International journal of applied biology and pharmaceutical technology最新文献_第2页

A Study on Association of Diabetes Mellitus and Hypertension with Their Demographics and Blood Parameters – A Pilot Study 糖尿病和高血压与人口统计学和血液参数的相关性研究-一项初步研究

International journal of applied biology and pharmaceutical technology Pub Date : 2021-01-01 DOI: 10.26502/ijabpt.202109

Priyanka Singh, S. Saxena, Sanjay Kumar Singh, S. Chandra, A. Chandra, P. Vijay

引用次数: 0

Identification of Crucial Degs and Hub Genes in Focal Segmental Glomerulosclerosis: A Bioinformatics Study 局灶节段性肾小球硬化关键基因和枢纽基因的鉴定:一项生物信息学研究

International journal of applied biology and pharmaceutical technology Pub Date : 2021-01-01 DOI: 10.26502/ijabpt.202112

B. Rai, P. Mishra, Mehar Hasan Asif, Swasti Tiwari

引用次数: 0

Seperation of bioactive compounds from Haemolymph of scarab beetle Scarabaeus sacer (Coleoptera: Scarabaeidae) by GC-MS and determination of its antimicrobial activity 用气相色谱-质谱法分离金龟甲(鞘翅目:金龟甲科)血淋巴中活性物质及其抑菌活性

International journal of applied biology and pharmaceutical technology Pub Date : 2021-01-01 DOI: 10.26502/ijabpt.202113

Nancy Taha Mohamed, Doaa Hassan Abdelsalam, Ahmed Salem El-Ebiarie, M. Elaasser

{"title":"Seperation of bioactive compounds from Haemolymph of scarab beetle Scarabaeus sacer (Coleoptera: Scarabaeidae) by GC-MS and determination of its antimicrobial activity","authors":"Nancy Taha Mohamed, Doaa Hassan Abdelsalam, Ahmed Salem El-Ebiarie, M. Elaasser","doi":"10.26502/ijabpt.202113","DOIUrl":"https://doi.org/10.26502/ijabpt.202113","url":null,"abstract":"This study aimed to investigate the bioactive compounds in the haemolymph of scarab beetle Scarabaeus sacer by using the Gas chromatography–mass spectrometry (GS-MS) analysis. The identification of the bioactive compounds is based on peak area, retention time, molecular formula and molecular weight. There are 129 compounds are detected in the haemolymph of scarab beetle and 43 of them were reported to have a bioactivity. The most analyzed bioactive compounds are alcohols, steroids, fatty acids and terpenoids. The current study also test the antimicrobial activity of scarab beetle haemolymph against gram-negative bacteria (Escherichia coli, Enterobacter cloacae, grampositive bacteria (Staphylococcus aureus, Bacillus subtilis), and fungi (Aspergillus fumigatus and Candida albicans). The haemolymph has highest antibacterial activity against gram negative bacteria Enterobacter cloacae, Int J Appl Biol Pharm 2021; 12 (4): 461-480 DOI: 10.26502/ijabpt.202113 International Journal of Applied Biology and Pharmaceutical Technology Vol. 12 No. 4 December 2021. 462 Escherichia coli respectively and against gram-positive bacteria Bacillus subtilis, Staphylococcus aureus respectively. No antifungal activity has been detected.","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cytotoxicity and Preliminary Analysis of the Pro-apoptotic and Cell Cycle Arrest Effects of Lantana ukambensis Against Colorectal Cancer Cells. 大肠癌细胞的细胞毒性及促凋亡和细胞周期阻滞作用的初步分析。

International journal of applied biology and pharmaceutical technology Pub Date : 2020-01-01 Epub Date: 2020-08-07

Wamtinga Richard Sawadogo, Yun Luo, Bethany Elkington, Tong-Chuan He, Chong-Zhi Wang, Chun-Su Yuan

{"title":"Cytotoxicity and Preliminary Analysis of the Pro-apoptotic and Cell Cycle Arrest Effects of Lantana ukambensis Against Colorectal Cancer Cells.","authors":"Wamtinga Richard Sawadogo, Yun Luo, Bethany Elkington, Tong-Chuan He, Chong-Zhi Wang, Chun-Su Yuan","doi":"","DOIUrl":"","url":null,"abstract":"Lantana ukambensis (Vatke) Verdc. (Verbenaceae) is a seasonal herb widely spread in the West African region. The whole plant is used for the treatment of wounds, infections, and inflammatory pathologies. The purpose of this research is to evaluate the cytotoxicity and to analyze the probable pro-apototic, and cell cycle arrest effects of L. ukambensis methylene chloride extract and its fractions against HCT-116 and HT-29 colorectal cancer cells using preliminary tests in order to highlight the interest of this plant in the search of new anticancer molecules. The dried powder of the whole plant was extracted by methylene chloride maceration for 24 hours and the extract was divided into five fractions. The cytotoxicity of the crude extract and fractions were evaluated by the MTS assay. The most active fractions were subjected to some preliminary assays including crystal violet, Hoechst staining, cell cycle arrest, and annexin V/PI assays on the cancer cells to highlight the probable mechanism of action of these fractions. The methylene chloride, ethyl acetate, and 1-butanol fractions of L. ukambensis crude extract demonstrated significant antiproliferative effects on HCT-116 and HT-29 cell growth with IC50 values ranging between 2 to 15 μg/mL. 1-butanol and ethyl acetate fractions decreased the G1 phase by 20.53% and 28.47% and increased the G2/M by 23.47% and 25.90% respectively on HCT-116. Moreover, 1-butanol fraction increased the cumulative value of apoptotic cells by 49.77% on HCT-116 and ethyl acetate fraction increased this value by 53.37% at 15 μg/mL after 48 hours of exposure. The outcome of this study suggests the potential of 1-butanol and ethyl acetate fractions for the isolation of anticancer molecules against colorectal cancer.","PeriodicalId":93105,"journal":{"name":"International journal of applied biology and pharmaceutical technology","volume":"11 3","pages":"170-187"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38465310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Occurrence of an Intraosseus Squamous Cell Carcinoma in Association with Squamous Odontogenic Tumor of Mandible 罕见的骨内鳞状细胞癌合并下颌骨鳞状牙源性肿瘤

International journal of applied biology and pharmaceutical technology Pub Date : 1900-01-01 DOI: 10.26502/ijabpt.202108

Nilesh D Pardhe, P. Vijay, Manika Arora, N. Mathur

引用次数: 0