Journal of hormones最新文献

{"title":"Involvement of Ovarian Estradiol Biosynthesis and Pituitary FSH Expression in the Mechanism of Human Chorionic Gonadotropin Stimulation of Uterine Growth in Immature Female Rats","authors":"Sandrine Rafert, J. Mariot, D. Klett, Y. Combarnous","doi":"10.1155/2016/6923239","DOIUrl":"https://doi.org/10.1155/2016/6923239","url":null,"abstract":"In a previous work, we showed that human Chorionic Gonadotropin (hCG) alone is able to stimulate uterine ponderal growth in immature female rats. In the present paper, we provide new information indicating that a single 100 ng hCG injection increased ovarian androgen availability and aromatase activity. These changes are consistent with an increase in ovarian estradiol secretion. Ovarian activin βA and activin βB subunit RNAs expression were also increased following hCG injection. Most interestingly, this treatment also led to an increase in FSHβ subunit mRNA expression in the pituitary, which might be due to hCG-stimulated ovarian activin secretion. We have not been able so far to follow the kinetics of the plasma concentrations of activin and FSH in hCG-treated animals compared to control animals. This has to be explored in the future to provide a more complete assessment of our model.","PeriodicalId":93206,"journal":{"name":"Journal of hormones","volume":"2016 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6923239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64496434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychophysiological Stress Reactivity Relationships across the Menstrual Cycle.","authors":"Karen C Olson,&nbsp;Haley A Carroll,&nbsp;M Kathleen B Lustyk","doi":"10.1155/2015/631250","DOIUrl":"https://doi.org/10.1155/2015/631250","url":null,"abstract":"<p><p>While evidence suggests that women exhibit psychophysiological differences in stress reactivity across the menstrual cycle, the relationships among psychological and physiological stress reactivity states are not well understood. Healthy, normally cycling women (<i>N</i> = 44) participated in two counterbalanced laboratory sessions during the follicular and luteal phases where heart rate and subjective stress were assessed in response to stressors. There were no differences in the magnitudes of psychophysiological stress responses across the cycle. Psychological and physiological states were largely unrelated in the follicular phase but interrelationships were found in the luteal phase and these relationships were influenced by autonomic perception and trait anxiety. For women with high trait anxiety, autonomic perception appeared to buffer psychological and physiological stress reactivity during the luteal phase, suggesting that autonomic perception may be a protective factor for more anxious women during times of acute stress.</p>","PeriodicalId":93206,"journal":{"name":"Journal of hormones","volume":"2015 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/631250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38941870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perturbation of the Hematopoietic Profile by Anabolic Androgenic Steroids","authors":"J. Mullen, Nina Gårevik, J. Schulze, A. Rane, L. B. Bergman, L. Ekström","doi":"10.1155/2014/510257","DOIUrl":"https://doi.org/10.1155/2014/510257","url":null,"abstract":"Objective. The aim of this study was to investigate the hematopoietic profile in AAS abusers, during or short after their last abuse and approximately six months later. Moreover, we studied if supraphysiological doses of testosterone influence the concentration of hemoglobin and erythropoietin in healthy volunteers. Design and Methods. Subjects ( ) were recruited through an antidoping hotline. The hematological profile was measured when the subjects entered the study and approximately 6 months later. Testosterone enanthate (500 mg) was administered to healthy volunteers ( ). Gene expression was studied in human hek293 cells exposed to 1 μM testosterone. Results. Decreased levels of hemoglobin, erythrocyte volume fraction, and erythrocyte counts were observed after 6 months without the use of AAS. Results in volunteers show that hemoglobin increased 3% four and 15 days after testosterone administration, whereas EPO was significantly increased by 38% four days after dose. Agreeingly, in vitro study shows that testosterone induces the mRNA level of EPO with 65% after 24-hour exposure. Conclusion. These results indicate that supraphysiological doses of testosterone may cause a perturbation in the hematopoietic profile. This is of interest in relation to the adverse cardiovascular effects observed in AAS abusers.","PeriodicalId":93206,"journal":{"name":"Journal of hormones","volume":"2014 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2014-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/510257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64527652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Literature Review of the Epidemiology of Nongenetic Forms of Hypogonadism in Adult Males","authors":"V. Zarotsky, Ming-Yi Huang, W. Carman, A. Morgentaler, P. Singhal, D. Coffin, T. Jones","doi":"10.1155/2014/190347","DOIUrl":"https://doi.org/10.1155/2014/190347","url":null,"abstract":"This study summarizes the literature on the prevalence, incidence, and proportion of patients receiving treatment for male hypogonadism and a systematic literature search was performed for articles published in the last 20 years. Of the 97 studies identified, 96 examined the prevalence, 2 examined the incidence, and 4 examined the proportion of males with hypogonadism patients receiving treatment. Based on studies conducted in Europe and USA, the prevalence of hypogonadism in the general population ranged from 2.1% to 12.8% of middle-aged to older men, with an estimated incidence of 12 new cases per 1,000 person-years. Prevalence was higher among patients with comorbid conditions, such as type 2 diabetes mellitus and obesity. Approximately 10–12% of men with hypogonadism were receiving testosterone treatment. This literature review suggests that there is potentially a significant burden of hypogonadism in the general population. Burden seems to increase with age and in the presence of certain disease conditions. Data suggests that many hypogonadal men who may benefit from testosterone replacement are not receiving treatment. This may be the result of underdiagnosis of the disease, lack of awareness by patients or physicians, irregularities surrounding the diagnostic criteria, and deficiency of long-term safety studies.","PeriodicalId":93206,"journal":{"name":"Journal of hormones","volume":"2014 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2014-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/190347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64383761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Cutaneous Wound Healing of Ovariectomized Mouse at 12 Weeks with That of SHAM and Estrogen-Administered Mice","authors":"Kanae Mukai, Yuriko Miyasaka, Kana Takata, T. Urai, Yukari Nakajima, Emi Komatsu, J. Sugama, T. Nakatani","doi":"10.1155/2014/484258","DOIUrl":"https://doi.org/10.1155/2014/484258","url":null,"abstract":"The aim of this experiment was to investigate the effect of 17-estradiol on cutaneous wound healing in 12-week ovariectomized (OVX) female mice. Eight-week-old female mice were divided into three groups: administration of 17-estradiol after OVX (OVX","PeriodicalId":93206,"journal":{"name":"Journal of hormones","volume":"1 1","pages":"484258-1-484258-6"},"PeriodicalIF":0.0,"publicationDate":"2014-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/484258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64515765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Intraoperative Parathormone Assay as an Index to Successful Parathyroidectomy","authors":"R. Shenoy, A. Behl, T. Pawar","doi":"10.1155/2014/750401","DOIUrl":"https://doi.org/10.1155/2014/750401","url":null,"abstract":"Introduction. Surgery is the definitive treatment for primary hyperparathyroidism (PHP). Focused approaches for excision of single gland pathology are gaining popularity. Preoperative parathyroid localization and intraoperative parathormone (IOPTH) assay are essential components of successful parathyroidectomy using focused approach. Objective. To evaluate the efficacy of IOPTH in patients undergoing surgery for PHP. Methods. Retrospective review of twelve patients who underwent surgery for PHP at tertiary corporate hospital in Mumbai, India, between January 2009 and December 2012. Results. IOPTH had true results in 10 patients (83%) and led to unnecessary further exploration in 1 patient (8%). The concordance rate between ultrasonogram, sestamibi, and IOPTH was 66%. The mean decay of IOPTH was 65%, and all patients were normocalcemic at the end of six months. Conclusion. IOPTH is a useful adjunct to predict successful removal of the involved gland.","PeriodicalId":93206,"journal":{"name":"Journal of hormones","volume":"2014 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2014-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/750401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64654520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvements in Chronic Primary Insomnia after Exercise Training Are Correlated with Changes in Metabolic and Hormonal Profile","authors":"A. A. Teixeira, G. S. Passos, F. Ruiz, E. S. Alves, D. Poyares, M. Santana, S. Tufik, M. Mello","doi":"10.1155/2014/246342","DOIUrl":"https://doi.org/10.1155/2014/246342","url":null,"abstract":"Objective. The objective of this study was to correlate metabolic and hormonal parameters before and after 8, 16, and 24 weeks (wk) of moderate aerobic training in individuals with chronic primary insomnia. Method. Four male and sixteen female volunteers (adults, sedentary, and healthy) performed exercise training for 24 weeks. Blood and Pittsburgh Sleep Quality Index (PSQI) was obtained at baseline, 8, 16, and 24 wk of training. Results. PSQI scores decreased after 8, 16, and 24 wk of training regarding baseline values. Indeed, total sleep time (TST) increased after 16 and 24 wk of exercise training regarding baseline values. The correlations were analyzed using the delta ( ) values ( <path id=\"x38\" d=\"M249 635q70 0 116 -43t46 -105q0 -46 -28 -80q-22 -25 -80 -64q62 -35 97 -75t35 -99q0 -81 -63 -131t-135 -50q-83 0 -137.5 45.5t-54.5 123.5q0 52 45 95q29 28 89 64q-109 62 -109 155q0 66 50.5 115t128.5 49zM238 603q-42 0 -67.5 -31t-25.5 -72q0 -50 32.5 -79.5\u0000t98.5 -62.5q61 48 61 124q0 59 -29.5 90t-69.5 31zM248 20q46 0 76.5 33.5t30.5 89.5q0 50 -39 85.5t-110 71.5q-81 -54 -81 -137q0 -67 35.5 -105t87.5 -38z\">  wk less baseline; <path id=\"x36\" d=\"M137 343l67 33q37 17 63 17q79 0 129.5 -53t50.5 -131q0 -92 -58 -156.5t-147 -64.5t-147 68t-58 182q0 63 17 119t43 95.5t61.5 72t69 52t67.5 31.5q62 22 128 33l6 -32q-56 -11 -108 -35q-149 -71 -184 -231zM227 337q-47 0 -95 -27q-6 -23 -6 -70q0 -93 36 -155.5\u0000t96 -62.5q53 0 78 45.5t25 105.5q0 68 -35 116t-99 48z\">  wk less baseline; <path id=\"x33\" d=\"M285 378v-2q65 -13 102 -54.5t37 -97.5q0 -57 -30.5 -104.5t-74 -75t-85.5 -42t-72 -14.5q-31 0 -59.5 11t-40.5 23q-19 18 -16 36q1 16 23 33q13 10 24 0q58 -51 124 -51q55 0 88 40t33 112q0 64 -39 96.5t-88 32.5q-29 0 -64 -11l-6 29q77 25 118 57.5t41 84.5\u0000q0 45 -26.5 69.5t-68.5 24.5q-67 0 -120 -79l-20 20l43 63q51 56 127 56h1q66 0 107 -37t41 -95q0 -42 -31 -71q-22 -23 -68 -54z\">  wk less baseline). We have observed a negative correlation for between TST and cortisol, a positive correlation for between TST and growth hormone, a negative correlation for between TST and VLDL, a negative correlation for between TST and triacylglycerols, and a negative correlation for and between TST and thyroid-stimulating hormone. Conclusion. The exercise training improved the sleep quality of patients with chronic primary insomnia.","PeriodicalId":93206,"journal":{"name":"Journal of hormones","volume":"2014 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2014-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/246342","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64402128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of 17β-Estradiol Administration on Cutaneous Wound Healing in 24-Week Ovariectomized Female Mice","authors":"Kanae Mukai, Yukari Nakajima, T. Urai, Emi Komatsu, Kana Takata, Yuriko Miyasaka, Nasruddin, J. Sugama, T. Nakatani","doi":"10.1155/2014/234632","DOIUrl":"https://doi.org/10.1155/2014/234632","url":null,"abstract":"Estrogen replacement promotes cutaneous wound healing in 8–10-week young ovariectomized female mice. However, research using aged ovariectomized female mice has not been reported, to the best of our knowledge. Therefore, we investigated the effect of 17β-estradiol on cutaneous wound healing using 24-week middle-aged ovariectomized female mice. Twenty-week-old female mice were divided into three groups: medication with 17β-estradiol after ovariectomy (OVX","PeriodicalId":93206,"journal":{"name":"Journal of hormones","volume":"2014 1","pages":"234632"},"PeriodicalIF":0.0,"publicationDate":"2014-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/234632","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64395552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic Cardiovascular Control in Hyperthyroid Women during Sleep","authors":"E. Tobaldini, M. Pecis, M. Bulgheroni, M. Muratori, M. Bevilacqua, N. Montano","doi":"10.1155/2013/813264","DOIUrl":"https://doi.org/10.1155/2013/813264","url":null,"abstract":"Hyperthyroidism is characterized by hyperadrenergic symptoms (i.e., tachycardia, anxiety, and increased metabolic state). Although hyperthyroid patients often complain about an impairment of sleep, no data are available on sleep characteristics and autonomic cardiovascular control during sleep in these patients. We aimed to assess sleep qualitative indices and autonomic cardiovascular regulation during sleep in hyperthyroidism (Hyperthyr) and after treatment. Six subjects with a first diagnosis of Graves’ disease or hyperfunctioning nodule underwent a complete polysomnographic study (PSG) at the time of diagnosis and after the treatment, when they became euthyroid (Euthyr). ECG and respiratory signals were extracted and samples of consecutive 250–300 beats were analyzed using linear spectral and nonlinear entropy analysis of heart rate variability (HRV), during the different sleep stages. Heart rate was decreased and total power increased in Euthyr compared to Hyperthyr, both during wake and sleep; no changes of the sympathovagal balance were observed. Entropy analysis showed that regularity index was reduced in Euthyr compared to Hyperthyr, suggesting changes in the complexity of the cardiovascular control. Periodic leg movements (PLM) were reduced in Euthyr compared to Hyperthyr. In conclusion, hyperthyroidism seems to be associated with an increased sleep fragmentation, due to PLM and an altered cardiac autonomic control.","PeriodicalId":93206,"journal":{"name":"Journal of hormones","volume":"2013 1","pages":"813264"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/813264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64265207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary Melatonin Concentrations in a Sitting and a Standing Position","authors":"T. Kozaki, Toshihiko Arata, Ayaka Kubokawa","doi":"10.1155/2013/236325","DOIUrl":"https://doi.org/10.1155/2013/236325","url":null,"abstract":"This study aimed to examine differences in salivary melatonin concentrations between the sitting and standing positions. Ten subjects (age range: 20–22 years; 5 males and 5 females) participated in the study and provided written consent. In the sitting condition, the subjects sat on a chair from 23:30 h to 1:00 h, whereas in the standing condition, the subjects sat on a chair from 23:30 h to 0:30 h and stood on the floor from 0:30 h to 1:00 h. Saliva samples were obtained at 0:25 h and 1:00 h from all subjects. The experiment was performed under a dim light condition (<10 lx). No significant differences were observed in melatonin concentrations between the two positions at 0:25 h; however, melatonin concentrations in the standing condition were significantly greater than those in the sitting condition at 1:00 h. These results show that melatonin secretion is significantly greater in the standing position than that in the sitting position.","PeriodicalId":93206,"journal":{"name":"Journal of hormones","volume":"2013 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2013-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/236325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64393968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}