Novel approaches in cancer study最新文献_第5页

Targeting Bombesin Peptide Receptors for Cancer Imaging: Perspective in Prostate, Lung and Breast Cancer 靶向炸弹素肽受体用于癌症成像:前列腺癌、肺癌和乳腺癌的前景

Novel approaches in cancer study Pub Date : 2020-10-09 DOI: 10.31031/NACS.2020.05.000611

Raunak Varshney

{"title":"Targeting Bombesin Peptide Receptors for Cancer Imaging: Perspective in Prostate, Lung and Breast Cancer","authors":"Raunak Varshney","doi":"10.31031/NACS.2020.05.000611","DOIUrl":"https://doi.org/10.31031/NACS.2020.05.000611","url":null,"abstract":"One of the main reasons for focus on these particular cancer as prostate and breast cancers are the most common types cancer in men and women respectively. However small and non-small cell lung cancer are most frequent in both. The molecular basis for the utility of radiopeptides is due to their peptide receptor over expression by certain tumours [1]. Peptides are more important elements in fundamental biological processes due to their specificity for controlling various biological functions through their specific receptors naturally. The increased attention for peptides or their receptors for imaging cancer is due to their expression/over expression in many primary human cancers and their ability to target specific receptor. The clinical impact of radiolabelled peptides has been observed in theranostics by diagnosis of location of tumours and their metastases by receptor scintigraphy and by facilitating receptor radiotherapy of tumours for treatment. However, the research on peptide based radioligand seems to be slight aperture in the huge oncological area, but the receptor targeting by short peptide of over expressed receptors in tumours has become very important for cancer imaging [2].","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41918598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Interim Breast Cancer Care during the COVID-19 Pandemic 新冠肺炎大流行期间的癌症临时护理

Novel approaches in cancer study Pub Date : 2020-09-30 DOI: 10.31031/NACS.2020.05.000610

Savan Shah

引用次数: 0

Immune-Metabolic Stress in Purulent-Inflammatory Diseases of the Skin and Soft Tissues 皮肤和软组织化脓性炎症性疾病的免疫代谢应激

Novel approaches in cancer study Pub Date : 2020-09-28 DOI: 10.31031/NACS.2020.05.000615

Zemskov Vm, R. ASh, Zemskov Am, V. Zoloedov, Chernitsyn, Zemskova Va, Peleshenko Ei, NeymannV, Pronko Kn

{"title":"Immune-Metabolic Stress in Purulent-Inflammatory Diseases of the Skin and Soft Tissues","authors":"Zemskov Vm, R. ASh, Zemskov Am, V. Zoloedov, Chernitsyn, Zemskova Va, Peleshenko Ei, NeymannV, Pronko Kn","doi":"10.31031/NACS.2020.05.000615","DOIUrl":"https://doi.org/10.31031/NACS.2020.05.000615","url":null,"abstract":"It is known that metabolic processes include free radical oxidations (ROS), which provide cells with energy to prepare plastic material, participate in the metabolism of carbohydrates, lipids, proteins, nucleic acids. ROS leads to the formation of primary (diene conjugate [DC], ketodienes [KD]) and secondary (malonic dialdehyde [MDA], bityrozine crosslinks [BC], Schiff ’s bases [SHB]) and other products that have a positive or negative effect on the biomembrane cells. For the leveling of ROS processes in the body, an endogenous antioxidant defense system (AOD) is developed, which consists of enzymatic and non-enzymatic links. The first group includes superoxide dismutase (SOD), catalase (C), peroxidase (P), glutathion peroxidase (GP), glutathione reductase (GR); to the second, glutathione (GL), alpha-tocopherol (vitamin E, VE), plasma antioxidant activity (AOA), total thiols, non-protein thiols, protein thiols (TT, NPT, PT), etc. [1,2]. It has been established that ROS products mainly implement a suppressive and AOD a modulating effect on the immune reactivity of patients [3]. At the same time, the direct link between immune-metabolic parameters, recognized by all authors is practically not documented [4-7].","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44809233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Current Clinical Applications and Challenges of Circulating Tumor Cells 循环肿瘤细胞的临床应用现状和挑战

Novel approaches in cancer study Pub Date : 2020-09-16 DOI: 10.31031/NACS.2020.05.000607

Shuyang Wang

引用次数: 0

Virtual Reality Technology and 3D Reconstruction in Hepatectomy 虚拟现实技术与肝切除术的三维重建

Novel approaches in cancer study Pub Date : 2020-09-03 DOI: 10.31031/NACS.2020.05.000606

Chengzu Li

引用次数: 0

Breast Cancer: A Public Health Issue that is also Subject of Social Construction 乳腺癌:一个公共卫生问题，也是社会建设的主题

Novel approaches in cancer study Pub Date : 2020-08-28 DOI: 10.31031/nacs.2020.05.000605

C. Ulloa

引用次数: 1

AdoMet Synergistically Enhances the Chemotherapeutic Action of Cisplatin and Improves Drug Efficacy in JHU-SCC-011 Laryngeal Squamous Cell Carcinoma AdoMet协同增强顺铂对JHU-SCC-011喉鳞状细胞癌的化疗作用并提高疗效

Novel approaches in cancer study Pub Date : 2020-08-04 DOI: 10.31031/nacs.2020.05.000603

M. Porcelli

{"title":"AdoMet Synergistically Enhances the Chemotherapeutic Action of Cisplatin and Improves Drug Efficacy in JHU-SCC-011 Laryngeal Squamous Cell Carcinoma","authors":"M. Porcelli","doi":"10.31031/nacs.2020.05.000603","DOIUrl":"https://doi.org/10.31031/nacs.2020.05.000603","url":null,"abstract":"Laryngeal squamous cell carcinoma (LSCC), an epithelial tumor that originates from larynx, is highly aggressive and more than 150.000 new cases are diagnosed each year [1,2]. Alcohol consumption, tobacco use and human papilloma virus (HPV) infections are the main risk factors for these types of cancer [3,4]. The main treatment options are surgery, radiotherapy, targeted therapy, and chemotherapy [1,2]. Despite significant progress in finding potential therapeutic targets to improve survival, mortality is still high. Several studies have focused on the discovery of new molecules, obtained from natural compounds, that demonstrate anticancer and anti-proliferation effect and can be used in combination with conventional chemotherapy agents for LSCC treatment. Among natural compounds, our research group focused its interest on S-adenosyl-L-methionine (AdoMet), a naturally occurring sulfur-containing nucleoside found ubiquitously in all living cells where it functions as the main biological methyl donor. The role of AdoMet in various cellular processes, such as proliferation, differentiation, cell cycle regulation, cell migration and apoptosis has been Abstract","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42594418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Expression and Gene Regulation Network of TFF1 in Esophageal Carcinoma TFF1在食管癌中的表达及其基因调控网络

Novel approaches in cancer study Pub Date : 2020-07-20 DOI: 10.31031/nacs.2020.05.000602

Xiaolong Li

{"title":"Expression and Gene Regulation Network of TFF1 in Esophageal Carcinoma","authors":"Xiaolong Li","doi":"10.31031/nacs.2020.05.000602","DOIUrl":"https://doi.org/10.31031/nacs.2020.05.000602","url":null,"abstract":"TFF1, one member of the trefoil factor family (TFFs), is an antiproteinolytic peptide. Abnormal TFF1 expression is associated with carcinogenesis. In order to investigate the expression of TFF1 in esophageal carcinoma and its potential gene regulatory network. We used sequencing data from the Cancer Genome Atlas database and Gene Expression Omnibus, analyzed TFF1 expression and gene regulation networks in esophageal carcinoma (ESCA). TFF1 expression profiling was analyzed using Oncomine TM, while TFF1 mutation and related functional networks were identified using cBioPortal. Linked Omics was used to identify differential gene expression with TFF1 and to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. We found that TFF1 is overexpressed in ESCA, and deletion is the most common TFF1 mutation type in ESCA, and TFF1 gene mutation may also significantly affect the prognosis of ESCA patients. Functional network analysis showed that TFF1 may play a role in ESCA by participating in NF-κB signaling pathway and Hippo signaling pathway. Our results demonstrate that data mining efficiently reveals information about TFF1 expression and potential regulatory networks in ESCA, laying a foundation for further study of the role of TFF1 in carcinogenesis.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49332545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiotherapy Recommendations in Covid-19 Pandemia: Mini-Review 新冠肺炎大流行病的放射治疗建议：Mini-Review

Novel approaches in cancer study Pub Date : 2020-07-06 DOI: 10.31031/nacs.2020.05.000601

B. Uysal

引用次数: 0

Phytochemicals for Controlling Obesity-Related Cancers 控制肥胖相关癌症的植物化学物质

Novel approaches in cancer study Pub Date : 2020-06-26 DOI: 10.31031/nacs.2020.04.000600

M. Roy

引用次数: 0