EC clinical and medical case reports最新文献

{"title":"Pilot study of a newly developed expiratory positive airway pressure device","authors":"I. Randhawa","doi":"10.15761/cmr.1000151","DOIUrl":"https://doi.org/10.15761/cmr.1000151","url":null,"abstract":"Background: Obstructive sleep apnea [OSA], a sleep-related breathing disorder that affects millions of people worldwide, is the result of partial or complete airflow obstruction that occurs during sleep. Oropharyngeal muscle relaxation during sleep can result in soft tissue collapse, with subsequent airflow impedance. During episodes of airflow obstruction, oxygen levels can drop precipitously, inducing a neurological arousal. Carbon dioxide build up interrupts sleep which triggers the respiratory drive for resumption of coordinated breathing. Complete wakefulness is rarely achieved during these episodes, but sleep quality is severely compromised. If left untreated, OSA may increase the risk of cardiovascular disease, arrhythmia, hypertension, stroke, diabetes, depression, obesity, and intellectual decline. Compliance with and tolerance of existing devices particularly the Continuous Positive Airway Pressure (CPAP) machine remains poor. Objectives: The present pilot study evaluates the utility of a newly developed mechanical nasal expiratory positive airway pressure [EPAP] device in OSA management. Method: A total of 19 adult subjects were recruited from two accredited sleep study centers based on a pre-existing, polysomnographic diagnosis of OSA with mild to moderate apnea-hypopnea index [AHI] scores. Sixteen subjects completed the study and underwent a standard polysomnography [PSG] procedure while wearing the nasal study device. The device consists of two cylindrical bodies with a ball-valve mechanism that creates airflow resistance during expiration, allowing for pneumatic splinting. Resulting data were compared to baseline PSG results, performed in the same sleep center as the study PSG. Results: Total apneas and hypopneas, respective indices for both, the cumulative apnea-hypopnea index, mean and minimum oxygen saturations during sleep, average and maximum heart rate during sleep, total desaturations and the desaturation index were evaluated and showed overall improvement. In the initial 6 patients, no significant improvement was observed in the overall indices; modifications were made to the device to minimize leak, and the subsequent 6 patients demonstrated a statistically significant improvement in obstructive indices and the minimum oxygen saturation achieved during sleep. Discussion: Thus far, 16 of 19 subjects have successfully completed a standard PSG with the nasal device. One subject aborted the study early due to emotional instability unrelated to the use of the device. Another subject with particularly small nasal passages reported that the device felt uncomfortably snug and aborted the study early as well. The remaining subjects tolerated the study well, without experiencing any appreciable side effects, and most patients have found the device to be comfortable. Ongoing improvements to the device have been implemented based on subject feedback in order to optimize comfort and efficacy of the device. Conclusion: This pilot study ","PeriodicalId":93173,"journal":{"name":"EC clinical and medical case reports","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84703470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum criteria for adipose derived stem cells","authors":"Hea-Jo Yoon, Woo Jung Ho","doi":"10.15761/CMR.1000145","DOIUrl":"https://doi.org/10.15761/CMR.1000145","url":null,"abstract":"Received: March 05, 2019; Accepted: March 18, 2019; Published: March 20, 2019 Adipose derived stem cells (ASCs) are derived from mesenchyme and have several general or unique characteristics. In order to be recognized as a mesenchymal stem cells, the following three criteria shall be satisfied. MSC must be plastic-adherent in standard culture conditions. The cells must be able to differentiate into trilineage mesenchymal differentiation pathways. ASCs must have a specific cell surface antigen expression.","PeriodicalId":93173,"journal":{"name":"EC clinical and medical case reports","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85882465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer cure – The protocol and explanation","authors":"A. Hague","doi":"10.15761/cmr.1000147","DOIUrl":"https://doi.org/10.15761/cmr.1000147","url":null,"abstract":"","PeriodicalId":93173,"journal":{"name":"EC clinical and medical case reports","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89776229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6-Pyruvoyl-tetrahydropterin synthase deficiency: The first Tunisian case","authors":"Fahmi N, Ichraf K, Haifa S, Neji T, Ilhem Tby, Moncef F","doi":"10.15761/CMR.1000148","DOIUrl":"https://doi.org/10.15761/CMR.1000148","url":null,"abstract":"We detected a first case of 6-Pyruvoyl-tetrahydropterin synthase deficiency in Neuropediatric department mongi Ben Hmida of Tunisia. Genetic analyses of PTS gene demonstrated a homozygous mutation; treatment had been started at the age of 3 years. *Correspondence to: Fahmi Nasrallah, Laboratory of Biochemistry, Rabta Hospital, 1007 Jebbari, Tunis, Tunisia, Tel: 216 71 561912, E-mail: fehmi56@yahoo.fr","PeriodicalId":93173,"journal":{"name":"EC clinical and medical case reports","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91485327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of circulating DNA (cDNA) alterations in several genes with established prognostic markers in a series of solid tumors treated with Multi Targeted Epigenetic therapy (MTET)","authors":"M. Nezami, S. Hager, Christian Klosowski","doi":"10.15761/cmr.1000150","DOIUrl":"https://doi.org/10.15761/cmr.1000150","url":null,"abstract":"In this article we review the dynamics of changes in the observed minor allele frequency fraction (MAF) as measured through circulating tumor DNA (ctDNA) of alterations in 8 target genes: NOTCH1, FGF2, MYC, RB1, ATM, MET, BRCA1, BRCA2, ATM, and VHL for which epigenetic dysregulation is identified in the literature to be most relevant to clinical response. We retrospectively examine a series of 54 oncology patients treated with multitargeted epigenetic therapy (MTET), a protocol used to treat solid tumors with epigenetically influenced driver genes. We examined the additional prognostic value of tracking such measurements of MAF with relation to their outcome, in the context of established survival markers including circulating tumor cells and PET imaging. In our cohort, observed levels of ctDNA changed rapidly marking it as a potential indicator for early molecular response. More than 50 percent reduction of ctDNA MAF and/or complete disappearance of CTC was used as major response after two weeks of the therapy. We concluded that molecular response identified in these 8 dysregulated genes, had independent prognostic value for outcome and could be used to generate further hypothesis in larger studies in solid tumors treated with this method. While previous research into the prognostic value of tracking ctDNA change has largely focused on specific cancer types or a specific gene, our study tracks several target genes over a variety of cancer types. *Correspondence to: MA Nezami, MD, President, Pacific Medical Center of Hope, Pacific Medical Center of Hope, Sahel Oncology, Fresno, CA, USA, E-mail: amnezami@yahoo.com","PeriodicalId":93173,"journal":{"name":"EC clinical and medical case reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79610781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passaging and cryopreservation during culture of human pluripotent stem cells","authors":"Woo Jung Ho, Hea-Jo Yoon","doi":"10.15761/CMR.1000146","DOIUrl":"https://doi.org/10.15761/CMR.1000146","url":null,"abstract":"","PeriodicalId":93173,"journal":{"name":"EC clinical and medical case reports","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80965780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validated HPTLC method for simultaneous estimation of metoprolol succinate and ramipril in bulk drug and marketed formulation","authors":"Kamini Sethy, J. Rao, K. Rajeswari, K. Nagoji","doi":"10.15761/cmr.1000152","DOIUrl":"https://doi.org/10.15761/cmr.1000152","url":null,"abstract":"This paper describes a new, simple, precise, and accurate HPTLC method for simultaneous estimation of Metoprolol succinate and Ramipril as the bulk drug and in tablet dosage forms. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of Methanol: Toluene: Ethyl Acetate: Ammonia (2.5:3:5:0.7v/v/v/v). Densitometric evaluation of the separated zones was performed at 209 nm. The two drugs were satisfactorily resolved with RF values 0.67, and 0.37 for Metoprolol Succinate and Ramipril, respectively. The accuracy and reliability of the method was assessed by evaluation of linearity (2000-12000 ng/spot for Metoprolol succinate and 200–1200 ng/spot for Ramipril), precision ( intra-day RSD 0.471–1.036% and inter-day RSD 1.085–1.580% for Metoprolol Succinate and intra-day RSD 1.057–1.63% and inter-day RSD 1.024–1.746% for Ramipril,), accuracy (98.95 ± 0.16 % for Metoprolol and 98.98 ± 0.41 % for Ramipril), and specificity, in accordance with ICH guidelines. *Correspondence to: K Raja Rajeswari, Sri Venkateswara College of Pharmacy, Etcherla-532410, Srikakulum District, Andhra Pradesh, India, Email: kamini.tiki@gmail.com","PeriodicalId":93173,"journal":{"name":"EC clinical and medical case reports","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89212838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain repair and general health improvement through human neurophysiology and repair physiology","authors":"G. Schalow","doi":"10.15761/CMR.1000144","DOIUrl":"https://doi.org/10.15761/CMR.1000144","url":null,"abstract":"In this review of Coordination Dynamics Therapy (CDT) it will be shown that, using human neurophysiology, pathophysiology and repair physiology, the human Central Nervous System (CNS) can partly be repaired by movement-based learning. Since most body functions are controlled by the nervous system, these body functions can be improved through CDT. Since physical exercise also improves the immune system and the cardio-vascular performance, cancer growth can be inhibited. CDT therefore helps to reduce the occurrence of cancer, heart attack, stroke, hypertension and bladder incontinence mainly by improving the cardiovascular performance and CNS functioning. This general health improvement became possible by the development of human neurophysiology and basic medical research. *Correspondence to: Giselher Schalow, Institute of Exercise Biology and Physiotherapy, Centre of Behavioural and Health Sciences, University of Tartu, 5 Jakobi Street, Tartu 51014, Estonia, E-mail: g_schalow@hotmail.com","PeriodicalId":93173,"journal":{"name":"EC clinical and medical case reports","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84769002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}