Medical research and innovations最新文献

{"title":"A commentary on rehabilitation effect of Liuzijue in water on patients with chronic obstructive pulmonary disease in stable period","authors":"Wang Zhenwei","doi":"10.15761/mri.1000158","DOIUrl":"https://doi.org/10.15761/mri.1000158","url":null,"abstract":"","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The updated use of dual HER2 blockade in breast cancer therapy: a project of an institutional experience","authors":"C. Georges, Moujaess Elissar","doi":"10.15761/mri.1000164","DOIUrl":"https://doi.org/10.15761/mri.1000164","url":null,"abstract":"Received: August 24, 2019; Accepted: September 20, 2019; Published: September 23, 2019 According to SEER database, more than 3 million women live with breast cancer worldwide. A recent statistical analysis evaluated the incidence and prevalence of breast cancer in Lebanese women, and revealed that it was the most prevalent cancer in Lebanon, accounting for 20% of all cancer cases, among the highest in the world. The average age-standardized incidence rate over 11 years (2005-2015) was 96.5 per 100,000, with a significantly increasing trend over time [1]. The adherence to the most recent guidelines in the treatment of breast cancer in the Lebanese population is a must, in order to obtain the best outcomes in terms of remission and survival.","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galectins participate in virus infection, friend or foe?","authors":"Wen-Hung Wang, Max R. Chang Ishcol, Chih-Yen Lin, Sheng-Fan Wang","doi":"10.15761/mri.1000154","DOIUrl":"https://doi.org/10.15761/mri.1000154","url":null,"abstract":"","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year clinical evaluation of e.max CAD and LavaTM ultimate laminate veneers with butt joint preparation (Randomized controlled clinical trial)","authors":"Mai Elgendi, Karim Rabie, A. Zaki","doi":"10.15761/mri.1000160","DOIUrl":"https://doi.org/10.15761/mri.1000160","url":null,"abstract":"Purpose: The aim of this clinical study was to evaluate ceramic laminate veneers constructed from Lithium disilicate (IPS e.max CAD), and resin nano-ceramic (Lava UltimateTM CAD/CAM) according to the modified United States of Public Health Service (USPHS) criteria over 12 months. Materials and methods: Twenty-eight ceramic laminate veneers (fourteen for each group) were placed in the Fixed Prosthodontics Department clinics, Faculty of Dentistry, Cairo University by one operator. The restorations were made using CEREC premium 4.4 CAD/CAM software with IPS e.max CAD and Lava UltimateTM CAD/CAM blocks. Modified USPHS criteria were used to evaluate the clinical performance of the restorations. Patient satisfaction were assessed using visual analogue scale. Fisher’s Exact test was used to compare between the two groups. Friedman’s test was used to study the changes by time in each group. Patient satisfaction scores (VAS scores) were presented as median and range values. Results: Regrading marginal adaptation, retention, and fracture, through the whole study period; all restorations in the two groups showed (Alpha) scores. While for marginal discoloration, all surfaces of restorations in the two groups showed (Alpha) scores till 6 months. While after 8, 10 and 12 months; the palatal surface of Lava Ultimate group showed (Bravo) scores. However, there was no statistically significant difference between the two groups after 12 months (P-value = 0.481). The overall satisfaction of restorations was very satisfied by 85.7% and satisfied by 14.3%. Conclusion: Both IPS e.max CAD and Lava Ultimate laminate veneers revealed high successful clinical performance over a period of 12 months follow up. *Correspondence to: Mai M ElGendi, Dentist at ministry of health, Cairo, Egypt, E-mail: mai.eltohami@dentistry.cu.edu.eg","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mice models of NAFLD-related HCC","authors":"Anna Chen, A. Lu, Jin Yang","doi":"10.15761/mri.1000162","DOIUrl":"https://doi.org/10.15761/mri.1000162","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) shows growing tendency across the world, thus requiring the convenient mice models mimic the pathology and pathogenesis of human disease to accelerate the findings of this disease. Herein, we summarized the mice model of NAFLD-HCC recently developed. *Correspondence to: Jin Yang, Translational Medicine Center, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, 310015, China, E-mail: hz_zhiy@163.com","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma treatment with its relation to changes in seasonal metabolism","authors":"Tarun Saxena, Azeema Ozefa Ali, M. Saxena","doi":"10.15761/mri.1000159","DOIUrl":"https://doi.org/10.15761/mri.1000159","url":null,"abstract":"Seasonal asthma/ post viral asthma produces epidemic like condition in developed and developing countries which causes a huge burden to the society socially as well as economically with an increase in morbidity and mortality. This review highlights the preventive steps in controlling seasonal asthma symptoms. *Correspondence to: Tarun Saxena, Department of Internal Medicine, Mittal Hospital and Research Centre, Ajmer, Rajasthan, India, Tel: +91-9829089284, E-mail: yogdiab@gmail.com/info@mittalhospital.com Received: June 07, 2019; Accepted: June 21, 2019; Published: June 24, 2019 Introduction The worldwide incidences of bronchial asthma are increasing. The correlation between metabolism (basal metabolic rate/BMR) and asthma treatment is less clear in the literature due to the presence of multiple risk factors in the causation of asthma. Seasonal variations are also reported in both BMR and asthma [1-7]. Methods Various studies have been used to review the process [1-16]. Results: Studies describe that metabolism changes with environmental temperature and season. It is also found that the asthma epidemic occurs during the change of season i.e. winter to summer, maximum attack rate during spring; and summer to winter, maximum attack rate during autumn/pre-winter. A clear association of asthma exacerbation and exposure to environmental air temperature is found. If environmental temperature opposes existing metabolism e.g. rise in temperature during spring tries to reduce BMR opposite to high BMR of winters and conversely in autumn low BMR of summer is opposed by mild cool air in pre winter. This alteration exacerbates asthma symptoms. In winter and spring, the metabolism remains high and asthma symptoms respond well to substances which increase the metabolic rate, such as clove. In summer and autumn, the metabolism remains low and asthma symptoms respond well to substances which reduce the metabolic rate, like rose petal jam [1,2,3,7]. Conclusion The possible mechanism by which change in metabolism affects inflammation in the tracheobronchial tree seems to involve the respiratory tract, as one of the sites of heat and water release and thermoregulation in the body. During Winter/spring there is a high metabolic state which causes heat preservation in the body along with the respiratory tract. When there is an increase in temperature or any viral exposure then it opposes the existing metabolism of the body which leads to heat or water release in the body as well as in the respiratory tract in the form of inflammation in the respiratory tract with exacerbation of asthmatic symptoms. When such patients are administered hot substances like clove which has properties to increase the body metabolism will revert to its previous metabolism. Thus there will be heat preservation in the body and respiratory tract and decrease in inflammation in the respiratory tract and this, in turn, will help to reduce the symptoms of asthma. During Summer/Autumn there is a l","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary forms of subcortical small vessel disease. The need for registries","authors":"G. Paraskevas, V. Constantinides, E. Kararizou, S. Vassilopoulou, P. Paraskevas, E. Kapaki","doi":"10.15761/mri.1000152","DOIUrl":"https://doi.org/10.15761/mri.1000152","url":null,"abstract":"Hereditary forms of subcortical small vessel disease (SSVD) leading to vascular cognitive impairment (VCI) comprise a heterogeneous group of rare genetic disorders, suitable for the study of the mechanisms and relationship between SSVD and VCI. Since these disorders are rare, better knowledge of their clinical, genetic, imaging and biochemical characteristics may be achievable only through registries which additional may help in better recruitment of patients for studies. A great amount of our current knowledge on these disorders has been gained through registries and data bases. International registries may further help in expanding our experience in epidemiological or even preventive and therapeutic aspects of hereditary SSVD.","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute coronary syndromes and diagnostic methods","authors":"M. Demirel, Ibrahim Donmez, E. Uçaroğlu, A. Yüksel","doi":"10.15761/mri.1000167","DOIUrl":"https://doi.org/10.15761/mri.1000167","url":null,"abstract":"Despite decreased incidence and mortality rates in recent years, coronary heart diseases remain one of the leading causes of death. According to TEKHARF study by the Turkish Cardiology Society, 2 million people have coronary artery disease in Turkey. According to TEKHARF data, cardiovascular diseases are responsible for 45% of all deaths in our country [3]. It is estimated that the number of patients with heart disease will reach 3.4 million if this negative situation, similar to the rates in developed countries, continues [2].","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic withdrawal of bariatric ring with the use of plastic prosthesis – A case report","authors":"Maíra L Schwaab, Victor O Derossi, E. N. Usuy, César Lazzarotto, A. Hofstaetter","doi":"10.15761/mri.1000156","DOIUrl":"https://doi.org/10.15761/mri.1000156","url":null,"abstract":"The silicone ring of Roux-en-Y Gastric Bypass can determine benefits in long-term weight loss [1], but complications occur in about 1% of cases [2]. For example, ring slip, which consists of distal displacement, outside the gastric pouch towards the jejunum, causes secondary compression and symptoms such as post-eating vomiting, food intolerance and even malnutrition [3,4]. The technique for removing the ring by surgery is more frequently used [5], but in this case-report we will describe an endoscopic approach of removal [6,7]. The objective of this case report is to demonstrate the endoscopic technique of gastric ring removal through the use of self-expanding plastic prosthesis.","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of adherence to chronic obstructive pulmonary disease prescribing guidelines- A single centre study","authors":"V. Khalil, A. Hua, S. Lam","doi":"10.15761/mri.1000161","DOIUrl":"https://doi.org/10.15761/mri.1000161","url":null,"abstract":"","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}