Open access journal of toxicology最新文献

Heparin-induced Thrombocytopenia: A Narrative Review of Clinical Implications 肝素诱导的血小板减少症：临床意义的叙述性综述

Open access journal of toxicology Pub Date : 2023-05-03 DOI: 10.19080/oajt.2023.05.555668

M. Gomez

{"title":"Heparin-induced Thrombocytopenia: A Narrative Review of Clinical Implications","authors":"M. Gomez","doi":"10.19080/oajt.2023.05.555668","DOIUrl":"https://doi.org/10.19080/oajt.2023.05.555668","url":null,"abstract":"Heparin-induced thrombocytopenia is a rare immune-mediated complication of heparin therapy, characterized by a decrease in platelet count by more than 50% of the baseline. Typically occurs between 5 to 10 days after the initiation of heparin. Incidence in the United States ranges from 0.2% to 3.0%, depending on the population studied and the diagnostic criteria used. HIT has been categorized into two types: HIT type I and II. While HIT type I is a benign, non-immune mediated response presenting with mild self-limited thrombocytopenia, HIT type II is a severe, immune-mediated, potentially fatal complication that requires urgent diagnosis and management. Moreover, Type II is the most common form of HIT. Signs and symptoms may include a sudden onset of pain, redness, and swelling or ecchymosis in extremities. For diagnosis, the 4Ts score is a widely used clinical scoring system that can help assess the probability of HIT based on the timing of thrombocytopenia onset, degree of thrombocytopenia, presence of thrombosis, and other clinical factors. Diagnostic confirmation can be pursued with the help of immunoassays or functional assays such as ELISA and/or SRA. The first step in managing HIT is to discontinue all heparin exposure. Secondly, non-heparin anticoagulation medication must be initiated quickly. As a final step, it may be necessary to switch from parenteral to oral anticoagulation following the resolution of HIT.","PeriodicalId":93132,"journal":{"name":"Open access journal of toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42129822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemokine Ligand 2 – Chemokines Receptor 2 As A Noval Drug Target 趋化因子配体2-趋化因子受体2作为新的药物靶点

Open access journal of toxicology Pub Date : 2022-11-02 DOI: 10.19080/oajt.2022.05.555665

Kinjal S. Gamit

引用次数: 0

Advances in Lipotoxicity Research on Hepatocellular Carcinoma 肝细胞癌脂肪毒性研究进展

Open access journal of toxicology Pub Date : 2022-06-23 DOI: 10.19080/oajt.2022.05.555664

Quanjun Wang

引用次数: 0

Ischemia-modified Albumin as a Marker of Coronary Ischemia in Acute Organophosphorus-poisoned Patients: a Case-Control Study in Mansoura University Poison Unit 缺血修饰白蛋白作为急性有机磷中毒患者冠状动脉缺血的标志物:曼苏拉大学中毒单元的病例对照研究

Open access journal of toxicology Pub Date : 2022-06-20 DOI: 10.19080/oajt.2022.05.555663

引用次数: 0

The Repercussions of Corona Virus-Related Disorders in Women Having a Neurologic Impact 女性冠状病毒相关疾病对神经系统的影响

Open access journal of toxicology Pub Date : 2022-05-24 DOI: 10.19080/oajt.2022.05.555660

Saravanakumar Kasimbedu

引用次数: 0

High-Dose Poisoning, “Body Packers” Case That Ended in An Emergency: A Case Report 高剂量中毒，以紧急情况结束的“尸体包装者”案件:案件报告

Open access journal of toxicology Pub Date : 2021-12-16 DOI: 10.19080/oajt.2021.05.555659

A. Çakır

{"title":"High-Dose Poisoning, “Body Packers” Case That Ended in An Emergency: A Case Report","authors":"A. Çakır","doi":"10.19080/oajt.2021.05.555659","DOIUrl":"https://doi.org/10.19080/oajt.2021.05.555659","url":null,"abstract":"“Body Packing” refers to the condition of being concealed in the anus or vagina (insertion into the body), filling the body (swallowing) for international illegal drug trafficking [1-3]. The first case of body packing was reported in the literature in 1973, with a case who swallowed a cannabis-filled condom and was hospitalized due to intestinal obstruction [4]. It is frequently observed that people with low socioeconomic level, youngmiddle age group and frequently low addiction level are users or non-users [5]. In addition, there was an increase in the types of substances carried and improvements in the form of substance packaging in body carrier. Body transport has become a major phenomenon with airline transport, as the customs still do not have the technology to detect this situation and a large amount of drug trafficking can be done at a time. The most common death in “body packing” cases is the result of acute toxicity occurring at high doses due to rupture of the packs. In addition, acute toxicity can be seen because the packages are semi-permeable. Deaths are rarely reported in the literature due to mechanical complications other than poisoning [4-6]. Therefore, it is necessary to diagnose these patients and start treatment as soon as possible. Radiological imaging has an important role in detecting body packages in drug carriers [7].","PeriodicalId":93132,"journal":{"name":"Open access journal of toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46040368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heavy Metal Toxicity in Ayurvedic Drug Formulated using Tinospora cordifolia (Giloy) – An Approach to Probe the Veracity Behind the Blanket Assertions 用丁香菇(Giloy)配制的阿育吠陀药物中的重金属毒性——探究地毯式断言背后的真实性的方法

Open access journal of toxicology Pub Date : 2021-10-28 DOI: 10.19080/oajt.2021.05.555657

Shan Sasidharan

引用次数: 0

Initial Assessment of the Minamata Convention on Mercury in Dentistry in Senegal 塞内加尔牙科汞问题水俣公约的初步评估

Open access journal of toxicology Pub Date : 2021-09-23 DOI: 10.19080/oajt.2021.05.555656

A. Touré

引用次数: 0

Mitochondrial Toxicity can be Assessed by Measuring Mitochondrial Membrane Potentials at Single Cell Level 线粒体毒性可以通过在单细胞水平上测量线粒体膜电位来评估

Open access journal of toxicology Pub Date : 2021-08-31 DOI: 10.19080/oajt.2021.05.555654

S. Ozcelik

引用次数: 0

Clinical And Evolutive Characteristics in Acute Toxic Methemoglobinemia in Children 儿童急性中毒性高铁血红蛋白血症的临床和进化特点

Open access journal of toxicology Pub Date : 2021-07-02 DOI: 10.19080/oajt.2021.05.555652

Gabriela Viorela Nitescu

引用次数: 0