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Herbal Medicine for Cancer Treatment: Main Force or Supplement? 中药治疗癌症:主力还是辅助?
Novel approaches in cancer study Pub Date : 2020-04-06 DOI: 10.31031/NACS.2020.04.000587
W. Ho
{"title":"Herbal Medicine for Cancer Treatment: Main Force or Supplement?","authors":"W. Ho","doi":"10.31031/NACS.2020.04.000587","DOIUrl":"https://doi.org/10.31031/NACS.2020.04.000587","url":null,"abstract":"The Estimated numbers of new cancer cases and deaths in 2020 will be an estimated. 1.8 million new cancer cases diagnosed and 606,520 cancer deaths in the United States and there were 17 million new cases of cancer worldwide in 2018 [1]. The four most common cancers occurring worldwide are lung, female breast, bowel and prostate. A person’s risk of developing cancer depends on different factors, including age, genetics, and exposure to some potentially known carcinogens and those which are believed to be carcinogenic. Some avoidable lifestyle factors including smoking can increase cancer risk. However, cancer risk factors are similar worldwide. Insufficient exercise, alcohol, imbalanced diet, and obesity, and various infections account for a considerable proportion of cancers worldwide. Prevalence of any one of the risk factors varies in different ethnic groups and can vary by region and country, which contributes to variation of cancer incidence rates of the common types of cancer worldwide.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46487761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Brain Metastases Using the Current Predictive Models: Is the Problem Solved? 使用当前预测模型治疗脑转移瘤：问题解决了吗？
Novel approaches in cancer study Pub Date : 2020-03-19 DOI: 10.31031/NACS.2020.04.000586
E. Abdelaal, Katie Delahunty
{"title":"Treatment of Brain Metastases Using the Current Predictive Models: Is the Problem Solved?","authors":"E. Abdelaal, Katie Delahunty","doi":"10.31031/NACS.2020.04.000586","DOIUrl":"https://doi.org/10.31031/NACS.2020.04.000586","url":null,"abstract":"Brain metastases from solid tumours are the most common intracranial tumours [1] and it occur in 40% of patients with cancer [2]. The most common primary tumours that metastasize to the brain are lung(40%),breast (25%) and melanoma (20%) [3]. The incidence is expected to be on the increase, due to improved survival, with use of modern cytotoxic drugs, targeted therapy, immunotherapy and modern radiotherapy techniques, in addition to greater use of magnetic resonance imaging of the brain. Brain metastases are common in the elderly, defined as above 60 years [4], and the interval between diagnosis of the primary and the development of brain metastases is variable, however some reported an average of 19 months [5] and adenocarcinoma is the commonest histology that metastasizes to the brain [6].","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47766021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Oxidative Stress in Cancer 氧化应激在癌症中的作用
Novel approaches in cancer study Pub Date : 2020-03-19 DOI: 10.31031/nacs.2020.04.000585
K. Dasari, Chikezie O Madu, Yi Lu
{"title":"The Role of Oxidative Stress in Cancer","authors":"K. Dasari, Chikezie O Madu, Yi Lu","doi":"10.31031/nacs.2020.04.000585","DOIUrl":"https://doi.org/10.31031/nacs.2020.04.000585","url":null,"abstract":"Oxidative stress has increasingly been considered a factor in numerous diseases and cancers because of its extensive presence throughout the body. Reactive Oxygen Species (ROS), generated continuously from oxidative phosphorylation and received from various exogenous sources, are constantly used as a key molecule","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46411920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Changing Landscape of Cholangiocarcinoma 胆管癌的发展前景
Novel approaches in cancer study Pub Date : 2020-03-06 DOI: 10.31031/nacs.2020.04.000584
A. Saharia
{"title":"Changing Landscape of Cholangiocarcinoma","authors":"A. Saharia","doi":"10.31031/nacs.2020.04.000584","DOIUrl":"https://doi.org/10.31031/nacs.2020.04.000584","url":null,"abstract":"The annual incidence of cholangiocarcinoma in the United States from 2001 to 2015 was 1.26 per 100,000 people per year. The incidence rates have increased over this time period, specifically for intrahepatic cholangiocarcinoma. According to the SEER data base, the average 5-year survival rate of localized intra-hepatic cholangiocarcinoma is 24% and that of extrahepatic is 15%. Native Americans have the highest incidence in the United States, about 6 times more than non-natives [1]. Occupational exposure to 1, 2 DCP and or dichloromethane has been documented in people working in the printing industry in Japan [2]. Chlonorchis Sinensis, oriental liver fluke; Opisthorchis Viverrini as well as chronic hepatolithiasis increase chance of developing the disease [3].","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46759740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Immunosuppressive Significance of Lactate Dehydrogenase (LDH) Blood Levels in Metastatic Cancer Patients 癌症转移患者血清乳酸脱氢酶水平的免疫抑制意义
Novel approaches in cancer study Pub Date : 2020-03-05 DOI: 10.31031/nacs.2020.04.000583
P. Lissoni
{"title":"The Immunosuppressive Significance of Lactate Dehydrogenase (LDH) Blood Levels in Metastatic Cancer Patients","authors":"P. Lissoni","doi":"10.31031/nacs.2020.04.000583","DOIUrl":"https://doi.org/10.31031/nacs.2020.04.000583","url":null,"abstract":"In addition to the well-known negative prognostic significance of the abnormally high blood levels of lactate dehydrogenase LDH in most neoplasms, more recently it has been shown that the evidence of abnormally low values of lymphocyte-to-monocyte ratio (LMR) may also predict a poor prognosis in human tumors. On these bases, a preliminary study was carried out to evaluate which relationship may occur between LMR and LDH levels in metastatic cancer patients. The study included 100 metastatic solid tumor patients. Breast, lung and gastrointestinal tract tumors were the neoplasms most frequent in our patients. levels showed significantly lower values of LMR. Since the occurrence of low LMR values is the expression of an immunosuppressive status, the association between LDH high levels and low LMR values would suggest that LDH may predict a poor prognosis in metastatic cancer not only by reflecting tumor extension, but also for its potential immunosuppressive status.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46873535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Third Ventricle’s Chordoid Gliomas 第三脑室脊索样胶质瘤
Novel approaches in cancer study Pub Date : 2020-01-13 DOI: 10.31031/NACS.2020.04.000579
B. Saberi
{"title":"Third Ventricle’s Chordoid Gliomas","authors":"B. Saberi","doi":"10.31031/NACS.2020.04.000579","DOIUrl":"https://doi.org/10.31031/NACS.2020.04.000579","url":null,"abstract":"This is a brief review on the Third Ventricle’s Chordoid Gliomas and their pathogenesis. Chordoid gliomas of the third ventricle are histologically characterized by chordoma-like features. These rare tumors can be seen mostly in the adult patients group specifically in the women population. These solid tumors are well-circumscribed which are adhered to the wall of the third ventricle [1]. Their location is in the anterior part of the third ventricle. These glioma tumors may be extended to reach the suprasellar region. Also, they may cause a hydrocephalus which is obstructive in nature. Regarding differential diagnosis for chordoid glioma, chordoid meningioma and chordoma should be of notice [2]. Chordomas contain physaliphorous cells. They also stain positive for cytokeratins. CD34 and lack of immunoreactivity for Glial fibrillary acidic protein, can also be seen in these tumors. These findings differentiate chordomas from gliomas Chordoid meningiomas show some meningeal features like psammoma bodies and whorl formation. Also, cordoid meningiomas are negative for CD34 and Glial fibrillary acidic protein and positive for Epithelial Abstract Chordoid gliomas are low grade tumors which are most commonly seen in women and in the adult popu-lation. Clinical signs and symptoms of these tumors are mostly related to hydrocephalus which is obstructive in nature. Headache, nausea, visual disturbances, imbalances in the endocrine system and autonomic dysfunction can be seen in these tumors. MRI with contrast is the best diagnostic imaging method for such tumors. The best treatment method for such tumors would be complete surgical resection. In case of incomplete resection, the prognosis can be poorer in comparison with complete surgical resection.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43997676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On The Mechanism of Human Carcinogenesis 论人类致癌机制
Novel approaches in cancer study Pub Date : 2020-01-12 DOI: 10.31031/nacs.2022.06.000646
D. Dix
{"title":"On The Mechanism of Human Carcinogenesis","authors":"D. Dix","doi":"10.31031/nacs.2022.06.000646","DOIUrl":"https://doi.org/10.31031/nacs.2022.06.000646","url":null,"abstract":"","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43156384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glioblastoma: Targeting Angiogenesis and Tyrosine Kinase Pathways. 胶质母细胞瘤:靶向血管生成和酪氨酸激酶途径。
Novel approaches in cancer study Pub Date : 2020-01-01 Epub Date: 2020-05-29
Ali S Arbab, Meser M Ali
{"title":"Glioblastoma: Targeting Angiogenesis and Tyrosine Kinase Pathways.","authors":"Ali S Arbab,&nbsp;Meser M Ali","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Angiogenesis is a hallmark of glioblastoma (GBM) and remains an important therapeutic target in its treatment, especially for recurrent GBM. GBMs are characterized by the release of vascular endothelial growth factor (VEGF), an important regulator and promoter of angiogenesis. Therefore, antiangiogenic therapies (AATs) targeting VEGF or VEGF receptors (VEGFRs) were designed and thought to be an effective tool for controlling the growth of GBM. However, recent results of different clinical trials using humanized monoclonal antibodies against VEGF (bevacizumab), as well as tyrosine kinase inhibitors (TKIs) that target different VEGFRs alone or in combination with other therapeutic agents demonstrated mixed results, with the majority of reports indicating that GBM developed resistance against antiangiogenic treatments.</p>","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":"4 5","pages":"398-401"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486014/pdf/nihms-1621465.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38375200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Detection of Epstein Barr Virus, Human Papilloma Virus Types 16,18 in Breast Cancer Patients in Khartoum State Sudan 苏丹喀土穆癌症患者中16、18型人乳头瘤病毒、EB病毒的分子检测
Novel approaches in cancer study Pub Date : 2019-12-09 DOI: 10.31031/nacs.2019.04.000576
Khalid A Enan
{"title":"Molecular Detection of Epstein Barr Virus, Human Papilloma Virus Types 16,18 in Breast Cancer Patients in Khartoum State Sudan","authors":"Khalid A Enan","doi":"10.31031/nacs.2019.04.000576","DOIUrl":"https://doi.org/10.31031/nacs.2019.04.000576","url":null,"abstract":"","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47900942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Detection of Epstein Barr Virus, Human Papilloma Virus Types 16,18 in Breast Cancer Patients in Khartoum State Sudan 苏丹喀土穆州乳腺癌患者Epstein Barr病毒、人乳头瘤病毒16、18型的分子检测
Novel approaches in cancer study Pub Date : 2019-12-09 DOI: 10.31031/nacs.2019.03.000576
K. Enan
{"title":"Molecular Detection of Epstein Barr Virus, Human Papilloma Virus Types 16,18 in Breast Cancer Patients in Khartoum State Sudan","authors":"K. Enan","doi":"10.31031/nacs.2019.03.000576","DOIUrl":"https://doi.org/10.31031/nacs.2019.03.000576","url":null,"abstract":"Results: The results show that eight out of 70 patients were positive for EBV virus (11.4%) Of these positive patients, 3(4.2%) were 30-50, 3(4.2%) were 51-80 and 2(2.8%) were 81-100 years old, respectively. Seven out of the 70 patients were positive for HPV type 18(10%). Of these positive patients, 5 (7.1%) were 30-50years old and 2 (2.9%) were 50-80 years old. None of the patients were found positive for HPV type 16. No significant differences were found between age groups as regards infection by EBV or HPV type 18 viruses.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47847471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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