. A. Bill, Olga B Soto, C. Vines

{"title":"C-C Chemokine Receptor Seven (CCR7): Coming of Age In Vaccines","authors":"C. A. Bill, Olga B Soto, C. Vines","doi":"10.17140/vroj-1-102","DOIUrl":"https://doi.org/10.17140/vroj-1-102","url":null,"abstract":"In casual conversation with non-medical individuals, it is common for them to ask: why do we not have a cure for cancer or vaccinations for all diseases? It seems somewhat logical to assume that after so many years of research that cures should be readily available, diseases in general should simply require a pill or jab and that somehow, if scientists are not deliberately hiding these cures, then they must be asleep at the wheel. A typical response to such questions focuses on the complexity of the different cancers/diseases and that there will be no “one cure fits all”. When it comes to vaccinations, there is absolutely no doubt that many vaccines are extremely effective and a multitude of publications can attest to this and cite how many lives have been saved because of our vaccination programs; indeed, vaccinations typically pop up on a list of reasons why humans today are living substantially longer than at any previous time in history.1-3 Nevertheless, there is always an overriding and to some extent embarrassing realization that despite the relative success of vaccines we still do not, for the most part, know how to make consistently effective vaccines and that often it boils down to a trial and error procedure to establish the best vaccine for a given target","PeriodicalId":93237,"journal":{"name":"Vaccination research : open journal","volume":"36 1","pages":"7 - 9"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87549825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovations in Microbial Biodiscovery, Targeting Silent Metabolism and New Chemical Diversity 微生物发现的创新，针对沉默代谢和新的化学多样性

Vaccination research : open journal Pub Date : 2013-07-17 DOI: 10.14264/UQL.2017.734

Zeinab G. Khalil

引用次数: 0