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Commentary on A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen therapy (TWO2) in the treatment of chronic diabetic foot ulcers: The TWO2 study 一项多国、多中心、随机、双盲、安慰剂对照试验，旨在评估周期性伤口局部氧疗(TWO2)治疗慢性糖尿病足溃疡的疗效:TWO2研究

Medical research and innovations Pub Date : 2019-01-01 DOI: 10.15761/mri.1000165

R. Frykberg

{"title":"Commentary on A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen therapy (TWO2) in the treatment of chronic diabetic foot ulcers: The TWO2 study","authors":"R. Frykberg","doi":"10.15761/mri.1000165","DOIUrl":"https://doi.org/10.15761/mri.1000165","url":null,"abstract":"Topical Oxygen therapy (TOT) in various forms has been used for the treatment of chronic wounds for over fifty years [1-6 ]. Its effectiveness has been disputed despite many positive clinical and animal reports attesting to its benefits towards promoting wound healing. Various delivery mechanisms have been utilized in this regard including continuous delivery of oxygen (CDO) under low or very low Oxygen tensions or Cyclical Pressurized topical delivery generally within a localized extremity chamber. Hyperbaric Oxygen Therapy (HBOT) proponents have long criticized the ability of TOT to have a meaningful effect on wound repair in the absence of systemic delivery of Oxygen [7]. Despite the many inconsistent wound healing clinical studies of HBOT itself [8-13], most criticisms of TOT, notwithstanding the skepticism mentioned above, are due to an extremely limited number of robust high-quality investigations. We therefore performed a study to assess the efficacy of multi-modality cyclical pressure Topical Wound Oxygen (TWO2) homecare therapy in healing refractory diabetic foot ulcers (DFU) that had failed to heal with standard of care (SOC) alone [14].","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Healing comparison of porcine cutaneous incisions made with cold steel scalpel, standard electrosurgical blade, and a novel tissue dissector. 冷钢手术刀、标准电刀和新型组织解剖刀对猪皮肤切口愈合的比较。

Medical research and innovations Pub Date : 2017-10-01 Epub Date: 2017-10-27 DOI: 10.15761/MRI.1000124

Albert Y Wu, Thomas J Baldwin, Bhupendra C Patel, Jeffrey W Clymer, Ryan D Lewis

{"title":"Healing comparison of porcine cutaneous incisions made with cold steel scalpel, standard electrosurgical blade, and a novel tissue dissector.","authors":"Albert Y Wu, Thomas J Baldwin, Bhupendra C Patel, Jeffrey W Clymer, Ryan D Lewis","doi":"10.15761/MRI.1000124","DOIUrl":"https://doi.org/10.15761/MRI.1000124","url":null,"abstract":"Background: Standard electrosurgery provides superior hemostasis compared to a cold steel scalpel, but inferior tissue healing. A novel electrosurgical blade with an advanced waveform, the MEGADYNE ACE BLADE™ 700 Soft Tissue Dissector (ACE), was designed to provide both excellent hemostasis and wound healing. This study compared ACE to scalpel and standard electrosurgery in a porcine model of wound healing.Methods: Skin incisions from six pigs were evaluated at time points of 0, 1, 2, 3 and 6 weeks after application of the three devices. Histopathology was performed on samples from each time point. For each non-initial time point, the healing incisions were photographed for later evaluation by expert graders, and excised for wound strength testing.Results: Time 0 photomicrographs showed a gradient of thermal tissue damage by initial incision, ranging from no damage made by the scalpel, minimal damage made by ACE, and twice the ACE damage made by a nonstick PTFE-coated electrosurgical blade. Histopathologic analysis at 6 weeks showed comparable dermal scar width measurements for scalpel and ACE incisions. Scars were wider for incisions made by standard electrosurgical blade. Wound strength was greater for scalpel and ACE than for standard electrosurgery. Cosmetic results at 6 weeks were not significantly different between scalpel and ACE incisions, while standard electrosurgical blade incisions were significantly inferior to ACE (odds ratio: 53.4, p<0.001).Conclusion: The MEGADYNE ACE BLADE™ 700 Soft Tissue Dissector represents a significant improvement in electrosurgical technology for skin incisions and dispels the traditional concerns of delayed healing and poor cosmetic result that have been attributed to using conventional electrosurgical blades for skin incisions.","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38508341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

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