AdoMet Synergistically Enhances the Chemotherapeutic Action of Cisplatin and Improves Drug Efficacy in JHU-SCC-011 Laryngeal Squamous Cell Carcinoma

Novel approaches in cancer study Pub Date : 2020-08-04 DOI:10.31031/nacs.2020.05.000603

M. Porcelli

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引用次数: 2

Abstract

Laryngeal squamous cell carcinoma (LSCC), an epithelial tumor that originates from larynx, is highly aggressive and more than 150.000 new cases are diagnosed each year [1,2]. Alcohol consumption, tobacco use and human papilloma virus (HPV) infections are the main risk factors for these types of cancer [3,4]. The main treatment options are surgery, radiotherapy, targeted therapy, and chemotherapy [1,2]. Despite significant progress in finding potential therapeutic targets to improve survival, mortality is still high. Several studies have focused on the discovery of new molecules, obtained from natural compounds, that demonstrate anticancer and anti-proliferation effect and can be used in combination with conventional chemotherapy agents for LSCC treatment. Among natural compounds, our research group focused its interest on S-adenosyl-L-methionine (AdoMet), a naturally occurring sulfur-containing nucleoside found ubiquitously in all living cells where it functions as the main biological methyl donor. The role of AdoMet in various cellular processes, such as proliferation, differentiation, cell cycle regulation, cell migration and apoptosis has been Abstract

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AdoMet协同增强顺铂对JHU-SCC-011喉鳞状细胞癌的化疗作用并提高疗效

喉鳞状细胞癌（LSCC）是一种起源于喉部的上皮肿瘤，具有高度侵袭性，每年诊断出超过150000例新病例[1，2]。饮酒、吸烟和人类乳头状瘤病毒（HPV）感染是这些类型癌症的主要危险因素[3，4]。主要的治疗选择是手术、放疗、靶向治疗和化疗[1，2]。尽管在寻找提高生存率的潜在治疗靶点方面取得了重大进展，但死亡率仍然很高。几项研究的重点是发现从天然化合物中获得的新分子，这些分子具有抗癌和抗增殖作用，可与传统化疗药物联合用于LSCC治疗。在天然化合物中，我们的研究小组将兴趣集中在S-腺苷-L-甲硫氨酸（AdoMet）上，这是一种天然存在的含硫核苷，广泛存在于所有活细胞中，是主要的生物甲基供体。摘要AdoMet在各种细胞过程中的作用，如增殖、分化、细胞周期调节、细胞迁移和凋亡

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Novel approaches in cancer study

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