Sumerianz journal of medical and healthcare最新文献

{"title":"Prevalence of Coronavirus Disease 2019 (COVID-19) Among Children Age Groups","authors":"Saber A. M. El-Sayed, Mostafa M. Ahmady, Bashir Abdalla Hassan","doi":"10.47752//SJMH.41.40.45","DOIUrl":"https://doi.org/10.47752//SJMH.41.40.45","url":null,"abstract":"In our study prevalence of coronavirus Disease 2019 (COVID-19) among Children age groups, by diagnosis, symptoms, and treatment of COVID-19 in children. The incidence of COVID-19 among children under 18 years was 1.8 % based on the reported studies, where the mortality rate in the same age group was 0.3 %. No death has been reported in children under 10-years old. It has also been reported that the case fatality rates for the age groups of 0-9 years and 10-19 years are zero and 0.2%, respectively. Cai, et al. [1] There are some studies that report children with COVID-19 having rashes, symptoms and signs similar to Kawasaki’s disease. Heart complications were observed in these cases of Kawasaki’s disease. the levels of bilirubin and hepatic enzymes are the best markers for diagnosing the severity of the disease in the affected children. Large number of angiotensin converting enzyme 2 (ACE2) receptors on cell surfaces, effective innate immune system, and high level of blood lymphocyte have been reported to be the potent reasons for lower incidence of severe symptoms of COVID-19 among children. Children with severe COVID-19 clinical symptoms, especially those suffering from upper respiratory tract symptoms and signs and pneumonia, also children with gastrointestinal tract symptoms and signs as vomiting and diarrhea must be hospitalized similar to adults, while quarantine and home isolations are required for those having mild symptoms. Antiviral medication (Remdesivir, darunavir, ribavirin, oseltamivir, tocilizumab, umifenovir and favipiravir,) ACE inhibitors, interferon-α 2b, co-therapy with azithromycin, inhaling iNO, inhaled bronchodilators and oxygen therapy can be used for treatment. The best treatment for affected children without any clinical and infection symptoms, home isolation protocol has been recommended.","PeriodicalId":93143,"journal":{"name":"Sumerianz journal of medical and healthcare","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44515101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novelistic Biomaterial from Natural Source: its Isolation and Physico-Chemical Characterization","authors":"Sushant Kumar, N. Madhav, A. Verma, K. Pathak, S. Pandey","doi":"10.47752/SJMH.41.32.39","DOIUrl":"https://doi.org/10.47752/SJMH.41.32.39","url":null,"abstract":"The objective of this research was to isolate the biomaterial from Juglans regia and explore its different inbuilt polymeric properties by performing different physico-chemical analysis. As we know there are a number of polymers available and frequently used in design and delivery of novel drug targeting tool or carrier systems. But isolated biomaterial from natural source have proved about their novelistic different properties like biodegradable, bioretardant, bioadhesive, filmability etc. These properties are the key factor in design the novel drug targeting tool. So these polymeric properties identified in the natural source biomaterials have drawn the attention of researchers. So in this study the isolated biomaterial was subjected to various physicochemical evaluations along with spectral analysis including UV, FT-IR, Mass and 1H NMR, SEM, rheological characteristics and cell-line toxicity study The isolated biomaterial was found tom be polymeric in nature having a numerous functional properties. On the basis of its inbuilt polymeric properties, the biomaterial isolated from Juglan regia seed, can be used as an alternative to available standard polymers at very economical scale. The isolated biopolymer consisted of a unique polymeric properties similar to available standard polymers.","PeriodicalId":93143,"journal":{"name":"Sumerianz journal of medical and healthcare","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41904363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimalarial Drugs and COVID -19","authors":"M. Builders, J. Simeon, T. Ogundeko, P. Builders","doi":"10.47752/SJMH.312.111.116","DOIUrl":"https://doi.org/10.47752/SJMH.312.111.116","url":null,"abstract":"The coronavirus disease 2019 (COVID-19) is a novel virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that is ravaging the world. Therefore, the need to find new preventive and therapeutic drug at the earliest possible time additionally to the implementation of preventive measures such as early detection, isolation and treatment of cases as well as minimization of transmission through physical interaction. Moreover, specific vaccines and yet effective treatment that target the 2019. This review focuses on the use of antimalarial drugs as therapeutics interventions for COVID-19.","PeriodicalId":93143,"journal":{"name":"Sumerianz journal of medical and healthcare","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45078242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalities About Caring Mental Illness and Impact on Family Caregivers in Chinese Community: A Ten Years Narrative Review Study","authors":"Balthazar Nkundimana, L. Kuang, F. Gao, Xiaoming Xu","doi":"10.31124/advance.13273253","DOIUrl":"https://doi.org/10.31124/advance.13273253","url":null,"abstract":"Background: Worldwide, the burden of mental health is increasing day by day. The WHO alerts countries that diseases caused by mental health will occupy the second rank on the rest of non-communicable diseases. The increase of mental diseases is always associated with the increase of multiple challenges in primary caregivers who are mostly family members of the patient. China is one of nations with high prevalence of mental health disorders. Like many other countries caregiving mental health in china would have challenges and opportunities. This study aimed to narratively combine studies on family caregivers of psychiatric illness in China thereby making an objective conclusion Methods: A matrix method was narratively used in this study. Studies conducted in Chinese community which includes studies in main land China, Hong Kong and Taiwan conducted in the period between 2008-2019 were considered. 47 studies were considered for analysis and five main themes were found for consideration. Results: The findings in this study are summarized in the following themes 1. High burden and burnout of care and influencing factors, 2. The high stigma of caregivers 3. The low quality of life of caregivers 4. the social support. 5. Care and intervention for caregivers of psychiatric disorders. Conclusion: caregivers of psychiatric illness in Chinese community face challenges that are in some cases different to the rest of the world however there are many similarities with the rest of the world that are found. To overcome these challenges, all parties are called to play its assigned role in the eradication of these challenges. There is a need of strengthening the available opportunities and the common understanding of the problem is required in Chinese community.","PeriodicalId":93143,"journal":{"name":"Sumerianz journal of medical and healthcare","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49485183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network-Centric Identification of Disease Co-Occurrences: A Systems Biology Approach","authors":"Tammanna R. Sahrawat, D. Talwar","doi":"10.47752/sjmh.311.103.110","DOIUrl":"https://doi.org/10.47752/sjmh.311.103.110","url":null,"abstract":"Complex diseases that occur by perturbations of molecular pathways and genetic factors result in pathophysiology of diseases. Network-centric systems biology approaches play an important role in understanding disease complexity. Diabetes, cardiovascular disease and depression are such complex diseases that have been reported to be comorbid in various epidemiological studies but there are no reports of the genetic and underlying factors which may be responsible for their reported co-occurrences. The present study was undertaken to investigate the molecular factors responsible for co-occurrence of diabetes, depression and cardiovascular disease using in-silico network systems biology approach. Genes common amongst these three diseases were retrieved from DisGeNET, a database of human diseases and their interactions were retrieved from STRING database. The resulting network containing 99 nodes (which represent genes) and 1252 edges (which represent various interactions between nodes) was analyzed using Cytoscape v: 3.7.2 and its various plug-ins i.e. ClusterONE, Cytohubba, ClueGO and Cluepedia. The hub genes identified in the present study namely IL1B, VEGFA, LEP, CAT, CXCL8, PLG, IL6, IL10, PTGS2, TLR4 and AKT1 were found to be enriched in various metabolic pathways and several mechanisms such as inflammation. These genes and their protein products may act as potential biomarkers for early detection of predisposition to diseases and potential therapeutic targets based on the common molecular underpinnings of co-occurrence of diabetes, depression and cardiovascular disease.","PeriodicalId":93143,"journal":{"name":"Sumerianz journal of medical and healthcare","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48629095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Vernonia Amygdalina on Plasma Lipid Profile, Liver and Kidney Enzymes in Rats with Streptozotocin-Induced Diabetes","authors":"Gabriel Olukayode Ajayi, Elvis Uchechukwu Obi, Elizabeth Namesegua Elegbeleye, Precious Titilayo Obayemi, Oyindamola Mary Edamisan","doi":"10.47752/sjmh.311.93.102","DOIUrl":"https://doi.org/10.47752/sjmh.311.93.102","url":null,"abstract":"Diabetes mellitus is a non-communicable disease which has been associated with liver and kidney injuries, and at the same time affects lipid profiles. The aim of this study was to investigate the role of Vernonia amygdalina (VAM) on plasma lipid profile, liver and kidney enzymes in rats with streptozotocin -induced diabetes. Twenty-five male albino wistar rats weighing between 137 and 223 g were randomly grouped into five of five rats per group as follows: control, diabetic, diabetic + metformin (MET), diabetic + VAM at 150, 300 mg/kg. Diabetes was induced by administration of 45 mg/kg body weight streptozotocin (STZ) dissolved in citrate buffer (0.01 M, pH 4.5) by single intraperitoneal injection. Three days after, when diabetes was confirmed, MET and VAM were administered daily by oral gavage for 7 days. Animals were fasted overnight after the last administration of MET and VAM, sacrificed, blood was collected and plasma prepared for lipid profile estimation. Liver and kidney were collected, weighed, homogenized and supernatants obtained for enzymes and biochemical assays. There were no significant (p>0.05) change in the weights of animal, liver and kidney, liver/rat and kidney/rat ratios, plasma cholesterol (CHOL) concentration, activities of liver and kidney aspartate aminotransferase (AST), alanine aminotransferase (ALT), liver gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), and liver and kidney total protein (TPRO) concentrations; significant (p<0.05) decrease in triglyceride (TRIG), high density lipoprotein-cholesterol (HDL), low density lipoprotein-cholesterol (LDL), very low density lipoprotein-cholesterol (VLDL); and significant (p<0.05) increase in fasting blood glucose (FBG) level, kidney GGT, LDH activities, liver and kidney creatinine (CREA) and total bilirubin (TBIL) concentrations of diabetic (STZ) rats compared with normal control. The treatment of the diabetic rats with MET and VAM significantly modulated positively these parameters compared with the diabetic rats. This study further explains the protective role played by VAM in dyslipidaemia, liver and kidney injuries resulting from diabetes.","PeriodicalId":93143,"journal":{"name":"Sumerianz journal of medical and healthcare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42292274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Real-World Outcomes of Recurrent Kawasaki Disease","authors":"T. Nakada","doi":"10.47752/sjmh.310.87.92","DOIUrl":"https://doi.org/10.47752/sjmh.310.87.92","url":null,"abstract":"Studies have shown that recurrent Kawasaki disease (KD) is a risk factor for resistance to initial intravenous immunoglobulin (IVIG) therapy and development of coronary artery lesions (CALs). However, current real-world outcomes of recurrent KD patients remain unclear. The objective of this retrospective study was to elucidate the outcomes of recurrent KD patients in the era of 2 g/kg IVIG therapy. Data were included from 201 KD patients who underwent acute-phase treatment from January 2009 to September 2020, with 184 (91.5%) receiving 2 g/kg IVIG therapy. The patients were divided into 7 with (recurrent group) and 194 without (nonrecurrent group) recurrent KD. At the first onset, the rates of initial IVIG therapy resistance (28.6% vs. 21.5%, P = 1.000), rescue therapy (14.3% vs. 14.4%, P = 1.000), and CALs (0.0% vs. 2.6%, P = 1.000) were similar between the recurrent and nonrecurrent groups. The rates of initial IVIG therapy resistance (14.3% vs. 21.5%, P = 1.000), rescue therapy (14.3% vs. 14.4%, P = 1.000), and CALs (0.0% vs. 2.6%, P = 1.000) were also similar between the recurrent group at the second onset and the nonrecurrent group at the first onset. KD recurrence may no longer be a risk factor for developing CALs in the era of 2 g/kg IVIG therapy, unless CALs appear at the initial episode.","PeriodicalId":93143,"journal":{"name":"Sumerianz journal of medical and healthcare","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44163742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Enhanced Recovery Pathway on Hysterectomy Complications in Suez Canal University Hospital and General Hospital at Ismailia City","authors":"Heba Ahmed Galal Atia, Eman Ahmed Keshk, Inas Mohamed Abd-Allah","doi":"10.47752/sjmh/310.77.86","DOIUrl":"https://doi.org/10.47752/sjmh/310.77.86","url":null,"abstract":"Background: The enhanced recovery pathway concept emerged as a multimodal approach directed at optimizing the patient experience, standardizing perioperative care, and improving surgical outcomes. Aim: to evaluate the effect of enhanced recovery pathway on hysterectomy complications for women in Suez Canal University Hospital and General Hospital in Ismailia City. Design: - A quasi-experimental study design was used in this study. Sample: - convenient sample consist of 132 women undergoing hysterectomy operation. Tool: - Structured interviewing questionnaire included questions personal and socio-demographic characteristics and -Obstetric, gynecological, surgical history and follow up assessment checklist. Results: - the majority of women in two groups were complained from bleeding (65.2% in control group and 60.6% in study group). 54.5 % of control group and 42.4% of study group had fibroid as a medical diagnosis. The highest frequency women (60.6% in control group and 43.9% in study group) had 1-6 month as time of current complained. The women in the study group were less likely to suffer from complications as fever, vaginal prolapse and pneumothorax compared to those in control group. Differences observed are statistically significant P= (0.023, 0.049, 0.004). Conclusion: The result of the study concluded that women undergoing hysterectomy operation who received enhanced recovery pathway protocol were more likely to decrease the incidence of post-operative complications than women who didn’t. Recommendation: - Health care settings should emphasize the importance of coordination between health care members relating to the application of the evidenced key elements of enhanced recovery pathway management regarding hysterectomy.","PeriodicalId":93143,"journal":{"name":"Sumerianz journal of medical and healthcare","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44613423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Enhanced Recovery Pathway on Hysterectomy Complications in Suez Canal University Hospital and General Hospital at Ismailia City","authors":"Heba Ahmed Galal Atia, Eman Ahmed Keshk, I. M. Abd-Allah","doi":"10.47752/sjmh.310.77.86","DOIUrl":"https://doi.org/10.47752/sjmh.310.77.86","url":null,"abstract":"Background: The enhanced recovery pathway concept emerged as a multimodal approach directed at optimizing the patient experience, standardizing perioperative care, and improving surgical outcomes. Aim: to evaluate the effect of enhanced recovery pathway on hysterectomy complications for women in Suez Canal University Hospital and General Hospital in Ismailia City. Design: - A quasi-experimental study design was used in this study. Sample: - convenient sample consist of 132 women undergoing hysterectomy operation. Tool: - Structured interviewing questionnaire included questions personal and socio-demographic characteristics and -Obstetric, gynecological, surgical history and follow up assessment checklist. Results: - the majority of women in two groups were complained from bleeding (65.2% in control group and 60.6% in study group). 54.5 % of control group and 42.4% of study group had fibroid as a medical diagnosis. The highest frequency women (60.6% in control group and 43.9% in study group) had 1-6 month as time of current complained. The women in the study group were less likely to suffer from complications as fever, vaginal prolapse and pneumothorax compared to those in control group. Differences observed are statistically significant P= (0.023, 0.049, 0.004). Conclusion: The result of the study concluded that women undergoing hysterectomy operation who received enhanced recovery pathway protocol were more likely to decrease the incidence of post-operative complications than women who didn’t. Recommendation: - Health care settings should emphasize the importance of coordination between health care members relating to the application of the evidenced key elements of enhanced recovery pathway management regarding hysterectomy.","PeriodicalId":93143,"journal":{"name":"Sumerianz journal of medical and healthcare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70925319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hazard Exposure with Health and Safety Outcomes Hinder the Work Ability of Salt Farm Workers in Thailand.","authors":"Pimpan Silpasuwan,&nbsp;Dusit Sujirarat,&nbsp;Pornpimol Kongtip,&nbsp;Sukhontatip Inbamrung,&nbsp;Susan Woskie","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Unsafe environments and occupational hazards have been documented and are contributing to health risks for salt farm workers in Thailand. Whether exposures with various health hazards and outcomes affect work ability among these workers is uncertain. This study aimed to examine the effects of hazard exposures with health risks and outcomes, including accidents, for work ability among salt farm workers.</p><p><strong>Methods: </strong>A cross-sectional study was completed with 120 salt farm workers recruited from the largest salt farm company in Samutsakorn Province during January and February 2014. Face to face interviews were conducted using a structured questionnaire comprised of worker characteristics, working conditions, safety and health problems related to work, and a work ability index (questionnaire reliability =0.84) through a worksite visit. The MIMIC model was used to determine direct and indirect causal effects of work-related health hazards and outcomes on work ability.</p><p><strong>Results: </strong>Among 120 salt farmers, 61% were female and 77% had primary educations. Average age and work experience was 49.5 years (SD = 13.7) and 23.7 years (SD = 13.5), respectively. 66% worked more than 5 days per week and 21.3% had at least one accident in the past 3 months. The results of structure equation analysis revealed that healthy skin was related to heat exposure (β=.35, p=.01) and directly influenced work ability (β=.37, p=.01), Eye irritation was influenced by length of work time (β=.24, p=.05), and harmonized the predictive value of the model at a high level (χ²=94.51, df=73, p-value =0.05, χ²/df=1.29. RMSEA= 0.066).</p><p><strong>Conclusion: </strong>Results for the MIMIC model indicate that two factors, bright sunlight and strong wind exposure over an extended work period, could be having crucial impacts on skin and eye health of salt farm workers. These factors might be protected against using PPE and health examinations with positive health outcomes directly improving work ability. Substantial governmental action with community leadership is needed immediately so action plans are instituted to improve occupational safety and health.</p>","PeriodicalId":93143,"journal":{"name":"Sumerianz journal of medical and healthcare","volume":"2 10","pages":"125-133"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8a/e0/nihms-1626660.PMC7544155.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38477697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}